Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (698 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.707, 5-year impact factor: 5.773
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77954511322&partnerID=40&md5=3fa813238031c87a98df5143b35a5862
Keywords: Comet Assay, Di(2-Ethylhexyl)phthalate, Dna Damage, Glutathione Peroxidase, Mono(2-Ethylhexyl)phthalate, Oxidative Stress, Selenium, Phthalic Acid 2 Ethylhexyl Monoester, Phthalic Acid Bis(2 Ethylhexyl) Ester, Selenomethionine, Sodium Selenite, Antioxidant Activity, Article, Cell Protection, Cell Strain Lncap, Cell Viability, Controlled Study, Cytotoxicity, Drug Mechanism, Genotoxicity, Human, Human Cell, Priority Journal, Cell Survival, Diethylhexyl Phthalate, Dose-Response Relationship, Tumor Cells, Cultured, Animalia, Antioxidants Pharmacology , Cell Survival Drug Effects , Diethylhexyl Phthalate Analogs, Derivatives Antagonists, Inhibitors Pharmacology , Selenomethionine Pharmacology , Sodium Selenite Pharmacology,
Affiliations:
*** IBB - CNR ***
INAC/SCIB/LAN, CEA de Grenoble, 17 rue des Martyrs, 38054 Grenoble, France
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Sihhiye-Ankara, Turkey
References:
Dröge, W., Free radicals in the physiological control of cell function (2002) Physiol. Rev., 82, pp. 47-9
Turner, T.T., Lysiak, J.J., Oxidative stress: a common factor in testicular dysfunction (2008) J. Androl., 29, pp. 488-498
Soory, M., Relevance of nutritional antioxidants in metabolic syndrome, ageing and cancer: potential for therapeutic targeting (2009) Infect. Disord. Drug Targets, 9, pp. 400-414
Fischer, J.L., Lancia, J.K., Mathur, A., Smith, M.L., Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex (2006) Anticancer Res., 26, pp. 899-904
Ganther, D.E., Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoixn reductase (1999) Carcinogenesis, 20, pp. 1657-1666
Duffield-Lillico, A.J., Reid, M.E., Turnbull, B.W., Combs, G.F., Slate, E.H., Fischbach, L.A., Marshall, J.R., Clark, L.C., Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial (2002) Cancer Epidemiol. Biomarkers Prev., 11, pp. 630-639
Oberley, T.D., Zhong, W., Szweda, L.I., Oberley, L.W., Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium (2000) Prostate, 44, pp. 144-155
Zhong, W., Oberley, T.D., Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line (2001) Cancer Res., 61, pp. 7071-7078
Chung, L.W., Li, W., Gleave, M.E., Hsieh, J.T., Wu, H.C., Sikes, R.A., Zhau, H.E., Rubin, J.S., Human prostate cancer model: roles of growth factors and extracellular matrices (1992) J. Cell Biochem. Suppl., 16 H, pp. 99-105
Rusyn, I., Peters, J.M., Cunningham, M.L., Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver (2006) Crit. Rev. Toxicol., 36, pp. 459-479
Lyche, J.L., Gutleb, A.C., Bergman, A., Eriksen, G.S., Murk, A.J., Ropstad, E., Saunders, M., Skaare, J.U., Reproductive and developmental toxicity of phthalates (2009) J Toxicol. Environ. Health B Crit. Rev., 12, pp. 225-249
Noriega, N.C., Howdeshell, K.L., Furr, J., Lambright, C.R., Wilson, V.S., Gray, L.E., Pubertal administration of DEHP delays puberty, suppresses testosterone production, and inhibits reproductive tract development in male Sprague-Dawley and Long-Evans rats (2009) Toxicol. Sci., 111, pp. 163-178
Zhang, Y.H., Lin, L., Liu, Z.W., Jiang, X.Z., Chen, B.H., Disruption effects of monophthalate exposures on inter-Sertoli tight junction in a two-compartment culture model (2008) Environ. Toxicol., 23, pp. 302-308
