Clinical And Magnetic Resonance Imaging Predictors Of Disease Progression In Multiple Sclerosis: A Nine-Year Follow-Up Study(900 views)(PDF restricted275 views) Lavorgna L, Bonavita S, Ippolito D, Lanzillo R, Salemi G, Patti F, Valentino P, Coniglio G, Buccafusca M, Paolicelli D, D'Ambrosio A, Bresciamorra V, Savettieri G, Zappia M, Alfano B, Gallo A, Simone I, Tedeschi G
Mult Scler (ISSN: 1352-4585, 1477-0970), 2014 Feb; 20(2): 220-226.
Second University of Naples, II Clinic of Neurology, Piazza Miraglia, 2, 80138-Naples, Italy
Neurological Institute for Diagnosis and Care Hermitage Capodimonte, Naples, Italy
Department of Neurological Sciences, University Federico II, Naples, Italy
Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Italy
Department DANA GF Ingrassia, Section of Neurosciences, University of Catania, Italy
Department of Medical Sciences, Institute of Neurology, University Magna Graecia, Italy
Biostructure and Bioimaging Institute, National Research Council, Italy
References: Not available.
Clinical And Magnetic Resonance Imaging Predictors Of Disease Progression In Multiple Sclerosis: A Nine-Year Follow-Up Study
Objective: The objective of this paper is to identify clinical or magnetic resonance imaging (MRI) predictors of longterm clinical progression in a large cohort of multiple sclerosis (MS) patients. Methods: A total of 241 relapsing-remitting (RR) MS patients were included in a nine-year follow-up (FU) study. The reference MRIs were acquired at baseline (BL) as part of a multicenter, cross-sectional, clinical-MRI study. Volumetric MRI metrics were measured by a fully automated, operator-independent, multi-parametric segmentation method. Clinical progression was evaluated as defined by: conversion from RR to secondary progressive (SP) disease course; progression of Expanded Disability Status Scale (EDSS); achievement and time to reach EDSS 4. Results: We concluded that conversion from RR to SP (OR 0. 79; CI 0. 7-0. 9), progression of EDSS (OR 0. 85; CI 0. 77- 0. 93), achievement of EDSS 4 (OR 0. 8; CI 0. 7-0. 9), and time to reach EDSS 4 (HR 0. 88; CI 0. 82-0. 94) were all predicted by BL gray matter (GM) volume and, except for progression of EDSS, by BL EDSS (respectively: (OR 2. 88; CI 1. 9-4. 36), (OR 2. 7; CI 1. 7-4. 2), (HR 3. 86; CI 1. 94-7. 70)). Conclusions: BL GM volume and EDSS are the best long-term predictors of disease progression in RRMS patients with a relatively long and mild disease. 2013 The Author (s)
Clinical And Magnetic Resonance Imaging Predictors Of Disease Progression In Multiple Sclerosis: A Nine-Year Follow-Up Study
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