Copper (II) ions modulate Angiogenin activity in human endothelial cells (424 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.905, 5-year impact factor: 4.172
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84922270924&partnerID=40&md5=4ba92c7c1a8a5807f948d238e389d7a7
Keywords: Als, Angiogenesis, Copper, Human Endothelial Cells, Copper Ion, Messenger Rna, Mitogen Activated Protein Kinase 1, Alzheimer Disease, Article, Cell Migration, Cellular Distribution, Confocal Microscopy, Enzyme Phosphorylation, Gene Expression, Human Cell, Immunofluorescence, Parkinson Disease, Protein Expression, Protein Localization, Real Time Polymerase Chain Reaction, Reverse Transcription Polymerase Chain Reaction, Umbilical Vein Endothelial Cell,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Pisa, ViaBonanno 6Pisa, Italy
Department of Chemical Sciences, University of Catania, Viale Andrea Doria, 6Catania, Italy
Institute of Biostructures and Bioimages, National Council of Research (CNR), Viale Andrea Doria, 6Catania, Italy
References:
Aparicio-Erriu, I. M., Prehn, J. H., Molecular mechanisms in amyotrophic lateral sclerosis: The role of angiogenin, a secreted rnase (2012) Front Neurosci, 6, p. 16
Arena, G., Pappalardo, G., Sovago, I., Rizzarelli, E., Copper (II) interaction with amyloid-: Affinity and speciation (2012) Coord Chem Rev, 256, pp. 3-12
Asada, S., Takahashi, T., Isodono, K., Adachi, A., Imoto, H., Ogata, T., Ueyama, T., Oh, H., Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis (2008) Am J Physiol Heart Circ Physiol, 295, pp. H2512-H2521
Ayton, S., Lei, P., Bush, A. I., Metallostasis in Alzheimer's disease (2013) Free Radic Biol Med, 62, pp. 76-89
Badet, J., Soncin, F., Guitton, J. -D., Lamare, O., Cartwrigth, T., Barritault, D., Specific binding of angiogenin to calf pulmonary artery endothelial cells (1989) Proc Natl Acad Sci USA, 86, pp. 8427-8431
Cavallucci, V., D'Amelio, M., Cecconi, F., A toxicity in Alzheimer's disease (2012) Mol Neurobiol, 45, pp. 366-378
Chen, C. C., Chen, Y. C., Hsiao, H. Y., Chang, C., Chern, Y., Neurovascular abnormalities in brain disorders: Highlights with angiogenesis and magnetic resonance imaging studies (2013) J Biomed Sci, 20, p. 47
Connolly, D. T., Olander, J. V., Heuvelman, D., Nelson, R., Monsell, R., Siegel, N., Haymore, B. L., Feder, J., Human vascular permeability factor. Isolation from U937 cells (1989) J Biol Chem, 264, pp. 20017-20024
Crabtree, B., Thiyagarajan, N., Prior, S. H., Wilson, P., Iyer, S., Ferns, T., Shapiro, R., Acharya, K. R., Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis (2007) Biochemistry, 46, pp. 11810-11818
D'Andrea, L. D., Romanelli, A., Di Stasi, R., Pedone, C., Bioinorganic aspects of angiogenesis (2010) Dalton Trans, 39, pp. 7625-7636
Del Giudice, R., Monti, D. M., Sarcinelli, C., Arciello, A., Piccoli, R., Hu, G. F., Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin (2014) Cell Death Dis, 5, p. e1097
Drachman, D. A., The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease (2014) Alzheimers Dement, 10, pp. 372-380
Emara, M. M., Ivanov, P., Hickman, T., Dawra, N., Tisdale, S., Kedersha, N., Hu, G. F., Anderson, P., Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly (2010) J Biol Chem, 285, pp. 10959-10968
Finney, L., Mandava, S., Ursos, L., Zhang, W., Rodi, D., Vogt, S., Legnini, D., Glesne, D., X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis (2007) Proc Natl Acad Sci USA, 104, pp. 2247-2252
Gao, X., Xu, Z., Mechanisms of action of angiogenin (2008) Acta Biochim Biophys Sin, 40, pp. 619-624
Greenway, M. J., Andersen, P. M., Russ, C., Ennis, S., Cashman, S., Donaghy, C., Patterson, V., Hardiman, O., ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis (2006) Nat Genet, 38, pp. 411-413
Hardy, J. A., Higgins, G. A., Alzheimer's disease: The amyloid cascade hypothesis (1992) Science, 256, pp. 184-185
Holloway, D. E., Hares, M. C., Shapiro, R., Subramanian, V., Acharya, K. R., High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins (2001) Protein Expr Purif, 22, pp. 307-317
Hu, G. F., Riordan, J. F., Vallee, B. L., Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities (1994) Proc Natl Acad Sci USA, 91, pp. 12096-12100
Hu, G. F., Copper stimulates proliferation of human endothelial cells under culture (1998) J Cell Biochem, 69, pp. 326-335
Hu, G. F., Neomycin inhibits angiogenin-induced angiogenesis (1998) Proc Natl Acad Sci USA, 95, pp. 9791-9795
