Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (541 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.022, 5-year impact factor: 3.424
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79960846480&partnerID=40&md5=a69d887b29132674c8d07d8aef36c95c
Keywords: Cd Spectroscopy, Luciferase Assay, Surface Plasmon Resonance, Human Immunodeficiency Virus Proteinase, I Kappa B Alpha, Transactivator Protein, Article, Binding Affinity, Chemical Mutagenesis, Circular Dichroism, Hela Cell, Human Cell, Immunoprecipitation, In Vitro Study, Molecular Recognition, Nonhuman, Protein Binding, Protein Expression, Protein Folding, Protein Immobilization, Protein Protein Interaction, Protein Synthesis, Western Blotting, Amino Acid Sequence, Binding Sites, Cell Nucleus, Hiv-1, I-Kappa B Proteins, Kinetics, Molecular Sequence Data, Nf-Kappa B, Structure-Activity Relationship, Tat Gene Products, Metabolism, Chemistry,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16, 80134 Naples, Italy.
Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Viale Europa-Germaneto, 88100 Catanzaro, Italy
Department of Biological Sciences, University Federico II of Naples, Via Mezzocannone 16, 80134 Naples, Italy
Department of Biochemistry and Medical Biotechnology, University Federico II of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
References:
Jones, S., Thornton, J. M., Principles of protein-protein interactions (1996) Proceedings of the National Academy of Sciences of the United States of America, 93 (1), pp. 13-20. , DOI 10. 1073/pnas. 93. 1. 1
Gordo, S., Giralt, E., Knitting and untying the protein network: Modulation of protein ensembles as a therapeutic strategy (2009) Protein Sci., 18, pp. 481-493
Vendrell, M., Molero, A., Gonz lez, S., P rez-Capote, K., Lluis, C., McCormick, P. J., Franco, R., Royo, M., Biotin ergopeptide probes for dopamine receptors (2011) J. Med. Chem., 24, pp. 1080-1090
Paramelle, D., Enjalbal, C., Amblard, M., Forest, E., Heymann, M., Cantel, S., Geourjon, C., Subra, G., Solid-Phase Cross-Linking (SPCL): A new tool for protein structure studies (2011) Proteomics, 11 (7), pp. 1277-1286
Lu, D., Windsor, M. A., Gellman, S. H., Keck, J. L., Peptide inhibitors identify roles for SSB C-terminal residues in SSB/exonuclease i complex formation (2009) Biochemistry, 48 (29), pp. 6764-6771
Alcaro, M. C., Vinci, V., D'Ursi, A. M., Scrima, M., Chelli, M., Giuliani, S., Meini, S., Papini, A. M., Bradykinin antagonists modified with dipeptide mimetic beta-turn inducers (2006) Bioorg. Med. Chem. Lett., 16, pp. 2387-2390
Calvanese, L., Marasco, D., Doti, N., Saporito, A., D'Auria, G., Paolillo, L., Ruvo, M., Falcigno, L., Structural investigations on the Nodal-Cripto binding: A theoretical and experimental approach (2010) Biopolymers, 93, pp. 1011-1021
Kumar, R., Nanduri, B., HPIDB - A unified resource for host-pathogen interactions (2010) BMC Bioinform., 11 (SUPPL. 6), p. 16
Brady, J., Kashanchi, F., Tat gets the "green" light on transcription initiation (2005) Retrovirology, 2, p. 69
Kashanchi, F., Piras, G., Radonovich, M. F., Duvall, J. F., Fattaey, A., Chiang, C. M., Roeder, R. G., Brady, J. N., Direct interaction of human TFIID with the HIV-1 transactivator Tat (1994) Nature, 367, pp. 295-299
Liu, J., Perkins, N. D., Schmid, R. M., Nabel, G. J., Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription (1992) J. Virol., 66, pp. 3883-3887
Jeang, K. -T., Chun, R., Lin, N. H., Gatignol, A., Glabe, C. G., Fan, H., In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor (1993) Journal of Virology, 67 (10), pp. 6224-6233
Benkirane, M., Chun, R. F., Xiao, H., Ogryzko, V. V., Howard, B. H., Nakatani, Y., Jeang, K. -T., Activation of integrated provirus requires histone acetyltransferase: P300 and P/CAF are coactivators for HIV-1 Tat (1998) Journal of Biological Chemistry, 273 (38), pp. 24898-24905. , DOI 10. 1074/jbc. 273. 38. 24898
Marzio, G., Tyagi, M., Gutierrez, M. I., Giacca, M., HIV-1 Tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter (1998) Proceedings of the National Academy of Sciences of the United States of America, 95 (23), pp. 13519-13524. , DOI 10. 1073/pnas. 95. 23. 13519
