Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (550 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
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Paper type: Journal Article,
Impact factor: 3.279, 5-year impact factor: 2.836
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84856283957&partnerID=40&md5=9d7fa5fb9a4c038dfdf902a99acff4f0
Keywords: Comet Assay, Dna Repair, Hogg1, Oxidative Dna Damage, Selenium, Hydrogen Peroxide, Methylmethane Sulfonate, Selenomethionine, Sodium Selenite, Unclassified Drug, Antineoplastic Activity, Antioxidant Activity, Article, Cell Strain Lncap, Cell Viability, Controlled Study, Cytotoxicity, Drug Effect, Genotoxicity, Human, Human Cell, Low Drug Dose, Molecular Mechanics, Oxidative Stress, Prostate Adenocarcinoma, Treatment Response, Ultraviolet A Radiation, Anticarcinogenic Agents, Cell Line, Tumor, Cell Survival, Deoxyguanosine, Dna Fragmentation, Glutathione Peroxidase, Oxidation-Reduction, Prostatic Neoplasms, Thioredoxin-Disulfide Reductase, Ultraviolet Rays,
Affiliations:
*** IBB - CNR ***
Laboratoire des L é Sions des Acides Nucl é Iques, SCIB, INAC, 17 rue des Martyrs, Grenoble Cedex 9, F-38054, France
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey
University of Illinois at Chicago, Department of Pathology, 840 South Wood, Chicago, IL, United States
References:
Meuillet, E., Stratton, S., Prasad Cherukuri, D., Goulet, A.C., Kagey, J., Porterfield, B., Nelson, M.A., Chemoprevention of prostate cancer with selenium: An update on current clinical trials and preclinical findings (2004) J Cell Biochem, 91 (3), pp. 443-45
Lu, J., Holmgren, A., Selenoproteins (2009) J Biol Chem, 284 (2), pp. 723-727
Rayman, M.P., The use of high-selenium yeast to raise selenium status: How does it measure up? (2004) British Journal of Nutrition, 92 (4), pp. 557-573. , DOI 10.1079/BJN20041251
Letavayova, L., Vlckova, V., Brozmanova, J., Selenium: From cancer prevention to DNA damage (2006) Toxicology, 227 (1-2), pp. 1-14. , DOI 10.1016/j.tox.2006.07.017, PII S0300483X06004665
Arthur, J.R., McKenzie, R.C., Beckett, G.J., Selenium in the immune system (2003) Journal of Nutrition, 133 (5 SUPPL. 2), pp. 1457S-1459S
Fischer, J.L., Lancia, J.K., Mathur, A., Smith, M.L., Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex (2006) Anticancer Res, 26 (2 A), pp. 899-904
Mustacich, D., Powis, G., Thioredoxin reductase (2000) Biochemical Journal, 346 (1), pp. 1-8. , DOI 10.1042/0264-6021:3460001
Lobanov, A.V., Hatfield, D.L., Gladyshev, V.N., Eukaryotic selenoproteins and selenoproteomes (2009) Biochim Biophys Acta, 1790 (11), pp. 1424-1428
Hawkes, W.C., Alkan, Z., Regulation of redox signaling by selenoproteins (2010) Biol Trace Elem Res, 134 (3), pp. 235-251
Broadley, M.R., White, P.J., Bryson, R.J., Meacham, M.C., Bowen, H.C., Johnson, S.E., Hawkesford, M.J., Tucker, M., Biofortification of UK food crops with selenium (2006) Proceedings of the Nutrition Society, 65 (2), pp. 169-181. , DOI 10.1079/PNS2006490
Zhao, R., Domann, F.E., Zhong, W., Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells (2006) Molecular Cancer Therapeutics, 5 (12), pp. 3275-3284. , DOI 10.1158/1535-7163.MCT-06-0400
Zhao, R., Xiang, N., Domann, F.E., Zhong, W., Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells (2006) Cancer Res, 66, pp. 2296-2304
Li, G.-X., Lee, H.-J., Wang, Z., Hu, H., Liao, J.D., Watts, J.C., Combs Jr., G.F., LuJ. Junxuan, Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite (2008) Carcinogenesis, 29 (5), pp. 1005-1012. , DOI 10.1093/carcin/bgn007
Gudkov, A.V., Converting p53 from a killer into a healer (2002) Nature Medicine, 8 (11), pp. 1196-1198. , DOI 10.1038/nm1102-1196