Hu, G. F., Xu, C. J., Riordan, J. F., Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA (2000) J Cell Biochem, 76, pp. 452-462
Iakovidis, I., Delimaris, I., Piperakis, S. M., Copper and its complexes in medicine: A biochemical approach (2011) Mol Biol Int, 2011, p. 594529
Jang, S. H., Kang, D. K., Chang, S. I., Scheraga, H. A., Shin, H. C., High level production of bovine angiogenin in E. Coli by an efficient refolding procedure (2004) Biotechnol Lett, 26, pp. 1501-1504
Jellinger, K. A., The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations (2013) Int Rev Neurobiol, 110, pp. 1-47
Jimi, S. I., Ito, K. I., Kohno, K., Ono, M., Kuwano, M., Itagaki, Y., Ishikawa, H., Modulation by bovine angiogenin of tubular morphogenesis and expression of plasminogen activator in bovine endothelial cells (1995) Biochem Biophys Res Commun, 211, pp. 476-483
Kelleher, R. J., Soiza, R. L., Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder? (2013) Am J Cardiovasc Dis, 3, pp. 197-226
Khoo, C. P., Micklem, K., Watt, S. M., A comparison of methods for quantifying angiogenesis in the Matrigel assay in vitro (2011) Tissue Eng Part C Methods, 17, pp. 895-906
Kieran, D., Sebastia, J., Greenway, M. J., King, M. A., Connaughton, D., Concannon, C. G., Fenner, B., Prehn, J. H., Control of motoneuron survival by angiogenin (2008) J Neurosci, 28, pp. 14056-14061
Kim, Y. N., Kim, D. H., Decreased serum angiogenin level in Alzheimer's disease (2012) Prog Neuro-Psychoph, 38, pp. 116-120
Kishimoto, K., Liu, S., Tsuji, T., Olson, K. A., Hu, G. F., Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis (2005) Oncogene, 24, pp. 445-456
La Mendola, D., Magr, A., Vagliasindi, L. I., Hansson., Bonomo, R. P., Rizzarelli, E., Copper (II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (2010) Dalton Trans, pp. 10678-106784
La Mendola, D., Farkas, D., Bellia, F., Magr, A., Travaglia, A., Hansson., Rizzarelli, E., Probing the copper (II) binding features of angiogenin. Similarities and differences between a N-terminus peptide fragment and the recombinant human protein (2012) Inorg Chem, 51, pp. 128-141
Lang, M., Fan, Q., Wang, L., Zheng, Y., Xiao, G., Wang, X., Wang, W., Zhou, B., Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A 42-induced Alzheimer's disease-like symptoms (2013) Neurobiol Aging, 34, pp. 2604-2612
Lee, F. S., Vallee, B. L., Characterization of ribonucleolytic activity of angiogenin towards tRNA. Biochem (1989) Biophys Res Commun, 161, pp. 121-126
Li, R., Riordan, J. F., Hu, G., Nuclear translocation of human angiogenin in cultured human umbilical artery endothelial cells is microtubule and lysosome independent (1997) Biochem Biophys Res Commun, 238, pp. 305-312
Li, S., Hu, G. F., Emerging role of angiogenin in stress response and cell survival under adverse conditions (2012) J Cell Physiol, 227, pp. 2822-2826
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Padhi, A. K., Kumar, H., Vasaikar, S. V., Jayaram, B., Gomes, J., Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis (2012) PLoS One, p. e32479
Park, J. H., Lee, D. W., Park, K. S., Elevated serum copper and ceruloplasmin levels in Alzheimer's disease (2014) Asia Pac Psychiatry, 6, pp. 38-45
Pe a, M. M., Lee, J., Thiele, D. J., A delicate balance: Homeostatic control of copper uptake and distribution (1999) J Nutr, 129, pp. 1251-1260
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Sen, C. K., Khanna, S., Venojarvi, M., Trikha, P., Ellison, E. C., Hunt, T. K., Roy, S., Copper-induced vascular endothelial growth factor expression and wound healing (2002) Am J Physiol Heart Circ Physiol, 282, pp. H1821-H1827
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Wong, S. K., A 384-well cell-based phospho-ERK assay for dopamine D2 and D3 receptors (2004) Anal Biochem, 333, pp. 265-272
Wei, S., Gao, X., Du, J., Su, J., Xu, Z., Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics (2011) PLoS One, 6, p. e28797
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Yang, S. H., Sharrocks, A. D., Whitmarsh, A. J., MAP kinase signalling cascades and transcriptional regulation (2013) Gene, 513, pp. 1-13
Yeo, K. J., Hwang, E., Min, K. M., Jee, J. G., Lee, C. K., Hwang, K. Y., Jeon, Y. H., Cheong, H. K., The dual binding site of angiogenin and its inhibition mechanism: The crystal structure of the rat angiogenin-heparin complex (2014) Chem Commun (Camb), 50, pp. 12966-12969
