Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?(639 views) Bera S, De Rosa V, Rachidi W, Diamond AM
Keywords: Ebselen, Selenite, Selenomethionine, Selenoprotein, Sodium Selenite, Aberrant Crypt Focus, Bladder Cancer, Cancer Incidence, Cancer Mortality, Cancer Prevention, Carcinogenesis, Chemoprophylaxis, Controlled Clinical Trial (topic), Dna Damage, Dna Repair, Drug Efficacy, Drug Mechanism, Human, Lung Cancer, Nonhuman, Priority Journal, Prostate Cancer, Review, Animals, Chemoprevention, Dietary Supplements, Dna Adducts, Glutathione Peroxidase, Models, Neoplasms, Thioredoxin-Disulfide Reductase, Drug Effects, Metabolism, Administration, Dosage, Dna Adducts Drug Effects
, Dna Repair Drug Effects
, Glutathione Peroxidase Metabolism
, Neoplasms Prevention, Selenium Administration, Selenoproteins Metabolism
, Thioredoxin-Disulfide Reductase Metabolism,
Affiliations: *** IBB - CNR ***
Department of Pathology, University of Illinois at Chicago, Chicago, IL, United States
Université Joseph Fourier, Grenoble 1, CEA, INAC, SCIB, Laboratoire Lésions des Acides Nucléiques, 17 rue des Martyrs, F-38054 Grenoble Cedex 9, France
Istituto di Biostrutture e Bioimmagini, CNR, Via De Amicis 95 Naples, Italy
References: Clark, L.C., Combs Jr., G.F., Turnbull, B.W., Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin A randomized controlled trial (1996) JAMA, 276, pp. 1957-1963. , Nutritional Prevention of Cancer Study Grou
Lippman, S.M., Klein, E.A., Goodman, P.J., Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT (2009) JAMA, 301, pp. 39-51
Klein, E.A., Thompson Jr., I.M., Tangen, C.M., Vitamin E and the risk of prostate cancer the selenium and vitamin e cancer prevention trial (select (2011) JAMA, 306, pp. 1549-1556
Schrauzer, G.N., White, D.A., Schneider, C.J., Cancer mortality correlation studies III: Statistical associations with dietary selenium intakes (1977) Bioinorg. Chem, 7, pp. 23-31
Davis, C.D., Tsuji, P.A., Milner, J.A., Selenoproteins and cancer prevention (2012) Annu. Rev. Nutr, 32, pp. 73-95
Rayman, M.P., Selenium and human health (2012) Lancet, 379, pp. 1256-1268
Amaral, A.F., Cantor, K.P., Silverman, D.T., Malats, N., Selenium and bladder cancer risk: A meta-Analysis (2010) Cancer Epidemiol. Biomarkers Prev, 19, pp. 2407-2415
Etminan, M., FitzGerald, J.M., Gleave, M., Chambers, K., Intake of selenium in the prevention of prostate cancer: A systematic review and meta-Analysis (2005) Cancer Causes Control, 16, pp. 1125-1131
Brinkman, M., Reulen, R.C., Kellen, E., Buntinx, F., Zeegers, M.P., Are men with low selenium levels at increased risk of prostate cancer? (2006) Eur. J.Cancer, 42, pp. 2463-2471
Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Cooley, K., Seely, A., Sagar, S., Seely, D., Selenium and lung cancer: A systematic review and meta analysis (2011) PLoS ONE, 6, pp. e26259
Dennert, G., Zwahlen, M., Brinkman, M., Vinceti, M., Zeegers, M.P., Horneber, M., Selenium for preventing cancer (2011) Cochrane Database Syst. Rev, 5, pp. CD005195
Lee, E.H., Myung, S.K., Jeon, Y.J., Kim, Y., Chang, Y.J., Ju, W., Seo, H.G., Huh, B.Y., Effects of selenium supplements on cancer prevention: Meta-Analysis of randomized controlled trials (2011) Nutr. Cancer, 63, pp. 1185-1195