Ge, R.S., Chen, G.R., Tanrikut, C., Hardy, M.P., Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations (2007) Reprod. Toxicol., 23, pp. 366-373
Gazouli, M., Yao, Z.X., Boujrad, N., Corton, J.C., Culty, M., Papadopoulos, V., Effect of peroxisome proliferators on Leydig cell peripheral-type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: role of the peroxisome proliferator-activator receptor alpha (2002) Endocrinology, 143, pp. 2571-2583
O'Brien, M.L., Spear, B.T., Glauert, H.P., Role of oxidative stress in peroxisome proliferator-mediated carcinogenesis (2005) Crit. Rev. Toxicol., 35, pp. 61-88
Anderson, D., Yu, T.W., Hincal, F., Effect of some phthalate esters in human cells in the comet assay (1999) Teratog. Carcinog. Mutagen., 19, pp. 275-280
Kleinsasser, N.H., Harréus, U.A., Kastenbauer, E.R., Wallner, B.C., Sassen, A.W., Staudenmaier, R., Rettenmeier, A.W., Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay (2004) Toxicol. Lett., 148, pp. 83-90
Cory, A.H., Owen, T.C., Barltrop, J.A., Cory, J.G., Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture (1991) Cancer Commun., 3, pp. 207-212
Flohé, L., Günzler, W.A., Assays of glutathione peroxidase (1984) Methods Enzymol., 105, pp. 114-121
Arner, E.S., Zhong, L., Holmgren, A., Preparation and assay of mammalian thioredoxin and thioredoxin reductase (1999) Methods Enzymol., 300, pp. 226-239
Goldberg, D.M., Spooner, R.J., Glutathione reductase (1983) Methods of enzymatic analysis, pp. 258-265. , Verlag Chemie, Basal, H.U. Bergmeyer, J. Bergmeyer, M. Grabl (Eds.)
Habig, W.H., Pabst, M.J., Jakoby, W.B., Glutathion S-transferases, the first enzymatic step in mercapturic acid formation (1974) Biol. Chem., 249, pp. 7130-7139
Akerboom, T.P., Sies, H., Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples (1981) Methods Enzymol., 77, pp. 373-382
Krieg, R.C., Dong, Y., Schwamborn, K., Knuechel, R., Protein quantification and its tolerance for different interfering reagents using the BCA-method with regard to 2D SDS PAGE (2005) J. Biochem. Biophys. Methods, 65, pp. 13-19
Singh, N.P., McCoy, M.T., Tice, R.R., Schneider, E.L., A simple technique for quantitation of low levels of DNA damage in individual cells (1988) Exp. Cell Res., 175, pp. 184-191
Tice, R.R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Sasaki, Y.F., Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing (2000) Environ. Mol. Mutagen., 35, pp. 206-221
Rusyn, I., Kadiiska, M.B., Dikalova, A., Kono, H., Yin, M., Tsuchiya, K., Mason, R.P., Thurman, R.G., Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells (2001) Mol. Pharmacol., 59, pp. 744-750
Kasahara, E., Sato, E.F., Miyoshi, M., Konaka, R., Hiramoto, K., Sasaki, J., Tokuda, M., Inoue, M., Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate (2002) Biochem. J., 365, pp. 849-856
Onorato, T.M., Brown, P.W., Morris, P.L., Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2 (2008) J. Androl., 29, pp. 293-303
Mansur, D.B., Hao, H., Gladyshev, V.N., Korotkov, K.V., Hu, Y., Moustafa, M.E., El-Saadani, M.A., Diamond, A.M., Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines (2000) Biochem. Pharmacol., 60, pp. 489-497
Bhamre, S., Whitin, J.C., Cohen, H.J., Selenomethionine does not affect PSA secretion independent of its effect on LNCaP cell growth (2003) Prostate, 54, pp. 315-321