Yoshioka, N., Wang, L., Kishimoto, K., Tsuji, T., Hu, G. F., A therapeutic target for prostate cancer based on angiogenin-stimulated angiogenesis and cancer cell proliferation (2006) Proc Natl Acad Sci U S A, 103, pp. 14519-14524
Aparicio-Erriu, I.M., Prehn, J.H., Molecular mechanisms in amyotrophic lateral sclerosis: The role of angiogenin, a secreted rnase (2012) Front Neurosci, 6, p. 16
Chen, C.C., Chen, Y.C., Hsiao, H.Y., Chang, C., Chern, Y., Neurovascular abnormalities in brain disorders: Highlights with angiogenesis and magnetic resonance imaging studies (2013) J Biomed Sci, 20, p. 47
Connolly, D.T., Olander, J.V., Heuvelman, D., Nelson, R., Monsell, R., Siegel, N., Haymore, B.L., Feder, J., Human vascular permeability factor. Isolation from U937 cells (1989) J Biol Chem, 264, pp. 20017-20024
D'Andrea, L.D., Romanelli, A., Di Stasi, R., Pedone, C., Bioinorganic aspects of angiogenesis (2010) Dalton Trans, 39, pp. 7625-7636
Drachman, D.A., The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease (2014) Alzheimers Dement, 10, pp. 372-380
Emara, M.M., Ivanov, P., Hickman, T., Dawra, N., Tisdale, S., Kedersha, N., Hu, G.F., Anderson, P., Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly (2010) J Biol Chem, 285, pp. 10959-10968
Greenway, M.J., Andersen, P.M., Russ, C., Ennis, S., Cashman, S., Donaghy, C., Patterson, V., Hardiman, O., ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis (2006) Nat Genet, 38, pp. 411-413
Hardy, J.A., Higgins, G.A., Alzheimer's disease: The amyloid cascade hypothesis (1992) Science, 256, pp. 184-185
Holloway, D.E., Hares, M.C., Shapiro, R., Subramanian, V., Acharya, K.R., High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins (2001) Protein Expr Purif, 22, pp. 307-317
Hu, G.F., Riordan, J.F., Vallee, B.L., Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities (1994) Proc Natl Acad Sci USA, 91, pp. 12096-12100
Hu, G.F., Copper stimulates proliferation of human endothelial cells under culture (1998) J Cell Biochem, 69, pp. 326-335
Hu, G.F., Neomycin inhibits angiogenin-induced angiogenesis (1998) Proc Natl Acad Sci USA, 95, pp. 9791-9795
Hu, G.F., Xu, C.J., Riordan, J.F., Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA (2000) J Cell Biochem, 76, pp. 452-462
Jang, S.H., Kang, D.K., Chang, S.I., Scheraga, H.A., Shin, H.C., High level production of bovine angiogenin in E. Coli by an efficient refolding procedure (2004) Biotechnol Lett, 26, pp. 1501-1504
Jellinger, K.A., The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations (2013) Int Rev Neurobiol, 110, pp. 1-47
Jimi, S.I., Ito, K.I., Kohno, K., Ono, M., Kuwano, M., Itagaki, Y., Ishikawa, H., Modulation by bovine angiogenin of tubular morphogenesis and expression of plasminogen activator in bovine endothelial cells (1995) Biochem Biophys Res Commun, 211, pp. 476-483
Kelleher, R.J., Soiza, R.L., Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder? (2013) Am J Cardiovasc Dis, 3, pp. 197-226
Khoo, C.P., Micklem, K., Watt, S.M., A comparison of methods for quantifying angiogenesis in the Matrigel assay in vitro (2011) Tissue Eng Part C Methods, 17, pp. 895-906
Kim, Y.N., Kim, D.H., Decreased serum angiogenin level in Alzheimer's disease (2012) Prog Neuro-Psychoph, 38, pp. 116-120
Lee, F.S., Vallee, B.L., Characterization of ribonucleolytic activity of angiogenin towards tRNA. Biochem (1989) Biophys Res Commun, 161, pp. 121-126
Li, S., Hu, G.F., Emerging role of angiogenin in stress response and cell survival under adverse conditions (2012) J Cell Physiol, 227, pp. 2822-2826
McAuslan, B.R., Reilly, W., Endothelial cell phagokinesis in response to specific metal ions (1980) Exp Cell Res, 130, pp. 147-157
Padhi, A.K., Kumar, H., Vasaikar, S.V., Jayaram, B., Gomes, J., Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis (2012) PLoS One, p. e32479
Park, J.H., Lee, D.W., Park, K.S., Elevated serum copper and ceruloplasmin levels in Alzheimer's disease (2014) Asia Pac Psychiatry, 6, pp. 38-45
Peña, M.M., Lee, J., Thiele, D.J., A delicate balance: Homeostatic control of copper uptake and distribution (1999) J Nutr, 129, pp. 1251-1260
Raju, K.S., Alessandri, G., Ziche, M., Gullino, P.M., Ceruloplasmin, copper ions, and angiogenesis (1982) J Natl Cancer Inst, 69, pp. 1183-1188
Schafe, G.E., Swank, M.W., Rodrigues, S.M., Debiec, J., Doyère, V., Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo (2008) Learn Mem, 15, pp. 55-62