Hottiger, M. O., Nabel, G. J., Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein (1998) Journal of Virology, 72 (10), pp. 8252-8256
Clark, E., Santiago, F., Deng, L., Chong, S., De La Fuente, C., Wang, L., Fu, P., Kashanchi, F., (2000) J. Virol., 74, pp. 5040-5052
Ambrosino, C., Palmieri, C., Puca, A., Trimboli, F., Schiavone, M., Olimpico, F., Ruocco, M. R., Scala, G., Physical and functional interaction of HIV-1 Tat with E2F-4, a transcriptional regulator of mammalian cell cycle (2002) Journal of Biological Chemistry, 277 (35), pp. 31448-31458. , DOI 10. 1074/jbc. M112398200
Amini, S., Mameli, G., Del Valle, L., Skowronska, A., Reiss, K., Gelman, B. B., White, M. K., Sawaya, B. E., P73 interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28 (2005) Molecular and Cellular Biology, 25 (18), pp. 8126-8138. , DOI 10. 1128/MCB. 25. 18. 8126-8138. 2005
Ammosova, T., Jerebtsova, M., Beullens, M., Lesage, B., Jackson, A., Kashanchi, F., Southerland, W., Nekhai, S., Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein (2005) Journal of Biological Chemistry, 280 (43), pp. 36364-36371. , DOI 10. 1074/jbc. M503673200
Benasser, Y., Jeang, K. T., HIV-1 Tat interaction with Dicer: Requirement for RNA (2006) Retrovirology, 20, p. 95
Beg, A. A., Finco, T. S., Nantermet, P. V., Baldwin Jr., A. S., Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I B: A mechanism for NF- B activation (1993) Molecular and Cellular Biology, 13 (6), pp. 3301-3310
Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D., Miyamoto, S., Rel/NF-kappaB/IkappaB family: Intimate tales of association and dissociation (1995) Genes and Development, 9 (22), pp. 2723-2735
Puca, A., Fiume, G., Palmieri, C., Trimboli, F., Olimpico, F., Scala, G., Quinto, I., IkappaB-alpha represses the transcriptional activity of the HIV-1 Tat transactivator by promoting its nuclear export (2007) J. Biol. Chem., 282, pp. 37146-37157
Nabel, G., Baltimore, D., An inducible transcription factor activates expression of human immunodeficiency virus in T cells (1987) Nature, 326 (6114), pp. 711-713. , DOI 10. 1038/326711a0
Mallardo, M., Dragonetti, E., Baldassarre, F., Ambrosino, C., Scala, G., Quinto, I., An NF- B site in the 5'-untranslated leader region of the human immunodeficiency virus type 1 enhances the viral expression in response to NF- B-activating stimuli (1996) Journal of Biological Chemistry, 271 (34), pp. 20820-20827. , DOI 10. 1074/jbc. 271. 34. 20820
Kwon, H., Pelletier, N., DeLuca, C., Genin, P., Cisternas, S., Lin, R., Wainberg, M. A., Hiscott, J., Inducible expression of I B represser mutants interferes with NF- B activity and HIV-1 replication in Jurkat T cells (1998) Journal of Biological Chemistry, 273 (13), pp. 7431-7440. , DOI 10. 1074/jbc. 273. 13. 7431
Quinto, I., Mallardo, M., Baldassarre, F., Scala, G., Englund, G., Jeang, K. T., Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development (1999) J. Biol. Chem., 274, pp. 17567-17572
Quinto, I., Puca, A., Greenhouse, J., Silvera, P., Yalley-Ogunro, J., Lewis, M. G., Palmieri, C., Scala, G., High Attenuation and Immunogenicity of a Simian Immunodeficiency Virus Expressing a Proteolysis-resistant Inhibitor of NF- B (2004) Journal of Biological Chemistry, 279 (3), pp. 1720-1728. , DOI 10. 1074/jbc. M309375200
Ferreiro, D. U., Komives, E. A., Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha (2010) Biochemistry, 49, pp. 1560-1567
Kanarek, N., London, N., Schueler-Furman, O., Ben-Neriah, Y., Ubiquitination and degradation of the inhibitors of NF-kappaB (2010) Cold Spring Harb. Perspect. Biol., 2, p. 000166
Jacobs, M. D., Harrison, S. C., Structure of an IkappaBalpha/NF-kappaB complex (1998) Cell, 95, pp. 749-758
Huxford, T., Huang, D. -B., Malek, S., Ghosh, G., The crystal structure of the I B /NF- B complex reveals mechanisms of NF- B inactivation (1998) Cell, 95 (6), pp. 759-770. , DOI 10. 1016/S0092-8674 (00) 81699-2
