In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent (690 views)
Mol Pharm (ISSN: 1543-8384), 2011; 8(5): 1750-1756.
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Paper type: Journal Article,
Impact factor: 4.782, 5-year impact factor: 5.634
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80053467204&partnerID=40&md5=58be3c08f3896b3ce2a4f437b062956c
Keywords: Contrast Agent, Gadolinium, Melanoma, Microenvironment, Redox, Tumor, 2 Pyridinedithio, Contrast Medium, Gadoteridol, Gadoteridol Pdp, N Ethylmaleimide, Thiol Derivative, Tris(2 Carboxyethyl)phosphine, Unclassified Drug, Animal Cell, Animal Experiment, Animal Model, Article, Cell Membrane, Controlled Study, Drug Uptake, In Vivo Study, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Oxidation Reduction Reaction, Priority Journal, Signal Transduction, Tumor Xenograft, Biological Transport, Cell Line, Coordination Complexes, Injections, Intralesional, Kinetics, Ligands, Limit Of Detection, Inbred C57bl, N-Ethylmaleimide-Sensitive Proteins, Sulfhydryl Reagents, Sulfides,
Affiliations:
*** IBB - CNR ***
Institute for Biostructures and Bioimages (CNR), C/o Molecular Biotechnology Center (University of Turin), Via Nizza 52, I-10126 Torino, Italy
Department of Environmental and Life Sciences, Università Del Piemonte Orientale A. Avogadro, Viale T. Michel 11, I-15121 Alessandria, Italy
Department of Chemisty, IFM and Center for Molecular Imaging, University of Turin, Via Nizza 52, I-10126 Torino, Italy
References:
Gatenby, R.A., Gillies, R.J., Why do cancers have high aerobic glycolysis? (2004) Nature Reviews Cancer, 4 (11), pp. 891-899. , DOI 10.1038/nrc147
Rofstad, E.K., Microenvironment-induced cancer metastasis (2000) International Journal of Radiation Biology, 76 (5), pp. 589-605
Raghunand, N., Jagadish, B., Trouard, T.P., Galons, J.-P., Gillies, R.J., Mash, E.A., Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin (2006) Magnetic Resonance in Medicine, 55 (6), pp. 1272-1280. , DOI 10.1002/mrm.20904
Jonas, C.R., Ziegler, T.R., Gu, L.H., Jones, D.P., Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line (2002) Free Radical Biology and Medicine, 33 (11), pp. 1499-1506. , DOI 10.1016/S0891-5849(02)01081-X, PII S089158490201081X
Jonas, C.R., Gu, L.H., Nkabyo, Y.S., Mannery, Y.O., Avissar, N.E., Sax, H.C., Jones, D.P., Ziegler, T.R., Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells (2003) Am. J. Physiol., 285, pp. 1421-R1429
Rehman, F., Shanmugasundaram, P., Schrey, M.P., Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: Potential role in drug-induced cytotoxicity (2004) British Journal of Cancer, 91 (10), pp. 1821-1828. , DOI 10.1038/sj.bjc.6602212
Prezioso, J.A., Shields, D., Wang, N., Rosenstein, M., Role of gamma-glutamyltranspeptidase-mediated glutathione transport on the radiosensitivity of B16 melanoma variant cell lines (1994) Int. J. Radiat. Oncol. Biol. Phys., 30, pp. 373-381
Paolicchi, A., Lorenzini, E., Perego, P., Supino, R., Zunino, F., Comporti, M., Pompella, A., Extra-cellular thiol metabolism in clones of human metastatic melanoma with different gamma-glutamyl transpeptidase expression: Implications for cell response to platinum-based drugs (2002) International Journal of Cancer, 97 (6), pp. 740-745. , DOI 10.1002/ijc.10110
Glunde, K., Gillies, R.J., Neeman, M., Bhujwalla, Z.M., (2010) Molecular Imaging: Principles and Practice, pp. 844-863. , Weissleder, R. Ross, B. D. Rehemtulla, A. Gambhir, S. S. Eds. PMPH-USA: Beijing
Glunde, K., Pathak, A.P., Bhujwalla, Z.M., Molecular-functional imaging of cancer: To image and imagine (2007) Trends in Molecular Medicine, 13 (7), pp. 287-297. , DOI 10.1016/j.molmed.2007.05.002, PII S147149140700086X
Penet, M.-F., Pathak, A.P., Raman, V., Ballesteros, P., Artemov, D., Bhujwalla, Z.M., Noninvasive Multiparametric Imaging of Metastasis-Permissive Microenvironments in a Human Prostate Cancer Xenograft (2009) Cancer Res., 69 (22), pp. 8822-8829
Neeman, M., Provenzale, J.M., Dewhirst, M.W., Magnetic resonance imaging applications in the evaluation of tumor angiogenesis (2001) Seminars in Radiation Oncology, 11 (1), pp. 70-82
Bhujwalla, Z.M., Artemov, D., Ballesteros, P., Cerdan, S., Gillies, R.J., Solaiyappan, M., Combined vascular and extracellular pH imaging of solid tumors (2002) NMR in Biomedicine, 15 (2), pp. 114-119. , DOI 10.1002/nbm.743
Garcia-Espinosa, M.A., Rodrigues, T.B., Sierra, A., Benito, M., Fonseca, C., Gray, H.L., Bartnik, B.L., Cerdan, S., Cerebral glucose metabolism and the glutamine cycle as detected by in vivo and in vitro 13C NMR spectroscopy (2004) Neurochemistry International, 45 (2-3), pp. 297-303. , DOI 10.1016/j.neuint.2003.08.014, PII S0197018603002845
Manzoor, A.A., Yuan, H., Palmer, G.M., Viglianti, B.L., Dewhirst, M.K., (2010) Molecular Imaging: Principles and Practice, pp. 756-780. , Weissleder, R. Ross, B. D. Rehemtulla, A. Gambhir, S. S. PMPH-USA: Beijing
Cook, J.A., Gius, D., Wink, D.A., Krishna, M.C., Russo, A., Mitchell, J.B., Oxidative stress, redox, and the tumor microenvironment (2004) Seminars in Radiation Oncology, 14 (3), pp. 259-266. , DOI 10.1016/j.semradonc.2004.04.001, PII S1053429604000529
Groves, A.M., Win, T., Ben Haim, S., Ell, P.J., Non-[18F]FDG PET in clinical oncology (2007) Lancet Oncol., 8, pp. 822-830
Rischin, D., Hicks, R.J., Fisher, R., Binns, D., Corry, J., Porceddu, S., Peters, L.J., Prognostic significance of [ 18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: A substudy of Trans-Tasman Radiation Oncology Group study 98.02 (2006) Journal of Clinical Oncology, 24 (13), pp. 2098-2104. , DOI 10.1200/JCO.2005.05.2878
Eschmann, S.-M., Paulsen, F., Reimold, M., Dittmann, H., Welz, S., Reischl, G., MacHulla, H.-J., Bares, R., Prognostic impact of hypoxia imaging with 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy (2005) Journal of Nuclear Medicine, 46 (2), pp. 253-260
Hyodo, F., Soule, B.P., Matsumoto, K.-I., Matsumoto, S., Cook, J.A., Hyodo, E., Sowers, A.L., Mitchell, J.B., Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance Imaging (2008) J. Pharm. Pharmacol., 60 (8), pp. 1049-1060
Aime, S., Botta, M., Gianolio, E., Terreno, E., A p(O 2)-responsive MRI contrast agent based on the redox switch of manganese(II/III) - Porphyrin complexes (2000) Angewandte Chemie - International Edition, 39 (4), pp. 747-750. , DOI 10.1002/(SICI)1521-3773(20000218)39:4<747::AID-ANIE747> 3.0. CO
Moriarty-Craige, S.E., Jones, D.P., Extracellular thiols and thiol/disulfide redox in metabolism (2004) Annual Review of Nutrition, 24, pp. 481-509. , DOI 10.1146/annurev.nutr.24.012003.132208
Schafer, F.Q., Buettner, G.R., Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple (2001) Free Radical Biology and Medicine, 30 (11), pp. 1191-1212. , DOI 10.1016/S0891-5849(01)00480-4, PII S0891584901004804
Ghezzi, P., Oxidoreduction of protein thiols in redox regulation (2005) Biochemical Society Transactions, 33 (6), pp. 1378-1381. , DOI 10.1042/BST20051378
Sahaf, B., Heydari, K., Herzenberg, L.A., Herzenberg, L.A., Lymphocyte surface thiol levels (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (7), pp. 4001-4005. , DOI 10.1073/pnas.2628032100