Sen, C.K., Khanna, S., Venojarvi, M., Trikha, P., Ellison, E.C., Hunt, T.K., Roy, S., Copper-induced vascular endothelial growth factor expression and wound healing (2002) Am J Physiol Heart Circ Physiol, 282, pp. H1821-H1827
Steidinger, T.U., Standaert, D.G., Yacoubian, T.A., A neuroprotective role for angiogenin in models of Parkinson's disease (2011) J Neurochem, 116, pp. 334-341
Wong, S.K., A 384-well cell-based phospho-ERK assay for dopamine D2 and D3 receptors (2004) Anal Biochem, 333, pp. 265-272
Yang, S.H., Sharrocks, A.D., Whitmarsh, A.J., MAP kinase signalling cascades and transcriptional regulation (2013) Gene, 513, pp. 1-13
Yeo, K.J., Hwang, E., Min, K.M., Jee, J.G., Lee, C.K., Hwang, K.Y., Jeon, Y.H., Cheong, H.K., The dual binding site of angiogenin and its inhibition mechanism: The crystal structure of the rat angiogenin-heparin complex (2014) Chem Commun (Camb), 50, pp. 12966-12969
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.905, 5-year impact factor: 4.172
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84922270924&partnerID=40&md5=4ba92c7c1a8a5807f948d238e389d7a7
Keywords: Als, Angiogenesis, Copper, Human Endothelial Cells, Copper Ion, Messenger Rna, Mitogen Activated Protein Kinase 1, Alzheimer Disease, Article, Cell Migration, Cellular Distribution, Confocal Microscopy, Enzyme Phosphorylation, Gene Expression, Human Cell, Immunofluorescence, Parkinson Disease, Protein Expression, Protein Localization, Real Time Polymerase Chain Reaction, Reverse Transcription Polymerase Chain Reaction, Umbilical Vein Endothelial Cell,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Pisa, ViaBonanno 6Pisa, Italy
Department of Chemical Sciences, University of Catania, Viale Andrea Doria, 6Catania, Italy
Institute of Biostructures and Bioimages, National Council of Research (CNR), Viale Andrea Doria, 6Catania, Italy
References:
Aparicio-Erriu, I. M., Prehn, J. H., Molecular mechanisms in amyotrophic lateral sclerosis: The role of angiogenin, a secreted rnase (2012) Front Neurosci, 6, p. 16
Arena, G., Pappalardo, G., Sovago, I., Rizzarelli, E., Copper (II) interaction with amyloid-: Affinity and speciation (2012) Coord Chem Rev, 256, pp. 3-12
Asada, S., Takahashi, T., Isodono, K., Adachi, A., Imoto, H., Ogata, T., Ueyama, T., Oh, H., Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis (2008) Am J Physiol Heart Circ Physiol, 295, pp. H2512-H2521
Ayton, S., Lei, P., Bush, A. I., Metallostasis in Alzheimer's disease (2013) Free Radic Biol Med, 62, pp. 76-89
Badet, J., Soncin, F., Guitton, J. -D., Lamare, O., Cartwrigth, T., Barritault, D., Specific binding of angiogenin to calf pulmonary artery endothelial cells (1989) Proc Natl Acad Sci USA, 86, pp. 8427-8431
Cavallucci, V., D'Amelio, M., Cecconi, F., A toxicity in Alzheimer's disease (2012) Mol Neurobiol, 45, pp. 366-378
Chen, C. C., Chen, Y. C., Hsiao, H. Y., Chang, C., Chern, Y., Neurovascular abnormalities in brain disorders: Highlights with angiogenesis and magnetic resonance imaging studies (2013) J Biomed Sci, 20, p. 47
Connolly, D. T., Olander, J. V., Heuvelman, D., Nelson, R., Monsell, R., Siegel, N., Haymore, B. L., Feder, J., Human vascular permeability factor. Isolation from U937 cells (1989) J Biol Chem, 264, pp. 20017-20024
Crabtree, B., Thiyagarajan, N., Prior, S. H., Wilson, P., Iyer, S., Ferns, T., Shapiro, R., Acharya, K. R., Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis (2007) Biochemistry, 46, pp. 11810-11818
D'Andrea, L. D., Romanelli, A., Di Stasi, R., Pedone, C., Bioinorganic aspects of angiogenesis (2010) Dalton Trans, 39, pp. 7625-7636
Del Giudice, R., Monti, D. M., Sarcinelli, C., Arciello, A., Piccoli, R., Hu, G. F., Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin (2014) Cell Death Dis, 5, p. e1097
Drachman, D. A., The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease (2014) Alzheimers Dement, 10, pp. 372-380
Emara, M. M., Ivanov, P., Hickman, T., Dawra, N., Tisdale, S., Kedersha, N., Hu, G. F., Anderson, P., Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly (2010) J Biol Chem, 285, pp. 10959-10968
Finney, L., Mandava, S., Ursos, L., Zhang, W., Rodi, D., Vogt, S., Legnini, D., Glesne, D., X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis (2007) Proc Natl Acad Sci USA, 104, pp. 2247-2252