Zhuo, P., Goldberg, M., Herman, L., Lee, B.S., Wang, H., Brown, R.L., Foster, C.B., Diamond, A.M., Cancer Res. Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme (2009) Cancer Res., 69, pp. 8183-8190
Hu, Y.J., Diamond, A.M., Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium (2003) Cancer Res., 63, pp. 3347-3351
Baliga, M.S., Wang, H., Zhuo, P., Schwartz, J.L., Diamond, A.M., Selenium and GPx-1 overexpression protect mammalian cells against UV-induced DNA damage (2007) Biol. Trace Elem. Res., 115, pp. 227-242
Hayes, J.D., Pulford, D.J., The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance (1995) Crit. Rev. Biochem. Mol. Biol., 30, pp. 445-600
Gromer, S., Urig, S., Becker, K., The thioredoxin system-from science to clinic (2004) Med. Res. Rev., 24, pp. 40-89
Arnér, E.S., Holmgren, A., Physiological functions of thioredoxin and thioredoxin reductase (2000) Eur. J. Biochem., 267, pp. 6102-6109
Xia, L., Nordman, T., Olsson, J.M., Damdimopoulos, A., Björkhem-Bergman, L., Nalvarte, I., Eriksson, L.C., Björnstedt, M., The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress (2003) Biol. Chem., 278, pp. 2141-2146
Gandin, V., Nyström, C., Rundlöf, A.K., Jönsson-Videsäter, K., Schönlau, F., Hörkkö, J., Björnstedt, M., Fernandes, A.P., Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells (2009) FEBS J., 276, pp. 532-540
Hauser, R., Meeker, J.D., Singh, N.P., Silva, M.J., Ryan, L., Duty, S., Calafat, A.M., DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites (2007) Hum. Reprod., 22, pp. 688-695
Emonet-Piccardi, N., Richard, M.J., Ravanat, J.L., Signorini, N., Cadet, J., Béani, J.C., Protective effects of antioxidants against UVA-induced DNA damage in human skin fibroblasts in culture (1998) Free Radic. Res., 29, pp. 307-313
Rafferty, T.S., Green, M.H., Lowe, J.E., Arlett, C., Hunter, J.A., Beckett, G.J., McKenzie, R.C., Effects of selenium compounds on induction of DNA damage by broadband ultraviolet radiation in human keratinocytes (2003) Br. J. Dermatol., 148, pp. 1001-1009
Waters, D.J., Shen, S., Cooley, D.M., Bostwick, D.G., Qian, J., Combs, G.F., Glickman, L.T., Morris, J.S., Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate (2003) J. Natl. Cancer Inst., 95, pp. 237-241
Letavayová, L., Vlcková, V., Brozmanová, J., Selenium: from cancer prevention to DNA damage (2006) Toxicology, 227, pp. 1-14
Seko, Y., Saito, Y., Kitahara, J., Imura, N., Active oxygen generation by the reaction of selenite with reduced glutathione in vitro (1989) Selenium in biology and medicine, pp. 70-73. , Springer-Verlag, Berlin, A. Wendel (Ed.)
Stewart, M.S., Spallholz, J.E., Neldner, K.H., Pence, B.C., Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis (1999) Free Radic. Biol. Med., 26, pp. 42-48
Hartwig, A., Blessing, H., Schwerdtle, T., Walter, I., Modulation of DNA repair processes by arsenic and selenium compounds (2003) Toxicology, 193, pp. 161-169
Li, G.X., Hu, H., Jiang, C., Schuster, T., Lü, J., Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells (2007) Int. J. Cancer, 120, pp. 2034-2043
Seo, Y.R., Sweeney, C., Smith, M.L., Selenomethionine induction of DNA repair response in human fibroblasts (2002) Oncogene, 21, pp. 3663-3669
Collins, A.R., Harrington, V., Drew, J., Melvin, R., Nutritional modulation of DNA repair in a human intervention study (2003) Carcinogenesis, 24, pp. 511-515
