Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (360 views)
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.134, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930606333&partnerID=40&md5=7db94d1066a49036d7004d9d642516cc
Keywords: Gold Complexes, Gold-Based Drugs, Mechanisms Of Action, Metallodrugs, Protein–ligand Interactions, Protein-Ligand Interactions, Egg White, Lysozyme, Saccharin Sodium, Article, Binding Site, Chemical Analysis, Crystal Structure, Crystallization, Electrospray Mass Spectrometry, Protein Binding, X Ray Diffraction,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, Via Cintia, Naples, Italy
CNR Institute of Biostructure and Bioimages, Via Mezzocannone 16, Naples, Italy
References:
Baugher, J.F., Grossweiner, L.I., Lewis, J., Intramolecular energy-transfer in lysozyme-eosin complex (1974) J Chem Soc Faraday Trans II, 70, pp. 1389-1398. , 1:CAS:528:DyaE2MXisl2nsw%3D%3
Bertrand, B., Casini, A., A golden future in medicinal inorganic chemistry: The promise of anticancer gold organometallic compounds (2014) Dalton Trans, 43, pp. 4209-4219. , 1:CAS:528:DC%2BC2cXislCjsr4%3D 24225667
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., Caffeine-based gold (I) N-heterocyclic carbenes as possible anticancer agents: Synthesis and biological properties (2014) Inorg Chem, 53, pp. 2296-2303. , 1:CAS:528:DC%2BC2cXhslSjt7g%3D 24499428
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., Bioinorganic and medicinal chemistry: Aspects of gold (I)-protein complexes (2011) Dalton Trans, 4, pp. 2099-2111
Cattaruzza, L., Fregona, D., Mongiat, M., Ronconi, L., Fassina, A., Colombatti, A., Aldinucci, D., Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts (2011) Int J Cancer, 128, pp. 206-215. , 1:CAS:528:DC%2BC3cXhtlequ7rL 20209498
Ma, C., Ott, I., Casini, A., Gold organometallics with biological properties (2015) Bioorganometallic Chemistry: Applications in Drug Discovery Biocatalysis, and Imaging, , Wiley, Boston
Dalla Via, L., Nardon, C., Fregona, D., Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: A challenge for the future (2012) Future Med Chem, 4, p. 525. , 1:CAS:528:DC%2BC38XktVajs7w%3D 22416778
De Almeida, A., Oliveira, B.L., Correia, J.D.G., Soveral, G., Casini, A., Emerging protein targets for metal-based pharmaceutical agents: An update (2013) Coord Chem Rev, 257, p. 2689
Emsley, P., Cowtan, K., Coot: Model-building tools for molecular graphics (2004) Acta Crystallogr D, 60, pp. 2126-2132. , 15572765
Faust, A., Puehringer, S., Darowski, N., Panjikar, S., Diederichs, K., Mueller, U., Weiss, M.S., Update on the tutorial for learning and teaching macromolecular crystallography (2010) J Appl Crystallogr, 4, pp. 1230-1237
Ferraro, G., Massai, L., Messori, L., Merlino, A., Cisplatin binding to human serum albumin: A structural study (2015) Chem Commun (Camb), 51, pp. 9436-9439
Gabbiani, C., Massai, L., Scaletti, F., Michelucci, E., Maiore, L., Cinellu, M.A., Messori, L., Protein metalation by metal-based drugs: Reactions of cytotoxic gold compounds with cytochrome C and lysozyme (2012) J Biol Inorg Chem, 17, pp. 1293-1302. , 1:CAS:528:DC%2BC38Xhs1agtLjP 23132507
Helliwell, J.R., Tanley, S.W., The crystal structure analysis of the relative binding of cisplatin and carboplatin in a mixture with histidine in a protein studied at 100 and 300 K with repeated X-ray irradiation (2013) Acta Crystallogr D, 69, pp. 121-125. , 1:CAS:528:DC%2BC3sXitF2g 23275170