Mosavi, L. K., Cammett, T. J., Desrosiers, D. C., Peng, Z. -Y., The ankyrin repeat as molecular architecture for protein recognition (2004) Protein Science, 13 (6), pp. 1435-1448. , DOI 10. 1110/ps. 03554604
Li, J., Mahajan, A., Tsai, M. -D., Ankyrin repeat: A unique motif mediating protein-protein interactions (2006) Biochemistry, 45 (51), pp. 15168-15178. , DOI 10. 1021/bi062188q
Bergqvist, S., Ghosh, G., Komives, E. A., The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface (2008) Protein Sci., 17, pp. 2051-2058
Sue, S. C., Cervantes, C., Komives, E. A., Dyson, H. J., Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex (2008) J. Mol. Biol., 380, pp. 917-931
Mathes, E., O'Dea, E. L., Hoffmann, A., Ghosh, G., NF- B dictates the degradation pathway of I B (2008) EMBO Journal, 27 (9), pp. 1357-1367. , DOI 10. 1038/emboj. 2008. 73, PII EMBOJ200873
Ferreiro, D. U., Cervantes, C. F., Truhlar, S. M., Cho, S. S., Wolynes, P. G., Komives, E. A., Stabilizing IkappaBalpha by "consensus" design (2007) J. Mol. Biol., 365, pp. 1201-1216
Truhlar, S. M. E., Torpey, J. W., Komives, E. A., Regions of I B that are critical for its inhibition of NF- BDNA interaction fold upon binding to NF- B (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (50), pp. 18951-18956. , http: //www. pnas. org/cgi/reprint/103/50/18951, DOI 10. 1073/pnas. 0605794103
Croy, C. H., Bergqvist, S., Huxford, T., Ghosh, G., Komives, E. A., Biophysical characterization of the free I B ankyrin repeat domain in solution (2004) Protein Science, 13 (7), pp. 1767-1777. , DOI 10. 1110/ps. 04731004
Bergqvist, S., Croy, C. H., Kjaergaard, M., Huxford, T., Ghosh, G., Komives, E. A., Thermodynamics Reveal that Helix Four in the NLS of NF- B p65 Anchors I B, Forming a Very Stable Complex (2006) Journal of Molecular Biology, 360 (2), pp. 421-434. , DOI 10. 1016/j. jmb. 2006. 05. 014, PII S0022283606005808
Bergqvist, S., Alverdi, V., Mengel, B., Hoffmann, A., Ghosh, G., Komives, E. A., Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha (2009) Proc. Natl. Acad. Sci. U. S. A., 106, pp. 19328-19333
Ruvo, M., Scarallo, A., Vecchio, G., Palombo, G., Fassina, G., Synthesis and biological characterization of HIV-TAT [1-86] BH10 (1996) Peptides, pp. 771-772
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Nicholson, M. W., Barclay, A. N., Singer, M. S., Rosen, S. D., Van Der Merwe, P. A., Affinity and kinetic analysis of L-selectin (CD62L) binding to glycosylation-dependent cell-adhesion molecule-1 (1998) Journal of Biological Chemistry, 273 (2), pp. 763-770. , DOI 10. 1074/jbc. 273. 2. 763
Betzi, S., Restouin, A., Opi, S., Arold, S. T., Parrot, I., Guerlesquin, F., Morelli, X., Collette, Y., Protein-protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 19256-19261
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Chang, N. S., The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression (2002) J. Biol. Chem., 277, pp. 10323-10331
Aguilera, C., Hoya-Arias, R., Haegeman, G., Espinosa, L., Bigas, A., Recruitment of I B to the hes1 promoter is associated with transcriptional repression (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (47), pp. 16537-16542. , DOI 10. 1073/pnas. 0404429101
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.022, 5-year impact factor: 3.424
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79960846480&partnerID=40&md5=a69d887b29132674c8d07d8aef36c95c
Keywords: Cd Spectroscopy, Luciferase Assay, Surface Plasmon Resonance, Human Immunodeficiency Virus Proteinase, I Kappa B Alpha, Transactivator Protein, Article, Binding Affinity, Chemical Mutagenesis, Circular Dichroism, Hela Cell, Human Cell, Immunoprecipitation, In Vitro Study, Molecular Recognition, Nonhuman, Protein Binding, Protein Expression, Protein Folding, Protein Immobilization, Protein Protein Interaction, Protein Synthesis, Western Blotting, Amino Acid Sequence, Binding Sites, Cell Nucleus, Hiv-1, I-Kappa B Proteins, Kinetics, Molecular Sequence Data, Nf-Kappa B, Structure-Activity Relationship, Tat Gene Products, Metabolism, Chemistry,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16, 80134 Naples, Italy.
Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Viale Europa-Germaneto, 88100 Catanzaro, Italy
Department of Biological Sciences, University Federico II of Naples, Via Mezzocannone 16, 80134 Naples, Italy
Department of Biochemistry and Medical Biotechnology, University Federico II of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
References:
Jones, S., Thornton, J. M., Principles of protein-protein interactions (1996) Proceedings of the National Academy of Sciences of the United States of America, 93 (1), pp. 13-20. , DOI 10. 1073/pnas. 93. 1. 1
Gordo, S., Giralt, E., Knitting and untying the protein network: Modulation of protein ensembles as a therapeutic strategy (2009) Protein Sci., 18, pp. 481-493
Vendrell, M., Molero, A., Gonz lez, S., P rez-Capote, K., Lluis, C., McCormick, P. J., Franco, R., Royo, M., Biotin ergopeptide probes for dopamine receptors (2011) J. Med. Chem., 24, pp. 1080-1090
Paramelle, D., Enjalbal, C., Amblard, M., Forest, E., Heymann, M., Cantel, S., Geourjon, C., Subra, G., Solid-Phase Cross-Linking (SPCL): A new tool for protein structure studies (2011) Proteomics, 11 (7), pp. 1277-1286
Lu, D., Windsor, M. A., Gellman, S. H., Keck, J. L., Peptide inhibitors identify roles for SSB C-terminal residues in SSB/exonuclease i complex formation (2009) Biochemistry, 48 (29), pp. 6764-6771
Alcaro, M. C., Vinci, V., D'Ursi, A. M., Scrima, M., Chelli, M., Giuliani, S., Meini, S., Papini, A. M., Bradykinin antagonists modified with dipeptide mimetic beta-turn inducers (2006) Bioorg. Med. Chem. Lett., 16, pp. 2387-2390
Calvanese, L., Marasco, D., Doti, N., Saporito, A., D'Auria, G., Paolillo, L., Ruvo, M., Falcigno, L., Structural investigations on the Nodal-Cripto binding: A theoretical and experimental approach (2010) Biopolymers, 93, pp. 1011-1021
Kumar, R., Nanduri, B., HPIDB - A unified resource for host-pathogen interactions (2010) BMC Bioinform., 11 (SUPPL. 6), p. 16
Brady, J., Kashanchi, F., Tat gets the "green" light on transcription initiation (2005) Retrovirology, 2, p. 69
Kashanchi, F., Piras, G., Radonovich, M. F., Duvall, J. F., Fattaey, A., Chiang, C. M., Roeder, R. G., Brady, J. N., Direct interaction of human TFIID with the HIV-1 transactivator Tat (1994) Nature, 367, pp. 295-299
Liu, J., Perkins, N. D., Schmid, R. M., Nabel, G. J., Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription (1992) J. Virol., 66, pp. 3883-3887
Jeang, K. -T., Chun, R., Lin, N. H., Gatignol, A., Glabe, C. G., Fan, H., In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor (1993) Journal of Virology, 67 (10), pp. 6224-6233
Benkirane, M., Chun, R. F., Xiao, H., Ogryzko, V. V., Howard, B. H., Nakatani, Y., Jeang, K. -T., Activation of integrated provirus requires histone acetyltransferase: P300 and P/CAF are coactivators for HIV-1 Tat (1998) Journal of Biological Chemistry, 273 (38), pp. 24898-24905. , DOI 10. 1074/jbc. 273. 38. 24898
Marzio, G., Tyagi, M., Gutierrez, M. I., Giacca, M., HIV-1 Tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter (1998) Proceedings of the National Academy of Sciences of the United States of America, 95 (23), pp. 13519-13524. , DOI 10. 1073/pnas. 95. 23. 13519
Hottiger, M. O., Nabel, G. J., Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein (1998) Journal of Virology, 72 (10), pp. 8252-8256
Clark, E., Santiago, F., Deng, L., Chong, S., De La Fuente, C., Wang, L., Fu, P., Kashanchi, F., (2000) J. Virol., 74, pp. 5040-5052
Ambrosino, C., Palmieri, C., Puca, A., Trimboli, F., Schiavone, M., Olimpico, F., Ruocco, M. R., Scala, G., Physical and functional interaction of HIV-1 Tat with E2F-4, a transcriptional regulator of mammalian cell cycle (2002) Journal of Biological Chemistry, 277 (35), pp. 31448-31458. , DOI 10. 1074/jbc. M112398200
Amini, S., Mameli, G., Del Valle, L., Skowronska, A., Reiss, K., Gelman, B. B., White, M. K., Sawaya, B. E., P73 interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28 (2005) Molecular and Cellular Biology, 25 (18), pp. 8126-8138. , DOI 10. 1128/MCB. 25. 18. 8126-8138. 2005
Ammosova, T., Jerebtsova, M., Beullens, M., Lesage, B., Jackson, A., Kashanchi, F., Southerland, W., Nekhai, S., Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein (2005) Journal of Biological Chemistry, 280 (43), pp. 36364-36371. , DOI 10. 1074/jbc. M503673200
Benasser, Y., Jeang, K. T., HIV-1 Tat interaction with Dicer: Requirement for RNA (2006) Retrovirology, 20, p. 95
Beg, A. A., Finco, T. S., Nantermet, P. V., Baldwin Jr., A. S., Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I B: A mechanism for NF- B activation (1993) Molecular and Cellular Biology, 13 (6), pp. 3301-3310
Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D., Miyamoto, S., Rel/NF-kappaB/IkappaB family: Intimate tales of association and dissociation (1995) Genes and Development, 9 (22), pp. 2723-2735
Puca, A., Fiume, G., Palmieri, C., Trimboli, F., Olimpico, F., Scala, G., Quinto, I., IkappaB-alpha represses the transcriptional activity of the HIV-1 Tat transactivator by promoting its nuclear export (2007) J. Biol. Chem., 282, pp. 37146-37157
Nabel, G., Baltimore, D., An inducible transcription factor activates expression of human immunodeficiency virus in T cells (1987) Nature, 326 (6114), pp. 711-713. , DOI 10. 1038/326711a0