Laffon, B., Valdiglesias, V., Pásaro, E., Méndez, J., The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair in human leukocytes (2010) Biol. Trace Elem. Res., 133, pp. 12-19
Gladyshev, V.N., Hatfield, D.L., Selenocysteine-containing proteins in mammals (1999) J. Biomed. Sci., 6, pp. 151-160
Calvo, A., Xiao, N., Kang, J., Best, C.J., Leiva, I., Emmert-Buck, M.R., Jorcyk, C., Green, J.E., Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors (2002) Cancer Res., 62, pp. 5325-5335
Kumaraswamy, E., Malykh, A., Korotkov, K.V., Kozyavkin, S., Hu, Y., Kwon, S.Y., Moustafa, M.E., Gladyshev, V.N., Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology (2000) J. Biol. Chem., 275, pp. 35540-35547
Rhee, S.G., Chae, H.Z., Kim, K., Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling (2005) Free Radic. Biol. Med., 38, pp. 1543-1552
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.707, 5-year impact factor: 5.773
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77954511322&partnerID=40&md5=3fa813238031c87a98df5143b35a5862
Keywords: Comet Assay, Di(2-Ethylhexyl)phthalate, Dna Damage, Glutathione Peroxidase, Mono(2-Ethylhexyl)phthalate, Oxidative Stress, Selenium, Phthalic Acid 2 Ethylhexyl Monoester, Phthalic Acid Bis(2 Ethylhexyl) Ester, Selenomethionine, Sodium Selenite, Antioxidant Activity, Article, Cell Protection, Cell Strain Lncap, Cell Viability, Controlled Study, Cytotoxicity, Drug Mechanism, Genotoxicity, Human, Human Cell, Priority Journal, Cell Survival, Diethylhexyl Phthalate, Dose-Response Relationship, Tumor Cells, Cultured, Animalia, Antioxidants Pharmacology , Cell Survival Drug Effects , Diethylhexyl Phthalate Analogs, Derivatives Antagonists, Inhibitors Pharmacology , Selenomethionine Pharmacology , Sodium Selenite Pharmacology,
Affiliations:
*** IBB - CNR ***
INAC/SCIB/LAN, CEA de Grenoble, 17 rue des Martyrs, 38054 Grenoble, France
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Sihhiye-Ankara, Turkey
References:
Dröge, W., Free radicals in the physiological control of cell function (2002) Physiol. Rev., 82, pp. 47-9
Turner, T.T., Lysiak, J.J., Oxidative stress: a common factor in testicular dysfunction (2008) J. Androl., 29, pp. 488-498
Soory, M., Relevance of nutritional antioxidants in metabolic syndrome, ageing and cancer: potential for therapeutic targeting (2009) Infect. Disord. Drug Targets, 9, pp. 400-414
Fischer, J.L., Lancia, J.K., Mathur, A., Smith, M.L., Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex (2006) Anticancer Res., 26, pp. 899-904
Ganther, D.E., Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoixn reductase (1999) Carcinogenesis, 20, pp. 1657-1666
Duffield-Lillico, A.J., Reid, M.E., Turnbull, B.W., Combs, G.F., Slate, E.H., Fischbach, L.A., Marshall, J.R., Clark, L.C., Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial (2002) Cancer Epidemiol. Biomarkers Prev., 11, pp. 630-639
Oberley, T.D., Zhong, W., Szweda, L.I., Oberley, L.W., Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium (2000) Prostate, 44, pp. 144-155
Zhong, W., Oberley, T.D., Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line (2001) Cancer Res., 61, pp. 7071-7078
Chung, L.W., Li, W., Gleave, M.E., Hsieh, J.T., Wu, H.C., Sikes, R.A., Zhau, H.E., Rubin, J.S., Human prostate cancer model: roles of growth factors and extracellular matrices (1992) J. Cell Biochem. Suppl., 16 H, pp. 99-105
