Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (427 views)
Radiat Oncol (ISSN: 1748-717x), 2015 Apr 8; 10(1): 80-80.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.466, 5-year impact factor: 2.768
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928013703&partnerID=40&md5=f154e10fdfc188bbbbd807cba9911ab5
Keywords: Lkb Model, Multivariate Model, Ntcp, Radiation Induced Rectum Toxicity, Acute Toxicity, Adult, Aged, Area Under The Curve, Article, Bootstrapping, Cancer Localization, Cancer Patient, Cancer Radiotherapy, Computer Assisted Radiotherapy, Disease Severity, External Beam Radiotherapy, Follow Up, Gastrointestinal Toxicity, Histogram, Human, Lyman Kutcher Burman Normal Tissue Complication Probability Model, Major Clinical Study, Prediction, Predictive Value, Prostate, Prostate Cancer, Radiation Dose, Radiation Dose Fractionation, Radiation Injury, Rectum Injury, Scoring System, Statistical Model, Controlled Study, Intermethod Comparison, Lyman Kutcher Burman Model, Mathematical Model, Maximum Likelihood Method, Multivariate Logistic Regression Analysis, Receiver Operating Characteristic, Statistical Analysis, Gastrointestinal Diseases, Diagnosis, Etiology, Theoretical, Prostatic Neoplasms, Roc Curve, Radiation Injuries, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Intensity-Modulated, Adverse Effects,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Council of Research (CNR), Naples, Italy. vittoria.davino@ibb.cnr.it.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy. m.conson@gmail.com.
References:
Kutcher, G.J., Burman, C., Calculation of complication probability factors for non-uniform normal tissue irradiation: the effective volume method (1989) Int J Radiat Oncol Biol Phys, 16, pp. 1623-163
Burman, C., Kutcher, G.J., Emami, B., Goitein, M., Fitting of normal tissue tolerance data to an analytic function (1991) Int J Radiat Oncol Biol Phys, 21, pp. 123-135
Rancati, T., Fiorino, C., Gagliardi, G., Cattaneo, G.M., Sanguineti, G., Casanova Borca, V., Fitting late rectal bleeding data using different NTCP models: results from an Italian multi-centric study (AIROPROS0101) (2004) Radiother Oncol, 73, pp. 21-32
Liu, M., Moiseenko, V., Agranovich, A., Karvat, A., Kwan, W., Saleh, Z.H., Normal Tissue Complication Probability (NTCP) modeling of late rectal bleeding following external beam radiotherapy for prostate cancer: A Test of the QUANTEC-recommended NTCP model (2010) Acta Oncol, 49, pp. 1040-1044
Ospina, J.D., Zhu, J., Chira, C., Bossi, A., Delobel, J.B., Beckendorf, V., Random forests to predict rectal toxicity following prostate cancer radiation therapy (2014) Int J Radiat Oncol Biol Phys, 89, pp. 1024-1031
Benadjaoud, M.A., Blanchard, P., Shwartz, B., Champoudry, J., Bouaita, R., Lefkopoulos, D., Functional Data Analysis in NTCP Modeling: A New Method to Explore the Radiation Dose-Volume effects (2014) Int J Radiation Oncol Biol Phys, 90, pp. 654-663
Gulliford, S.L., Partridge, M., Sydes, M.R., Webb, S., Evans, P.M., Dearnaley, D.P., Parameters for the Lyman Kutcher Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for specific rectal complications observed in clinical practise (2012) Radiother Oncol, 102, pp. 347-351
Defraene, G., Bergh, L., Al-Mamgani, A., Haustermans, K., Heemsbergen, W., Heuvel, F., The benefits of including clinical factors in rectal normal tissue complication probability modeling after radiotherapy for prostate cancer (2012) Int J Radiat Oncol Biol Phys, 82, pp. 1233-1242
Peeters, S.T., Hoogeman, M.S., Heemsbergen, W.D., Hart, A.A.M., Koper, P.C.M., Lebesque, J.V., Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling (2006) Int J Radiat Oncol Biol Phys, 66, pp. 11-19
Fiorino, C., Cozzarini, C., Vavassori, V., Sanguineti, G., Bianchi, C., Cattaneo, G.M., Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer: analysis of a large group of patients pooled from three institutions (2002) Radiother Oncol, 64, pp. 1-12
Fellin, G., Fiorino, C., Rancati, T., Vavassori, V., Baccolini, M., Bianchi, C., Clinical and dosimetric predictors of late rectal toxicity after conformal radiation for localized prostate cancer: results of a large multicenter observational study (2009) Radiother Oncol, 93, pp. 197-202