Gao, X., Xu, Z., Mechanisms of action of angiogenin (2008) Acta Biochim Biophys Sin, 40, pp. 619-624
Greenway, M. J., Andersen, P. M., Russ, C., Ennis, S., Cashman, S., Donaghy, C., Patterson, V., Hardiman, O., ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis (2006) Nat Genet, 38, pp. 411-413
Hardy, J. A., Higgins, G. A., Alzheimer's disease: The amyloid cascade hypothesis (1992) Science, 256, pp. 184-185
Holloway, D. E., Hares, M. C., Shapiro, R., Subramanian, V., Acharya, K. R., High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins (2001) Protein Expr Purif, 22, pp. 307-317
Hu, G. F., Riordan, J. F., Vallee, B. L., Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities (1994) Proc Natl Acad Sci USA, 91, pp. 12096-12100
Hu, G. F., Copper stimulates proliferation of human endothelial cells under culture (1998) J Cell Biochem, 69, pp. 326-335
Hu, G. F., Neomycin inhibits angiogenin-induced angiogenesis (1998) Proc Natl Acad Sci USA, 95, pp. 9791-9795
Hu, G. F., Xu, C. J., Riordan, J. F., Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA (2000) J Cell Biochem, 76, pp. 452-462
Iakovidis, I., Delimaris, I., Piperakis, S. M., Copper and its complexes in medicine: A biochemical approach (2011) Mol Biol Int, 2011, p. 594529
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Copper (II) ions modulate Angiogenin activity in human endothelial cells
Angiogenin (ANG), a member of the secreted ribonuclease family, is a potent angiogenesis stimulator that interacts with endothelial cells inducing a wide range of responses. Metal ions dyshomeostasis play a fundamental role in the onset of neurodegenerative diseases, in particular copper that is also involved in angiogenesis processes. It is known that vascular pathologies are present in neurodegenerative diseases and Angiogenin is down-regulated in Alzheimer and Parkinson diseases, as well as it has been found as one of the mutated genes in amyotrophic lateral sclerosis (ALS). Copper (II) induces an increase of Angiogenin binding to endothelial cells but, so far, the relationship between copper-ANG and angiogenesis induction remain unclear. Herein, the effects of copper (II) ions on Angiogenin activity and expression were evaluated. The binding of copper was demonstrated to affect the intracellular localization of the protein decreasing its nuclear translocation. Moreover, the ANG-copper (II) system negatively affects the protein-induced angiogenesis, as well as endothelial cells migration. Surprisingly, copper also reveals the ability to modulate the Angiogenin transcription. These results highlight the tight relationship between copper and Angiogenin, pointing out the biological relevance of ANG-copper system in the regulation of endothelial cell function, and revealing a possible new mechanism at the basis of vascular pathologies. Copyright 2015 Elsevier Ltd. All rights reserved
Angiogenin (ANG), a member of the secreted ribonuclease family, is a potent angiogenesis stimulator that interacts with endothelial cells inducing a wide range of responses. Metal ions dyshomeostasis play a fundamental role in the onset of neurodegenerative diseases, in particular copper that is also involved in angiogenesis processes. It is known that vascular pathologies are present in neurodegenerative diseases and Angiogenin is down-regulated in Alzheimer and Parkinson diseases, as well as it has been found as one of the mutated genes in amyotrophic lateral sclerosis (ALS). Copper (II) induces an increase of Angiogenin binding to endothelial cells but, so far, the relationship between copper-ANG and angiogenesis induction remain unclear. Herein, the effects of copper (II) ions on Angiogenin activity and expression were evaluated. The binding of copper was demonstrated to affect the intracellular localization of the protein decreasing its nuclear translocation. Moreover, the ANG-copper (II) system negatively affects the protein-induced angiogenesis, as well as endothelial cells migration. Surprisingly, copper also reveals the ability to modulate the Angiogenin transcription. These results highlight the tight relationship between copper and Angiogenin, pointing out the biological relevance of ANG-copper system in the regulation of endothelial cell function, and revealing a possible new mechanism at the basis of vascular pathologies. Copyright 2015 Elsevier Ltd. All rights reserved