Bespalov, V.G., Panchenko, A.V., Murazov, I.A.G., Chepik, O.F., Influence of sodium selenite on carcinogenesis of the prostate and other organs induced by methylnitrosourea and testosterone in rats (2011) Vopr. Onkol, 57, pp. 486-492
Overvad, K., Thorling, E.B., Bjerring, P., Ebbesen, P., Selenium inhibits UV-light-induced skin carcinogenesis in hairless mice (1985) Cancer Lett, 27, pp. 163-170
Li, L., Xie, Y., El-Sayed, W.M., Szakacs, J.G., Franklin, M.R., Roberts, J.C., Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse (2005) J.Biochem. Mol. Toxicol, 19, pp. 396-405
Cekan, E., Tribukait, B., Vokal-Borek, H., Protective effect of selenium against ionizing radiation-induced malformations in mice (1985) Acta Radiol. Oncol, 24, pp. 267-271
Wang, L., Bonorden, M.J., Li, G.X., Lee, H.J., Hu, H., Zhang, Y., Liao, J.D., Lü, J., Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit (2009) Cancer Prev. Res, 2, pp. 484-495
El-Bayoumy, K., Sinha, R., Mechanisms of mammary cancer chemoprevention by organoselenium compounds (2004) Mutat. Res, 551, pp. 181-197
El-Bayoumy, K., (1991) Role of Selenium in Cancer Prevention, , J.B. Lippincott Co. Philadelphia
Ip, C., Lessons from basic research in selenium and cancer prevention (1998) J.Nutr, 128, pp. 1845-1854
Amberg, R., Mizutani, T., Wu, X.Q., Gross, H.J., Selenocysteine synthesis in mammalia: An identity switch from tRNA(Ser) to tRNA(Sec (1996) J.Mol. Biol, 263, pp. 8-19
Berry, M.J., Banu, L., Chen, Y.Y., Mandel, S.J., Kieffer, J.D., Harney, J.W., Larsen, P.R., Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region (1991) Nature, 353, pp. 273-276
Caban, K., Copeland, P.R., Size matters: A view of selenocysteine incorporation from the ribosome (2006) Cell Mol. Life Sci, 63, pp. 73-81
Ferguson, L.R., Karunasinghe, N., Zhu, S., Wang, A.H., Selenium and its' role in the maintenance of genomic stability (2012) Mutat. Res, 733, pp. 100-110
Zhuo, P., Diamond, A.M., Molecular mechanisms by which selenoproteins affect cancer risk and progression (2009) Biochim. Biophys. Acta, 1790, pp. 1546-1554
Irons, R., Carlson, B.A., Hatfield, D.L., Davis, C.D., Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression (2006) J.Nutr, 136, pp. 1311-1317
Moustafa, M.E., Carlson, B.A., El-Saadani, M.A., Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA (2001) Mol. Cell Biol, 21, pp. 3840-3852
El-Bayoumy, K., Das, A., Boyiri, T., Desai, D., Sinha, R., Pittman, B., Amin, S., Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells (2003) Chem. Biol. Interact, 146, pp. 179-190
Ejadi, S., Bhattacharya, I.D., Voss, K., Singletary, K., Milner, J.A., In vitro and in vivo effects of sodium selenite on1 7,12-dimethylbenz[a] anthraceneYDNA adduct formation in isolated rat mammary epithelial cells (1989) Carcinogenesis, 10, pp. 823-826
Liu, J.Z., Gilbert, K., Parker, H.M., Haschek, W.M., Milner, J.A., Inhibition of 7 12-dimethylbenz(a)anthracene-induced mammary tumors and DNA adducts by dietary selenite (1991) Cancer Res, 51, pp. 4613-4617
Liu, J.Z., Milner, J.A., Age, dietary selenium and quantity of 7,12-dimethylbenz(a)anthracene influence the in vivo occurrence of rat mammary DNA adducts (1992) J.Nutr, 122, pp. 1361-1368
Brigelius-Flohé, R., Kipp, A., Glutathione peroxidases in different stages of carcinogenesis (2009) Biochim. Biophys. Acta, 1790, pp. 1555-1568
