Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (387 views)
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
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Paper type: Journal Article,
Impact factor: 1.817, 5-year impact factor: 2.023
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84929346953&partnerID=40&md5=138fc8ddbe3fb56e9832a56a355d1cb3
Keywords: Drosophila Melanogaster, Innate Immunity, Lipopolysaccharide, Pseudomonas Entomophila, Structural Analysis, Antigens, Fatty Acids, Immunology, Antagonistic Activity, Fruit Flies, Immunological Properties, Repetitive Units, Bacteria, Galactose, Glucose, Heptose, Lipid A, O Antigen, Phenol, Pullulanase, Article, Chemical Analysis, Chemical Composition, Controlled Study, Enzyme Linked Immunosorbent Assay, Gel Permeation Chromatography, Hek293 Cell Line, Heteronuclear Multiple Bond Correlation, Heteronuclear Nuclear Magnetic Resonance, Heteronuclear Single Quantum Coherence, Human, Human Cell, Hydrolysis, Lipid Composition, Mass Fragmentography, Nonhuman, Nuclear Magnetic Resonance Spectroscopy, Nuclear Overhauser Effect, Polyacrylamide Gel Electrophoresis, Priority Journal, Proton Nuclear Magnetic Resonance, Tandem Mass Spectrometry, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli federico II, Complesso Universitario Monte S.Angelo, Via Cintia 4, Napoli, Italy
Dipartimento di Biologia e Biotecnologie C. Darwin Sapienza-Università di Roma, Piazzale Aldo Moro, 5, Roma, Italy
Istituto di Chimica e Tecnologia Dei Polimeri-ICTP - CNR, Via P. Gaifami 18, Catania, Italy
Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00185 Roma - Italia, Roma, Italy
Dipartimento di Agraria, Via Università 100, Portici, NA, Italy
References:
Vallet-Gely, I., Lemaitre, B., Boccard, F., (2008) Nat Rev Micro, 6, pp. 302-31
Vodovar, N., Vinals, M., Liehl, P., Basset, A., Degrouard, J., Soellman, P., (2005) PNAS, 102 (32), pp. 11414-11419
Opota, O., Vallet-Gély, I., Vincentelli, R., Kellenberger, C., Iacovache, I., Gonzalez, M.R., (2011) PLoS Pathog, 7 (9), p. e1002259
Chakrabarti, S., Liehl, P., Buchon, N., Lemaitre, B., (2012) Cell Host Microbe, 12 (1), pp. 60-70
Silipo, A., De Castro, C., Lanzetta, R., Parrilli, M., Molinaro, A., (2010) Prokaryotic Cell Wall Compounds - Structure and Biochemistry, p. 133. , H. Kçnig, H. Claus, A. Varma, Springer Heidelberg
De Castro, C., Holst, O., Lanzetta, R., Parrilli, M., Molinaro, A., (2012) Protein Pept Lett, 19 (10), pp. 1040-1044
Holst, O., Molinaro, A., (2009) Microbial Glycobiology: Structures Relevance and Applications, pp. 29-56. , A. Moran, P. Brennan, O. Holst, M. von Itszstein, Elsevier San Diego, CA
Alexander, C., Rietschel, E.T., (2001) J Endotoxin Res, 7, pp. 167-202
Molinaro, A., Holst, O., Di Lorenzo, F., Callaghan, M., Nurisso, A., D'Errico, G., (2015) Chem Eur J, 21, pp. 500-519
Silipo, A., Molinaro, A., (2011) Bacterial Lipopolysaccharides: Structure, Chemical Synthesis, Biogenesis and Interaction with Host Cells, pp. 1-20. , Y.A. Knirel, M.A. Valvano, Springer Wien
Leulier, F., Parquet, C., Pili-Floury, S., Ryu, J.H., Caroff, M., Lee, W.J., (2003) Nat Immunol, 4, pp. 478-484
Kaneko, T., Goldman, W.E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., (2004) IMD Pathw Immun, 20, pp. 637-649
