Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations
Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations(940 views) Autiero I, Langella E, Saviano M
Keywords: Amyloid, Amyloid Beta Protein, Amyloid Beta-Protein (1-42), Ligand, Peptide, Peptide Fragment, Protein Binding, Trehalose, Amyloid Beta Protein (1 42), Chemical Phenomena, Chemical Structure, Chemistry, Conformation, Human, Hydrogen Bond, Metabolism, Molecular Dynamics, Protein Multimerization, Protein Secondary Structure, Protein Stability, Article, Amyloid Beta-Peptides, Hydrogen Bonding, Hydrophobic And Hydrophilic Interactions, Models, Molecular Conformation, Molecular Dynamics Simulation, Protein Structure, Amyloid Chemistry Metabolism
, Amyloid Beta-Peptides Chemistry Metabolism
, Peptide Fragments Chemistry Metabolism
, Trehalose Chemistry
Affiliations: *** IBB - CNR ***
National Research Council, Institute of Biostructures and Bioimaging, 80138 Naples, Italy
References: Not available.
Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations
An attractive strategy to contrast the Alzheimer disease (AD) is represented by the development of -sheet breaker peptides (BSB). -sheet breakers constitute a class of compounds which have shown a good efficacy in preventing the A fibrillogenesis; however, their mechanism of action has not been precisely understood. In this context, we have studied the structural basis underlying the inhibitory effect of A (1-42) fibrillogenesis explicated by two promising trehalose-conjugated BSB peptides using an all-atom molecular dynamics (MD) approach. Our simulations suggest that the binding on the two protofibril ends occurs through different binding modes. In particular, binding on the odd edge (chain A) is guided by a well defined hydrophobic cleft, which is common to both ligands. Moreover, targeting chain A entails a significant structure destabilization leading to a partial loss of structure and is an energetically favoured process. A significant contribution of the trehalose moiety to the stability of the complexes emerged from our results. The energetically favoured hydrophobic cleft detected on chain A could represent a good starting point for the design of new molecules with improved anti-aggregating features. 2013 The Royal Society of Chemistry
Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations
Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations
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