Rusyn, I., Peters, J.M., Cunningham, M.L., Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver (2006) Crit. Rev. Toxicol., 36, pp. 459-479
Lyche, J.L., Gutleb, A.C., Bergman, A., Eriksen, G.S., Murk, A.J., Ropstad, E., Saunders, M., Skaare, J.U., Reproductive and developmental toxicity of phthalates (2009) J Toxicol. Environ. Health B Crit. Rev., 12, pp. 225-249
Noriega, N.C., Howdeshell, K.L., Furr, J., Lambright, C.R., Wilson, V.S., Gray, L.E., Pubertal administration of DEHP delays puberty, suppresses testosterone production, and inhibits reproductive tract development in male Sprague-Dawley and Long-Evans rats (2009) Toxicol. Sci., 111, pp. 163-178
Zhang, Y.H., Lin, L., Liu, Z.W., Jiang, X.Z., Chen, B.H., Disruption effects of monophthalate exposures on inter-Sertoli tight junction in a two-compartment culture model (2008) Environ. Toxicol., 23, pp. 302-308
Ge, R.S., Chen, G.R., Tanrikut, C., Hardy, M.P., Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations (2007) Reprod. Toxicol., 23, pp. 366-373
Gazouli, M., Yao, Z.X., Boujrad, N., Corton, J.C., Culty, M., Papadopoulos, V., Effect of peroxisome proliferators on Leydig cell peripheral-type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: role of the peroxisome proliferator-activator receptor alpha (2002) Endocrinology, 143, pp. 2571-2583
O'Brien, M.L., Spear, B.T., Glauert, H.P., Role of oxidative stress in peroxisome proliferator-mediated carcinogenesis (2005) Crit. Rev. Toxicol., 35, pp. 61-88
Anderson, D., Yu, T.W., Hincal, F., Effect of some phthalate esters in human cells in the comet assay (1999) Teratog. Carcinog. Mutagen., 19, pp. 275-280
Kleinsasser, N.H., Harréus, U.A., Kastenbauer, E.R., Wallner, B.C., Sassen, A.W., Staudenmaier, R., Rettenmeier, A.W., Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay (2004) Toxicol. Lett., 148, pp. 83-90
Cory, A.H., Owen, T.C., Barltrop, J.A., Cory, J.G., Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture (1991) Cancer Commun., 3, pp. 207-212
Flohé, L., Günzler, W.A., Assays of glutathione peroxidase (1984) Methods Enzymol., 105, pp. 114-121
Arner, E.S., Zhong, L., Holmgren, A., Preparation and assay of mammalian thioredoxin and thioredoxin reductase (1999) Methods Enzymol., 300, pp. 226-239
Goldberg, D.M., Spooner, R.J., Glutathione reductase (1983) Methods of enzymatic analysis, pp. 258-265. , Verlag Chemie, Basal, H.U. Bergmeyer, J. Bergmeyer, M. Grabl (Eds.)
Habig, W.H., Pabst, M.J., Jakoby, W.B., Glutathion S-transferases, the first enzymatic step in mercapturic acid formation (1974) Biol. Chem., 249, pp. 7130-7139
Akerboom, T.P., Sies, H., Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples (1981) Methods Enzymol., 77, pp. 373-382
Krieg, R.C., Dong, Y., Schwamborn, K., Knuechel, R., Protein quantification and its tolerance for different interfering reagents using the BCA-method with regard to 2D SDS PAGE (2005) J. Biochem. Biophys. Methods, 65, pp. 13-19
Singh, N.P., McCoy, M.T., Tice, R.R., Schneider, E.L., A simple technique for quantitation of low levels of DNA damage in individual cells (1988) Exp. Cell Res., 175, pp. 184-191
Tice, R.R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Sasaki, Y.F., Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing (2000) Environ. Mol. Mutagen., 35, pp. 206-221
Rusyn, I., Kadiiska, M.B., Dikalova, A., Kono, H., Yin, M., Tsuchiya, K., Mason, R.P., Thurman, R.G., Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells (2001) Mol. Pharmacol., 59, pp. 744-750