Westphal, O., Jann, K., (1965) Methods Carbohydr Chem, 5, pp. 83-91
Nigro, G., Fazio, L.L., Martino, M.C., Rossi, G., Tattoli, I., Liparoti, I., (2008) Cell Microbiol, 10, pp. 682-695
Hanley, P., Musset, B., Renigunta, V., Limberg, S.H., Dalpke, A.H., Sus, R., (2004) Proc Natl Acad Sci U S A, 101 (25), pp. 9479-9484
De Castro, C., Parrilli, M., Holst, O., Molinaro, A., (2010) Methods Enzymol, 480, pp. 89-115
Leontein, K., Lönngren, J., (1978) Methods Carbohydr Chem, 62, pp. 359-362
States, D.J., Haberkorn, R.A., Ruben, D.J., (1982) J Magn Reson, 48, pp. 286-292
Bock, K., Pedersen, S., (1983) Adv Carbohydr Chem Biochem, 41, pp. 27-65
Sturiale, L., Palmigiano, A., Silipo, A., Knirel, Y.A., Anisimov, A.P., Lanzetta, R., (2011) J Mass Spectrom, 46, pp. 1135-1142
Sturiale, L., Garozzo, D., Silipo, A., Lanzetta, R., Parrilli, M., Molinaro, A., (2005) Rapid Commun Mass Spectrom, 19, pp. 1829-1834
Flad, H.D., Loppnow, H., Rietschel, E.T., Ulmer, A.J., (1993) Immunobiology, 187 (3-5), pp. 303-316
Raetz, R.H., Whitfield, C., (2002) Annu Rev Biochem, 71, pp. 635-700
Paciello, I., Silipo, A., Lembo-Fazio, L., Curcurù, L., Zumsteg, A., Noël, G., (2013) Proc Natl Acad Sci, 110, pp. E4345-E4354
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.817, 5-year impact factor: 2.023
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84929346953&partnerID=40&md5=138fc8ddbe3fb56e9832a56a355d1cb3
Keywords: Drosophila Melanogaster, Innate Immunity, Lipopolysaccharide, Pseudomonas Entomophila, Structural Analysis, Antigens, Fatty Acids, Immunology, Antagonistic Activity, Fruit Flies, Immunological Properties, Repetitive Units, Bacteria, Galactose, Glucose, Heptose, Lipid A, O Antigen, Phenol, Pullulanase, Article, Chemical Analysis, Chemical Composition, Controlled Study, Enzyme Linked Immunosorbent Assay, Gel Permeation Chromatography, Hek293 Cell Line, Heteronuclear Multiple Bond Correlation, Heteronuclear Nuclear Magnetic Resonance, Heteronuclear Single Quantum Coherence, Human, Human Cell, Hydrolysis, Lipid Composition, Mass Fragmentography, Nonhuman, Nuclear Magnetic Resonance Spectroscopy, Nuclear Overhauser Effect, Polyacrylamide Gel Electrophoresis, Priority Journal, Proton Nuclear Magnetic Resonance, Tandem Mass Spectrometry, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli federico II, Complesso Universitario Monte S.Angelo, Via Cintia 4, Napoli, Italy
Dipartimento di Biologia e Biotecnologie C. Darwin Sapienza-Università di Roma, Piazzale Aldo Moro, 5, Roma, Italy
Istituto di Chimica e Tecnologia Dei Polimeri-ICTP - CNR, Via P. Gaifami 18, Catania, Italy
Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00185 Roma - Italia, Roma, Italy
Dipartimento di Agraria, Via Università 100, Portici, NA, Italy
References:
Vallet-Gely, I., Lemaitre, B., Boccard, F., (2008) Nat Rev Micro, 6, pp. 302-31
Vodovar, N., Vinals, M., Liehl, P., Basset, A., Degrouard, J., Soellman, P., (2005) PNAS, 102 (32), pp. 11414-11419
Opota, O., Vallet-Gély, I., Vincentelli, R., Kellenberger, C., Iacovache, I., Gonzalez, M.R., (2011) PLoS Pathog, 7 (9), p. e1002259
Chakrabarti, S., Liehl, P., Buchon, N., Lemaitre, B., (2012) Cell Host Microbe, 12 (1), pp. 60-70
Silipo, A., De Castro, C., Lanzetta, R., Parrilli, M., Molinaro, A., (2010) Prokaryotic Cell Wall Compounds - Structure and Biochemistry, p. 133. , H. Kçnig, H. Claus, A. Varma, Springer Heidelberg