Mallardo, M., Dragonetti, E., Baldassarre, F., Ambrosino, C., Scala, G., Quinto, I., An NF- B site in the 5'-untranslated leader region of the human immunodeficiency virus type 1 enhances the viral expression in response to NF- B-activating stimuli (1996) Journal of Biological Chemistry, 271 (34), pp. 20820-20827. , DOI 10. 1074/jbc. 271. 34. 20820
Kwon, H., Pelletier, N., DeLuca, C., Genin, P., Cisternas, S., Lin, R., Wainberg, M. A., Hiscott, J., Inducible expression of I B represser mutants interferes with NF- B activity and HIV-1 replication in Jurkat T cells (1998) Journal of Biological Chemistry, 273 (13), pp. 7431-7440. , DOI 10. 1074/jbc. 273. 13. 7431
Quinto, I., Mallardo, M., Baldassarre, F., Scala, G., Englund, G., Jeang, K. T., Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development (1999) J. Biol. Chem., 274, pp. 17567-17572
Quinto, I., Puca, A., Greenhouse, J., Silvera, P., Yalley-Ogunro, J., Lewis, M. G., Palmieri, C., Scala, G., High Attenuation and Immunogenicity of a Simian Immunodeficiency Virus Expressing a Proteolysis-resistant Inhibitor of NF- B (2004) Journal of Biological Chemistry, 279 (3), pp. 1720-1728. , DOI 10. 1074/jbc. M309375200
Ferreiro, D. U., Komives, E. A., Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha (2010) Biochemistry, 49, pp. 1560-1567
Kanarek, N., London, N., Schueler-Furman, O., Ben-Neriah, Y., Ubiquitination and degradation of the inhibitors of NF-kappaB (2010) Cold Spring Harb. Perspect. Biol., 2, p. 000166
Jacobs, M. D., Harrison, S. C., Structure of an IkappaBalpha/NF-kappaB complex (1998) Cell, 95, pp. 749-758
Huxford, T., Huang, D. -B., Malek, S., Ghosh, G., The crystal structure of the I B /NF- B complex reveals mechanisms of NF- B inactivation (1998) Cell, 95 (6), pp. 759-770. , DOI 10. 1016/S0092-8674 (00) 81699-2
Mosavi, L. K., Cammett, T. J., Desrosiers, D. C., Peng, Z. -Y., The ankyrin repeat as molecular architecture for protein recognition (2004) Protein Science, 13 (6), pp. 1435-1448. , DOI 10. 1110/ps. 03554604
Li, J., Mahajan, A., Tsai, M. -D., Ankyrin repeat: A unique motif mediating protein-protein interactions (2006) Biochemistry, 45 (51), pp. 15168-15178. , DOI 10. 1021/bi062188q
Bergqvist, S., Ghosh, G., Komives, E. A., The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface (2008) Protein Sci., 17, pp. 2051-2058
Sue, S. C., Cervantes, C., Komives, E. A., Dyson, H. J., Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex (2008) J. Mol. Biol., 380, pp. 917-931
Mathes, E., O'Dea, E. L., Hoffmann, A., Ghosh, G., NF- B dictates the degradation pathway of I B (2008) EMBO Journal, 27 (9), pp. 1357-1367. , DOI 10. 1038/emboj. 2008. 73, PII EMBOJ200873
Ferreiro, D. U., Cervantes, C. F., Truhlar, S. M., Cho, S. S., Wolynes, P. G., Komives, E. A., Stabilizing IkappaBalpha by "consensus" design (2007) J. Mol. Biol., 365, pp. 1201-1216
Truhlar, S. M. E., Torpey, J. W., Komives, E. A., Regions of I B that are critical for its inhibition of NF- BDNA interaction fold upon binding to NF- B (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (50), pp. 18951-18956. , http: //www. pnas. org/cgi/reprint/103/50/18951, DOI 10. 1073/pnas. 0605794103
Croy, C. H., Bergqvist, S., Huxford, T., Ghosh, G., Komives, E. A., Biophysical characterization of the free I B ankyrin repeat domain in solution (2004) Protein Science, 13 (7), pp. 1767-1777. , DOI 10. 1110/ps. 04731004
Bergqvist, S., Croy, C. H., Kjaergaard, M., Huxford, T., Ghosh, G., Komives, E. A., Thermodynamics Reveal that Helix Four in the NLS of NF- B p65 Anchors I B, Forming a Very Stable Complex (2006) Journal of Molecular Biology, 360 (2), pp. 421-434. , DOI 10. 1016/j. jmb. 2006. 05. 014, PII S0022283606005808
Bergqvist, S., Alverdi, V., Mengel, B., Hoffmann, A., Ghosh, G., Komives, E. A., Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha (2009) Proc. Natl. Acad. Sci. U. S. A., 106, pp. 19328-19333
Ruvo, M., Scarallo, A., Vecchio, G., Palombo, G., Fassina, G., Synthesis and biological characterization of HIV-TAT [1-86] BH10 (1996) Peptides, pp. 771-772
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Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction
Protein protein interactions play fundamental roles in physiological and pathological biological processes. The characterization of the structural determinants of protein-protein recognition represents an important step for the development of molecular entities able to modulate these interactions. We have recently found that I kappa B-alpha (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) blocks the HIV-1 expression and replication in a NF-kappa B-independent manner by directly binding to the virus-encoded Tat transactivator. Here, we report the evaluation of the entity of binding of I kappa B-alpha to Tat through in vitro Surface Plasmon Resonance assay. Moreover, by designing and characterizing a set of peptides of the C-terminus region of I kappa B-alpha, we show that the peptide corresponding to the I kappa B-alpha sequence 262-287 was able to bind to Tat with high affinity (300 nM). The characterization of a number of I kappa B-alpha-based peptides also provided insights into their intrinsic folding properties. These findings have been corroborated by mutagenesis studies on the full-length I kappa B-alpha, which unveil that different I kappa B-alpha residues are involved in NF-kappa B or Tat recognition. (C) 2011 Elsevier Masson SAS. All rights reserved.