Jerome-Morais, A., Wright, M.E., Liu, R., Yang, W., Jackson, M.I., Combs Jr., G.F., Diamond, A.M., Inverse association between glutathione peroxidase activity and both selenium-binding protein 1 levels and Gleason score in human prostate tissue (2012) Prostate, 72, pp. 1006-1012
Karunasinghe, N., Ryan, J., Tuckey, J., Masters, J., Jamieson, M., Clarke, L.C., Marshall, J.R., Ferguson, L.R., DNA stability and serum selenium levels in a high-risk group for prostate cancer (2004) Cancer Epidemiol. Biomarkers Prev, 13, pp. 391-397
Waters, D.J., Shen, S., Glickman, L.T., Cooley, D.M., Bostwick, D.G., Qian, J., Combs Jr., G.F., Morris, J.S., Prostate cancer risk and DNA damage: Translational significance of selenium supplementation in a canine model (2005) Carcinogenesis, 26, pp. 1256-1262
Valdiglesias, V., Pásaro, E., Méndez, J., Laffon, B., In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: A review (2010) Arch. Toxicol, 84, pp. 337-351
Brozmanová, J., Mániková, D., Vlčková, V., Chovanec, M., Selenium: A double-edged sword for defense and offence in cancer (2010) Arch. Toxicol, 84, pp. 919-938
Seo, Y.R., Sweeney, C., Smith, M.L., Selenomethionine induction of DNA repair response in human fibroblasts (2002) Oncogene, 21, pp. 3663-3669
Laffon, B., Valdiglesias, V., Pásaro, E., Méndez, J., The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair in human leukocytes (2010) Biol. Trace Elem. Res, 133, pp. 12-19
De Rosa, V., Erkekoǧlu, P., Forestier, A., Favier, A., Hincal, F., Diamond, A.M., Douki, T., Rachidi, W., Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (2012) Free Radic. Res, 46, pp. 105-116
Zeng, H., Jackson, M.I., Cheng, W.H., Combs Jr., G.F., Chemical form of selenium affects its uptake, transport, and glutathione peroxidase activity in the human intestinal Caco-2 cell model (2011) Biol. Trace Elem. Res, 143, pp. 1209-1218
Gammelgaard, B., Jackson, M.I., Gabel-Jensen, C., Surveying selenium speciation from soil to cellYforms and transformations (2011) Anal. Bioanal. Chem, 399, pp. 1743-1763
Karlenius, T.C., Shah, F., Yu, W.C., Hawkes, H.J., Tinggi, U., Clarke, F.M., Tonissen, K.F., The selenium content of cell culture serum influences redox-regulated gene expression (2011) Biotechniques, 50, pp. 295-301
Leist, M., Raab, B., Maurer, S., Rösick, U., Brigelius-Flohé, R., Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate peroxide-induced genotoxicity (1996) Free Radic. Biol. Med, 21, pp. 297-306
Zhuo, P., Goldberg, M., Herman, L., Lee, B.S., Wang, H., Brown, R.L., Foster, C.B., Diamond, A.M., Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme (2009) Cancer Res, 69, pp. 8183-8190
Zaichick, S., Zaichick, V., Nosenko, S., Moskvina, I., Mass fractions of 52 trace elements and zinc/trace element content ratios in intact human prostates investigated by inductively coupled plasma mass spectrometry (2012) Biol. Trace Elem. Res, 149, pp. 171-83
Kohler, S.W., Provost, G.S., Fieck, A., Kretz, P.L., Bullock, W.O., Sorge, J.A., Putman, D.L., Short, J.M., Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice (1991) Proc. Natl Acad. Sci. USA, 88, pp. 7958-7962
Zeng, H., Uthus, E.O., Ross, S.A., Davis, C.D., High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver (2009) Biol. Trace Elem. Res, 131, pp. 71-80
