Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (879 views)
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
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Paper type: Journal Article,
Impact factor: 2.46, 5-year impact factor: 2.349
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904538729&partnerID=40&md5=6d5acc50c0de3c6c85a7099c9056cf1d
Keywords: Low Degree Bone Pain, Palliation, Radionuclide Therapy, Sm-153 Edtmp, Analgesic Agent, Antineoplastic Agent, Etidronic Acid Tc 99m, Lexidronam Samarium Sm 153, Nonsteroid Antiinflammatory Agent, Zoledronic Acid, Adult, Article, Bleeding, Blood Toxicity, Bone Marrow Suppression, Bone Metastasis, Bone Scintiscanning, Breast Cancer, Cancer Chemotherapy, Cancer Hormone Therapy, Cancer Palliative Therapy, Cancer Patient, Cancer Radiotherapy, Clinical Article, Clinical Evaluation, Controlled Study, Drug Efficacy, Drug Safety, Female, Human, Infection, Lung Cancer, Multimodality Cancer Therapy, Pain Assessment, Physician, Priority Journal, Radioisotope Therapy, Risk Reduction, Treatment Duration, Treatment Outcome, Treatment Response, Visual Analog Scale, 80 And Over, Bone Neoplasms Radiotherapy, Middle Aged, Pain Radiotherapy, Palliative Care Methods, Samarium Therapeutic Use, Procedures, Very Elderly,
Affiliations:
*** IBB - CNR ***
Istituto di Ricovero e Cura Carattere Scientifico, Centro di Riferimento Oncologico di Basilicata, via P. Pio 1, 85028 Rionero in Vulture, Italy
Institute of Biostructure and Bioimages, National Council of Research, Naples, Italy
University of Texas Southwestern, Dallas, TX, United States
References:
Not available.
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.46, 5-year impact factor: 2.349
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904538729&partnerID=40&md5=6d5acc50c0de3c6c85a7099c9056cf1d
Keywords: Low Degree Bone Pain, Palliation, Radionuclide Therapy, Sm-153 Edtmp, Analgesic Agent, Antineoplastic Agent, Etidronic Acid Tc 99m, Lexidronam Samarium Sm 153, Nonsteroid Antiinflammatory Agent, Zoledronic Acid, Adult, Article, Bleeding, Blood Toxicity, Bone Marrow Suppression, Bone Metastasis, Bone Scintiscanning, Breast Cancer, Cancer Chemotherapy, Cancer Hormone Therapy, Cancer Palliative Therapy, Cancer Patient, Cancer Radiotherapy, Clinical Article, Clinical Evaluation, Controlled Study, Drug Efficacy, Drug Safety, Female, Human, Infection, Lung Cancer, Multimodality Cancer Therapy, Pain Assessment, Physician, Priority Journal, Radioisotope Therapy, Risk Reduction, Treatment Duration, Treatment Outcome, Treatment Response, Visual Analog Scale, 80 And Over, Bone Neoplasms Radiotherapy, Middle Aged, Pain Radiotherapy, Palliative Care Methods, Samarium Therapeutic Use, Procedures, Very Elderly,
Affiliations:
*** IBB - CNR ***
Istituto di Ricovero e Cura Carattere Scientifico, Centro di Riferimento Oncologico di Basilicata, via P. Pio 1, 85028 Rionero in Vulture, Italy
Institute of Biostructure and Bioimages, National Council of Research, Naples, Italy
University of Texas Southwestern, Dallas, TX, United States
References:
Not available.
Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain
We evaluated the pain response and daily discomfort in patients suffering from a borderline degree of bone pain due to breast or lung cancer bone metastases, who had undergone early palliative radionuclide treatment. The results were compared with those from patients who had received standard analgesic therapy. Twenty-one patients (65.7 ± 3 years; 17 women) with metastatic bone cancer underwent samarium-153 (Sm-153) ethylene diamine tetramethylene phosphonate (EDTMP) administration (group A) and 18 patients (64.3 ± 8 years; 16 women) continued to receive standard analgesics (group B; control group). The patients kept a daily pain diary assessing both their discomfort and the pain at specific sites by means of a visual analog scale, rating from 0 (no discomfort-no pain) to 10 (worst discomfort-pain). These diaries were reviewed weekly for 2 months and three physicians rated the pain response on a scale from -2 (considerable deterioration) to +2 (considerable improvement). Baseline characteristics were similar in both groups. The reduction of total discomfort and of bone pain in group A was significantly greater compared to group B (p < 0.0001). A significant improvement of clinical conditions was observed in group A, where the physician rate changed from -1 to 1, compared to group B in which the rate changed from -1 to 0. Sm-153 EDTMP therapy can be considered for patients with bone pain from breast and lung cancer in advance, i.e., before the establishment of severe pain syndrome. © 2013 The Japanese Society for Bone and Mineral Research and Springer.
We evaluated the pain response and daily discomfort in patients suffering from a borderline degree of bone pain due to breast or lung cancer bone metastases, who had undergone early palliative radionuclide treatment. The results were compared with those from patients who had received standard analgesic therapy. Twenty-one patients (65.7 ± 3 years; 17 women) with metastatic bone cancer underwent samarium-153 (Sm-153) ethylene diamine tetramethylene phosphonate (EDTMP) administration (group A) and 18 patients (64.3 ± 8 years; 16 women) continued to receive standard analgesics (group B; control group). The patients kept a daily pain diary assessing both their discomfort and the pain at specific sites by means of a visual analog scale, rating from 0 (no discomfort-no pain) to 10 (worst discomfort-pain). These diaries were reviewed weekly for 2 months and three physicians rated the pain response on a scale from -2 (considerable deterioration) to +2 (considerable improvement). Baseline characteristics were similar in both groups. The reduction of total discomfort and of bone pain in group A was significantly greater compared to group B (p < 0.0001). A significant improvement of clinical conditions was observed in group A, where the physician rate changed from -1 to 1, compared to group B in which the rate changed from -1 to 0. Sm-153 EDTMP therapy can be considered for patients with bone pain from breast and lung cancer in advance, i.e., before the establishment of severe pain syndrome. © 2013 The Japanese Society for Bone and Mineral Research and Springer.
Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain
| ▼ Animal Care, interventional procedures, anesthesia and analgesia of murine models in preclinical imaging |
Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain
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Total impact factor: 42.863 (22.133 excluding Abstracts).
Total 5 year impact factor: 46.489 (25.325 excluding Abstracts).
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