Protein protein interactions play fundamental roles in physiological and pathological biological processes. The characterization of the structural determinants of protein-protein recognition represents an important step for the development of molecular entities able to modulate these interactions. We have recently found that I kappa B-alpha (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) blocks the HIV-1 expression and replication in a NF-kappa B-independent manner by directly binding to the virus-encoded Tat transactivator. Here, we report the evaluation of the entity of binding of I kappa B-alpha to Tat through in vitro Surface Plasmon Resonance assay. Moreover, by designing and characterizing a set of peptides of the C-terminus region of I kappa B-alpha, we show that the peptide corresponding to the I kappa B-alpha sequence 262-287 was able to bind to Tat with high affinity (300 nM). The characterization of a number of I kappa B-alpha-based peptides also provided insights into their intrinsic folding properties. These findings have been corroborated by mutagenesis studies on the full-length I kappa B-alpha, which unveil that different I kappa B-alpha residues are involved in NF-kappa B or Tat recognition. (C) 2011 Elsevier Masson SAS. All rights reserved.
Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction
| ▼ Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors |
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Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
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GrassoG, Satriano C, Milardi D
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Marasco D, Messori L, Marzo T, Merlino A
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (444 views)
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
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Sandomenico A, Severino V, Chambery A, Focà A, Focà G, Farina C, Ruvo M
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Stelitano V, Brandt A, Fernicola S, Franceschini S, Giardina G, Pica A, Rinaldo S, Sica F, Cutruzzola F
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (323 views)
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
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Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA
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D'Agata R, Spoto G
* Surface plasmon resonance imaging for nucleic acid detection (326 views)
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D'Agata R, Spoto G
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
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Pilla P, Sandomenico A, Malachovsk V, Borriello A, Giordano M, Cutolo A, Ruvo M, Cusano A
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* GSM48878: CD8 IL2-D2 (374 views)
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
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D'Agata R, Breveglieri G, Zanoli LM, Borgatti M, Spoto G, Gambari R
* Direct Detection of Point Mutations in Nonamplified Human Genomic DNA (646 views)
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
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Impact Factor: 2.484
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (443 views)
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (347 views)
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Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
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Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (457 views)
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (553 views)
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Impact Factor: 10.558
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (456 views)
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (373 views)
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (371 views)
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Impact Factor: 5.361
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (536 views)
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D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (275 views)
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (359 views)
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Impact Factor: 0
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Sandomenico A, Monti SM, Marasco D, Dathan N, Palumbo R, Saviano M, Ruvo M
* Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site (1612 views)
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Grasso G, D'Agata R, Zanoli L, Spoto G
* Microfluidic networks for surface plasmon resonance imaging real-time kinetics experiments (264 views)
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Impact Factor: 2.579
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Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
* Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme (364 views)
Eur Biophys J (ISSN: 1432-1017, 0175-7571, 0175-7571linking), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (439 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (419 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (408 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (388 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Grasso G, Rizzarelli E, Spoto G
* How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin (338 views)
Bba-Gen Subjects (ISSN: 0006-3002, 1570-9639, 0925-4439), 2008 Jul; 1784(7-8): 1122-1126.