Kumar, M.S., Pollok, K.E., Smith, M.L., Selenomethionine or methylseleninic acid inhibits mutagenesis of a reporter gene in mouse bone marrow (2010) Anticancer Res, 30, pp. 291-293
Zachara, B.A., Gromadzinska, J., Palus, J., Zbrog, Z., Swiech, R., Twardowska, E., Wasowicz, W., The effect of selenium supplementation in the prevention of DNA damage in white blood cells of hemodialyzed patients: A pilot study (2011) Biol. Trace Elem. Res, 142, pp. 274-283
Ravoori, S., Srinivasan, C., Pereg, D., Robertson, L.W., Ayotte, P., Gupta, R.C., Protective effects of selenium against DNA adduct formation in Inuit environmentally exposed to (2010) PCBs Environ Int, 36, pp. 980-986
Venkitaraman, A.R., Cancer susceptibility and the functions of BRCA1 and BRCA2 (2002) Cell, 108, pp. 171-182
Hartman, A.R., Ford, J.M., BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair (2002) Nat. Genet, 32, pp. 180-184
Fischer, J.L., Lancia, J.K., Mathur, A., Smith, M.L., Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex (2006) Anticancer. Res, 26, pp. 899-904
Baliga, M.S., Wang, H., Zhuo, P., Schwartz, J.L., Diamond, A.M., Selenium and GPx-1 overexpression protect mammalian cells against UV-induced DNA damage (2007) Biol. Trace Elem. Res, 115, pp. 227-242
Kotsopoulos, J., Chen, Z., Vallis, K.A., Poll, A., Ghadirian, P., Kennedy, G., Ainsworth, P., Narod, S.A., Toenail selenium status and DNA repair capacity among female BRCA1 mutation carriers (2010) Cancer Causes Control, 21, pp. 679-687
Kowalska, E., Narod, S.A., Huzarski, T., Zajaczek, S., Huzarska, J., Gorski, B., Lubinski, J., Increased rates of chromosome breakage in BRCA1 carriers are normalized by oral selenium supplementation (2005) Cancer Epidemiol. Biomarkers Prev, 14, pp. 1302-1306
Dziaman, T., Huzarski, T., Gackowski, D., Selenium supplementation reduced oxidative DNA damage in adnexectomized BRCA1 mutations carriers (2009) Cancer Epidemiol. Biomarkers Prev, 18, pp. 2923-2929
Karunasinghe, N., Han, D.Y., Zhu, S., Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: Relationship to markers of oxidative stress in men from Auckland, New Zealand (2012) Genes Nutr, 7, pp. 179-190
Cominetti, C., De Bortoli, M.C., Purgatto, E., Ong, T.P., Moreno, F.S., Garrido Jr., A.B., Cozzolino, S.M., Associations between glutathione peroxidase-1 Pro198Leu polymorphism selenium status and DNA damage levels in obese women after consumption of Brazil nuts (2011) Nutrition, 27, pp. 891-896
Bravard, A., Vacher, M., Moritz, E., Vaslin, L., Hall, J., Epe, B., Radicella, J.P., Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity (2009) Cancer Res, 69, pp. 3642-3649
Chen, L., Elahi, A., Pow-Sang, J., Lazarus, P., Park, J., Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer (2003) J.Urol, 170, pp. 2471-2474
Zeng, H., Davis, C.D., Finley, J.W., Effect of selenium-enriched broccoli diet on differential gene expression in min mouse liver(1 2 (2003) J Nutr Biochem, 14, pp. 227-231
Nasr, M., Fedele, M.J., Esser, K.A., Diamond, A.M., GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells (2004) Free Radic. Biol. Med, 37, pp. 187-195
Lubos, E., Loscalzo, J., Handy, D.E., Glutathione peroxidase-1 in health and disease: From molecular mechanisms to therapeutic opportunities (2011) Antioxid. Redox Signal, 15, pp. 1957-1997