Digilio, G., Menchise, V., Gianolio, E., Catanzaro, V., Carrera, C., Napolitano, R., Fedeli, F., Aime, S., Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for MRI cell labelling (2010) J. Med. Chem., 53, pp. 4877-4890
Laragione, T., Gianazza, E., Tonelli, R., Bigini, P., Mennini, T., Casoni, F., Massignan, T., Ghezzi, P., Regulation of redox-sensitive exofacial protein thiols in CHO cells (2006) Biological Chemistry, 387 (10-11), pp. 1371-1376. , DOI 10.1515/BC.2006.172, PII BCHM38710111371
Jiang, X.-M., Fitzgerald, M., Grant, C.M., Hogg, P.J., Redox Control of Exofacial Protein Thiols/Disulfides by Protein Disulfide Isomerase (1999) J. Biol. Chem., 274, pp. 2416-2423
Laragione, T., Bonetto, V., Casoni, F., Massignan, T., Bianchi, G., Gianazza, E., Ghezzi, P., Redox regulation of surface protein thiols: Identification of integrin α-4 as a molecular target by using redox proteomics (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (25), pp. 14737-14741. , DOI 10.1073/pnas.2434516100
Digilio, G., Catanzaro, V., Fedeli, F., Gianolio, E., Menchise, V., Napolitano, R., Gringeri, C., Aime, S., Targeting exofacial protein thiols with GdIII complexes. An efficient procedure for MRI cell labelling (2009) Chem. Commun., pp. 893-895
Carrera, C., Digilio, G., Baroni, S., Burgio, D., Consol, S., Fedeli, F., Longo, D., Aime, S., Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds (2007) Dalton Transactions, (43), pp. 4980-4987. , DOI 10.1039/b705088g
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-254
Crich, S.G., Biancone, L., Cantaluppi, V., Duo, D., Esposito, G., Russo, S., Camussi, G., Aime, S., Improved Route for the Visualization of Stem Cells Labeled with a Gd-/Eu-Chelate as Dual (MRI and Fluorescence) Agent (2004) Magnetic Resonance in Medicine, 51 (5), pp. 938-944. , DOI 10.1002/mrm.20072
Crich, S.G., Cabella, C., Barge, A., Belfiore, S., Ghirelli, C., Lattuada, L., Lanzardo, S., Aime, S., In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes (2006) Journal of Medicinal Chemistry, 49 (16), pp. 4926-4936. , DOI 10.1021/jm0601093
Deneke, S.M., Thiol-based antioxidants (2001) Curr. Top. Cell. Regul., 36, pp. 151-180
Andersson, A., Lendgren, A., Hultberg, B., Effect of thiol oxidation and thiol export from erythrocytes on determination of redox status of homocysteine and other thiols in plasma from healthy subjects and patients with cerebral infarction (1995) Clin. Chem., 41, pp. 361-366
Peters Jr., T., (1996) All about Albumin
Biochemistry, Genetics and Medical Applications, , Academic Press: London
Raghunand, N., Guntle, G.P., Gokhale, V., Nichol, G.S., Mash, E.A., Jagadish, B., Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4, 7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging (2010) J. Med. Chem., 53, pp. 6747-6757
Mol Pharm (ISSN: 1543-8384), 2011; 8(5): 1750-1756.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.782, 5-year impact factor: 5.634
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80053467204&partnerID=40&md5=58be3c08f3896b3ce2a4f437b062956c
Keywords: Contrast Agent, Gadolinium, Melanoma, Microenvironment, Redox, Tumor, 2 Pyridinedithio, Contrast Medium, Gadoteridol, Gadoteridol Pdp, N Ethylmaleimide, Thiol Derivative, Tris(2 Carboxyethyl)phosphine, Unclassified Drug, Animal Cell, Animal Experiment, Animal Model, Article, Cell Membrane, Controlled Study, Drug Uptake, In Vivo Study, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Oxidation Reduction Reaction, Priority Journal, Signal Transduction, Tumor Xenograft, Biological Transport, Cell Line, Coordination Complexes, Injections, Intralesional, Kinetics, Ligands, Limit Of Detection, Inbred C57bl, N-Ethylmaleimide-Sensitive Proteins, Sulfhydryl Reagents, Sulfides,
Affiliations:
*** IBB - CNR ***
Institute for Biostructures and Bioimages (CNR), C/o Molecular Biotechnology Center (University of Turin), Via Nizza 52, I-10126 Torino, Italy
Department of Environmental and Life Sciences, Università Del Piemonte Orientale A. Avogadro, Viale T. Michel 11, I-15121 Alessandria, Italy
Department of Chemisty, IFM and Center for Molecular Imaging, University of Turin, Via Nizza 52, I-10126 Torino, Italy
References:
Gatenby, R.A., Gillies, R.J., Why do cancers have high aerobic glycolysis? (2004) Nature Reviews Cancer, 4 (11), pp. 891-899. , DOI 10.1038/nrc147
Rofstad, E.K., Microenvironment-induced cancer metastasis (2000) International Journal of Radiation Biology, 76 (5), pp. 589-605
Raghunand, N., Jagadish, B., Trouard, T.P., Galons, J.-P., Gillies, R.J., Mash, E.A., Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin (2006) Magnetic Resonance in Medicine, 55 (6), pp. 1272-1280. , DOI 10.1002/mrm.20904
Jonas, C.R., Ziegler, T.R., Gu, L.H., Jones, D.P., Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line (2002) Free Radical Biology and Medicine, 33 (11), pp. 1499-1506. , DOI 10.1016/S0891-5849(02)01081-X, PII S089158490201081X
Jonas, C.R., Gu, L.H., Nkabyo, Y.S., Mannery, Y.O., Avissar, N.E., Sax, H.C., Jones, D.P., Ziegler, T.R., Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells (2003) Am. J. Physiol., 285, pp. 1421-R1429
Rehman, F., Shanmugasundaram, P., Schrey, M.P., Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: Potential role in drug-induced cytotoxicity (2004) British Journal of Cancer, 91 (10), pp. 1821-1828. , DOI 10.1038/sj.bjc.6602212
Prezioso, J.A., Shields, D., Wang, N., Rosenstein, M., Role of gamma-glutamyltranspeptidase-mediated glutathione transport on the radiosensitivity of B16 melanoma variant cell lines (1994) Int. J. Radiat. Oncol. Biol. Phys., 30, pp. 373-381
Paolicchi, A., Lorenzini, E., Perego, P., Supino, R., Zunino, F., Comporti, M., Pompella, A., Extra-cellular thiol metabolism in clones of human metastatic melanoma with different gamma-glutamyl transpeptidase expression: Implications for cell response to platinum-based drugs (2002) International Journal of Cancer, 97 (6), pp. 740-745. , DOI 10.1002/ijc.10110
Glunde, K., Gillies, R.J., Neeman, M., Bhujwalla, Z.M., (2010) Molecular Imaging: Principles and Practice, pp. 844-863. , Weissleder, R. Ross, B. D. Rehemtulla, A. Gambhir, S. S. Eds. PMPH-USA: Beijing
Glunde, K., Pathak, A.P., Bhujwalla, Z.M., Molecular-functional imaging of cancer: To image and imagine (2007) Trends in Molecular Medicine, 13 (7), pp. 287-297. , DOI 10.1016/j.molmed.2007.05.002, PII S147149140700086X
Penet, M.-F., Pathak, A.P., Raman, V., Ballesteros, P., Artemov, D., Bhujwalla, Z.M., Noninvasive Multiparametric Imaging of Metastasis-Permissive Microenvironments in a Human Prostate Cancer Xenograft (2009) Cancer Res., 69 (22), pp. 8822-8829
Neeman, M., Provenzale, J.M., Dewhirst, M.W., Magnetic resonance imaging applications in the evaluation of tumor angiogenesis (2001) Seminars in Radiation Oncology, 11 (1), pp. 70-82
Bhujwalla, Z.M., Artemov, D., Ballesteros, P., Cerdan, S., Gillies, R.J., Solaiyappan, M., Combined vascular and extracellular pH imaging of solid tumors (2002) NMR in Biomedicine, 15 (2), pp. 114-119. , DOI 10.1002/nbm.743