Fiorino, C., Fellin, G., Rancati, T., Vavassori, V., Bianchi, C., Borca, V.C., Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: preliminary results of a multicenter prospective study (2008) Int J Radiat Oncol Biol Phys, 70, pp. 1130-1137
Hamstra, D.A., Stenmark, M.H., Ritter, T., Litzenberg, D., Jackson, W., Johnson, S., Age and comorbid illness are associated with late rectal toxicity following dose-escalated radiation therapy for prostate cancer (2012) Int J Radiat Oncol Biol Phys, 85, pp. 1246-1253
Cella, L., D'Avino, V., Liuzzi, R., Conson, M., Doria, F., Faiella, A., Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (2013) Radiat Oncol, 8, p. 221
Gay, H.A., Barthold, H.J., O'Meara, E., Bosch, W.R., Naqa, I., Al-Lozi, R., Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas (2012) Int J Radiat Oncol Biol Phys, 83, pp. e353-e362
Cox, J.D., Stetz, J., Pajak, T.F., Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) (1995) Int J Radiat Oncol Biol Phys, 31, pp. 1341-1346
Niemierko, A., Reporting and analyzing dose distributions: a concept of equivalent uniform dose (1997) Med Phys, 24, pp. 103-110
Cella, L., Palma, G., Deasy, J.O., Oh, J.H., Liuzzi, R., D'Avino, V., Complication Probability Models for Radiation-Induced Heart Valvular Dysfunction: Do Heart-Lung Interactions Play a Role? (2014) PLoS One, 9, p. e111753
Venzon, D.J., Moolgavkar, S.H., A Method for Computing Profile-Likelihood-Based Confidence Intervals (1988) J R Stat Soc Ser C (Appl Stat), 37, pp. 87-94
Semenenko, V.A., Li, X.A., Lyman-Kutcher-Burman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data (2008) Phys Med Biol, 53, pp. 737-755
Steyerberg, E.W., Vickers, A.J., Cook, N.R., Gerds, T., Gonen, M., Obuchowski, N., Assessing the performance of prediction models: a framework for traditional and novel measures (2010) Epidemiology, 21, pp. 128-138
Cella, L., Lomax, A., Miralbell, L., New techniques in hadrontherapy: intensity modulated proton beams (2001) Phys Med, 17, pp. 100-102
Yamazaki, H., Nakamura, S., Nishimura, T., Yoshida, K., Yoshioka, Y., Koizumi, M., Transitioning from conventional radiotherapy to intensity-modulated radiotherapy for localized prostate cancer: changing focus from rectal bleeding to detailed quality of life analysis (2014) J Radiat Res, 55, pp. 1033-1047
Michalski, J.M., Gay, H., Jackson, A., Tucker, S.L., Deasy, J.O., Radiation dose-volume effects in radiation-induced rectal injury (2010) Int J Radiat Oncol Biol Phys, 76, pp. S123-S129
Trojková, D., Judas, L., Trojek, T., Optimizing the parameters of the Lyman-Kutcher-Burman, Källman, and Logit+EUD models for the rectum - a comparison between normal tissue complication probability and clinical data (2014) Radiat Phys Chem, 104, pp. 279-282
Thor, M., Apte, A., Deasy, J.O., Muren, L.P., Dose/volume-response relations for rectal morbidity using planned and simulated motion-inclusive dose distributions (2013) Radiother Oncol, 109, pp. 388-393
Falco, M.D., D'Andrea, M., Fedele, D., Barbarino, R., Benassi, M., Giudice, E., Preliminary experience of a predictive model to define rectal volume and rectal dose during the treatment of prostate cancer (2011) Br J Radiol, 84, pp. 819-825
Mavroidis, P., Axelsson, S., Hyodynmaa, S., Rajala, J., Pitkanen, M.A., Lind, B.K., Effects of positioning uncertainty and breathing on dose delivery and radiation pneumonitis prediction in breast cancer (2002) Acta Oncol, 41, pp. 471-485
Hoogeman, M.S., Herk, M., Yan, D., Boersma, L.J., Koper, P.C.M., Lebesque, J.V., A model to simulate day-to-day variations in rectum shape (2002) Int J Radiat Oncol Biol Phys, 54, pp. 615-625
Sohn, M., Yan, D., Liang, J., Meldolesi, E., Vargas, C., Alber, M., Incidence of late rectal bleeding in high-dose conformal radiotherapy of prostate cancer using equivalent uniform dose-based and dose-volume-based normal tissue complication probability models (2007) Int J Radiat Oncol Biol Phys, 67, pp. 1066-1073
Tucker, S.L., Dong, L., Bosch, W.R., Michalski, J., Winter, K., Mohan, R., Late rectal toxicity on RTOG 94-06: analysis using a mixture Lyman model (2010) Int J Radiat Oncol Biol Phys, 78, pp. 1253-1260
Deasy, J.O., Comments on the use of the Lyman-Kutcher-Burman model to describe tissue response to non uniform irradiation (2000) Int J Radiat Oncol Biol Phys, 47, pp. 1458-1460