Kasahara, E., Sato, E.F., Miyoshi, M., Konaka, R., Hiramoto, K., Sasaki, J., Tokuda, M., Inoue, M., Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate (2002) Biochem. J., 365, pp. 849-856
Onorato, T.M., Brown, P.W., Morris, P.L., Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2 (2008) J. Androl., 29, pp. 293-303
Mansur, D.B., Hao, H., Gladyshev, V.N., Korotkov, K.V., Hu, Y., Moustafa, M.E., El-Saadani, M.A., Diamond, A.M., Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines (2000) Biochem. Pharmacol., 60, pp. 489-497
Bhamre, S., Whitin, J.C., Cohen, H.J., Selenomethionine does not affect PSA secretion independent of its effect on LNCaP cell growth (2003) Prostate, 54, pp. 315-321
Zhuo, P., Goldberg, M., Herman, L., Lee, B.S., Wang, H., Brown, R.L., Foster, C.B., Diamond, A.M., Cancer Res. Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme (2009) Cancer Res., 69, pp. 8183-8190
Hu, Y.J., Diamond, A.M., Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium (2003) Cancer Res., 63, pp. 3347-3351
Baliga, M.S., Wang, H., Zhuo, P., Schwartz, J.L., Diamond, A.M., Selenium and GPx-1 overexpression protect mammalian cells against UV-induced DNA damage (2007) Biol. Trace Elem. Res., 115, pp. 227-242
Hayes, J.D., Pulford, D.J., The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance (1995) Crit. Rev. Biochem. Mol. Biol., 30, pp. 445-600
Gromer, S., Urig, S., Becker, K., The thioredoxin system-from science to clinic (2004) Med. Res. Rev., 24, pp. 40-89
Arnér, E.S., Holmgren, A., Physiological functions of thioredoxin and thioredoxin reductase (2000) Eur. J. Biochem., 267, pp. 6102-6109
Xia, L., Nordman, T., Olsson, J.M., Damdimopoulos, A., Björkhem-Bergman, L., Nalvarte, I., Eriksson, L.C., Björnstedt, M., The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress (2003) Biol. Chem., 278, pp. 2141-2146
Gandin, V., Nyström, C., Rundlöf, A.K., Jönsson-Videsäter, K., Schönlau, F., Hörkkö, J., Björnstedt, M., Fernandes, A.P., Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells (2009) FEBS J., 276, pp. 532-540
Hauser, R., Meeker, J.D., Singh, N.P., Silva, M.J., Ryan, L., Duty, S., Calafat, A.M., DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites (2007) Hum. Reprod., 22, pp. 688-695
Emonet-Piccardi, N., Richard, M.J., Ravanat, J.L., Signorini, N., Cadet, J., Béani, J.C., Protective effects of antioxidants against UVA-induced DNA damage in human skin fibroblasts in culture (1998) Free Radic. Res., 29, pp. 307-313
Rafferty, T.S., Green, M.H., Lowe, J.E., Arlett, C., Hunter, J.A., Beckett, G.J., McKenzie, R.C., Effects of selenium compounds on induction of DNA damage by broadband ultraviolet radiation in human keratinocytes (2003) Br. J. Dermatol., 148, pp. 1001-1009
Waters, D.J., Shen, S., Cooley, D.M., Bostwick, D.G., Qian, J., Combs, G.F., Glickman, L.T., Morris, J.S., Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate (2003) J. Natl. Cancer Inst., 95, pp. 237-241
Letavayová, L., Vlcková, V., Brozmanová, J., Selenium: from cancer prevention to DNA damage (2006) Toxicology, 227, pp. 1-14
Seko, Y., Saito, Y., Kitahara, J., Imura, N., Active oxygen generation by the reaction of selenite with reduced glutathione in vitro (1989) Selenium in biology and medicine, pp. 70-73. , Springer-Verlag, Berlin, A. Wendel (Ed.)