Garcia-Espinosa, M.A., Rodrigues, T.B., Sierra, A., Benito, M., Fonseca, C., Gray, H.L., Bartnik, B.L., Cerdan, S., Cerebral glucose metabolism and the glutamine cycle as detected by in vivo and in vitro 13C NMR spectroscopy (2004) Neurochemistry International, 45 (2-3), pp. 297-303. , DOI 10.1016/j.neuint.2003.08.014, PII S0197018603002845
Manzoor, A.A., Yuan, H., Palmer, G.M., Viglianti, B.L., Dewhirst, M.K., (2010) Molecular Imaging: Principles and Practice, pp. 756-780. , Weissleder, R. Ross, B. D. Rehemtulla, A. Gambhir, S. S. PMPH-USA: Beijing
Cook, J.A., Gius, D., Wink, D.A., Krishna, M.C., Russo, A., Mitchell, J.B., Oxidative stress, redox, and the tumor microenvironment (2004) Seminars in Radiation Oncology, 14 (3), pp. 259-266. , DOI 10.1016/j.semradonc.2004.04.001, PII S1053429604000529
Groves, A.M., Win, T., Ben Haim, S., Ell, P.J., Non-[18F]FDG PET in clinical oncology (2007) Lancet Oncol., 8, pp. 822-830
Rischin, D., Hicks, R.J., Fisher, R., Binns, D., Corry, J., Porceddu, S., Peters, L.J., Prognostic significance of [ 18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: A substudy of Trans-Tasman Radiation Oncology Group study 98.02 (2006) Journal of Clinical Oncology, 24 (13), pp. 2098-2104. , DOI 10.1200/JCO.2005.05.2878
Eschmann, S.-M., Paulsen, F., Reimold, M., Dittmann, H., Welz, S., Reischl, G., MacHulla, H.-J., Bares, R., Prognostic impact of hypoxia imaging with 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy (2005) Journal of Nuclear Medicine, 46 (2), pp. 253-260
Hyodo, F., Soule, B.P., Matsumoto, K.-I., Matsumoto, S., Cook, J.A., Hyodo, E., Sowers, A.L., Mitchell, J.B., Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance Imaging (2008) J. Pharm. Pharmacol., 60 (8), pp. 1049-1060
Aime, S., Botta, M., Gianolio, E., Terreno, E., A p(O 2)-responsive MRI contrast agent based on the redox switch of manganese(II/III) - Porphyrin complexes (2000) Angewandte Chemie - International Edition, 39 (4), pp. 747-750. , DOI 10.1002/(SICI)1521-3773(20000218)39:4<747::AID-ANIE747> 3.0. CO
Moriarty-Craige, S.E., Jones, D.P., Extracellular thiols and thiol/disulfide redox in metabolism (2004) Annual Review of Nutrition, 24, pp. 481-509. , DOI 10.1146/annurev.nutr.24.012003.132208
Schafer, F.Q., Buettner, G.R., Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple (2001) Free Radical Biology and Medicine, 30 (11), pp. 1191-1212. , DOI 10.1016/S0891-5849(01)00480-4, PII S0891584901004804
Ghezzi, P., Oxidoreduction of protein thiols in redox regulation (2005) Biochemical Society Transactions, 33 (6), pp. 1378-1381. , DOI 10.1042/BST20051378
Sahaf, B., Heydari, K., Herzenberg, L.A., Herzenberg, L.A., Lymphocyte surface thiol levels (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (7), pp. 4001-4005. , DOI 10.1073/pnas.2628032100
Digilio, G., Menchise, V., Gianolio, E., Catanzaro, V., Carrera, C., Napolitano, R., Fedeli, F., Aime, S., Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for MRI cell labelling (2010) J. Med. Chem., 53, pp. 4877-4890
Laragione, T., Gianazza, E., Tonelli, R., Bigini, P., Mennini, T., Casoni, F., Massignan, T., Ghezzi, P., Regulation of redox-sensitive exofacial protein thiols in CHO cells (2006) Biological Chemistry, 387 (10-11), pp. 1371-1376. , DOI 10.1515/BC.2006.172, PII BCHM38710111371
Jiang, X.-M., Fitzgerald, M., Grant, C.M., Hogg, P.J., Redox Control of Exofacial Protein Thiols/Disulfides by Protein Disulfide Isomerase (1999) J. Biol. Chem., 274, pp. 2416-2423
Laragione, T., Bonetto, V., Casoni, F., Massignan, T., Bianchi, G., Gianazza, E., Ghezzi, P., Redox regulation of surface protein thiols: Identification of integrin α-4 as a molecular target by using redox proteomics (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (25), pp. 14737-14741. , DOI 10.1073/pnas.2434516100
Digilio, G., Catanzaro, V., Fedeli, F., Gianolio, E., Menchise, V., Napolitano, R., Gringeri, C., Aime, S., Targeting exofacial protein thiols with GdIII complexes. An efficient procedure for MRI cell labelling (2009) Chem. Commun., pp. 893-895
Carrera, C., Digilio, G., Baroni, S., Burgio, D., Consol, S., Fedeli, F., Longo, D., Aime, S., Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds (2007) Dalton Transactions, (43), pp. 4980-4987. , DOI 10.1039/b705088g
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-254
Crich, S.G., Biancone, L., Cantaluppi, V., Duo, D., Esposito, G., Russo, S., Camussi, G., Aime, S., Improved Route for the Visualization of Stem Cells Labeled with a Gd-/Eu-Chelate as Dual (MRI and Fluorescence) Agent (2004) Magnetic Resonance in Medicine, 51 (5), pp. 938-944. , DOI 10.1002/mrm.20072
Crich, S.G., Cabella, C., Barge, A., Belfiore, S., Ghirelli, C., Lattuada, L., Lanzardo, S., Aime, S., In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes (2006) Journal of Medicinal Chemistry, 49 (16), pp. 4926-4936. , DOI 10.1021/jm0601093
Deneke, S.M., Thiol-based antioxidants (2001) Curr. Top. Cell. Regul., 36, pp. 151-180
Andersson, A., Lendgren, A., Hultberg, B., Effect of thiol oxidation and thiol export from erythrocytes on determination of redox status of homocysteine and other thiols in plasma from healthy subjects and patients with cerebral infarction (1995) Clin. Chem., 41, pp. 361-366
Peters Jr., T., (1996) All about Albumin
Biochemistry, Genetics and Medical Applications, , Academic Press: London
Raghunand, N., Guntle, G.P., Gokhale, V., Nichol, G.S., Mash, E.A., Jagadish, B., Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4, 7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging (2010) J. Med. Chem., 53, pp. 6747-6757
In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent
Murine melanoma B16 cells display on the extracellular side of the plasma membrane a large number of reactive protein thiols (exofacial protein thiols, EPTs). These EPTs can be chemically labeled with Gd-DO3A-PDP, a Gd(III)-based MRI contrast agent bearing a 2-pyridinedithio chemical function for the recognition of EPTs. Uptake of gadolinium up to 10 9 Gd atoms per cell can be achieved. The treatment of B16 cells ex vivo with a reducing agent such as tris(2-carboxyethyl)phosphine (TCEP) results in an increase by 850% of available EPTs and an increase by 45% of Gd uptake. Blocking EPTs with N-ethylmaleimide (NEM) caused a decrease by 84% of available EPTs and a decrease by 55% of Gd uptake. The amount of Gd taken up by B16 cells is therefore dependent upon the availability of EPTs, whose actual level in turn changes according to the extracellular redox microenvironment. Then Gd-DO3A-PDP has been assessed for the labeling of tumor cells in vivo on B16.F10 melanoma tumor-bearing mice. Gd-DO3A-PDP (or Gd-DO3A as the control) has been injected directly into the tumor region at a dose level of 0.1 μmol and the signal enhancement in MR images followed over time. The washout kinetics of Gd-DO3A-PDP from tumor is very slow if compared to that of control Gd-DO3A, and 48 h post injection, the gadolinium-enhancement is still clearly visible. Therefore, B16 cells can be labeled ex vivo as well as in vivo according to a common EPTs-dependent route, provided that high levels of the thiol reactive probe can be delivered to the tumor. © 2011 American Chemical Society.
