Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme
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Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (596 views)

Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A

Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.

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Paper type: Journal Article,

Impact factor: 2.134, 5-year impact factor: 2.638

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930606333&partnerID=40&md5=7db94d1066a49036d7004d9d642516cc

Keywords: Gold Complexes, Gold-Based Drugs, Mechanisms Of Action, Metallodrugs, Protein–ligand Interactions, Protein-Ligand Interactions, Egg White, Lysozyme, Saccharin Sodium, Article, Binding Site, Chemical Analysis, Crystal Structure, Crystallization, Electrospray Mass Spectrometry, Protein Binding, X Ray Diffraction,

Affiliations:
*** IBB - CNR ***

Department of Chemical Sciences, University of Naples Federico II, Via Cintia, Naples, Italy
CNR Institute of Biostructure and Bioimages, Via Mezzocannone 16, Naples, Italy


References:
Not available.
Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme

A new crystal structure is reported here for the adduct formed in the reaction between NH4 [Au(Sac)2], AuSac2, a cytotoxic homoleptic gold(I) complex with the saccharinate ligand, and the model protein hen egg white lysozyme. To produce this adduct, AuSac2 breaks down and releases both saccharinate ligands. The resulting Au(I) ions bind the protein to ND1 and NE2 atoms of His15 but also to SD atom of the zero-solvent accessible Met105 side chain, which is located in the protein hydrophobic box. The unexpected existence of this secondary gold(I) binding site is confirmed by spectroscopic and spectrometric measurements in solution. Graphical Abstract: [Figure not available: see fulltext.] © 2015 Springer Science+Business Media New York.
Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme

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Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme

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Messori L, Cinellu MA, Merlino A
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
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12 Records (12 excluding Abstracts).
Total impact factor: 62.099 (62.099 excluding Abstracts).
Total 5 year impact factor: 60.459 (60.459 excluding Abstracts).

Last modified by Giuseppina De Rosa  on Sunday 12 July 2020, 13:14:50
596 views. Last view on Monday 07 April 2025, 12:11:44