Imoto, T., Johnson, L.N., North, A.C.T., Phillips, D.C., Rupley, J.A., Vertebrate lysozyme (1972) The Enzymes, pp. 665-868. , D. Boyer (eds) 3 7 Academic Press New York
Imoto, T., Forster, L.S., Rupley, J.A., Tanaka, F., Fluorescence of lysozyme: Emissions from tryptophan residues 62 and 108 and energy migration (1972) Proc Natl Acad Sci USA, 69 (5), pp. 1151-1155. , 1:CAS:528:DyaE38XktlSru74%3D 426651 4504329
Jori, G., Galliazzo, G., Scoffone, E., Further studies on the hematoporphyrin-sensitized photooxidation of lysozyme (1971) Experientia, 27, pp. 379-380. , 1:CAS:528:DyaE3MXksVGjtbo%3D 5581087
Kuramitsu, S., Kurihara, S., Ikeda, K., Hamaguchi, I., Fluorescence spectra of hen, turky, and human lysozymes excited at 305 nm (1978) J Biochem, 83, pp. 159-170. , 1:CAS:528:DyaE1cXosFWrtg%3D%3D 24044
Marcon, G., Carotti, S., Coronnello, M., Messori, L., Mini, E., Orioli, P., Mazzei, T., Minghetti, G., Gold (III) complexes with bipyridyl ligands: Solution chemistry, cytotoxicity, and DNA binding properties (2002) J Med Chem, 45, pp. 1672-1677. , 1:CAS:528:DC%2BD38XhslOgur8%3D 11931621
Messori, L., Balerna, A., Ascone, I., Castellano, C., Gabbiani, C., Casini, A., Marchioni, C., Castellano, A.C., X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins (2011) J Biol Inorg Chem, 16, pp. 491-499. , 1:CAS:528:DC%2BC3cXhs1WmurrF 21181484
Messori, L., Scaletti, F., Massai, L., Cinellu, M.A., Gabbiani, C., Vergara, A., Merlino, A., The mode of action of anticancer gold-based drugs: A structural perspective (2013) Chem Commun, 49, pp. 10100-10102. , 1:CAS:528:DC%2BC3sXhsFOisrjE
Messori, L., Marzo, T., Gabbiani, C., Valdes, A.A., Quiroga, A.G., Merlino, A., Peculiar features in the crystal structure of the adduct formed between cis-PtI
2
(NH
3
)
2
and hen egg white lysozyme (2013) Inorg Chem, 52, pp. 13827-13829. , 1:CAS:528:DC%2BC3sXhvVWmsL%2FF 24256441
Messori, L., Cinellu, M.A., Merlino, A., Protein recognition of gold-based drugs: 3d structure of the complex formed when lysozyme reacts with aubipy(c.) (2014) ACS Med Chem Lett, 5, pp. 1110-1113. , 1:CAS:528:DC%2BC2cXht1Git7zJ 25313321
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., Chemistry and biology of two novel gold (I) carbene complexes as prospective anticancer agents (2014) Inorg Chem, 53 (5), pp. 2396-2403. , 1:CAS:528:DC%2BC2cXis1ejt7k%3D 24547701
Murshudov, G.N., Skuba, K.P., Lebedev, A.A., Pannu, N.S., Steiner, R.A., Nicholls, R.A., Winn, M.D., Vagin, A.A., REFMAC5 for the refinement of macromolecular crystal structures (2011) Acta Crystallogr D, 67, pp. 355-367. , 1:CAS:528:DC%2BC3MXktFWqtbk%3D 3069751 21460454
Otwinowski, Z., Minor, W., Processing of X-ray diffraction data collected in oscillation mode (1997) Methods Enzymol, 276, pp. 307-326. , 1:CAS:528:DyaK2sXivFehsbw%3D
Pellegrini, E., Piano, D., Bowler, M.W., Direct cryocooling of naked crystals: Are cryoprotection agents always necessary? (2011) Acta Crystallogr D, 67, pp. 902-906. , 1:CAS:528:DC%2BC3MXhtF2qsb3N 21931222
Rigobello, M.P., Messori, L., Marcon, G., Cinellu, M.A., Bragadin, M., Folda, A., Scutari, G., Bindoli, A., Gold complexes inhibit mitochondrial thioredoxin reductase: Consequences on mitochondrial functions (2004) J Inorg Biochem, 98, pp. 1634-1641. , 1:CAS:528:DC%2BD2cXotF2mtbk%3D 15458826