Murine melanoma B16 cells display on the extracellular side of the plasma membrane a large number of reactive protein thiols (exofacial protein thiols, EPTs). These EPTs can be chemically labeled with Gd-DO3A-PDP, a Gd(III)-based MRI contrast agent bearing a 2-pyridinedithio chemical function for the recognition of EPTs. Uptake of gadolinium up to 10 9 Gd atoms per cell can be achieved. The treatment of B16 cells ex vivo with a reducing agent such as tris(2-carboxyethyl)phosphine (TCEP) results in an increase by 850% of available EPTs and an increase by 45% of Gd uptake. Blocking EPTs with N-ethylmaleimide (NEM) caused a decrease by 84% of available EPTs and a decrease by 55% of Gd uptake. The amount of Gd taken up by B16 cells is therefore dependent upon the availability of EPTs, whose actual level in turn changes according to the extracellular redox microenvironment. Then Gd-DO3A-PDP has been assessed for the labeling of tumor cells in vivo on B16.F10 melanoma tumor-bearing mice. Gd-DO3A-PDP (or Gd-DO3A as the control) has been injected directly into the tumor region at a dose level of 0.1 μmol and the signal enhancement in MR images followed over time. The washout kinetics of Gd-DO3A-PDP from tumor is very slow if compared to that of control Gd-DO3A, and 48 h post injection, the gadolinium-enhancement is still clearly visible. Therefore, B16 cells can be labeled ex vivo as well as in vivo according to a common EPTs-dependent route, provided that high levels of the thiol reactive probe can be delivered to the tumor. © 2011 American Chemical Society.
In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent
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In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent
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Sarnella A, Ferrara Y, Auletta L, Albanese S, Cerchia L, Alterio V, De Simone G, Supuran CT, Zannetti A
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Longo DL, Carella A, Corrado A, Pirotta E, Mohanta Z, Singh A, Stabinska J, Liu G, Mcmahon MT
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Link W, Ilardi G, Zannetti A
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Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
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Romdhane F, Villano D, Irrera P, Consolino L, Longo DL
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
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Cortini M, Armirotti A, Columbaro M, Longo DL, Di Pompo G, Cannas E, Maresca A, Errani C, Longhi A, Righi A, Carelli V, Baldini N, Avnet S
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Zöllner FG, Dastrù W, Irrera P, Longo DL, Bennett KM, Beeman SC, Bretthorst GL, Garbow JR
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Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
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Ponsiglione A, Nappi C, Imbriaco M, Ascione R, Megna R, Petretta M, Cuocolo A
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Irrera P, Consolino L, Dastrù W, Pedersen M, Zöllner FG, Longo DL
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Pedersen M, Irrera P, Dastrù W, Zöllner FG, Bennett KM, Beeman SC, Bretthorst GL, Garbow JR, Longo DL
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Pavuluri KD, Consolino L, Longo DL, Irrera P, Sun PZ, Mcmahon MT
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Angeli A, Carta F, Nocentini A, Winum J, Zalubovskis R, Akdemir A, Onnis V, Eldehna WM, Capasso C, De Simone G, Monti Simona M, Carradori S, Donald WA, Dedhar S, Supuran CT
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
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Belli S, Franco P, Iommelli F, De Vincenzo A, Brancaccio D, Telesca M, Merlino F, Novellino E, Ranson M, Del Vecchio S, Grieco P, Carotenuto A, Stoppelli MP
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Tear LR, Carrera C, Gianolio E, Aime S
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Hill BS, Sarnella A, D'Avino G, Zannetti A
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (135 views)
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Russi S, Verma HK, Laurino S, Mazzone P, Storto G, Nardelli A, Zoppoli P, Calice G, La Rocca F, Sgambato A, Lucci V, Falco G, Ruggieri V
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Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
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Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (242 views)
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Mcnitt DH, De Water LV, Marasco D, Berisio R, Lukomski S
* Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting (236 views)
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Camorani S, Fedele M, Zannetti A, Cerchia L
* TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities (345 views) (PDF 123 views)
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Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
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Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
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Di Gregorio E, Ferrauto G, Furlan C, Lanzardo S, Nuzzi R, Gianolio E, Aime S
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Arena F, Bardini P, Blasi F, Gianolio E, Marini G, Aime S
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Tedeschi E, Cocozza S, Borrelli P, Ugga L, Morra VB, Palma G
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (320 views)
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Srivastava K, Ferrauto G, Young Vg J, Aime S, Pierre VC
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Hill BS, Pelagalli A, Passaro N, Zannetti A
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Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
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Longo DL, Stefania R, Aime S, Oraevsky A
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
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Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
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Anemone A, Consolino L, Longo DL
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Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
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Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E
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Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
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Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
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Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
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Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
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Romeo V, Esposito A, Maurea S, Camera L, Mainenti PP, Palmieri G, Buonerba C, Salvatore M
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
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Tedeschi E, Russo C, Cocozza S, Palma G, Canna A, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Brescia Morra V, Brunetti A, Salvatore M
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Rsna 101st Scientific Assembly And Annual Meeting, 2015; N/D: N/D-N/D.
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Maurea S, Mainenti PP, Tambasco A, Imbriaco M, Mollica C, Laccetti E, Camera L, Liuzzi R, Salvatore M
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
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Impact Factor: 1.865
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Camera L, Sagnelli M, Guadagno P, Mainenti PP, Marra T, Scotto di Santolo M, Fei L, Salvatore M
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Ristori G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P, Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M, Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti M
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Ciarmiello A, Gaeta MC, Meniconi M, Milano A, Alfano B, Del Vecchio S, Salvatore M
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Iodice D, Di Donato O, Liccardo I, Lamanna L, Segreto S, Salvatore M, Imbriaco M
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
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Gargiulo P, Dellegrottaglie S, Bruzzese D, Savarese G, Scala O, Ruggiero D, D'Amore C, Paolillo S, Agostoni P, Bossone E, Soricelli A, Cuocolo A, Trimarco B, Perrone Filardi P
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Impact Factor: 6.752
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
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Maffei E, Midiri M, Russo V, Rengo M, Tedeschi C, Spagnolo P, Seitun S, Francone M, Guaricci AI, Carrabba N, Malagò R, Cuocolo A, Arcadi T, Catalano OA, Cademartiri F
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Impact Factor: 1.368
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Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
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Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
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Mancini M, Di Donato O, Saldalamacchia G, Liuzzi R, Rivellese A, Salvatore M
* Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking (441 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Mar; 118(2): 206-214.