Dale, E., Olsen, D.R., Fossa, S.D., Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy (1999) Int J Radiat Oncol Biol Phys, 43, pp. 385-391
Radiat Oncol (ISSN: 1748-717x), 2015 Apr 8; 10(1): 80-80.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.466, 5-year impact factor: 2.768
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928013703&partnerID=40&md5=f154e10fdfc188bbbbd807cba9911ab5
Keywords: Lkb Model, Multivariate Model, Ntcp, Radiation Induced Rectum Toxicity, Acute Toxicity, Adult, Aged, Area Under The Curve, Article, Bootstrapping, Cancer Localization, Cancer Patient, Cancer Radiotherapy, Computer Assisted Radiotherapy, Disease Severity, External Beam Radiotherapy, Follow Up, Gastrointestinal Toxicity, Histogram, Human, Lyman Kutcher Burman Normal Tissue Complication Probability Model, Major Clinical Study, Prediction, Predictive Value, Prostate, Prostate Cancer, Radiation Dose, Radiation Dose Fractionation, Radiation Injury, Rectum Injury, Scoring System, Statistical Model, Controlled Study, Intermethod Comparison, Lyman Kutcher Burman Model, Mathematical Model, Maximum Likelihood Method, Multivariate Logistic Regression Analysis, Receiver Operating Characteristic, Statistical Analysis, Gastrointestinal Diseases, Diagnosis, Etiology, Theoretical, Prostatic Neoplasms, Roc Curve, Radiation Injuries, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Intensity-Modulated, Adverse Effects,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Council of Research (CNR), Naples, Italy. vittoria.davino@ibb.cnr.it.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy. m.conson@gmail.com.
References:
Kutcher, G.J., Burman, C., Calculation of complication probability factors for non-uniform normal tissue irradiation: the effective volume method (1989) Int J Radiat Oncol Biol Phys, 16, pp. 1623-163
Burman, C., Kutcher, G.J., Emami, B., Goitein, M., Fitting of normal tissue tolerance data to an analytic function (1991) Int J Radiat Oncol Biol Phys, 21, pp. 123-135
Rancati, T., Fiorino, C., Gagliardi, G., Cattaneo, G.M., Sanguineti, G., Casanova Borca, V., Fitting late rectal bleeding data using different NTCP models: results from an Italian multi-centric study (AIROPROS0101) (2004) Radiother Oncol, 73, pp. 21-32
Liu, M., Moiseenko, V., Agranovich, A., Karvat, A., Kwan, W., Saleh, Z.H., Normal Tissue Complication Probability (NTCP) modeling of late rectal bleeding following external beam radiotherapy for prostate cancer: A Test of the QUANTEC-recommended NTCP model (2010) Acta Oncol, 49, pp. 1040-1044
Ospina, J.D., Zhu, J., Chira, C., Bossi, A., Delobel, J.B., Beckendorf, V., Random forests to predict rectal toxicity following prostate cancer radiation therapy (2014) Int J Radiat Oncol Biol Phys, 89, pp. 1024-1031
Benadjaoud, M.A., Blanchard, P., Shwartz, B., Champoudry, J., Bouaita, R., Lefkopoulos, D., Functional Data Analysis in NTCP Modeling: A New Method to Explore the Radiation Dose-Volume effects (2014) Int J Radiation Oncol Biol Phys, 90, pp. 654-663
Gulliford, S.L., Partridge, M., Sydes, M.R., Webb, S., Evans, P.M., Dearnaley, D.P., Parameters for the Lyman Kutcher Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for specific rectal complications observed in clinical practise (2012) Radiother Oncol, 102, pp. 347-351
Defraene, G., Bergh, L., Al-Mamgani, A., Haustermans, K., Heemsbergen, W., Heuvel, F., The benefits of including clinical factors in rectal normal tissue complication probability modeling after radiotherapy for prostate cancer (2012) Int J Radiat Oncol Biol Phys, 82, pp. 1233-1242
Peeters, S.T., Hoogeman, M.S., Heemsbergen, W.D., Hart, A.A.M., Koper, P.C.M., Lebesque, J.V., Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling (2006) Int J Radiat Oncol Biol Phys, 66, pp. 11-19
Fiorino, C., Cozzarini, C., Vavassori, V., Sanguineti, G., Bianchi, C., Cattaneo, G.M., Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer: analysis of a large group of patients pooled from three institutions (2002) Radiother Oncol, 64, pp. 1-12
Fellin, G., Fiorino, C., Rancati, T., Vavassori, V., Baccolini, M., Bianchi, C., Clinical and dosimetric predictors of late rectal toxicity after conformal radiation for localized prostate cancer: results of a large multicenter observational study (2009) Radiother Oncol, 93, pp. 197-202