De Castro, C., Holst, O., Lanzetta, R., Parrilli, M., Molinaro, A., (2012) Protein Pept Lett, 19 (10), pp. 1040-1044
Holst, O., Molinaro, A., (2009) Microbial Glycobiology: Structures Relevance and Applications, pp. 29-56. , A. Moran, P. Brennan, O. Holst, M. von Itszstein, Elsevier San Diego, CA
Alexander, C., Rietschel, E.T., (2001) J Endotoxin Res, 7, pp. 167-202
Molinaro, A., Holst, O., Di Lorenzo, F., Callaghan, M., Nurisso, A., D'Errico, G., (2015) Chem Eur J, 21, pp. 500-519
Silipo, A., Molinaro, A., (2011) Bacterial Lipopolysaccharides: Structure, Chemical Synthesis, Biogenesis and Interaction with Host Cells, pp. 1-20. , Y.A. Knirel, M.A. Valvano, Springer Wien
Leulier, F., Parquet, C., Pili-Floury, S., Ryu, J.H., Caroff, M., Lee, W.J., (2003) Nat Immunol, 4, pp. 478-484
Kaneko, T., Goldman, W.E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., (2004) IMD Pathw Immun, 20, pp. 637-649
Westphal, O., Jann, K., (1965) Methods Carbohydr Chem, 5, pp. 83-91
Nigro, G., Fazio, L.L., Martino, M.C., Rossi, G., Tattoli, I., Liparoti, I., (2008) Cell Microbiol, 10, pp. 682-695
Hanley, P., Musset, B., Renigunta, V., Limberg, S.H., Dalpke, A.H., Sus, R., (2004) Proc Natl Acad Sci U S A, 101 (25), pp. 9479-9484
De Castro, C., Parrilli, M., Holst, O., Molinaro, A., (2010) Methods Enzymol, 480, pp. 89-115
Leontein, K., Lönngren, J., (1978) Methods Carbohydr Chem, 62, pp. 359-362
States, D.J., Haberkorn, R.A., Ruben, D.J., (1982) J Magn Reson, 48, pp. 286-292
Bock, K., Pedersen, S., (1983) Adv Carbohydr Chem Biochem, 41, pp. 27-65
Sturiale, L., Palmigiano, A., Silipo, A., Knirel, Y.A., Anisimov, A.P., Lanzetta, R., (2011) J Mass Spectrom, 46, pp. 1135-1142
Sturiale, L., Garozzo, D., Silipo, A., Lanzetta, R., Parrilli, M., Molinaro, A., (2005) Rapid Commun Mass Spectrom, 19, pp. 1829-1834
Flad, H.D., Loppnow, H., Rietschel, E.T., Ulmer, A.J., (1993) Immunobiology, 187 (3-5), pp. 303-316
Raetz, R.H., Whitfield, C., (2002) Annu Rev Biochem, 71, pp. 635-700
Paciello, I., Silipo, A., Lembo-Fazio, L., Curcurù, L., Zumsteg, A., Noël, G., (2013) Proc Natl Acad Sci, 110, pp. E4345-E4354
Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties
The structure and the immunology of the lipopolysaccharide (LPS) of Pseudomonas entomophila, an entomopathogenic bacterium isolated from the fruit fly Drosophila melanogaster, was characterized. The O-antigen portion was established and resulted to be built up of a repetitive unit constituted by four monosaccharide residues, all L configured, all deoxy at C-6 and with an acetamido function at C-2: →3)-α-l-FucNAc-(1→4)-α-l-FucNAc-(1→3)-α-l-FucNAc-(1→3)-β-l-QuiNAc-(1→ The structural analysis of lipid A, showed a mixture of different species. The diphosphorylated glucosamine backbone carries six fatty acids consistent with the composition C10:0 3(OH), C12:0 2(OH) and C12:0 3(OH), whereas other species differs by the number of phosphates and/or of fatty acids. The immunology experiments demonstrated that the LPS structure of P. entomophila displayed a low ability to engage the TLR4-mediated signaling correlated to a significant antagonistic activity toward hexa-acylated LPS structures. © 2015 Elsevier Ltd. All rights reserved.