Impact Factor: 1.368
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
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Sica G, Guida F, Bocchini G, Codella U, Mainenti PP, Tanga M, Scaglione M
* Errors in Imaging Assessment of Polytrauma Patients (675 views)
Seminars In Ultrasound Ct And Mri (ISSN: 0887-2171), 2012 Sep; 33(4): 337-346.
Impact Factor: 1.289
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Gringeri CV, Menchise V, Rizzitelli S, Cittadino E, Catanzaro V, Dati G, Chaabane L, Digilio G, Aime S
* Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (503 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Impact Factor: 2.872
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Maurea S, Fusari M, Imbriaco M, Camera L, Mainenti PP, Campione S, Santangelo M, Salvatore M
* Pitfalls in diagnostic imaging of cystic pancreatic masses: a case of true cystic lesion mimicking a mucinous cystadenoma (336 views)
Jop (ISSN: 1590-8577, 1590-0857), 2012 Jan 10; 13(1): 83-86.
Impact Factor: 0
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Greco A, Mancini M, Gargiulo S, Gramanzini M, Claudio PP, Brunetti A, Salvatore M
* Ultrasound biomicroscopy in small animal research: Applications in molecular and preclinical imaging (511 views)
J Biomed Biotechnol (ISSN: 1110-7243, 1110-7251), 2012; 2012: 519238-519238.
Impact Factor: 2.88
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (335 views)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (292 views)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (345 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (409 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (543 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (615 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Mainenti PP, Segreto S, Mancini M, Rispo A, Cozzolino I, Masone S, Rinaldi CR, Nardone G, Salvatore M
* Intestinal amyloidosis: two cases with different patterns of clinical and imaging presentation (386 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2010 May 28; 16(20): 2566-2570.
Impact Factor: 2.24
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Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (561 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
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Fusari M, Maurea S, Imbriaco M, Mollica C, Avitabile G, Soscia F, Camera L, Salvatore M
* Comparison between multislice CT and MR imaging in the diagnostic evaluation of patients with pancreatic masses (365 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2010 Apr; 115(3): 453-466.
Impact Factor: 1.618
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Matrone A, Russo M, Mollica C, Lombardi D, Lombardi G, Maurea S, Imbriaco M
* Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance (331 views)
Jop (ISSN: 1590-8577, 1590-0857), 2010 Mar 5; 11(2): 170-172.
Impact Factor: 0
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (386 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (600 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Maurea S, Caleo O, Mollica C, Imbriaco M, Mainenti PP, Palumbo C, Mancini M, Camera L, Salvatore M
* Comparative diagnostic evaluation with MR cholangiopancreatography, ultrasonography and CT in patients with pancreatobiliary disease (366 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Apr; 114(3): 390-402.
Impact Factor: 1.454
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (432 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (345 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
Impact Factor: 5.504
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (254 views)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Imbriaco M, Caprio MG, Limite G, Pace L, De Falco T, Capuano E, Salvatore M
* Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions (296 views)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2008 Nov; 191(5): 1323-1330.
Impact Factor: 2.94
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Lapi F, Cecchi E, Pedone C, Attanasio F, Banchelli G, Vannacci A, Di Pirro M, Moschini M, Berni V, Matucci R, Cini E, Scalia A, Tendi E, Mugelli A
* Safety aspects of iodinated contrast media related to their physicochemical properties: A pharmacoepidemiology study in two Tuscany hospitals (494 views)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 2008 Jul; 64(7): 723-737.
Impact Factor: 2.497
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Imbriaco M, Camera L, Manciuria A, Salvatore M
* A case of multiple intra-abdominal splenosis with computed tomography and magnetic resonance imaging correlative findings (287 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2008 Mar 7; 14(9): 1453-1455.
Impact Factor: 2.081
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Fonti R, Salvatore B, Quarantelli M, Sirignano C, Segreto S, Petruzziello F, Catalano L, Liuzzi R, Rotoli B, Del Vecchio S, Pace L, Salvatore M
* F-18-FDG PET/CT, Tc-99m-MIBI, and MRI in evaluation of patients with multiple myeloma (549 views)
J Nucl Med (ISSN: 0161-5505, 0161-1550, 1535-5667), 2008 Feb; 49(2): 195-200.
Impact Factor: 6.662
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (575 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Ragozzino A, Lassandro F, De Ritis R, Imbriaco M
* Value of MRI in three patients with major vascular injuries after laparoscopic cholecystectomy (250 views)
Emergency Radiology (ISSN: 1070-3004), 2007 Nov; 14(6): 443-447.
Impact Factor: 6.214
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Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G
* Acute appendicitis: Diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings (366 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 2055-2061.
Impact Factor: 3.405
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Pastore C, Franzese M, Sica F, Temussi P, Pastore A
* Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin (545 views)
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
Impact Factor: 3.396
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (693 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Del Giudice E, Bianchi MC, Tosetti M, Varrone A, Romano A, Crisanti AF, Titomanlio L, Imperati F
* Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? (331 views)
Epileptic Disord (ISSN: 1294-9361), 2006 Dec; 8(4): 289-293.
Impact Factor: 1.202
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Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (407 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (442 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (390 views) (PDF 231 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2006 Jul; 16(3): 224-235.
Impact Factor: 1.298
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Camera L, Mainenti PP, Di Giacomo A, Romano M, Rispo A, Alfinito F, Imbriaco M, Soscia E, Salvatore M
* Triphasic helical CT in Budd-Chiari syndrome: Patterns of enhancement in acute, subacute and chronic disease (410 views)
Clin Radiol (ISSN: 0009-9260), 2006 Apr; 61(4): 331-337.
Impact Factor: 1.665
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Tamburrini S, Brunetti A, Brown MA, Sirlin CB, Casola G
* CT appearance of the normal appendix in adults (387 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2005 Oct; 15(10): 2096-2103.
Impact Factor: 2.437
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Imbriaco M, Megibow AJ, Ragozzino A, Liuzzi R, Mainenti PP, Bortone S, Camera L, Salvatore M
* Value of the single-phase technique in MDCT assessment of pancreatic tumors (362 views)
Am J Roentgenol (ISSN: 0361-803x), 2005 Apr; 184(4): 1111-1117.
Impact Factor: 2.209
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Mainenti PP, Cantalupo T, Nicotra S, Camera L, Imbriaco M, Di Vizio D, Insabato L, Salvatore M
* Systemic amyloidosis: The CT sign of splenic hypoperfusion (305 views)
Amyloid (ISSN: 1350-6129), 2004 Dec; 11(4): 281-282.
Impact Factor: 1.886
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (351 views) (PDF 247 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
Impact Factor: 1.724
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (247 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Guzzi R, Milardi D, La Rosa C, Grasso D, Verbeet MP, Canters GW, Sportelli L
* The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin (307 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2003 Jan 15; 31(4-5): 163-170.
Impact Factor: 1.427
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Imbriaco M, Megibow AJ, Camera L, Pace L, Mainenti PP, Romano M, Selva G, Salvatore M
* Dual-phase versus single-phase helical CT to detect and assess resectability of pancreatic carcinoma (373 views)
Am J Roentgenol (ISSN: 0361-803x), 2002 Jun; 178(6): 1473-1479.
Impact Factor: 2.424
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Camera L, Bresciani M, Soscia E, Percopo V, Mainenti PP, Salvatore M
* Morphological imaging of gastroenteropancreatic neuroendocrine tumours (256 views)
Minerva Endocrinol (ISSN: 0391-1977, 1827-1634electronic, 0391-1977linking), 2001 Sep; 26(3): 123-128.
Impact Factor: 1.464
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Imbriaco M, Del Vecchio S, Riccardi A, Pace L, Di Salle F, Di Gennaro F, Salvatore M, Sodano A
* Scintimammography with Tc-99m-MIBI versus dynamic MRI for non-invasive characterization of breast masses (758 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2001 Jan; 28(1): 56-63.
