Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (705 views)
Radiat Oncol (ISSN: 1748-717x), 2015 Apr 8; 10(1): 80-80.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.466, 5-year impact factor: 2.768
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928013703&partnerID=40&md5=f154e10fdfc188bbbbd807cba9911ab5
Keywords: Lkb Model, Multivariate Model, Ntcp, Radiation Induced Rectum Toxicity, Acute Toxicity, Adult, Aged, Area Under The Curve, Article, Bootstrapping, Cancer Localization, Cancer Patient, Cancer Radiotherapy, Computer Assisted Radiotherapy, Disease Severity, External Beam Radiotherapy, Follow Up, Gastrointestinal Toxicity, Histogram, Human, Lyman Kutcher Burman Normal Tissue Complication Probability Model, Major Clinical Study, Prediction, Predictive Value, Prostate, Prostate Cancer, Radiation Dose, Radiation Dose Fractionation, Radiation Injury, Rectum Injury, Scoring System, Statistical Model, Controlled Study, Intermethod Comparison, Lyman Kutcher Burman Model, Mathematical Model, Maximum Likelihood Method, Multivariate Logistic Regression Analysis, Receiver Operating Characteristic, Statistical Analysis, Gastrointestinal Diseases, Diagnosis, Etiology, Theoretical, Prostatic Neoplasms, Roc Curve, Radiation Injuries, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Intensity-Modulated, Adverse Effects,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Council of Research (CNR), Naples, Italy. vittoria.davino@ibb.cnr.it.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy. m.conson@gmail.com.
References:
Not available.
Radiat Oncol (ISSN: 1748-717x), 2015 Apr 8; 10(1): 80-80.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.466, 5-year impact factor: 2.768
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928013703&partnerID=40&md5=f154e10fdfc188bbbbd807cba9911ab5
Keywords: Lkb Model, Multivariate Model, Ntcp, Radiation Induced Rectum Toxicity, Acute Toxicity, Adult, Aged, Area Under The Curve, Article, Bootstrapping, Cancer Localization, Cancer Patient, Cancer Radiotherapy, Computer Assisted Radiotherapy, Disease Severity, External Beam Radiotherapy, Follow Up, Gastrointestinal Toxicity, Histogram, Human, Lyman Kutcher Burman Normal Tissue Complication Probability Model, Major Clinical Study, Prediction, Predictive Value, Prostate, Prostate Cancer, Radiation Dose, Radiation Dose Fractionation, Radiation Injury, Rectum Injury, Scoring System, Statistical Model, Controlled Study, Intermethod Comparison, Lyman Kutcher Burman Model, Mathematical Model, Maximum Likelihood Method, Multivariate Logistic Regression Analysis, Receiver Operating Characteristic, Statistical Analysis, Gastrointestinal Diseases, Diagnosis, Etiology, Theoretical, Prostatic Neoplasms, Roc Curve, Radiation Injuries, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Intensity-Modulated, Adverse Effects,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Council of Research (CNR), Naples, Italy. vittoria.davino@ibb.cnr.it.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy. m.conson@gmail.com.
References:
Not available.
Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
Background: Gastrointestinal (GI) toxicity is a common effect following radiation therapy (RT) for prostate cancer. Purpose of the present work is to compare two Normal Tissue Complication Probability (NTCP) modelling approaches for prediction of late radio-induced GI toxicity after prostate external beam radiotherapy. Methods: The study includes 84 prostate cancer patients evaluated for late rectal toxicity after 3D conformal radiotherapy. Median age was 72years (range 53-85). All patients received a total dose of 76Gy to the prostate gland with daily fractions of 2Gy. The acute and late radio-induced GI complications were classified according to the RTOG/EORTC scoring system. Rectum dose-volume histograms were extracted for Lyman-Kutcher-Burman (LKB) NTCP model fitting using Maximum Likelihood Estimation. The bootstrap method was employed to test the fit robustness. The area under the receiver operating characteristic curve (AUC) was used to evaluate the predictive power of the LKB and to compare it with a multivariate logistic NTCP model previously determined. Results: At a median follow-up of 36months, 42% (35/84) of patients experienced grade 1-2 (G1-2) acute GI events while 25% (21/84) of patients developed G1-2 late GI events. The best-estimate of fitting parameters for LKB NTCP model for mild\\\\\\\\moderate GI toxicity resulted to be: D 50 =87.3Gy, m=0.37 and n=0.10. Bootstrap result showed that the parameter fit was robust. The AUC values for the LKB and for the multivariate logistic models were 0.60 and 0.75, respectively. Conclusions: We derived the parameters of the LKB model for mild\\\\\\\\moderate GI toxicity prediction and we compared its performance with that of a data-driven multivariate model. Compared to LKB, the multivariate model confirmed a higher predictive power as showed by the AUC values. © D'Avino et al.; licensee BioMed Central.