Stewart, M.S., Spallholz, J.E., Neldner, K.H., Pence, B.C., Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis (1999) Free Radic. Biol. Med., 26, pp. 42-48
Hartwig, A., Blessing, H., Schwerdtle, T., Walter, I., Modulation of DNA repair processes by arsenic and selenium compounds (2003) Toxicology, 193, pp. 161-169
Li, G.X., Hu, H., Jiang, C., Schuster, T., Lü, J., Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells (2007) Int. J. Cancer, 120, pp. 2034-2043
Seo, Y.R., Sweeney, C., Smith, M.L., Selenomethionine induction of DNA repair response in human fibroblasts (2002) Oncogene, 21, pp. 3663-3669
Collins, A.R., Harrington, V., Drew, J., Melvin, R., Nutritional modulation of DNA repair in a human intervention study (2003) Carcinogenesis, 24, pp. 511-515
Laffon, B., Valdiglesias, V., Pásaro, E., Méndez, J., The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair in human leukocytes (2010) Biol. Trace Elem. Res., 133, pp. 12-19
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Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells
Selenium is an essential cofactor in the key enzymes involved in cellular antioxidant defense. It plays a critical role in testis and reproduction and regulates DNA damage within the prostate. Phthalates are ubiquitous environmental contaminants that cause alterations in endocrine and spermatogenic functions in animals. The objective of this study was to investigate the cytotoxicity and genotoxicity potentials of di(2-ethylhexyl)phthalate (DEHP), the most widely used phthalate and its primary toxic metabolite mono(2-ethylhexyl)phthalate (MEHP), and their effects on the antioxidant balance in the LNCaP human prostate adenocarcinoma cell line. Protection by selenium supplementation with either sodium selenite (SS, 30. nM) or selenomethionine (SM, 10 μM) was also investigated. Both DEHP (3. mM) and MEHP (3 μM) caused significant decreases in cell viability; altered antioxidant status, particularly decreasing the GPx1 activity; and induced DNA damage as measured by the alkaline comet assay. Selenium supplementation was highly protective against cytotoxicity, partially prevented genotoxicity, and restored the antioxidant status. The results of this study suggested that the underlying mechanism of cytotoxicity and resulting disturbances produced by DEHP or MEHP was an an oxidative stress process and/or an effect on the expression of antioxidant enzymes, and accentuated the importance of selenium status, particularly with respect to the high probability of phthalate exposures and their adverse effects. © 2010 Elsevier Inc.
Selenium is an essential cofactor in the key enzymes involved in cellular antioxidant defense. It plays a critical role in testis and reproduction and regulates DNA damage within the prostate. Phthalates are ubiquitous environmental contaminants that cause alterations in endocrine and spermatogenic functions in animals. The objective of this study was to investigate the cytotoxicity and genotoxicity potentials of di(2-ethylhexyl)phthalate (DEHP), the most widely used phthalate and its primary toxic metabolite mono(2-ethylhexyl)phthalate (MEHP), and their effects on the antioxidant balance in the LNCaP human prostate adenocarcinoma cell line. Protection by selenium supplementation with either sodium selenite (SS, 30. nM) or selenomethionine (SM, 10 μM) was also investigated. Both DEHP (3. mM) and MEHP (3 μM) caused significant decreases in cell viability; altered antioxidant status, particularly decreasing the GPx1 activity; and induced DNA damage as measured by the alkaline comet assay. Selenium supplementation was highly protective against cytotoxicity, partially prevented genotoxicity, and restored the antioxidant status. The results of this study suggested that the underlying mechanism of cytotoxicity and resulting disturbances produced by DEHP or MEHP was an an oxidative stress process and/or an effect on the expression of antioxidant enzymes, and accentuated the importance of selenium status, particularly with respect to the high probability of phthalate exposures and their adverse effects. © 2010 Elsevier Inc.
Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells
| ▼ Gadd45 beta and its implication in chronic inflammation |
| ▼ Molecular dynamics simulation approach to study UV-induced DNA damage |
Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (496 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (790 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1000 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (364 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4500 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (893 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (887 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (307 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (605 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (484 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (483 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (622 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (506 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (676 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (524 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (652 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (408 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Impact Factor: 2.579
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Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (816 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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38 Records (35 excluding Abstracts).
Total impact factor: 197.4 (182.82 excluding Abstracts).
Total 5 year impact factor: 182.383 (168.046 excluding Abstracts).
Total impact factor: 197.4 (182.82 excluding Abstracts).
Total 5 year impact factor: 182.383 (168.046 excluding Abstracts).
698 views. Last view on Tuesday 30 May 2023, 21:59:18
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