Russo Krauss, I., Sica, F., Mattia, C.A., Merlino, A., Increasing the X-ray diffraction power of protein crystals by dehydration: The case of bovine serum albumin and a survey of literature data (2012) Int J Mol Sci, 13, pp. 3782-3800. , 22489183
Russo Krauss, I., Messori, L., Cinellu, M.A., Marasco, D., Sirignano, R., Merlino, A., Interactions of gold-based drugs with proteins: The structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold (III) compound Auoxo3 (2014) Dalton Trans, 43 (46), pp. 17483-17488. , 1:CAS:528:DC%2BC2cXhs1Wjsb%2FJ 25340580
Santos-Silva, T., Mukhopadhyay, A., Seixas, J.D., Bernardes, G.J., Romao, C.C., Romao, M.J., CORM-3 reactivity toward proteins: The crystal structure of a Ru (II) dicarbonyl-lysozyme complex (2011) J Am Chem Soc, 133, pp. 1192-1195. , 1:CAS:528:DC%2BC3MXit1emsg%3D%3D 21204537
Sutton, K.A., Black, P.J., Mercer, K.R., Garman, E.F., Owen, R.L., Snella, E.H., Bernhard, W.A., Insights into the mechanism of X-ray-induced disulfide-bond cleavage in lysozyme crystals based on EPR, optical absorption and X-ray diffraction studies (2013) Acta Crystallogr D, 69, pp. 2381-2394. , 1:CAS:528:DC%2BC3sXhvVyjt7%2FL 3852651 24311579
Tanley, S.W.M., Schreurs, A.M.M., Helliwell, J.R., Kroon-Batenburg, L.M.J., Experience with exchange and archiving of raw data: Comparison of data from two diffractometers and four software packages on a series of lysozyme crystals (2012) J Appl Crystallogr, 46, pp. 108-119. , 3547227 23396873
Tanley, S.W.M., Diederichs, K., Kroon-Batenburg, L.M.J., Schreurs, A.M.M., Helliwell, J.R., Experiences with archived raw diffraction images data: Capturing cisplatin after chemical conversion of carboplatin in high salt conditions for a protein crystal (2013) J Synchrotron Radiat, 20, pp. 880-883. , 1:CAS:528:DC%2BC3sXhs1SgsbnM 3795548 24121332
Teichberg, V.I., Sharon, N.N., A spectrofluorometric study of tryptophan 108 in hen egg-white lysozyme (1970) FEBS Lett, 7, pp. 171-174. , 1:CAS:528:DyaE3cXks1ars7c%3D 11947460
Urig, S., Fritz-Wolf, K., Réau, R., Herold-Mende, C., Tóth, K., Davioud-Charvet, E., Becker, K., Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases (2006) Angew Chem Int Ed, 45, pp. 1881-1886. , 1:CAS:528:DC%2BD28XjtVyjt7w%3D
Vergara, A., D'Errico, G., Montesarchio, D., Mangiapia, G., Paduano, L., Merlino, A., Interaction of anticancer ruthenium compounds with proteins: High-resolution X-ray structures and Raman microscopy studies of the adduct between hen egg white lysozyme and aziru (2013) Inorg Chem, 52, pp. 4157-4159. , 1:CAS:528:DC%2BC3sXksVyis7k%3D 23517183
Wang, J., Dauter, S.M., Alkire, R., Joachimiak, A., Dauter, Z., Triclinic lysozyme at 0.65 Å resolution (2007) Acta Crystallogr D, 63, pp. 1254-1268. , 1:CAS:528:DC%2BD2sXhsVaqsb3E 18084073
Zhou, J., Taylor, P., Dornan, J., Robinson, S.P., Walkinshaw, M.D., Sadler, P.J., First crystal structure of a medicinally relevant gold protein complex: Unexpected binding of [Au (PEt3)] + to histidine (2000) Angew Chem Int Ed, 39, pp. 2931-2934
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.134, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930606333&partnerID=40&md5=7db94d1066a49036d7004d9d642516cc
Keywords: Gold Complexes, Gold-Based Drugs, Mechanisms Of Action, Metallodrugs, Protein–ligand Interactions, Protein-Ligand Interactions, Egg White, Lysozyme, Saccharin Sodium, Article, Binding Site, Chemical Analysis, Crystal Structure, Crystallization, Electrospray Mass Spectrometry, Protein Binding, X Ray Diffraction,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, Via Cintia, Naples, Italy