Fiorino, C., Fellin, G., Rancati, T., Vavassori, V., Bianchi, C., Borca, V.C., Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: preliminary results of a multicenter prospective study (2008) Int J Radiat Oncol Biol Phys, 70, pp. 1130-1137
Hamstra, D.A., Stenmark, M.H., Ritter, T., Litzenberg, D., Jackson, W., Johnson, S., Age and comorbid illness are associated with late rectal toxicity following dose-escalated radiation therapy for prostate cancer (2012) Int J Radiat Oncol Biol Phys, 85, pp. 1246-1253
Cella, L., D'Avino, V., Liuzzi, R., Conson, M., Doria, F., Faiella, A., Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (2013) Radiat Oncol, 8, p. 221
Gay, H.A., Barthold, H.J., O'Meara, E., Bosch, W.R., Naqa, I., Al-Lozi, R., Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas (2012) Int J Radiat Oncol Biol Phys, 83, pp. e353-e362
Cox, J.D., Stetz, J., Pajak, T.F., Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) (1995) Int J Radiat Oncol Biol Phys, 31, pp. 1341-1346
Niemierko, A., Reporting and analyzing dose distributions: a concept of equivalent uniform dose (1997) Med Phys, 24, pp. 103-110
Cella, L., Palma, G., Deasy, J.O., Oh, J.H., Liuzzi, R., D'Avino, V., Complication Probability Models for Radiation-Induced Heart Valvular Dysfunction: Do Heart-Lung Interactions Play a Role? (2014) PLoS One, 9, p. e111753
Venzon, D.J., Moolgavkar, S.H., A Method for Computing Profile-Likelihood-Based Confidence Intervals (1988) J R Stat Soc Ser C (Appl Stat), 37, pp. 87-94
Semenenko, V.A., Li, X.A., Lyman-Kutcher-Burman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data (2008) Phys Med Biol, 53, pp. 737-755
Steyerberg, E.W., Vickers, A.J., Cook, N.R., Gerds, T., Gonen, M., Obuchowski, N., Assessing the performance of prediction models: a framework for traditional and novel measures (2010) Epidemiology, 21, pp. 128-138
Cella, L., Lomax, A., Miralbell, L., New techniques in hadrontherapy: intensity modulated proton beams (2001) Phys Med, 17, pp. 100-102
Yamazaki, H., Nakamura, S., Nishimura, T., Yoshida, K., Yoshioka, Y., Koizumi, M., Transitioning from conventional radiotherapy to intensity-modulated radiotherapy for localized prostate cancer: changing focus from rectal bleeding to detailed quality of life analysis (2014) J Radiat Res, 55, pp. 1033-1047
Michalski, J.M., Gay, H., Jackson, A., Tucker, S.L., Deasy, J.O., Radiation dose-volume effects in radiation-induced rectal injury (2010) Int J Radiat Oncol Biol Phys, 76, pp. S123-S129
Trojková, D., Judas, L., Trojek, T., Optimizing the parameters of the Lyman-Kutcher-Burman, Källman, and Logit+EUD models for the rectum - a comparison between normal tissue complication probability and clinical data (2014) Radiat Phys Chem, 104, pp. 279-282
Thor, M., Apte, A., Deasy, J.O., Muren, L.P., Dose/volume-response relations for rectal morbidity using planned and simulated motion-inclusive dose distributions (2013) Radiother Oncol, 109, pp. 388-393
Falco, M.D., D'Andrea, M., Fedele, D., Barbarino, R., Benassi, M., Giudice, E., Preliminary experience of a predictive model to define rectal volume and rectal dose during the treatment of prostate cancer (2011) Br J Radiol, 84, pp. 819-825
Mavroidis, P., Axelsson, S., Hyodynmaa, S., Rajala, J., Pitkanen, M.A., Lind, B.K., Effects of positioning uncertainty and breathing on dose delivery and radiation pneumonitis prediction in breast cancer (2002) Acta Oncol, 41, pp. 471-485
Hoogeman, M.S., Herk, M., Yan, D., Boersma, L.J., Koper, P.C.M., Lebesque, J.V., A model to simulate day-to-day variations in rectum shape (2002) Int J Radiat Oncol Biol Phys, 54, pp. 615-625
Sohn, M., Yan, D., Liang, J., Meldolesi, E., Vargas, C., Alber, M., Incidence of late rectal bleeding in high-dose conformal radiotherapy of prostate cancer using equivalent uniform dose-based and dose-volume-based normal tissue complication probability models (2007) Int J Radiat Oncol Biol Phys, 67, pp. 1066-1073
Tucker, S.L., Dong, L., Bosch, W.R., Michalski, J., Winter, K., Mohan, R., Late rectal toxicity on RTOG 94-06: analysis using a mixture Lyman model (2010) Int J Radiat Oncol Biol Phys, 78, pp. 1253-1260