Papp, L.V., Lu, J., Holmgren, A., Khanna, K.K., From selenium to selenoproteins: Synthesis, identity, and their role in human health (2007) Antioxidants and Redox Signaling, 9 (7), pp. 775-806. , DOI 10.1089/ars.2007.1528
Grollman, A.P., Moriya, M., Mutagenesis by 8-oxoguanine: An enemy within (1993) Trends in Genetics, 9 (7), pp. 246-249. , DOI 10.1016/0168-9525(93)90089-Z
Bravard, A., Vacher, M., Gouget, B., Coutant, A., De Boisferon, F.H., Marsin, S., Chevillard, S., Radicella, J.P., Redox regulation of human OGG1 activity in response to cellular oxidative stress (2006) Molecular and Cellular Biology, 26 (20), pp. 7430-7436. , DOI 10.1128/MCB.00624-06
Seo, Y.R., Kelley, M.R., Smith, M.L., Selenomethionine regulation of p53 by a ref1-dependent redox mechanism (2002) Proceedings of the National Academy of Sciences of the United States of America, 99 (22), pp. 14548-14553. , DOI 10.1073/pnas.212319799
Duffield-Lillico, A.J., Dalkin, B.L., Reid, M.E., Turnbull, B.W., Slate, E.H., Jacobs, E.T., Marshall, J.R., Clark, L.C., Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: An analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial (2003) BJU International, 91 (7), pp. 608-612. , DOI 10.1046/j.1464-410X.2003.04167.x
Waters, D.J., Shen, S., Cooley, D.M., Bostwick, D.G., Qian, J., Combs Jr., G.F., Glickman, L.T., Morris, J.S., Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate (2003) Journal of the National Cancer Institute, 95 (3), pp. 237-241
Chan, J.M., Oh, W.K., Xie, W., Regan, M.M., Stampfer, M.J., King, I.B., Plasma selenium, manganese superoxide dismutase, and intermediate-or high-risk prostate cancer (2009) J Clin Oncol, 27 (22), pp. 3577-3583
Erkekoglu, P., Rachidi, W., De Rosa, V., Giray, B., Favier, A., Hincal, F., Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl) phthalate treatment in LNCaP cells (2010) Free Radic Biol Med, 49 (4), pp. 559-566
Flohe, L., Gunzler, W.A., Assays of glutathione peroxidase (1984) Methods in Enzymology, VOL. 105, pp. 114-121
Arner, E.S., Zhong, L., Holmgren, A., Preparation and assay of mammalian thioredoxin and thioredoxin reductase (1999) Meth Enzymol, 300, pp. 226-239
Krieg, R.C., Dong, Y., Schwamborn, K., Knuechel, R., Protein quantification and its tolerance for different interfering reagents using the BCA-method with regard to 2D SDS PAGE (2005) Journal of Biochemical and Biophysical Methods, 65 (1), pp. 13-19. , DOI 10.1016/j.jbbm.2005.08.005, PII S0165022X05001302
Helbock, H.J., Beckman, K.B., Shigenaga, M.K., Walter, P.B., Woodall, A.A., Yeo, H.C., Ames, B.N., DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine (1998) Proc Natl Acad Sci USA, 95, pp. 288-293
Mouret, S., Philippe, C., Gracia-Chantegrel, J., Banyasz, A., Karpati, S., Markovitsi, D., Douki, T., UVA-induced cyclobutane pyrimidine dimers in DNA: A direct photochemical mechanism? (2010) Org Biomol Chem, 8 (7), pp. 1706-1711
Frelon, S., Douki, T., Ravanat, J.L., Pouget, J.P., Tornabene, C., Cadet, J., High-performance liquid chromatography-tandem mass spectrometry measurement of radiation-induced base damage to isolated and cellular DNA (2000) Chem Res Toxicol, 13 (10), pp. 1002-1010
Baliga, M.S., Diwadkar-Navsariwala, V., Koh, T., Fayad, R., Fantuzzi, G., Diamond, A.M., Selenoprotein deficiency enhances radiation-induced micronuclei formation (2008) Mol Nutr Food Res, 52 (11), pp. 1300-1304
Rebsch, C.M., Penna III, F.J., Copeland, P.R., Selenoprotein expression is regulated at multiple levels in prostate cells (2006) Cell Research, 16 (12), pp. 940-948. , DOI 10.1038/sj.cr.7310117, PII 7310117
Ridley, A.J., Whiteside, J.R., McMillan, T.J., Allinson, S.L., Cellular and sub-cellular responses to UVA in relation to carcinogenesis (2009) Int J Radiat Biol, 85 (3), pp. 177-195