CNR Institute of Biostructure and Bioimages, Via Mezzocannone 16, Naples, Italy
References:
Baugher, J.F., Grossweiner, L.I., Lewis, J., Intramolecular energy-transfer in lysozyme-eosin complex (1974) J Chem Soc Faraday Trans II, 70, pp. 1389-1398. , 1:CAS:528:DyaE2MXisl2nsw%3D%3
Bertrand, B., Casini, A., A golden future in medicinal inorganic chemistry: The promise of anticancer gold organometallic compounds (2014) Dalton Trans, 43, pp. 4209-4219. , 1:CAS:528:DC%2BC2cXislCjsr4%3D 24225667
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., Caffeine-based gold (I) N-heterocyclic carbenes as possible anticancer agents: Synthesis and biological properties (2014) Inorg Chem, 53, pp. 2296-2303. , 1:CAS:528:DC%2BC2cXhslSjt7g%3D 24499428
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., Bioinorganic and medicinal chemistry: Aspects of gold (I)-protein complexes (2011) Dalton Trans, 4, pp. 2099-2111
Cattaruzza, L., Fregona, D., Mongiat, M., Ronconi, L., Fassina, A., Colombatti, A., Aldinucci, D., Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts (2011) Int J Cancer, 128, pp. 206-215. , 1:CAS:528:DC%2BC3cXhtlequ7rL 20209498
Ma, C., Ott, I., Casini, A., Gold organometallics with biological properties (2015) Bioorganometallic Chemistry: Applications in Drug Discovery Biocatalysis, and Imaging, , Wiley, Boston
Dalla Via, L., Nardon, C., Fregona, D., Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: A challenge for the future (2012) Future Med Chem, 4, p. 525. , 1:CAS:528:DC%2BC38XktVajs7w%3D 22416778
De Almeida, A., Oliveira, B.L., Correia, J.D.G., Soveral, G., Casini, A., Emerging protein targets for metal-based pharmaceutical agents: An update (2013) Coord Chem Rev, 257, p. 2689
Emsley, P., Cowtan, K., Coot: Model-building tools for molecular graphics (2004) Acta Crystallogr D, 60, pp. 2126-2132. , 15572765
Faust, A., Puehringer, S., Darowski, N., Panjikar, S., Diederichs, K., Mueller, U., Weiss, M.S., Update on the tutorial for learning and teaching macromolecular crystallography (2010) J Appl Crystallogr, 4, pp. 1230-1237
Ferraro, G., Massai, L., Messori, L., Merlino, A., Cisplatin binding to human serum albumin: A structural study (2015) Chem Commun (Camb), 51, pp. 9436-9439
Gabbiani, C., Massai, L., Scaletti, F., Michelucci, E., Maiore, L., Cinellu, M.A., Messori, L., Protein metalation by metal-based drugs: Reactions of cytotoxic gold compounds with cytochrome C and lysozyme (2012) J Biol Inorg Chem, 17, pp. 1293-1302. , 1:CAS:528:DC%2BC38Xhs1agtLjP 23132507
Helliwell, J.R., Tanley, S.W., The crystal structure analysis of the relative binding of cisplatin and carboplatin in a mixture with histidine in a protein studied at 100 and 300 K with repeated X-ray irradiation (2013) Acta Crystallogr D, 69, pp. 121-125. , 1:CAS:528:DC%2BC3sXitF2g 23275170
Imoto, T., Johnson, L.N., North, A.C.T., Phillips, D.C., Rupley, J.A., Vertebrate lysozyme (1972) The Enzymes, pp. 665-868. , D. Boyer (eds) 3 7 Academic Press New York
Imoto, T., Forster, L.S., Rupley, J.A., Tanaka, F., Fluorescence of lysozyme: Emissions from tryptophan residues 62 and 108 and energy migration (1972) Proc Natl Acad Sci USA, 69 (5), pp. 1151-1155. , 1:CAS:528:DyaE38XktlSru74%3D 426651 4504329
Jori, G., Galliazzo, G., Scoffone, E., Further studies on the hematoporphyrin-sensitized photooxidation of lysozyme (1971) Experientia, 27, pp. 379-380. , 1:CAS:528:DyaE3MXksVGjtbo%3D 5581087