Deasy, J.O., Comments on the use of the Lyman-Kutcher-Burman model to describe tissue response to non uniform irradiation (2000) Int J Radiat Oncol Biol Phys, 47, pp. 1458-1460
Dale, E., Olsen, D.R., Fossa, S.D., Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy (1999) Int J Radiat Oncol Biol Phys, 43, pp. 385-391
Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
Background: Gastrointestinal (GI) toxicity is a common effect following radiation therapy (RT) for prostate cancer. Purpose of the present work is to compare two Normal Tissue Complication Probability (NTCP) modelling approaches for prediction of late radio-induced GI toxicity after prostate external beam radiotherapy. Methods: The study includes 84 prostate cancer patients evaluated for late rectal toxicity after 3D conformal radiotherapy. Median age was 72years (range 53-85). All patients received a total dose of 76Gy to the prostate gland with daily fractions of 2Gy. The acute and late radio-induced GI complications were classified according to the RTOG/EORTC scoring system. Rectum dose-volume histograms were extracted for Lyman-Kutcher-Burman (LKB) NTCP model fitting using Maximum Likelihood Estimation. The bootstrap method was employed to test the fit robustness. The area under the receiver operating characteristic curve (AUC) was used to evaluate the predictive power of the LKB and to compare it with a multivariate logistic NTCP model previously determined. Results: At a median follow-up of 36months, 42% (35/84) of patients experienced grade 1-2 (G1-2) acute GI events while 25% (21/84) of patients developed G1-2 late GI events. The best-estimate of fitting parameters for LKB NTCP model for mild\\\\\\\\moderate GI toxicity resulted to be: D 50 =87.3Gy, m=0.37 and n=0.10. Bootstrap result showed that the parameter fit was robust. The AUC values for the LKB and for the multivariate logistic models were 0.60 and 0.75, respectively. Conclusions: We derived the parameters of the LKB model for mild\\\\\\\\moderate GI toxicity prediction and we compared its performance with that of a data-driven multivariate model. Compared to LKB, the multivariate model confirmed a higher predictive power as showed by the AUC values. © D'Avino et al.; licensee BioMed Central.
Background: Gastrointestinal (GI) toxicity is a common effect following radiation therapy (RT) for prostate cancer. Purpose of the present work is to compare two Normal Tissue Complication Probability (NTCP) modelling approaches for prediction of late radio-induced GI toxicity after prostate external beam radiotherapy. Methods: The study includes 84 prostate cancer patients evaluated for late rectal toxicity after 3D conformal radiotherapy. Median age was 72years (range 53-85). All patients received a total dose of 76Gy to the prostate gland with daily fractions of 2Gy. The acute and late radio-induced GI complications were classified according to the RTOG/EORTC scoring system. Rectum dose-volume histograms were extracted for Lyman-Kutcher-Burman (LKB) NTCP model fitting using Maximum Likelihood Estimation. The bootstrap method was employed to test the fit robustness. The area under the receiver operating characteristic curve (AUC) was used to evaluate the predictive power of the LKB and to compare it with a multivariate logistic NTCP model previously determined. Results: At a median follow-up of 36months, 42% (35/84) of patients experienced grade 1-2 (G1-2) acute GI events while 25% (21/84) of patients developed G1-2 late GI events. The best-estimate of fitting parameters for LKB NTCP model for mild\\\\\\\\moderate GI toxicity resulted to be: D
Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
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Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
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Impact Factor: 5.008
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De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, Tranfa F, Strianese D, Conson M, Bonavolontà G, Salvatore M, Pacelli R
* Radiation therapy in primary orbital lymphoma: A single institution retrospective analysis (496 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2009 Dec 7; 4(1): 60-60.