Bjelland, S., Seeberg, E., Mutagenicity, toxicity and repair of DNA base damage induced by oxidation (2003) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 531 (1-2), pp. 37-80. , DOI 10.1016/j.mrfmmm.2003.07.002
Shrivastav, N., Li, D., Essigmann, J.M., Chemical biology of mutagenesis and DNA repair: Cellular responses to DNA alkylation (2010) Carcinogenesis, 31 (1), pp. 59-70
Schuch, A.P., Menck, C.F., The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight (2010) J Photochem Photobiol B, 99 (3), pp. 111-116
Hu, Y.J., Diamond, A.M., Role of glutathione peroxidase 1 in breast cancer: Loss of heterozygosity and allelic differences in the response to selenium (2003) Cancer Research, 63 (12), pp. 3347-3351
Zhuo, P., Goldberg, M., Herman, L., Lee, B.S., Wang, H., Brown, R.L., Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme (2009) Cancer Res, 69 (20), pp. 8183-8190
Suzuki, K.T., Ogra, Y., Metabolic pathway for selenium in the body: Speciation by HPLC-ICP MS with enriched Se (2002) Food Additives and Contaminants, 19 (10), pp. 974-983. , DOI 10.1080/02652030210153578
Fischer, J.L., Mihelc, E.M., Pollok, K.E., Smith, M.L., Chemotherapeutic selectivity conferred by selenium: A role for p53-dependent DNA repair (2007) Molecular Cancer Therapeutics, 6 (1), pp. 355-361. , DOI 10.1158/1535-7163.MCT-06-0472
Seo, Y.R., Sweeney, C., Smith, M.L., Selenomethionine induction of DNA repair response in human fibroblasts (2002) Oncogene, 21 (23), pp. 3663-3669. , DOI 10.1038/sj/onc/1205468
Evans, A.R., Limp-Foster, M., Kelley, M.R., Going APE over ref-1 (2000) Mutat Res, 461 (2), pp. 83-108
Chen, L., Elahi, A., Pow-Sang, J., Lazarus, P., Park, J., Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer (2003) Journal of Urology, 170 (6), pp. 2471-2474. , DOI 10.1097/01.ju.0000087498.23008.bb
Smith, M.L., Lancia, J.K., Mercer, T.I., Ip, C., Selenium compounds regulate p53 by common and distinctive mechanisms (2004) Anticancer Research, 24 (3 A), pp. 1401-1408
Lippman, S.M., Klein, E.A., G, P.J., Effect of selenium and vitamin e on risk of prosatate cancer and other cancers: The selenium and vitamin e cancer prevention trial (SELECT) (2009) JAMA, 301 (1), pp. 39-51
Ledesma, M.C., Jung-Hynes, B., Schmit, T.L., Kumar, R., Mukhtar, H., Ahmad, N., Selenium and vitamin e for prostate cancer: Post-SELECT status (2010) Mol Med
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.279, 5-year impact factor: 2.836
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84856283957&partnerID=40&md5=9d7fa5fb9a4c038dfdf902a99acff4f0
Keywords: Comet Assay, Dna Repair, Hogg1, Oxidative Dna Damage, Selenium, Hydrogen Peroxide, Methylmethane Sulfonate, Selenomethionine, Sodium Selenite, Unclassified Drug, Antineoplastic Activity, Antioxidant Activity, Article, Cell Strain Lncap, Cell Viability, Controlled Study, Cytotoxicity, Drug Effect, Genotoxicity, Human, Human Cell, Low Drug Dose, Molecular Mechanics, Oxidative Stress, Prostate Adenocarcinoma, Treatment Response, Ultraviolet A Radiation, Anticarcinogenic Agents, Cell Line, Tumor, Cell Survival, Deoxyguanosine, Dna Fragmentation, Glutathione Peroxidase, Oxidation-Reduction, Prostatic Neoplasms, Thioredoxin-Disulfide Reductase, Ultraviolet Rays,
Affiliations:
*** IBB - CNR ***
Laboratoire des L é Sions des Acides Nucl é Iques, SCIB, INAC, 17 rue des Martyrs, Grenoble Cedex 9, F-38054, France
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey
University of Illinois at Chicago, Department of Pathology, 840 South Wood, Chicago, IL, United States
References:
Meuillet, E., Stratton, S., Prasad Cherukuri, D., Goulet, A.C., Kagey, J., Porterfield, B., Nelson, M.A., Chemoprevention of prostate cancer with selenium: An update on current clinical trials and preclinical findings (2004) J Cell Biochem, 91 (3), pp. 443-45
Lu, J., Holmgren, A., Selenoproteins (2009) J Biol Chem, 284 (2), pp. 723-727
Rayman, M.P., The use of high-selenium yeast to raise selenium status: How does it measure up? (2004) British Journal of Nutrition, 92 (4), pp. 557-573. , DOI 10.1079/BJN20041251
Letavayova, L., Vlckova, V., Brozmanova, J., Selenium: From cancer prevention to DNA damage (2006) Toxicology, 227 (1-2), pp. 1-14. , DOI 10.1016/j.tox.2006.07.017, PII S0300483X06004665
Arthur, J.R., McKenzie, R.C., Beckett, G.J., Selenium in the immune system (2003) Journal of Nutrition, 133 (5 SUPPL. 2), pp. 1457S-1459S
Fischer, J.L., Lancia, J.K., Mathur, A., Smith, M.L., Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex (2006) Anticancer Res, 26 (2 A), pp. 899-904
Mustacich, D., Powis, G., Thioredoxin reductase (2000) Biochemical Journal, 346 (1), pp. 1-8. , DOI 10.1042/0264-6021:3460001
Lobanov, A.V., Hatfield, D.L., Gladyshev, V.N., Eukaryotic selenoproteins and selenoproteomes (2009) Biochim Biophys Acta, 1790 (11), pp. 1424-1428
Hawkes, W.C., Alkan, Z., Regulation of redox signaling by selenoproteins (2010) Biol Trace Elem Res, 134 (3), pp. 235-251
Broadley, M.R., White, P.J., Bryson, R.J., Meacham, M.C., Bowen, H.C., Johnson, S.E., Hawkesford, M.J., Tucker, M., Biofortification of UK food crops with selenium (2006) Proceedings of the Nutrition Society, 65 (2), pp. 169-181. , DOI 10.1079/PNS2006490
Zhao, R., Domann, F.E., Zhong, W., Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells (2006) Molecular Cancer Therapeutics, 5 (12), pp. 3275-3284. , DOI 10.1158/1535-7163.MCT-06-0400
Zhao, R., Xiang, N., Domann, F.E., Zhong, W., Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells (2006) Cancer Res, 66, pp. 2296-2304
Li, G.-X., Lee, H.-J., Wang, Z., Hu, H., Liao, J.D., Watts, J.C., Combs Jr., G.F., LuJ. Junxuan, Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite (2008) Carcinogenesis, 29 (5), pp. 1005-1012. , DOI 10.1093/carcin/bgn007
Gudkov, A.V., Converting p53 from a killer into a healer (2002) Nature Medicine, 8 (11), pp. 1196-1198. , DOI 10.1038/nm1102-1196
Papp, L.V., Lu, J., Holmgren, A., Khanna, K.K., From selenium to selenoproteins: Synthesis, identity, and their role in human health (2007) Antioxidants and Redox Signaling, 9 (7), pp. 775-806. , DOI 10.1089/ars.2007.1528
Grollman, A.P., Moriya, M., Mutagenesis by 8-oxoguanine: An enemy within (1993) Trends in Genetics, 9 (7), pp. 246-249. , DOI 10.1016/0168-9525(93)90089-Z
Bravard, A., Vacher, M., Gouget, B., Coutant, A., De Boisferon, F.H., Marsin, S., Chevillard, S., Radicella, J.P., Redox regulation of human OGG1 activity in response to cellular oxidative stress (2006) Molecular and Cellular Biology, 26 (20), pp. 7430-7436. , DOI 10.1128/MCB.00624-06
Seo, Y.R., Kelley, M.R., Smith, M.L., Selenomethionine regulation of p53 by a ref1-dependent redox mechanism (2002) Proceedings of the National Academy of Sciences of the United States of America, 99 (22), pp. 14548-14553. , DOI 10.1073/pnas.212319799
Duffield-Lillico, A.J., Dalkin, B.L., Reid, M.E., Turnbull, B.W., Slate, E.H., Jacobs, E.T., Marshall, J.R., Clark, L.C., Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: An analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial (2003) BJU International, 91 (7), pp. 608-612. , DOI 10.1046/j.1464-410X.2003.04167.x
Waters, D.J., Shen, S., Cooley, D.M., Bostwick, D.G., Qian, J., Combs Jr., G.F., Glickman, L.T., Morris, J.S., Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate (2003) Journal of the National Cancer Institute, 95 (3), pp. 237-241