Kuramitsu, S., Kurihara, S., Ikeda, K., Hamaguchi, I., Fluorescence spectra of hen, turky, and human lysozymes excited at 305 nm (1978) J Biochem, 83, pp. 159-170. , 1:CAS:528:DyaE1cXosFWrtg%3D%3D 24044
Marcon, G., Carotti, S., Coronnello, M., Messori, L., Mini, E., Orioli, P., Mazzei, T., Minghetti, G., Gold (III) complexes with bipyridyl ligands: Solution chemistry, cytotoxicity, and DNA binding properties (2002) J Med Chem, 45, pp. 1672-1677. , 1:CAS:528:DC%2BD38XhslOgur8%3D 11931621
Messori, L., Balerna, A., Ascone, I., Castellano, C., Gabbiani, C., Casini, A., Marchioni, C., Castellano, A.C., X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins (2011) J Biol Inorg Chem, 16, pp. 491-499. , 1:CAS:528:DC%2BC3cXhs1WmurrF 21181484
Messori, L., Scaletti, F., Massai, L., Cinellu, M.A., Gabbiani, C., Vergara, A., Merlino, A., The mode of action of anticancer gold-based drugs: A structural perspective (2013) Chem Commun, 49, pp. 10100-10102. , 1:CAS:528:DC%2BC3sXhsFOisrjE
Messori, L., Marzo, T., Gabbiani, C., Valdes, A.A., Quiroga, A.G., Merlino, A., Peculiar features in the crystal structure of the adduct formed between cis-PtI
Messori, L., Cinellu, M.A., Merlino, A., Protein recognition of gold-based drugs: 3d structure of the complex formed when lysozyme reacts with aubipy(c.) (2014) ACS Med Chem Lett, 5, pp. 1110-1113. , 1:CAS:528:DC%2BC2cXht1Git7zJ 25313321
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., Chemistry and biology of two novel gold (I) carbene complexes as prospective anticancer agents (2014) Inorg Chem, 53 (5), pp. 2396-2403. , 1:CAS:528:DC%2BC2cXis1ejt7k%3D 24547701
Murshudov, G.N., Skuba, K.P., Lebedev, A.A., Pannu, N.S., Steiner, R.A., Nicholls, R.A., Winn, M.D., Vagin, A.A., REFMAC5 for the refinement of macromolecular crystal structures (2011) Acta Crystallogr D, 67, pp. 355-367. , 1:CAS:528:DC%2BC3MXktFWqtbk%3D 3069751 21460454
Otwinowski, Z., Minor, W., Processing of X-ray diffraction data collected in oscillation mode (1997) Methods Enzymol, 276, pp. 307-326. , 1:CAS:528:DyaK2sXivFehsbw%3D
Pellegrini, E., Piano, D., Bowler, M.W., Direct cryocooling of naked crystals: Are cryoprotection agents always necessary? (2011) Acta Crystallogr D, 67, pp. 902-906. , 1:CAS:528:DC%2BC3MXhtF2qsb3N 21931222
Rigobello, M.P., Messori, L., Marcon, G., Cinellu, M.A., Bragadin, M., Folda, A., Scutari, G., Bindoli, A., Gold complexes inhibit mitochondrial thioredoxin reductase: Consequences on mitochondrial functions (2004) J Inorg Biochem, 98, pp. 1634-1641. , 1:CAS:528:DC%2BD2cXotF2mtbk%3D 15458826
Russo Krauss, I., Sica, F., Mattia, C.A., Merlino, A., Increasing the X-ray diffraction power of protein crystals by dehydration: The case of bovine serum albumin and a survey of literature data (2012) Int J Mol Sci, 13, pp. 3782-3800. , 22489183
Russo Krauss, I., Messori, L., Cinellu, M.A., Marasco, D., Sirignano, R., Merlino, A., Interactions of gold-based drugs with proteins: The structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold (III) compound Auoxo3 (2014) Dalton Trans, 43 (46), pp. 17483-17488. , 1:CAS:528:DC%2BC2cXhs1Wjsb%2FJ 25340580
Santos-Silva, T., Mukhopadhyay, A., Seixas, J.D., Bernardes, G.J., Romao, C.C., Romao, M.J., CORM-3 reactivity toward proteins: The crystal structure of a Ru (II) dicarbonyl-lysozyme complex (2011) J Am Chem Soc, 133, pp. 1192-1195. , 1:CAS:528:DC%2BC3MXit1emsg%3D%3D 21204537