Impact Factor: 2.36
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (723 views) (PDF 259 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Acampa W, Cuocolo A, Petretta M, Bruno A, Castellani M, Finzi A, Gerundini P
* Tetrofosmin imaging in the detection of myocardial viability in patients with previous myocardial infarction: Comparison with sestamibi and Tl-201 scintigraphy (309 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Jan; 9(1): 33-40.
Impact Factor: 1.167
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Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (347 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Jan; 7(1): 8-15.
Impact Factor: 1.854
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Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (361 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
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* Steato-Score: Non-Invasive Quantitative Assessment of Liver Fat by Ultrasound Imaging (434 views)
Ultrasound Med Biol (ISSN: 0301-5629, 0301-5629linking), 2018; 44(8): 1585-1596.
Impact Factor: 2.494
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Alterio D, Gerardi MA, Cella L, Spoto R, Zurlo V, Sabbatini A, Fodor C, D'Avino V, Conson M, Valoriani F, Ciardo D, Pacelli R, Ferrari A, Maisonneuve P, Preda L, Bruschini R, Cossu Rocca M, Rondi E, Colangione S, Palma G, Dicuonzo S, Orecchia R, Sanguineti G, Jereczek-fossa BA
* Radiation-induced acute dysphagia: Prospective observational study on 42 head and neck cancer patients (436 views)
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2017 Sep 07; 193(11): 971-981.
Impact Factor: 2.459
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (618 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'Avino V, Conson M, Picardi M, Salvatore M, Pacelli R
* Predicting radiation-induced valvular heart damage (334 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Impact Factor: 3.73
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Cella L, Palma G, Deasy JO, Oh JH, Liuzzi R, D'Avino V, Conson M, Pugliese N, Picardi M, Salvatore M, Pacelli R
* Complication probability models for radiation-induced heart valvular dysfunction: Do heart-lung interactions play a role? (504 views) (PDF 207 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Oct 31; 9(10): 11175301-11175311.
Impact Factor: 3.234
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (441 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (379 views)
Acta Oncol (ISSN: 0284-186x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
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Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (391 views)
Radiation Oncology (ISSN: 1748-717x), 2013 Sep 23; 8(1): 221-221.
Impact Factor: 2.36
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Cammisa M, Correra A, Andreotti G, Cubellis MV
* Fabry_CEP: a tool to identify Fabry mutations responsive to pharmacological chaperones (415 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2013 Jul 24; 8: 111-111.
Impact Factor: 3.958
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Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (343 views)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (446 views) (PDF 236 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (423 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
De Cicco L, Cella L, Liuzzi R, Solla R, Farella A, Punzo G, Tranfa F, Strianese D, Conson M, Bonavolontà G, Salvatore M, Pacelli R
* Radiation therapy in primary orbital lymphoma: A single institution retrospective analysis (496 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2009 Dec 7; 4(1): 60-60.
Impact Factor: 2.36
View Export to BibTeX Export to EndNote
Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (723 views) (PDF 259 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Acampa W, Cuocolo A, Petretta M, Bruno A, Castellani M, Finzi A, Gerundini P
* Tetrofosmin imaging in the detection of myocardial viability in patients with previous myocardial infarction: Comparison with sestamibi and Tl-201 scintigraphy (309 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Jan; 9(1): 33-40.
Impact Factor: 1.167
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (347 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Jan; 7(1): 8-15.
Impact Factor: 1.854
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (361 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
17 Records (16 excluding Abstracts).
Total impact factor: 51.976 (48.018 excluding Abstracts).
Total 5 year impact factor: 56.887 (51.507 excluding Abstracts).
Total impact factor: 51.976 (48.018 excluding Abstracts).
Total 5 year impact factor: 56.887 (51.507 excluding Abstracts).
427 views. Last view on Wednesday 31 May 2023, 4:15:02
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