Chan, J.M., Oh, W.K., Xie, W., Regan, M.M., Stampfer, M.J., King, I.B., Plasma selenium, manganese superoxide dismutase, and intermediate-or high-risk prostate cancer (2009) J Clin Oncol, 27 (22), pp. 3577-3583
Erkekoglu, P., Rachidi, W., De Rosa, V., Giray, B., Favier, A., Hincal, F., Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl) phthalate treatment in LNCaP cells (2010) Free Radic Biol Med, 49 (4), pp. 559-566
Flohe, L., Gunzler, W.A., Assays of glutathione peroxidase (1984) Methods in Enzymology, VOL. 105, pp. 114-121
Arner, E.S., Zhong, L., Holmgren, A., Preparation and assay of mammalian thioredoxin and thioredoxin reductase (1999) Meth Enzymol, 300, pp. 226-239
Krieg, R.C., Dong, Y., Schwamborn, K., Knuechel, R., Protein quantification and its tolerance for different interfering reagents using the BCA-method with regard to 2D SDS PAGE (2005) Journal of Biochemical and Biophysical Methods, 65 (1), pp. 13-19. , DOI 10.1016/j.jbbm.2005.08.005, PII S0165022X05001302
Helbock, H.J., Beckman, K.B., Shigenaga, M.K., Walter, P.B., Woodall, A.A., Yeo, H.C., Ames, B.N., DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine (1998) Proc Natl Acad Sci USA, 95, pp. 288-293
Mouret, S., Philippe, C., Gracia-Chantegrel, J., Banyasz, A., Karpati, S., Markovitsi, D., Douki, T., UVA-induced cyclobutane pyrimidine dimers in DNA: A direct photochemical mechanism? (2010) Org Biomol Chem, 8 (7), pp. 1706-1711
Frelon, S., Douki, T., Ravanat, J.L., Pouget, J.P., Tornabene, C., Cadet, J., High-performance liquid chromatography-tandem mass spectrometry measurement of radiation-induced base damage to isolated and cellular DNA (2000) Chem Res Toxicol, 13 (10), pp. 1002-1010
Baliga, M.S., Diwadkar-Navsariwala, V., Koh, T., Fayad, R., Fantuzzi, G., Diamond, A.M., Selenoprotein deficiency enhances radiation-induced micronuclei formation (2008) Mol Nutr Food Res, 52 (11), pp. 1300-1304
Rebsch, C.M., Penna III, F.J., Copeland, P.R., Selenoprotein expression is regulated at multiple levels in prostate cells (2006) Cell Research, 16 (12), pp. 940-948. , DOI 10.1038/sj.cr.7310117, PII 7310117
Ridley, A.J., Whiteside, J.R., McMillan, T.J., Allinson, S.L., Cellular and sub-cellular responses to UVA in relation to carcinogenesis (2009) Int J Radiat Biol, 85 (3), pp. 177-195
Bjelland, S., Seeberg, E., Mutagenicity, toxicity and repair of DNA base damage induced by oxidation (2003) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 531 (1-2), pp. 37-80. , DOI 10.1016/j.mrfmmm.2003.07.002
Shrivastav, N., Li, D., Essigmann, J.M., Chemical biology of mutagenesis and DNA repair: Cellular responses to DNA alkylation (2010) Carcinogenesis, 31 (1), pp. 59-70
Schuch, A.P., Menck, C.F., The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight (2010) J Photochem Photobiol B, 99 (3), pp. 111-116
Hu, Y.J., Diamond, A.M., Role of glutathione peroxidase 1 in breast cancer: Loss of heterozygosity and allelic differences in the response to selenium (2003) Cancer Research, 63 (12), pp. 3347-3351
Zhuo, P., Goldberg, M., Herman, L., Lee, B.S., Wang, H., Brown, R.L., Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme (2009) Cancer Res, 69 (20), pp. 8183-8190
Suzuki, K.T., Ogra, Y., Metabolic pathway for selenium in the body: Speciation by HPLC-ICP MS with enriched Se (2002) Food Additives and Contaminants, 19 (10), pp. 974-983. , DOI 10.1080/02652030210153578
Fischer, J.L., Mihelc, E.M., Pollok, K.E., Smith, M.L., Chemotherapeutic selectivity conferred by selenium: A role for p53-dependent DNA repair (2007) Molecular Cancer Therapeutics, 6 (1), pp. 355-361. , DOI 10.1158/1535-7163.MCT-06-0472