The structure and the immunology of the lipopolysaccharide (LPS) of Pseudomonas entomophila, an entomopathogenic bacterium isolated from the fruit fly Drosophila melanogaster, was characterized. The O-antigen portion was established and resulted to be built up of a repetitive unit constituted by four monosaccharide residues, all L configured, all deoxy at C-6 and with an acetamido function at C-2: →3)-α-l-FucNAc-(1→4)-α-l-FucNAc-(1→3)-α-l-FucNAc-(1→3)-β-l-QuiNAc-(1→ The structural analysis of lipid A, showed a mixture of different species. The diphosphorylated glucosamine backbone carries six fatty acids consistent with the composition C10:0 3(OH), C12:0 2(OH) and C12:0 3(OH), whereas other species differs by the number of phosphates and/or of fatty acids. The immunology experiments demonstrated that the LPS structure of P. entomophila displayed a low ability to engage the TLR4-mediated signaling correlated to a significant antagonistic activity toward hexa-acylated LPS structures. © 2015 Elsevier Ltd. All rights reserved.
Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties
| ▼ Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity |
Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties
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Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2008 Jun; 1782(6): 378-384.
Impact Factor: 2.233
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (648 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
* Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (406 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
Impact Factor: 5.854
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (448 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
* A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (409 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Feb 20; 279(8): 6815-6823.
Impact Factor: 6.355
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (475 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (688 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Saviano M, Isernia C, Rossi F, Di Blasio B, Iacovino R, Mazzeo M, Pedone C, Benedetti E
Solid state structural analysis of the cyclooctapeptide cyclo-(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-D-Ala-Val(8)) (426 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 189-199.
Impact Factor: 2.405
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Pavone V, De Simone G, Nastri F, Galdiero S, Staiano N, Lombardi A, Pedone C
Multiple binding mode of reversible synthetic thrombin inhibitors. A comparative structural analysis (589 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 1998 Sep; 379(8-9): 987-1006.
Impact Factor: 2.636
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Lombardi A, Maglio O, Benedetti B, Di Blasio E, Saviano M, Nastri F, Pedone C, Pavone V
Pt(II) Complexes of Amino Acids and Peptides. II. Structural Analysis of trans-[Cl2-Pt-(H-Aib-OH)2] (429 views)
Inorg Chim Acta, 1992; 196: 241-246.
Impact Factor: 0
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* Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA (87 views)
Bba-Gen Subjects (ISSN: 0304-4165linking, 0005-2728, 0006-3002print), 2020 Dec; 1864(12): 129717-129717.
