Keywords: Biomarkers, Dopamine Transporter, Parkinson, S Disease, Spect, Urate, Uric Acid, Ioflupane I 123, Adult, Article, Caudate Nucleus, Controlled Study, Corpus Striatum, Disease Duration, Female, Hoehn And Yahr Scale, Human, Major Clinical Study, Middle Aged, Parkinson Disease, Putamen, Single Photon Emission Computer Tomography, Unified Parkinson Disease Rating Scale, Uric Acid Blood Level, 2-Carbomethoxy-8-(3-Fluoropropyl)-3-(4-Iodophenyl)tropane, Biological Marker, Radiopharmaceutical Agent, Tropane Derivative, Diagnostic Use, Early Diagnosis, Metabolism, Procedures, Scintiscanning, Dopamine Plasma Membrane Transport Proteins, Emission-Computed, Single-Photon,
Affiliations: *** IBB - CNR ***
Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II UniversityNaples, Italy
Institute of Biostructure and Bioimaging, CNRNaples, Italy
Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL), Institute of NeurologyLondon, United Kingdom
Dipartimento di Scienze Neurologiche e del Movimento, Universit di Verona, Policlinico Borgo RomaVerona, Italy
University of Naples ParthenopeNaples, Italy
IDC Hermitage-CapodimonteNaples, Italy
Department of Primary Care and Public Health, Imperial CollegeLondon, United Kingdom
Department of Public Health, Federico II UniversityNaples, Italy
Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, University of SalernoSalerno, Italy
References: Not available.
Uric Acid Relates To Dopamine Transporter Availability In Parkinson'S Disease
BACKGROUND: Diagnosing Parkinson's disease (PD) and tracking its progression may require the combination of reliable biomarkers. Among them, both serum uric acid (UA) and dopamine transporter (DaT) binding deserve more investigations.; AIMS OF THE STUDY: We aimed to investigate the relationship between serum UA levels and DaT availability in newly diagnosed, drug-naive PD patients, by means of semiquantitative [(123) I] FP-CIT-SPECT.; METHODS: We recruited 52 newly diagnosed, drug-naive PD patients, and performed serum UA dosage and [(123) I] FP-CIT-SPECT.; RESULTS: Pearson's correlation analysis showed that UA levels were significantly higher in patients with higher averaged, ipsilateral and contralateral DaT binding in caudate, putamen, and striatum.; CONCLUSIONS: We showed, for the first time, by regional semiquantitative analysis of DaT binding in PD patients that UA levels significantly correlates with the severity of dopaminergic impairment in caudate, putamen, and striatum. This study broadens our knowledge on the importance of UA as a biomarker of PD. 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Uric Acid Relates To Dopamine Transporter Availability In Parkinson'S Disease
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(429 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(674 views) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 ViewExport to BibTeXExport to EndNote
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(1597 views) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 ViewExport to BibTeXExport to EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(561 views) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 ViewExport to BibTeXExport to EndNote
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease(727 views) Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026. Impact Factor:0.913 ViewExport to BibTeXExport to EndNote