Copper (II) ions modulate Angiogenin activity in human endothelial cells
Copper (II) ions modulate Angiogenin activity in human endothelial cells
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* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (350 views)
Frontiers In Medicinal Chemistry, 2016; 9: 103-160.
Impact Factor: 0
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Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (434 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 159: 149-158.
Impact Factor: 3.348
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Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (237 views)
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Impact Factor: 0.56
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (487 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015 Jan; 142: 39-46.
Impact Factor: 3.205
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
* α-thalassemia associated with Hb instability: A tale of two features. The case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro (421 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(3): N/D-N/D.
Impact Factor: 3.057
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (470 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (671 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014 Oct; 6(10): 1841-1852.
Impact Factor: 3.585
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Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (468 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2014 May; 13(5): 1092-1104.
Impact Factor: 5.683
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (847 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (579 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (650 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (505 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (485 views)
Bmc Med Imaging (ISSN: 1471-2342, 1471-2342electronic), 2013 Sep 12; 13(1): 31-31.
Impact Factor: 0.983
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (616 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (415 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
Impact Factor: 1.862
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (448 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
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Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (495 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (439 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (607 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (497 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (370 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
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La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (409 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (624 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (530 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Esposito G, De Falco F, Tinto N, Testa F, Vitagliano L, Tandurella IC, Iannone L, Rossi S, Rinaldi E, Simonelli F, Zagari A, Salvatore F
* Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase (835 views)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2011 Dec; 32(12): 1460-1469.
Impact Factor: 5.686
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Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (360 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (484 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (449 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (499 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (543 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (464 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (638 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (574 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1135 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (397 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (443 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (304 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Criscuolo C, Filla A, Coppola G, Rinaldi C, Carbone R, Pinto S, Wang Q, De Leva MF, Salvatore E, Banfi S, Brunetti A, Quarantelli M, Geschwind DH, Pappata S, De Michele G
* Two novel CYP7B1 mutations in Italian families with SPG5: A clinical and genetic study (359 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2009 Sep; 256(8): 1252-1257.