Seo, Y.R., Kelley, M.R., Smith, M.L., Selenomethionine regulation of p53 by a ref1-dependent redox mechanism (2002) Proc. Natl Acad. Sci. USA, 99, pp. 14548-14553
Gudkov, A.V., Converting p53 from a killer into a healer (2002) Nat. Med, 8, pp. 1196-1198
Xiang, N., Zhao, R., Song, G., Zhong, W., Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells (2008) Carcinogenesis, 29, pp. 2175-2181
Zeng, H., Selenite and selenomethionine promote HL-60 cell cycle progression (2002) J. Nutr, 132, pp. 674-679
Hatfield, D.L., Gladyshev, V.N., The outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology (2009) Mol. Interv, 9, pp. 18-21
Rayman, M.P., Combs Jr., G.F., Waters, D.J., Selenium and vitamin E supplementation for cancer prevention (2009) JAMA, 301, pp. 1876-1877
Jung, H.J., Seo, Y.R., Current issues of selenium in cancer chemoprevention (2010) Biofactors, 36, pp. 153-158
Duffield-Lillico, A.J., Dalkin, B.L., Reid, M.E., Turnbull, B.W., Slate, E.H., Jacobs, E.T., Marshall, J.R., Clark, L.C., Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: An analysis of the complete treatment period of the nutritional prevention of cancer trial (2003) BJU Int, 91, pp. 608-612
Chiang, E.C., Shen, S., Kengeri, S.S., Xu, H., Combs, G.F., Morris, J.S., Bostwick, D.G., Waters, D.J., Defining the optimal selenium dose for prostate cancer risk reduction: Insights from the U-shaped relationship between selenium status, DNA damage, and apoptosis (2009) Dose Response, 8, pp. 285-300
Siviková, K., Piesová, E., Dianovský, J., The protection of Vitamin E and selenium against carbon tetrachloride-induced genotoxicity in ovine peripheral blood lymphocytes (2001) Mutat. Res, 494, pp. 135-142
Fahmy, M.A., Hassan, N.H., Farghaly, A.A., Hassan, E.E., Studies on the genotoxic effect of beryllium chloride and the possible protective role of selenium/vitamins A C and E (2008) Mutat. Res, 652, pp. 103-111
Grotto, D., Barcelos, G.R., Valentini, J., Antunes, L.M., Angeli, J.P., Garcia, S.C., Barbosa Jr., F., Low levels of methylmercury induce DNA damage in rats: Protective effects of selenium (2009) Arch. Toxicol, 83, pp. 249-254
Khalil, W.K., Booles, H.F., Protective role of selenium against over-expression of cancer-related apoptotic genes induced by o-cresol in rats (2011) Arh. Hig. Rada. Toksikol, 62, pp. 121-129
Lovell, M.A., Xiong, S., Lyubartseva, G., Markesbery, W.R., Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice (2009) Free Radic. Biol. Med, 46, pp. 1527-1533
Tripathi, D.N., Jena, G.B., Ebselen attenuates cyclophosphamide-induced oxidative stress and DNA damage in mice (2008) Free Radic. Res, 42, pp. 966-977
Chen, T., Wong, Y.S., In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis (2008) J.Agric. Food Chem, 56, pp. 4352-4358
Santos, R.A., Takahashi, C.S., Anticlastogenic and antigenotoxic effects of selenomethionine on doxorubicin-induced damage in vitro in human lymphocytes (2008) Food Chem. Toxicol, 46, pp. 671-677
Ferguson, L.R., Philpott, M., Karunasinghe, N., Dietary cancer and prevention using antimutagens (2004) Toxicology, 198, pp. 147-159
Dusinská, M., Kazimírová, A., Barancoková, M., Beno, M., Smolková, B., Horská, A., Raslová, K., Collins, A.R., Nutritional supplementation with antioxidants decreases chromosomal damage in humans (2003) Mutagenesis, 18, pp. 371-376
Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?