Prognostic Role Of 18f-Fluorodeoxyglucose Positron Emission Tomography/Ct In The Postoperative Evaluation Of Differentiated Thyroid Cancer Patients(322 views) Pace L, Klain M, Salvatore B, Nicolai E, Zampella E, Assante R, Pellegrino T, Storto G, Fonti R, Salvatore M
Keywords: Differentiated Thyroid Cancer, Fdg Pet Ct, Progression-Free Survival, Fluorodeoxyglucose F 18, Iodine 131, Levothyroxine, Thyroglobulin, Adult, Article, Cancer Prognosis, Cancer Recurrence, Cancer Staging, Cancer Survival, Clinical Feature, Computer Assisted Emission Tomography, Computer Assisted Tomography, Controlled Study, Distant Metastasis, Female, Follow Up, Human, Lymph Node, Major Clinical Study, Middle Aged, Postoperative Period, Progression Free Survival, Whole Body Scintiscanning,
Affiliations: *** IBB - CNR ***
Dipartimento di Medicina e Chirurgia, Universit degli Studi di SalernoSalerno, Italy
Dipartimento di Scienze Biomediche Avanzate, Universit degli Studi di Napoli Federico IINapoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via Tommaso De Amicis 95Napoli, Italy
IRCSS SDNNapoli, Italy
IRCSS CROBRionero in Vulture, Italy
From the *Dipartimento di Medicina e Chirurgia, Universita degli Studi di Salerno, Salerno
and IRCSS CROB, Rionero in Vulture, Italia.
daggerDipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli Federico II
double daggerIstituto di Biostrutture e Bioimmagini, CNR
section signIRCSS SDN, Napoli
and vertical lineIRCSS CROB, Rionero in Vulture, Italia.
References: Not available.
Prognostic Role Of 18f-Fluorodeoxyglucose Positron Emission Tomography/Ct In The Postoperative Evaluation Of Differentiated Thyroid Cancer Patients
PURPOSE: The aim of this study was to evaluate the role of F-FDG PET/CT performed after surgery but before radioiodine therapy in patients with differentiated thyroid cancer. PROCEDURES: FDG PET/CT was performed off l-thyroxine in 60 newly diagnosed differentiated thyroid cancer patients. Clinical and hematological evaluation as well as high-resolution neck ultrasound were performed. All patients underwent a complete follow-up (range, 6-67 months; mean [SD], 31. 7 [20. 6] months). The date of recurrence or the most recent office visit was recorded. Progression-free survival (PFS) is the primary end point of this study. Analysis was performed by Cox proportional hazards model. Survival curves were generated using Kaplan-Meier estimates, and the log-rank test was used to assess significance. RESULTS: FDG PET/CT was negative in 63% of patients, 20% had FDG thyroid bed uptake, 5% distant metastases, and 12% lymph node FDG uptake. In patients with positive FDG PET/CT scan (ie, those with distant metastases or lymph node uptake), a higher rate of recurrence was observed (50% vs 6%, P < 0. 05). Thyroglobulin, neck ultrasound, stage, and FDG PET/CT correlated with PFS at univariate analysis. At multivariate analysis, only thyroglobulin and FDG PET/CT continued to be predictors of PFS. Patients with a negative FDG PET/CT scan have a better PFS either in the whole group or in those with elevated thyroglobulin level (both > 2 ng/mL and > 10 ng/mL). CONCLUSIONS: FDG PET/CT was abnormal in 17% of patients. Moreover, FDG PET/CT has an independent prognostic role, with a better PFS in patients with a negative scan
Prognostic Role Of 18f-Fluorodeoxyglucose Positron Emission Tomography/Ct In The Postoperative Evaluation Of Differentiated Thyroid Cancer Patients
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Prognostic Role Of 18f-Fluorodeoxyglucose Positron Emission Tomography/Ct In The Postoperative Evaluation Of Differentiated Thyroid Cancer Patients