Impact Factor: 2.903
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14589 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (417 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
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Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
* Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (394 views)
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (421 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (466 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
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Impact Factor: 5.52
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
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Impact Factor: 2.26
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
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Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
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Impact Factor: 1.654
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Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (333 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
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Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (290 views)
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Impact Factor: 1.654
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
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Impact Factor: 2.882
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (349 views)
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Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
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Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
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Impact Factor: 9.38
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Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
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Impact Factor: 2.914
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
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Impact Factor: 1.148
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Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
* The chemical synthesis of the GstI protein by NCL on a X-Met site (645 views)
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Impact Factor: 2.48
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (730 views)
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Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Barone V, De Rienzo F, Langella E, Menziani MC, Rega N, Sola M
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Impact Factor: 3.73
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
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Impact Factor: 4.782
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Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
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Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (382 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (378 views)
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Impact Factor: 3.415
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
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Impact Factor: 10.231
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (312 views)
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (506 views)
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Impact Factor: 2.225
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (298 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (549 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Vecchio G
* Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis (427 views)
Analyst (ISSN: 0003-2654), 2003; 128(2): 134-136.
Impact Factor: 2.251
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (458 views)
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
New J Chem (ISSN: 1144-0546), 2002; 26(5): 593-600.
Impact Factor: 2.06
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (504 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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Conato C, Contino A, Maccarrone G, Magrì A, Remelli M, Tabbì G
Copper(II) complexes with L-lysine and L-ornithine: Is the side-chain involved in the coordination? A thermodynamic and spectroscopic study (324 views)
Thermochim Acta (ISSN: 0040-6031), 2000 Nov 13; 362(1-2): 13-23.
Impact Factor: 0.807
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (681 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
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Pasquali D, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA
Retinoic acid receptors α, β and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer (589 views)
Eur J Endocrinol (ISSN: 0804-4643), 1997 Oct; 137(4): 410-414.
Impact Factor: 1.968
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Cucinotta V, Grasso D, Grasso G, Milardi D
Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (398 views)
Nucleosides Nucleotides (ISSN: 0732-8311), 1997; 16(10-11): 1847-1854.
Impact Factor: 0.905
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Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
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* Thyroid Hormone Enhances Angiogenesis and the Warburg Effect in Squamous Cell Carcinomas (12 views)
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Impact Factor: 6.126
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Capasso D, Del Gatto A, Comegna D, Russo L, Fattorusso R, Saviano M, Di Gaetano S, Zaccaro L
* Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide (108 views)
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Impact Factor: 3.267
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Nawaz MI, Rezzola S, Tobia C, Coltrini D, Belleri M, Mitola S, Corsini M, Sandomenico A, Caporale A, Ruvo M, Presta M
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Impact Factor: 9.78
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Di Stasi R, Diana D, De Rosa L, Fattorusso R, D'Andrea LD
* Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain "7" (226 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Nov; 61(11): 860-872.
Impact Factor: 2.275
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Cimmino I, Margheri F, Prisco F, Perruolo G, D'Esposito V, Laurenzana A, Fibbi G, Paciello O, Doti N, Ruvo M, Miele C, Beguinot F, Formisano P, Oriente F
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Impact Factor: 5.391
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
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Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
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Wang L, Coric P, Broussy S, Di Stasi R, Zhou L, D'Andrea LD, Ji L, Vidal M, Bouaziz S, Liu WQ
* Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain "2" (224 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2019 May 1; 169: 65-75.
Impact Factor: 2.882
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Di Stasi R, De Rosa L, Diana D, Fattorusso R, D'Andrea LD
* Human Recombinant VEGFR2D4 Biochemical Characterization to Investigate Novel Anti-VEGFR2D4 Antibodies for Allosteric Targeting of VEGFR2 (287 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Apr 26; 61(7): 513-520.
Impact Factor: 2.275
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De Simone G
* Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350 (225 views)
Expert Opin Ther Pat (ISSN: 1744-7674electronic, 1354-3776linking), 2019 Jan; 29(1): 1-6.
Impact Factor: 3.699
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (379 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (481 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (338 views)
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Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E
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Impact Factor: 8
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
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Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Crich SG, Terreno E, Aime S
* Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis (253 views)
Adv Drug Deliver Rev (ISSN: 0169-409x), 2017 Sep 15; 119: 61-72.