Impact Factor: 3.464
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (852 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Maurea S, Maurelli L, Lastoria S, Cuocolo A, Brunetti A, Pace L, Caracò C, Klain M, Lupoli G, Salvatore M
Familial pheochromocytoma in Sipple's syndrome. A comparison between scintigraphy with 131I-meta-iodobenzylguanidine, computed tomography and echography (254 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992; 83(4): 486-490.
Impact Factor: 0.967
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Pace L, Cuocolo A, Nappi A, Nicolai E, Imbriaco M, Mangoni di Santo Stefano ML, Salvatore M
Myocardial scintigraphy with technetium 99m methoxyisobutylisonitrile. A comparison with coronary arteriography in patients with suspected ischemic cardiopathy (503 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 1992; 83(1-2): 97-100.
Impact Factor: 0.967
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Maurelli L, Cuocolo A, Lastoria S, Brunetti A, Maurea S, Lembo G, Klain M, Carac C, Salvatore M
131I-meta-iodobenzylguanidine scintigraphy in patients with a suspected pheochromocytoma. A comparison with CT and biohumoral parameters (487 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1991; 82(6): 839-843.
Impact Factor: 0.967
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* Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion (24 views)
J Exp Clin Cancer Res (ISSN: 0392-9078linking), 2022 Apr 2; 41(1): 122-122.
Impact Factor: 12.658
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Longo DL, Carella A, Corrado A, Pirotta E, Mohanta Z, Singh A, Stabinska J, Liu G, Mcmahon MT
* A snapshot of the vast array of diamagnetic CEST MRI contrast agents (6 views)
Nmr Biomed (ISSN: 0952-3480linking), 2022 Feb 20; N/D: e4715-N/D.
Impact Factor: 4.044
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Link W, Ilardi G, Zannetti A
* Editorial: Tumor Microenvironment: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression (18 views)
Front Oncol (ISSN: 2234-943xlinking), 2021 Aug 13; 11: 730815-730815.
Impact Factor: 4.848
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Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
* Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging (20 views)
Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
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Romdhane F, Villano D, Irrera P, Consolino L, Longo DL
* Evaluation of a similarity anisotropic diffusion denoising approach for improving in vivo CEST-MRI tumor pH imaging (23 views)
Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Jun; 85(6): 3479-3496.
Impact Factor: 3.635
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
* Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents (18 views)
Biomedicines (ISSN: 2227-9059linking), 2021 Apr 3; 9(4): N/D-N/D.
Impact Factor: 4.757
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (74 views)
Angew Chem Int Ed (ISSN: 1433-7851linking, 1521-3773electronic), 2021 Feb 19; 60(8): 4208-4214.
Impact Factor: 12.959
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Cortini M, Armirotti A, Columbaro M, Longo DL, Di Pompo G, Cannas E, Maresca A, Errani C, Longhi A, Righi A, Carelli V, Baldini N, Avnet S
* Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target (12 views)
Cancers (ISSN: 2072-6694linking), 2021 Jan 15; 13(2): N/D-N/D.
Impact Factor: 5.326
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Zöllner FG, Dastrù W, Irrera P, Longo DL, Bennett KM, Beeman SC, Bretthorst GL, Garbow JR
* Analysis Protocol for Dynamic Contrast Enhanced (DCE) MRI of Renal Perfusion and Filtration (19 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 637-653.
Impact Factor: 1.17
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Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (23 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
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Ponsiglione A, Nappi C, Imbriaco M, Ascione R, Megna R, Petretta M, Cuocolo A
* Cardiac magnetic resonance imaging during the COVID-19 pandemic: A southern Italian single-center experience (93 views)
Eur J Radiol Open (ISSN: 2352-0477electronic, 2352-0477linking), 2021; 8: 100319-100319.
Impact Factor: 0.654
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Irrera P, Consolino L, Dastrù W, Pedersen M, Zöllner FG, Longo DL
* Dynamic Contrast Enhanced (DCE) MRI-Derived Renal Perfusion and Filtration: Experimental Protocol (16 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 429-441.
Impact Factor: 1.17
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Pedersen M, Irrera P, Dastrù W, Zöllner FG, Bennett KM, Beeman SC, Bretthorst GL, Garbow JR, Longo DL
* Dynamic Contrast Enhancement (DCE) MRI-Derived Renal Perfusion and Filtration: Basic Concepts (28 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 205-227.
Impact Factor: 1.17
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Pavuluri KD, Consolino L, Longo DL, Irrera P, Sun PZ, Mcmahon MT
* Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol (11 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 455-471.
Impact Factor: 1.17
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Angeli A, Carta F, Nocentini A, Winum J, Zalubovskis R, Akdemir A, Onnis V, Eldehna WM, Capasso C, De Simone G, Monti Simona M, Carradori S, Donald WA, Dedhar S, Supuran CT
* Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment (83 views)
Metabolites, 2020 Oct 14; 10: 412-412.
Impact Factor: 4.097
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
* Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer (111 views) (PDF 48 views)
J Exp Clin Canc Res (ISSN: 0392-9078linking, 1756-9966, 1756-9966electronic), 2020 Sep 7; 39(1): 180-180.
Impact Factor: 7.068
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Belli S, Franco P, Iommelli F, De Vincenzo A, Brancaccio D, Telesca M, Merlino F, Novellino E, Ranson M, Del Vecchio S, Grieco P, Carotenuto A, Stoppelli MP
* Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides (77 views)
Cancers (ISSN: 2072-6694linking), 2020 Aug 24; 12(9): N/D-N/D.
Impact Factor: 6.126
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Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (74 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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Hill BS, Sarnella A, D'Avino G, Zannetti A
* Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer (220 views) (PDF 47 views)
Semin Cancer Biol (ISSN: 1044-579xlinking), 2020 Feb; 60: 202-213.
Impact Factor: 11.09
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (135 views)
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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Russi S, Verma HK, Laurino S, Mazzone P, Storto G, Nardelli A, Zoppoli P, Calice G, La Rocca F, Sgambato A, Lucci V, Falco G, Ruggieri V
* Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells (185 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2019 Jul 31; 20(15): N/D-N/D.
Impact Factor: 4.183
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Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
* MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis (283 views)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2019 Feb; 61(2): 155-162.
Impact Factor: 1.287
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Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (242 views)
Magn Reson Chem (ISSN: 0749-1581linking), 2019 Jan 24; N/D: N/D-N/D.
Impact Factor: 1.601
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Mcnitt DH, De Water LV, Marasco D, Berisio R, Lukomski S
* Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting (236 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2019; 26: 1933-1945.
Impact Factor: 3.9
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Camorani S, Fedele M, Zannetti A, Cerchia L
* TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities (345 views) (PDF 123 views)
Pharmaceuticals (ISSN: 1424-8247print, 1424-8247linking), 2018 Nov 13; 11(4): N/D-N/D.
Impact Factor: 4.286
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Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
* Superparamagnetic iron oxide nanocolloids in MRI studies of neuroinflammation (438 views)
J Neurosci Methods (ISSN: 0165-0270linking, 1872-678xelectronic), 2018 Jun 18; 310: 12-23.
Impact Factor: 2.668
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Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
* Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (219 views)
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Impact Factor: 1.505
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Di Gregorio E, Ferrauto G, Furlan C, Lanzardo S, Nuzzi R, Gianolio E, Aime S
* The Issue of Gadolinium Retained in Tissues: Insights on the Role of Metal Complex Stability by Comparing Metal Uptake in Murine Tissues Upon the Concomitant Administration of Lanthanum- and Gadolinium-Diethylentriamminopentaacetate (200 views)
Invest Radiol (ISSN: 1536-0210electronic, 0020-9996linking), 2018 Mar; 53(3): 167-172.
Impact Factor: 4.85
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Arena F, Bardini P, Blasi F, Gianolio E, Marini G, Aime S
* Gadolinium deposition, MRI hyperintensities, and glucose uptake in the hypoperfused rat brain after repeated administrations of Gadodiamide (185 views)
Neuroradiolgy, 2018; N/D: N/D-N/D.