Background: Gastrointestinal (GI) toxicity is a common effect following radiation therapy (RT) for prostate cancer. Purpose of the present work is to compare two Normal Tissue Complication Probability (NTCP) modelling approaches for prediction of late radio-induced GI toxicity after prostate external beam radiotherapy. Methods: The study includes 84 prostate cancer patients evaluated for late rectal toxicity after 3D conformal radiotherapy. Median age was 72years (range 53-85). All patients received a total dose of 76Gy to the prostate gland with daily fractions of 2Gy. The acute and late radio-induced GI complications were classified according to the RTOG/EORTC scoring system. Rectum dose-volume histograms were extracted for Lyman-Kutcher-Burman (LKB) NTCP model fitting using Maximum Likelihood Estimation. The bootstrap method was employed to test the fit robustness. The area under the receiver operating characteristic curve (AUC) was used to evaluate the predictive power of the LKB and to compare it with a multivariate logistic NTCP model previously determined. Results: At a median follow-up of 36months, 42% (35/84) of patients experienced grade 1-2 (G1-2) acute GI events while 25% (21/84) of patients developed G1-2 late GI events. The best-estimate of fitting parameters for LKB NTCP model for mild\\\\\\\\moderate GI toxicity resulted to be: D
Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
No results. |
Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
Other filter: ([btitle,keywords] "Multivariate Model" ...
Di Lascio N, Avigo C, Salvati A, Martini N, Ragucci M, Monti S, Prinster A, Chiappino D, Mancini M, D'Elia D, Ghiadoni L, Bonino F, Brunetto MR, Faita F
* Steato-Score: Non-Invasive Quantitative Assessment of Liver Fat by Ultrasound Imaging (723 views)
Ultrasound Med Biol (ISSN: 0301-5629, 0301-5629linking), 2018; 44(8): 1585-1596.
Impact Factor: 2.494
View Export to BibTeX Export to EndNote
Alterio D, Gerardi MA, Cella L, Spoto R, Zurlo V, Sabbatini A, Fodor C, D'Avino V, Conson M, Valoriani F, Ciardo D, Pacelli R, Ferrari A, Maisonneuve P, Preda L, Bruschini R, Cossu Rocca M, Rondi E, Colangione S, Palma G, Dicuonzo S, Orecchia R, Sanguineti G, Jereczek-fossa BA
* Radiation-induced acute dysphagia: Prospective observational study on 42 head and neck cancer patients (674 views)
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2017 Sep 07; 193(11): 971-981.
Impact Factor: 2.459
View Export to BibTeX Export to EndNote
Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (1425 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'Avino V, Conson M, Picardi M, Salvatore M, Pacelli R
* Predicting radiation-induced valvular heart damage (716 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Cella L, Palma G, Deasy JO, Oh JH, Liuzzi R, D'Avino V, Conson M, Pugliese N, Picardi M, Salvatore M, Pacelli R
* Complication probability models for radiation-induced heart valvular dysfunction: Do heart-lung interactions play a role? (1092 views) (PDF 253 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Oct 31; 9(10): 11175301-11175311.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (848 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (882 views)
Acta Oncol (ISSN: 0284-186x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
View Export to BibTeX Export to EndNote
Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (836 views)
Radiation Oncology (ISSN: 1748-717x), 2013 Sep 23; 8(1): 221-221.
Impact Factor: 2.36
View Export to BibTeX Export to EndNote
Cammisa M, Correra A, Andreotti G, Cubellis MV
* Fabry_CEP: a tool to identify Fabry mutations responsive to pharmacological chaperones (845 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2013 Jul 24; 8: 111-111.