Impact Factor: 2.233
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (420 views)
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
Impact Factor: 1.621
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Rossi M, Ruvo M, Marasco D, Colombo M, Cassani G, Verdoliva A
* Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide (415 views)
Mol Immunol (ISSN: 0161-5890), 2008 Jan; 45(1): 226-234.
Impact Factor: 3.555
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (245 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (406 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (324 views)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (437 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (398 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Impact Factor: 2.945
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Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (345 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
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D'Agata R, Grasso G, Iacono G, Spoto G, Vecchio G
* Lectin recognition of a new SOD mimic bioconjugate studied with surface plasmon resonance imaging (278 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Feb 21; 4(4): 610-612.
Impact Factor: 2.874
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (564 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Arena G, Contino A, D'Agata R, Sgarlata C, Spoto G
* Ordered anchored cavities at work: A new and rapid SPR-based method for the detection of trace amounts of Cs+ (401 views)
New J Chem (ISSN: 1144-0546), 2005; 29(11): 1393-1395.
Impact Factor: 2.574
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (382 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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* Novel insights on nucleopeptide binding: a spectroscopic and in silico investigation on the interaction of a thymine-bearing tetrapeptide with a homoadenine DNA (39 views)
Journal Of Molecular Liquids, 2021 Dec; 117975: 14140-14148.
Impact Factor: 6.165
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Riccardi C, Capasso D, Coppola A, Platella C, Montesarchio D, Di Gaetano S, Roviello GN, Musumeci D
* Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes (129 views)
Pharmaceuticals (ISSN: 1424-8247linking, 1424-8247print), 2020 Sep 30; 13(10): 284-284.
Impact Factor: 4.421
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D’errico S, Falanga AP, Capasso D, Di Gaetano S, Marzano M, Terracciano M, Roviello GN, Piccialli G, Oliviero G, Borbone N
* Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex (118 views)
Pharmaceutics (ISSN: 1999-4923linking), 2020 Jul 4; 12(7): 627-627.
Impact Factor: 4.421
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De Luca S, Verdoliva V, Saviano M, Fattorusso R, Diana D
* SPR and NMR characterization of the molecular interaction between A9 peptide and a model system of HER2 receptor: A fragment approach for selecting peptide structures specific for their target (112 views)
J Pept Sci (ISSN: 1075-2617linking, 1099-1387electronic), 2020 Feb; 26(2): e3231-e3231.
Impact Factor: 1.877
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (232 views)
J Chem Res (ISSN: 0162-0134linking, 0162-0134print), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
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Ferrucci V, De Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M
* Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition (431 views)
Brain (ISSN: 1460-2156electronic, 0006-8950linking), 2018 May 1; 141(5): 1300-1319.
Impact Factor: 9.915
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La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D
* Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces (380 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2017 May 04; 138: 106-115.
Impact Factor: 3.188
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1154 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D
* Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia (380 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2016 Sep 13; 7(37): 59129-59143.
Impact Factor: 5.168
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (414 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (372 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (504 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (639 views) (PDF 257 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
Impact Factor: 3.257
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Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
* Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (416 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Jan 15; 21(4): 283-293.
Impact Factor: 1.951
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GrassoG, Satriano C, Milardi D
* A neglected modulator of insulin-degrading enzyme activity and conformation: The pH (375 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2015; 203-204: 33-40.
Impact Factor: 2.363
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (501 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Falcigno L, D'Auria G, Calvanese L, Marasco D, Iacobelli R, Scognamiglio PL, Brun P, Danesin R, Pasqualin M, Castagliuolo I, Dettin M
* Osteogenic properties of a short BMP-2 chimera peptide (464 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(9): 700-709.
Impact Factor: 1.951
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Marasco D, Messori L, Marzo T, Merlino A
* Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme (696 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(22): 10392-10398.
Impact Factor: 4.177
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (444 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (480 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (448 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
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Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (381 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Binding ability of a thymine-functionalized oligolysine towards nucleic acids (325 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 997-1002.
Impact Factor: 2.793
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Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (338 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
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Cantisani M, Falanga A, Incoronato N, Russo L, De Simone A, Morelli G, Berisio R, Galdiero M, Galdiero S
* Conformational modifications of gB from herpes simplex virus type 1 analyzed by synthetic peptides (469 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8366-8376.
Impact Factor: 5.48
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Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (303 views)
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (881 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Sandomenico A, Severino V, Chambery A, Focà A, Focà G, Farina C, Ruvo M
* A Comparative Structural and Bioanalytical Study of IVIG Clinical Lots (324 views)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2013 Jul; 54(3): 983-995.