Impact Factor: 2.346
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Tedeschi E, Cocozza S, Borrelli P, Ugga L, Morra VB, Palma G
* Longitudinal assessment of dentate nuclei relaxometry during massive gadobutrol exposure (312 views)
Magn Reson Med Sci (ISSN: 1347-3182), 2018; 17(1): 100-104.
Impact Factor: 0
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (320 views)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
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Srivastava K, Ferrauto G, Young Vg J, Aime S, Pierre VC
* Eight-Coordinate, Stable Fe(II) Complex as a Dual (19)F and CEST Contrast Agent for Ratiometric pH Imaging (197 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Oct 16; 56(20): 12206-12213.
Impact Factor: 4.7
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Hill BS, Pelagalli A, Passaro N, Zannetti A
* Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype (316 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Sep 22; 8(42): 73296-73311.
Impact Factor: 5.168
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Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (697 views) (PDF 210 views)
Theranostics (ISSN: 1838-7640, 1838-7640electronic), 2017 Aug 22; 7(14): 3595-3607.
Impact Factor: 8.537
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Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (349 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
* Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin (459 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Mar 22; 7(1): 307-307.
Impact Factor: 4.122
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Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (520 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
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Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (211 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
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Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
* Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging (263 views)
Gastric Cancer (ISSN: 1436-3291, 1436-3291linking), 2016 Dec 19; 20(4): 629-639.
Impact Factor: 5.454
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Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E
* Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model (279 views)
Exp Neurol (ISSN: 0014-4886), 2016 Aug; 282: 66-77.
Impact Factor: 4.706
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Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (455 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2016 Feb 23; 26(12): 4577-4584.
Impact Factor: 3.967
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (447 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
* Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners (439 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2015 Oct 16; 75: 47-57.
Impact Factor: 8.387
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Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (247 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
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Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (346 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
* Appearance of hepatocellular carcinoma on gadoxetic acid-enhanced hepato-biliary phase MR imaging: a systematic review (263 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 0033-8362linking), 2015 Apr 22; 120(11): 1002-1011.
Impact Factor: 1.523
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Romeo V, Esposito A, Maurea S, Camera L, Mainenti PP, Palmieri G, Buonerba C, Salvatore M
* Correlative Imaging in a Patient with Cystic Thymoma: CT, MR and PET/CT Comparison (408 views)
Pol J Radiol (ISSN: 0137-7183, 1733-134x, 1733-134xlinking), 2015 Jan 13; 80(1): 22-26.
Impact Factor: 0.567
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
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Tedeschi E, Russo C, Cocozza S, Palma G, Canna A, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Brescia Morra V, Brunetti A, Salvatore M
* Does Gadolinium Change the Relaxometry of the Dentate Nuclei? A Quantitative Multi-parametric MRI Study (321 views)
Rsna 101st Scientific Assembly And Annual Meeting, 2015; N/D: N/D-N/D.
Impact Factor: 0
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Maurea S, Mainenti PP, Tambasco A, Imbriaco M, Mollica C, Laccetti E, Camera L, Liuzzi R, Salvatore M
* Diagnostic accuracy of MR imaging to identify and characterize focal liver lesions: comparison between gadolinium and superparamagnetic iron oxide contrast media (292 views)
Quant Imaging Med Surg (ISSN: 2223-4292, 2223-4292print, 2223-4306linking), 2014 Jun; 4(3): 181-189.
Impact Factor: 3.105
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (471 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Camera L, Sagnelli M, Guadagno P, Mainenti PP, Marra T, Scotto di Santolo M, Fei L, Salvatore M
* Colonic perforation by a transmural and transvalvular migrated retained sponge: Multi-detector computed tomography findings (358 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2014 Apr 21; 20(15): 4457-4461.
Impact Factor: 2.369
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Ristori G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P, Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M, Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti M
* Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS (538 views)
Neurology (ISSN: 0028-3878, 1526-632x, 0028-3878linking), 2014 Jan 7; 82(1): 41-48.
Impact Factor: 8.185
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Ciarmiello A, Gaeta MC, Meniconi M, Milano A, Alfano B, Del Vecchio S, Salvatore M
* Parametric MR dynamic imaging for breast lesions characterization and prediction of lymph nodes involvement (358 views)
Curr Radiopharm (ISSN: 1874-4710, 1874-4729), 2014; 7(2): 91-99.
Impact Factor: 0.643
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Iodice D, Di Donato O, Liccardo I, Lamanna L, Segreto S, Salvatore M, Imbriaco M
* Prevalence of extramammary findings on breast MRI: a large retrospective single-centre study (380 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Oct; 118(7): 1109-1118.
Impact Factor: 1.368
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (485 views)
Bmc Med Imaging (ISSN: 1471-2342, 1471-2342electronic), 2013 Sep 12; 13(1): 31-31.
Impact Factor: 0.983
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Gargiulo P, Dellegrottaglie S, Bruzzese D, Savarese G, Scala O, Ruggiero D, D'Amore C, Paolillo S, Agostoni P, Bossone E, Soricelli A, Cuocolo A, Trimarco B, Perrone Filardi P
* The prognostic value of normal stress cardiac magnetic resonance in patients with known or suspected coronary artery disease: a meta-analysis (467 views)
Circ Cardiovasc Imaging (ISSN: 1942-0080, 1941-9651), 2013 Jul; 6(4): 574-582.
Impact Factor: 6.752
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (471 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Maffei E, Midiri M, Russo V, Rengo M, Tedeschi C, Spagnolo P, Seitun S, Francone M, Guaricci AI, Carrabba N, Malagò R, Cuocolo A, Arcadi T, Catalano OA, Cademartiri F
* Rationale, design and methods of CTCA-PRORECAD (Computed Tomography Coronary Angiography Prognostic Registry for Coronary Artery Disease): A multicentre and multivendor registry (345 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2013 Jun; 118(4): 591-607.
Impact Factor: 1.368
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Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (346 views) (PDF 10 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
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Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
* A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (395 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2013 Apr 2; 52(14): 3926-3930.
Impact Factor: 11.336
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (472 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
Impact Factor: 5.475
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Mancini M, Di Donato O, Saldalamacchia G, Liuzzi R, Rivellese A, Salvatore M
* Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking (441 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Mar; 118(2): 206-214.
Impact Factor: 1.368
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
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Sica G, Guida F, Bocchini G, Codella U, Mainenti PP, Tanga M, Scaglione M
* Errors in Imaging Assessment of Polytrauma Patients (675 views)
Seminars In Ultrasound Ct And Mri (ISSN: 0887-2171), 2012 Sep; 33(4): 337-346.
Impact Factor: 1.289
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Gringeri CV, Menchise V, Rizzitelli S, Cittadino E, Catanzaro V, Dati G, Chaabane L, Digilio G, Aime S
* Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (503 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Impact Factor: 2.872
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Maurea S, Fusari M, Imbriaco M, Camera L, Mainenti PP, Campione S, Santangelo M, Salvatore M
* Pitfalls in diagnostic imaging of cystic pancreatic masses: a case of true cystic lesion mimicking a mucinous cystadenoma (336 views)
Jop (ISSN: 1590-8577, 1590-0857), 2012 Jan 10; 13(1): 83-86.
Impact Factor: 0
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Greco A, Mancini M, Gargiulo S, Gramanzini M, Claudio PP, Brunetti A, Salvatore M
* Ultrasound biomicroscopy in small animal research: Applications in molecular and preclinical imaging (511 views)
J Biomed Biotechnol (ISSN: 1110-7243, 1110-7251), 2012; 2012: 519238-519238.