Impact Factor: 3.422
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Majkowska-skrobek G, Latka A, Berisio R, Squeglia F, Maciejewska B, Briers Y, Drulis-kawa Z
* Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms (360 views)
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Impact Factor: 4.076
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Mercurio FA, Pirone L, Di Natale C, Marasco D, Pedone EM, Leone M
* Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2 (327 views)
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Impact Factor: 3.9
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Leggio L, Guarino F, Magrì A, Accardi-gheit R, Reina S, Specchia V, Damiano F, Tomasello MF, Tommasino M, Messina A
* Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs (317 views)
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Impact Factor: 4.259
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Squeglia F, Berisio R, Shibuya N, Kaku H
* Defense Against Pathogens: Structural Insights into the Mechanism of Chitin Induced Activation of Innate Immunity (267 views)
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Impact Factor: 3.469
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Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G
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Impact Factor: 4.122
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Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (291 views)
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Impact Factor: 4.41
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Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (323 views) (PDF 192 views)
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Impact Factor: 3.112
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Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (426 views)
Febs J (ISSN: 1742-464x), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
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Molinaro A, Holst O, Lorenzo FD, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamarí S
* Chemistry of lipid a: At the heart of innate immunity (1245 views) (PDF 305 views)
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Impact Factor: 5.771
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Kim JK, Son DW, Kim C-H, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
* Insect gut symbiont susceptibility to host antimicrobial peptides caused by alteration of the bacterial cell envelope (895 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2015; 290(34): 21042-21053.
Impact Factor: 4.258
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (363 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Avitabile C, D'Andrea LD, Romanelli A
* Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells (498 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2014 Mar 12; 4: 4293-4293.
Impact Factor: 5.578
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (554 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (488 views)
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Impact Factor: 3.534
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Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (488 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Impact Factor: 3.829
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (422 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (552 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (629 views)
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Impact Factor: 2.326
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Berisio R
* Editorial: cell processes in bacterial diseases (409 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (423 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (462 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (429 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (496 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (461 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (469 views)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
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Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G
* Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in Archaea by MarR family proteins (470 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 May 8; 388(3): 559-569.
Impact Factor: 3.871
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (403 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Daniele A, Cardillo G, Pennino C, Carbone MT, Scognamiglio D, Esposito L, Correra A, Castaldo G, Zagari A, Salvatore F
* Five human phenylalanine hydroxylase proteins identified in mild hyperphenylalaninemia patients are disease-causing variants (358 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2008 Jun; 1782(6): 378-384.
Impact Factor: 2.233
View Export to BibTeX Export to EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (648 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
* Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (406 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (448 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
* A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (409 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Feb 20; 279(8): 6815-6823.
Impact Factor: 6.355
View Export to BibTeX Export to EndNote
Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (475 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (688 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
Saviano M, Isernia C, Rossi F, Di Blasio B, Iacovino R, Mazzeo M, Pedone C, Benedetti E
Solid state structural analysis of the cyclooctapeptide cyclo-(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-D-Ala-Val(8)) (426 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 189-199.
Impact Factor: 2.405
View Export to BibTeX Export to EndNote
Pavone V, De Simone G, Nastri F, Galdiero S, Staiano N, Lombardi A, Pedone C
Multiple binding mode of reversible synthetic thrombin inhibitors. A comparative structural analysis (589 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 1998 Sep; 379(8-9): 987-1006.
Impact Factor: 2.636
View Export to BibTeX Export to EndNote
Lombardi A, Maglio O, Benedetti B, Di Blasio E, Saviano M, Nastri F, Pedone C, Pavone V
Pt(II) Complexes of Amino Acids and Peptides. II. Structural Analysis of trans-[Cl2-Pt-(H-Aib-OH)2] (429 views)
Inorg Chim Acta, 1992; 196: 241-246.
Impact Factor: 0
View Export to BibTeX Export to EndNote
42 Records (42 excluding Abstracts).
Total impact factor: 169.837 (169.837 excluding Abstracts).
Total 5 year impact factor: 177.412 (177.412 excluding Abstracts).
Total impact factor: 169.837 (169.837 excluding Abstracts).
Total 5 year impact factor: 177.412 (177.412 excluding Abstracts).
387 views. Last view on Saturday 18 March 2023, 8:10:06
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