Impact Factor: 2.275
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Stelitano V, Brandt A, Fernicola S, Franceschini S, Giardina G, Pica A, Rinaldo S, Sica F, Cutruzzola F
* Probing the activity of diguanylate cyclases and c-di-GMP phosphodiesterases in real-time by CD spectroscopy (451 views)
Nucleic Acids Res (ISSN: 0305-1048, 0305-5104, 1362-4962), 2013 Apr; 41(7): e79-e79.
Impact Factor: 4.188
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (323 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (325 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA
* Evolutionary screening and adsorption behavior of engineered M13 bacteriophage and derived dodecapeptide for selective decoration of gold interfaces (379 views)
J Colloid Interface Sci (ISSN: 0021-9797, 1095-7103electronic, 0021-9797linking), 2013 Jan 1; 389(1): 220-229.
Impact Factor: 1.646
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D'Agata R, Spoto G
* Surface plasmon resonance imaging for nucleic acid detection (326 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 573-584.
Impact Factor: 3.578
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (503 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (447 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Zanoli LM, D'Agata R, Spoto G
* Functionalized gold nanoparticles for ultrasensitive DNA detection (282 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2012 Feb; 402(5): 1759-1771.
Impact Factor: 3.659
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Pilla P, Sandomenico A, Malachovsk V, Borriello A, Giordano M, Cutolo A, Ruvo M, Cusano A
* A protein-based biointerfacing route toward label-free immunoassays with long period gratings in transition mode (373 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic, 0956-5663linking), 2012 Jan 15; 31(1): 486-491.
Impact Factor: 5.437
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* GSM48878: CD8 IL2-D2 (374 views)
Gene Expression Omnibus, 2011 Dec 2; 59(2): 302-308.
Impact Factor: 2.082
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (442 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
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D'Agata R, Breveglieri G, Zanoli LM, Borgatti M, Spoto G, Gambari R
* Direct Detection of Point Mutations in Nonamplified Human Genomic DNA (646 views)
Analytical Chemistry (ISSN: 0003-2700), 2011 Nov 15; 83(22): 8711-8717.
Impact Factor: 5.856
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
* Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation (331 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2011 Jul 1; 410(2): 339-344.
Impact Factor: 2.484
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (443 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 May; 77(5): 319-327.
Impact Factor: 2.282
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (347 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
* Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (390 views)
Nucleic Acids Res (ISSN: 1362-4962, 0305-1048, 1362-4962electronic), 2010 Dec; 38(22): 8239-8256.
Impact Factor: 7.836
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Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (457 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (553 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (456 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (373 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (371 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (536 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
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D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (275 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (359 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Sandomenico A, Monti SM, Marasco D, Dathan N, Palumbo R, Saviano M, Ruvo M
* Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site (1612 views)
Mol Immunol (ISSN: 0161-5890), 2009 Oct; 46(16): 3300-3309.
Impact Factor: 3.202
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Grasso G, D'Agata R, Zanoli L, Spoto G
* Microfluidic networks for surface plasmon resonance imaging real-time kinetics experiments (264 views)
Microchemical Journal (ISSN: 0026-265x), 2009 Sep; 93(1): 82-86.
Impact Factor: 2.579
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Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
* Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme (364 views)
Eur Biophys J (ISSN: 1432-1017, 0175-7571, 0175-7571linking), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (439 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (419 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (408 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (388 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Grasso G, Rizzarelli E, Spoto G
* How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin (338 views)
Bba-Gen Subjects (ISSN: 0006-3002, 1570-9639, 0925-4439), 2008 Jul; 1784(7-8): 1122-1126.
Impact Factor: 2.233
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (420 views)
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
Impact Factor: 1.621
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Rossi M, Ruvo M, Marasco D, Colombo M, Cassani G, Verdoliva A
* Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide (415 views)
Mol Immunol (ISSN: 0161-5890), 2008 Jan; 45(1): 226-234.
Impact Factor: 3.555
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (245 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (406 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (324 views)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (437 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (398 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Impact Factor: 2.945
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Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (345 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
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D'Agata R, Grasso G, Iacono G, Spoto G, Vecchio G
* Lectin recognition of a new SOD mimic bioconjugate studied with surface plasmon resonance imaging (278 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Feb 21; 4(4): 610-612.
Impact Factor: 2.874
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (564 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Arena G, Contino A, D'Agata R, Sgarlata C, Spoto G
* Ordered anchored cavities at work: A new and rapid SPR-based method for the detection of trace amounts of Cs+ (401 views)
New J Chem (ISSN: 1144-0546), 2005; 29(11): 1393-1395.
Impact Factor: 2.574
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (382 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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72 Records (69 excluding Abstracts).
Total impact factor: 257.792 (251.79 excluding Abstracts).
Total 5 year impact factor: 256.412 (247.43 excluding Abstracts).
Total impact factor: 257.792 (251.79 excluding Abstracts).
Total 5 year impact factor: 256.412 (247.43 excluding Abstracts).
541 views. Last view on Wednesday 09 February 2022, 22:01:32
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