Impact Factor: 13.66
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (389 views) (PDF 179 views)
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Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
* Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging (263 views)
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
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Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (724 views)
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Impact Factor: 3.348
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J
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Impact Factor: 0
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Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (350 views)
Frontiers In Medicinal Chemistry, 2016; 9: 103-160.
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Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (434 views)
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Impact Factor: 3.348
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Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (237 views)
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (487 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015 Jan; 142: 39-46.
Impact Factor: 3.205
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
* α-thalassemia associated with Hb instability: A tale of two features. The case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro (421 views)
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Impact Factor: 3.057
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (470 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
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Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014 Oct; 6(10): 1841-1852.
Impact Factor: 3.585
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Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (468 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2014 May; 13(5): 1092-1104.
Impact Factor: 5.683
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (847 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (579 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (650 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (505 views)
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Impact Factor: 3.534
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (485 views)
Bmc Med Imaging (ISSN: 1471-2342, 1471-2342electronic), 2013 Sep 12; 13(1): 31-31.
Impact Factor: 0.983
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (616 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (415 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
Impact Factor: 1.862
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (448 views)
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Impact Factor: 1.045
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Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
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Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (495 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (439 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (607 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (497 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (370 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
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La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (409 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (624 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (530 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Esposito G, De Falco F, Tinto N, Testa F, Vitagliano L, Tandurella IC, Iannone L, Rossi S, Rinaldi E, Simonelli F, Zagari A, Salvatore F
* Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase (835 views)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2011 Dec; 32(12): 1460-1469.
Impact Factor: 5.686
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Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (360 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (484 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (449 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (499 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (543 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (464 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (638 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (574 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1135 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (397 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (443 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (304 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Criscuolo C, Filla A, Coppola G, Rinaldi C, Carbone R, Pinto S, Wang Q, De Leva MF, Salvatore E, Banfi S, Brunetti A, Quarantelli M, Geschwind DH, Pappata S, De Michele G
* Two novel CYP7B1 mutations in Italian families with SPG5: A clinical and genetic study (359 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2009 Sep; 256(8): 1252-1257.
Impact Factor: 2.903
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14589 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (417 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
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Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
* Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (394 views)
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (421 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (466 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (937 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (333 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
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Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (290 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (464 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (465 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (349 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
Eur J Org Chem (ISSN: 1434-193x), 2007 Nov; (31): 5277-5283.
Impact Factor: 2.914
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
* The chemical synthesis of the GstI protein by NCL on a X-Met site (645 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Dec 5; 83(5): 508-518.
Impact Factor: 2.48
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (730 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Barone V, De Rienzo F, Langella E, Menziani MC, Rega N, Sola M
* A computational protocol to probe the role of solvation effects on the reduction potential of azurin mutants (273 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jan 1; 62(1): 262-269.
Impact Factor: 3.73
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (583 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
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Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (382 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (378 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (395 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (312 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2004 Jun 1; 567(1): 20-26.
Impact Factor: 3.843
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (506 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (298 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (549 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Vecchio G
* Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis (427 views)
Analyst (ISSN: 0003-2654), 2003; 128(2): 134-136.
Impact Factor: 2.251
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (458 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
New J Chem (ISSN: 1144-0546), 2002; 26(5): 593-600.
Impact Factor: 2.06
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (504 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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Conato C, Contino A, Maccarrone G, Magrì A, Remelli M, Tabbì G
Copper(II) complexes with L-lysine and L-ornithine: Is the side-chain involved in the coordination? A thermodynamic and spectroscopic study (324 views)
Thermochim Acta (ISSN: 0040-6031), 2000 Nov 13; 362(1-2): 13-23.
Impact Factor: 0.807
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (681 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
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Pasquali D, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA
Retinoic acid receptors α, β and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer (589 views)
Eur J Endocrinol (ISSN: 0804-4643), 1997 Oct; 137(4): 410-414.
Impact Factor: 1.968
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Cucinotta V, Grasso D, Grasso G, Milardi D
Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (398 views)
Nucleosides Nucleotides (ISSN: 0732-8311), 1997; 16(10-11): 1847-1854.
Impact Factor: 0.905
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Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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124 Records (118 excluding Abstracts).
Total impact factor: 482.609 (469.456 excluding Abstracts).
Total 5 year impact factor: 485.907 (471.215 excluding Abstracts).
Total impact factor: 482.609 (469.456 excluding Abstracts).
Total 5 year impact factor: 485.907 (471.215 excluding Abstracts).
424 views. Last view on Wednesday 24 May 2023, 1:56:23
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