Impact Factor: 2.88
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (335 views)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (292 views)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (345 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (409 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (543 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (615 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Mainenti PP, Segreto S, Mancini M, Rispo A, Cozzolino I, Masone S, Rinaldi CR, Nardone G, Salvatore M
* Intestinal amyloidosis: two cases with different patterns of clinical and imaging presentation (386 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2010 May 28; 16(20): 2566-2570.
Impact Factor: 2.24
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Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (561 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
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Fusari M, Maurea S, Imbriaco M, Mollica C, Avitabile G, Soscia F, Camera L, Salvatore M
* Comparison between multislice CT and MR imaging in the diagnostic evaluation of patients with pancreatic masses (365 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2010 Apr; 115(3): 453-466.
Impact Factor: 1.618
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Matrone A, Russo M, Mollica C, Lombardi D, Lombardi G, Maurea S, Imbriaco M
* Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance (331 views)
Jop (ISSN: 1590-8577, 1590-0857), 2010 Mar 5; 11(2): 170-172.
Impact Factor: 0
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (386 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (600 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Maurea S, Caleo O, Mollica C, Imbriaco M, Mainenti PP, Palumbo C, Mancini M, Camera L, Salvatore M
* Comparative diagnostic evaluation with MR cholangiopancreatography, ultrasonography and CT in patients with pancreatobiliary disease (366 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Apr; 114(3): 390-402.
Impact Factor: 1.454
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (432 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (345 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
Impact Factor: 5.504
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (254 views)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Imbriaco M, Caprio MG, Limite G, Pace L, De Falco T, Capuano E, Salvatore M
* Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions (296 views)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2008 Nov; 191(5): 1323-1330.
Impact Factor: 2.94
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Lapi F, Cecchi E, Pedone C, Attanasio F, Banchelli G, Vannacci A, Di Pirro M, Moschini M, Berni V, Matucci R, Cini E, Scalia A, Tendi E, Mugelli A
* Safety aspects of iodinated contrast media related to their physicochemical properties: A pharmacoepidemiology study in two Tuscany hospitals (494 views)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 2008 Jul; 64(7): 723-737.
Impact Factor: 2.497
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Imbriaco M, Camera L, Manciuria A, Salvatore M
* A case of multiple intra-abdominal splenosis with computed tomography and magnetic resonance imaging correlative findings (287 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2008 Mar 7; 14(9): 1453-1455.
Impact Factor: 2.081
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Fonti R, Salvatore B, Quarantelli M, Sirignano C, Segreto S, Petruzziello F, Catalano L, Liuzzi R, Rotoli B, Del Vecchio S, Pace L, Salvatore M
* F-18-FDG PET/CT, Tc-99m-MIBI, and MRI in evaluation of patients with multiple myeloma (549 views)
J Nucl Med (ISSN: 0161-5505, 0161-1550, 1535-5667), 2008 Feb; 49(2): 195-200.
Impact Factor: 6.662
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (575 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Ragozzino A, Lassandro F, De Ritis R, Imbriaco M
* Value of MRI in three patients with major vascular injuries after laparoscopic cholecystectomy (250 views)
Emergency Radiology (ISSN: 1070-3004), 2007 Nov; 14(6): 443-447.
Impact Factor: 6.214
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Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G
* Acute appendicitis: Diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings (366 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 2055-2061.
Impact Factor: 3.405
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Pastore C, Franzese M, Sica F, Temussi P, Pastore A
* Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin (545 views)
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
Impact Factor: 3.396
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (693 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Del Giudice E, Bianchi MC, Tosetti M, Varrone A, Romano A, Crisanti AF, Titomanlio L, Imperati F
* Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? (331 views)
Epileptic Disord (ISSN: 1294-9361), 2006 Dec; 8(4): 289-293.
Impact Factor: 1.202
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Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (407 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (442 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (390 views) (PDF 231 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2006 Jul; 16(3): 224-235.
Impact Factor: 1.298
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Camera L, Mainenti PP, Di Giacomo A, Romano M, Rispo A, Alfinito F, Imbriaco M, Soscia E, Salvatore M
* Triphasic helical CT in Budd-Chiari syndrome: Patterns of enhancement in acute, subacute and chronic disease (410 views)
Clin Radiol (ISSN: 0009-9260), 2006 Apr; 61(4): 331-337.
Impact Factor: 1.665
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Tamburrini S, Brunetti A, Brown MA, Sirlin CB, Casola G
* CT appearance of the normal appendix in adults (387 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2005 Oct; 15(10): 2096-2103.
Impact Factor: 2.437
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Imbriaco M, Megibow AJ, Ragozzino A, Liuzzi R, Mainenti PP, Bortone S, Camera L, Salvatore M
* Value of the single-phase technique in MDCT assessment of pancreatic tumors (362 views)
Am J Roentgenol (ISSN: 0361-803x), 2005 Apr; 184(4): 1111-1117.
Impact Factor: 2.209
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Mainenti PP, Cantalupo T, Nicotra S, Camera L, Imbriaco M, Di Vizio D, Insabato L, Salvatore M
* Systemic amyloidosis: The CT sign of splenic hypoperfusion (305 views)
Amyloid (ISSN: 1350-6129), 2004 Dec; 11(4): 281-282.
Impact Factor: 1.886
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (351 views) (PDF 247 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
Impact Factor: 1.724
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (247 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Guzzi R, Milardi D, La Rosa C, Grasso D, Verbeet MP, Canters GW, Sportelli L
* The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin (307 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2003 Jan 15; 31(4-5): 163-170.
Impact Factor: 1.427
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Imbriaco M, Megibow AJ, Camera L, Pace L, Mainenti PP, Romano M, Selva G, Salvatore M
* Dual-phase versus single-phase helical CT to detect and assess resectability of pancreatic carcinoma (373 views)
Am J Roentgenol (ISSN: 0361-803x), 2002 Jun; 178(6): 1473-1479.
Impact Factor: 2.424
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Camera L, Bresciani M, Soscia E, Percopo V, Mainenti PP, Salvatore M
* Morphological imaging of gastroenteropancreatic neuroendocrine tumours (256 views)
Minerva Endocrinol (ISSN: 0391-1977, 1827-1634electronic, 0391-1977linking), 2001 Sep; 26(3): 123-128.
Impact Factor: 1.464
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Imbriaco M, Del Vecchio S, Riccardi A, Pace L, Di Salle F, Di Gennaro F, Salvatore M, Sodano A
* Scintimammography with Tc-99m-MIBI versus dynamic MRI for non-invasive characterization of breast masses (758 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2001 Jan; 28(1): 56-63.
Impact Factor: 3.464
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (852 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Maurea S, Maurelli L, Lastoria S, Cuocolo A, Brunetti A, Pace L, Caracò C, Klain M, Lupoli G, Salvatore M
Familial pheochromocytoma in Sipple's syndrome. A comparison between scintigraphy with 131I-meta-iodobenzylguanidine, computed tomography and echography (254 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992; 83(4): 486-490.
Impact Factor: 0.967
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Pace L, Cuocolo A, Nappi A, Nicolai E, Imbriaco M, Mangoni di Santo Stefano ML, Salvatore M
Myocardial scintigraphy with technetium 99m methoxyisobutylisonitrile. A comparison with coronary arteriography in patients with suspected ischemic cardiopathy (503 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 1992; 83(1-2): 97-100.
Impact Factor: 0.967
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Maurelli L, Cuocolo A, Lastoria S, Brunetti A, Maurea S, Lembo G, Klain M, Carac C, Salvatore M
131I-meta-iodobenzylguanidine scintigraphy in patients with a suspected pheochromocytoma. A comparison with CT and biohumoral parameters (487 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1991; 82(6): 839-843.
Impact Factor: 0.967
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130 Records (125 excluding Abstracts).
Total impact factor: 462.804 (450.03 excluding Abstracts).
Total 5 year impact factor: 445.281 (432.142 excluding Abstracts).
Total impact factor: 462.804 (450.03 excluding Abstracts).
Total 5 year impact factor: 445.281 (432.142 excluding Abstracts).
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