Impact Factor: 3.958
View Export to BibTeX Export to EndNote
Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (776 views)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (863 views) (PDF 308 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (666 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, Tranfa F, Strianese D, Conson M, Bonavolontà G, Salvatore M, Pacelli R
* Radiation therapy in primary orbital lymphoma: A single institution retrospective analysis (1036 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2009 Dec 7; 4(1): 60-60.
Impact Factor: 2.36
View Export to BibTeX Export to EndNote
Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (1552 views) (PDF 334 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Acampa W, Cuocolo A, Petretta M, Bruno A, Castellani M, Finzi A, Gerundini P
* Tetrofosmin imaging in the detection of myocardial viability in patients with previous myocardial infarction: Comparison with sestamibi and Tl-201 scintigraphy (767 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Jan; 9(1): 33-40.
Impact Factor: 1.167
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (625 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Jan; 7(1): 8-15.
Impact Factor: 1.854
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (679 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
* Steato-Score: Non-Invasive Quantitative Assessment of Liver Fat by Ultrasound Imaging (723 views)
Ultrasound Med Biol (ISSN: 0301-5629, 0301-5629linking), 2018; 44(8): 1585-1596.
Impact Factor: 2.494
View Export to BibTeX Export to EndNote
Alterio D, Gerardi MA, Cella L, Spoto R, Zurlo V, Sabbatini A, Fodor C, D'Avino V, Conson M, Valoriani F, Ciardo D, Pacelli R, Ferrari A, Maisonneuve P, Preda L, Bruschini R, Cossu Rocca M, Rondi E, Colangione S, Palma G, Dicuonzo S, Orecchia R, Sanguineti G, Jereczek-fossa BA
* Radiation-induced acute dysphagia: Prospective observational study on 42 head and neck cancer patients (674 views)
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2017 Sep 07; 193(11): 971-981.
Impact Factor: 2.459
View Export to BibTeX Export to EndNote
Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (1425 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'Avino V, Conson M, Picardi M, Salvatore M, Pacelli R
* Predicting radiation-induced valvular heart damage (716 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Cella L, Palma G, Deasy JO, Oh JH, Liuzzi R, D'Avino V, Conson M, Pugliese N, Picardi M, Salvatore M, Pacelli R
* Complication probability models for radiation-induced heart valvular dysfunction: Do heart-lung interactions play a role? (1092 views) (PDF 253 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Oct 31; 9(10): 11175301-11175311.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (848 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (882 views)
Acta Oncol (ISSN: 0284-186x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
View Export to BibTeX Export to EndNote
Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (836 views)
Radiation Oncology (ISSN: 1748-717x), 2013 Sep 23; 8(1): 221-221.
Impact Factor: 2.36
View Export to BibTeX Export to EndNote
Cammisa M, Correra A, Andreotti G, Cubellis MV
* Fabry_CEP: a tool to identify Fabry mutations responsive to pharmacological chaperones (845 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2013 Jul 24; 8: 111-111.
Impact Factor: 3.958
View Export to BibTeX Export to EndNote
Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (776 views)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (863 views) (PDF 308 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (666 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, Tranfa F, Strianese D, Conson M, Bonavolontà G, Salvatore M, Pacelli R
* Radiation therapy in primary orbital lymphoma: A single institution retrospective analysis (1036 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2009 Dec 7; 4(1): 60-60.
Impact Factor: 2.36
View Export to BibTeX Export to EndNote
Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (1552 views) (PDF 334 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Acampa W, Cuocolo A, Petretta M, Bruno A, Castellani M, Finzi A, Gerundini P
* Tetrofosmin imaging in the detection of myocardial viability in patients with previous myocardial infarction: Comparison with sestamibi and Tl-201 scintigraphy (767 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Jan; 9(1): 33-40.
Impact Factor: 1.167
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (625 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Jan; 7(1): 8-15.
Impact Factor: 1.854
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (679 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
17 Records (16 excluding Abstracts).
Total impact factor: 51.976 (48.018 excluding Abstracts).
Total 5 year impact factor: 56.887 (51.507 excluding Abstracts).
Total impact factor: 51.976 (48.018 excluding Abstracts).
Total 5 year impact factor: 56.887 (51.507 excluding Abstracts).
705 views. Last view on Friday 25 April 2025, 10:32:49
ibb.cnr.it