Seo, Y.R., Sweeney, C., Smith, M.L., Selenomethionine induction of DNA repair response in human fibroblasts (2002) Oncogene, 21 (23), pp. 3663-3669. , DOI 10.1038/sj/onc/1205468
Evans, A.R., Limp-Foster, M., Kelley, M.R., Going APE over ref-1 (2000) Mutat Res, 461 (2), pp. 83-108
Chen, L., Elahi, A., Pow-Sang, J., Lazarus, P., Park, J., Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer (2003) Journal of Urology, 170 (6), pp. 2471-2474. , DOI 10.1097/01.ju.0000087498.23008.bb
Smith, M.L., Lancia, J.K., Mercer, T.I., Ip, C., Selenium compounds regulate p53 by common and distinctive mechanisms (2004) Anticancer Research, 24 (3 A), pp. 1401-1408
Lippman, S.M., Klein, E.A., G, P.J., Effect of selenium and vitamin e on risk of prosatate cancer and other cancers: The selenium and vitamin e cancer prevention trial (SELECT) (2009) JAMA, 301 (1), pp. 39-51
Ledesma, M.C., Jung-Hynes, B., Schmit, T.L., Kumar, R., Mukhtar, H., Ahmad, N., Selenium and vitamin e for prostate cancer: Post-SELECT status (2010) Mol Med
Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells
Epidemiological studies have demonstrated an inverse relationship between selenium (Se) intake and cancer incidence and/or mortality. However, the molecular mechanisms underlying the cancer chemopreventive activity of Se compounds remain largely unknown. The objective of this study was to investigate the effect of low doses of Se on the stimulation of DNA repair systems in response to four different qualities of DNA damage. P53-proficient LNCaP human prostate adenocarcinoma cells were grown either untreated or in the presence of low concentrations of two Se compounds (30° nM sodium selenite, or 10μM selenomethionine) and exposed to UVA, H 2O 2, methylmethane sulfonate (MMS) or UVC. Cell viability as well as DNA damage induction and repair were evaluated by the alkaline Comet assay. Overall, Se was shown to be a very potent protector against cell toxicity and genotoxicity induced by oxidative stress (UVA or H 2O 2) but not from the agents that induce other types of deleterious lesions (MMS or UVC). Furthermore, Se-treated cells exhibited increased oxidative DNA repair activity, indicating a novel mechanism of Se action. Therefore, the benefits of Se could be explained by a combination of antioxidant activity, the reduction in DNA damage and the enhancement of oxidative DNA repair capacity. © 2012 Informa UK, Ltd.
Epidemiological studies have demonstrated an inverse relationship between selenium (Se) intake and cancer incidence and/or mortality. However, the molecular mechanisms underlying the cancer chemopreventive activity of Se compounds remain largely unknown. The objective of this study was to investigate the effect of low doses of Se on the stimulation of DNA repair systems in response to four different qualities of DNA damage. P53-proficient LNCaP human prostate adenocarcinoma cells were grown either untreated or in the presence of low concentrations of two Se compounds (30° nM sodium selenite, or 10μM selenomethionine) and exposed to UVA, H 2O 2, methylmethane sulfonate (MMS) or UVC. Cell viability as well as DNA damage induction and repair were evaluated by the alkaline Comet assay. Overall, Se was shown to be a very potent protector against cell toxicity and genotoxicity induced by oxidative stress (UVA or H 2O 2) but not from the agents that induce other types of deleterious lesions (MMS or UVC). Furthermore, Se-treated cells exhibited increased oxidative DNA repair activity, indicating a novel mechanism of Se action. Therefore, the benefits of Se could be explained by a combination of antioxidant activity, the reduction in DNA damage and the enhancement of oxidative DNA repair capacity. © 2012 Informa UK, Ltd.
Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells
| ▼ Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events |
Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells
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Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (599 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
View Export to BibTeX Export to EndNote
Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (462 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (531 views)
Mol Biol Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
Impact Factor: 4.466
View Export to BibTeX Export to EndNote
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (639 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
View Export to BibTeX Export to EndNote
Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (474 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2012 Dec 7; 18(50): 15960-15971.
Impact Factor: 5.831
View Export to BibTeX Export to EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (675 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (872 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
Nastri F, Lista L, Ringhieri P, Vitale R, Faiella M, Andreozzi C, Travascio P, Maglio O, Lombardi A, Pavone V
* A Heme-Peptide Metalloenzyme Mimetic with Natural Peroxidase-Like Activity (435 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Apr; 17(16): 4444-4453.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (554 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
View Export to BibTeX Export to EndNote
De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (522 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
View Export to BibTeX Export to EndNote
Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (362 views)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Pedone E, Bartolucci S, Fiorentino G
* Sensing and adapting to environmental stress: The Archaeal tactic (327 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2004 Sep 1; 9: 2909-2926.
Impact Factor: 3.226
View Export to BibTeX Export to EndNote
Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (883 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
View Export to BibTeX Export to EndNote
Tabbì G, Fry SC, Bonomo RP
ESR study of the non-enzymic scission of xyloglucan by an ascorbate-H2O2-copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (311 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Apr; 84(3-4): 179-187.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (564 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
View Export to BibTeX Export to EndNote
Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (334 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
View Export to BibTeX Export to EndNote
Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (526 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
View Export to BibTeX Export to EndNote
Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (512 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
View Export to BibTeX Export to EndNote
Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (489 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
* A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair (142 views)
Cancers (ISSN: 2072-6694linking), 2019 Sep 28; 11(10): N/D-N/D.
Impact Factor: 6.102
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Dell'Acqua S, Bacchella C, Monzani E, Nicolis S, Di Natale G, Rizzarelli E, Casella L
* Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress (585 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Sep 18; 56(18): 11317-11325.
Impact Factor: 4.7
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Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (599 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
View Export to BibTeX Export to EndNote
Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (462 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (531 views)
Mol Biol Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
Impact Factor: 4.466
View Export to BibTeX Export to EndNote
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
View Export to BibTeX Export to EndNote
Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (639 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
View Export to BibTeX Export to EndNote
Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (474 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2012 Dec 7; 18(50): 15960-15971.
Impact Factor: 5.831
View Export to BibTeX Export to EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (675 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (872 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
Nastri F, Lista L, Ringhieri P, Vitale R, Faiella M, Andreozzi C, Travascio P, Maglio O, Lombardi A, Pavone V
* A Heme-Peptide Metalloenzyme Mimetic with Natural Peroxidase-Like Activity (435 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Apr; 17(16): 4444-4453.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (554 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
View Export to BibTeX Export to EndNote
De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (522 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
View Export to BibTeX Export to EndNote
Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (362 views)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Pedone E, Bartolucci S, Fiorentino G
* Sensing and adapting to environmental stress: The Archaeal tactic (327 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2004 Sep 1; 9: 2909-2926.
Impact Factor: 3.226
View Export to BibTeX Export to EndNote
Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (883 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
View Export to BibTeX Export to EndNote
Tabbì G, Fry SC, Bonomo RP
ESR study of the non-enzymic scission of xyloglucan by an ascorbate-H2O2-copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (311 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Apr; 84(3-4): 179-187.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (564 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
View Export to BibTeX Export to EndNote
Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (334 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
View Export to BibTeX Export to EndNote
Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (526 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
View Export to BibTeX Export to EndNote
Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (512 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
View Export to BibTeX Export to EndNote
Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (489 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
34 Records (32 excluding Abstracts).
Total impact factor: 142.244 (122.379 excluding Abstracts).
Total 5 year impact factor: 166.986 (138.541 excluding Abstracts).
Total impact factor: 142.244 (122.379 excluding Abstracts).
Total 5 year impact factor: 166.986 (138.541 excluding Abstracts).
550 views. Last view on Tuesday 28 March 2023, 14:22:08
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