Sutton, K.A., Black, P.J., Mercer, K.R., Garman, E.F., Owen, R.L., Snella, E.H., Bernhard, W.A., Insights into the mechanism of X-ray-induced disulfide-bond cleavage in lysozyme crystals based on EPR, optical absorption and X-ray diffraction studies (2013) Acta Crystallogr D, 69, pp. 2381-2394. , 1:CAS:528:DC%2BC3sXhvVyjt7%2FL 3852651 24311579
Tanley, S.W.M., Schreurs, A.M.M., Helliwell, J.R., Kroon-Batenburg, L.M.J., Experience with exchange and archiving of raw data: Comparison of data from two diffractometers and four software packages on a series of lysozyme crystals (2012) J Appl Crystallogr, 46, pp. 108-119. , 3547227 23396873
Tanley, S.W.M., Diederichs, K., Kroon-Batenburg, L.M.J., Schreurs, A.M.M., Helliwell, J.R., Experiences with archived raw diffraction images data: Capturing cisplatin after chemical conversion of carboplatin in high salt conditions for a protein crystal (2013) J Synchrotron Radiat, 20, pp. 880-883. , 1:CAS:528:DC%2BC3sXhs1SgsbnM 3795548 24121332
Teichberg, V.I., Sharon, N.N., A spectrofluorometric study of tryptophan 108 in hen egg-white lysozyme (1970) FEBS Lett, 7, pp. 171-174. , 1:CAS:528:DyaE3cXks1ars7c%3D 11947460
Urig, S., Fritz-Wolf, K., Réau, R., Herold-Mende, C., Tóth, K., Davioud-Charvet, E., Becker, K., Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases (2006) Angew Chem Int Ed, 45, pp. 1881-1886. , 1:CAS:528:DC%2BD28XjtVyjt7w%3D
Vergara, A., D'Errico, G., Montesarchio, D., Mangiapia, G., Paduano, L., Merlino, A., Interaction of anticancer ruthenium compounds with proteins: High-resolution X-ray structures and Raman microscopy studies of the adduct between hen egg white lysozyme and aziru (2013) Inorg Chem, 52, pp. 4157-4159. , 1:CAS:528:DC%2BC3sXksVyis7k%3D 23517183
Wang, J., Dauter, S.M., Alkire, R., Joachimiak, A., Dauter, Z., Triclinic lysozyme at 0.65 Å resolution (2007) Acta Crystallogr D, 63, pp. 1254-1268. , 1:CAS:528:DC%2BD2sXhsVaqsb3E 18084073
Zhou, J., Taylor, P., Dornan, J., Robinson, S.P., Walkinshaw, M.D., Sadler, P.J., First crystal structure of a medicinally relevant gold protein complex: Unexpected binding of [Au (PEt3)] + to histidine (2000) Angew Chem Int Ed, 39, pp. 2931-2934
Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme
A new crystal structure is reported here for the adduct formed in the reaction between NH4 [Au(Sac)2], AuSac2, a cytotoxic homoleptic gold(I) complex with the saccharinate ligand, and the model protein hen egg white lysozyme. To produce this adduct, AuSac2 breaks down and releases both saccharinate ligands. The resulting Au(I) ions bind the protein to ND1 and NE2 atoms of His15 but also to SD atom of the zero-solvent accessible Met105 side chain, which is located in the protein hydrophobic box. The unexpected existence of this secondary gold(I) binding site is confirmed by spectroscopic and spectrometric measurements in solution. Graphical Abstract: [Figure not available: see fulltext.] © 2015 Springer Science+Business Media New York.
A new crystal structure is reported here for the adduct formed in the reaction between NH
Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme
| ▼ Cell wall recognition events for biosensors development |
Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme
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* Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy (232 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 May 23; 23(29): 6942-6947.
Impact Factor: 5.16
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Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (328 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
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Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (421 views)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
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Ferraro G, Pica A, Russo Krauss I, Pane F, Amoresano A, Merlino A
* Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme (248 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2016; N/D: 1-10.
Impact Factor: 2.894
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (473 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Messori L, Cinellu MA, Merlino A
* Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c) (324 views)
Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875linking), 2014 Jul 31; 5(10): 1110-1113.
Impact Factor: 3.12
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
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Russo Krauss I, Messori L, Cinellu MA, Marasco D, Sirignano R, Merlino A
* Interactions of gold-based drugs with proteins: the structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold(III) compound Auoxo3 (339 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2014; 43(46): 17483-17488.
Impact Factor: 4.197
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Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
* The mode of action of anticancer gold-based drugs: a structural perspective (366 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
Impact Factor: 6.718
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* CD, UV, and In Silico Insights on the Effect of 1, 3-Bis(1'-uracilyl)-2-propanone on Serum Albumin Structure (7 views)
Biomolecules (ISSN: 2218-273xlinking), 2022 Aug 3; 12(8): 1071-1088.
Impact Factor: 6.064
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Scognamiglio PL, Vicidomini C, Fontanella F, De Stefano C, Palumbo R, Roviello GN
* Protein Binding of Benzofuran Derivatives: A CD Spectroscopic and In Silico Comparative Study of the Effects of 4-Nitrophenyl Functionalized Benzofurans and Benzodifurans on BSA Protein Structure (41 views)
Biomolecules (ISSN: 2218-273xlinking), 2022 Feb; 12(2): 262-273.
Impact Factor: 6.064
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (616 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Merlino A, Marzo T, Messori L
* Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy (232 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 May 23; 23(29): 6942-6947.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (328 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
View Export to BibTeX Export to EndNote
Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (421 views)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
View Export to BibTeX Export to EndNote
Ferraro G, Pica A, Russo Krauss I, Pane F, Amoresano A, Merlino A
* Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme (248 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2016; N/D: 1-10.
Impact Factor: 2.894
View Export to BibTeX Export to EndNote
Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (473 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
View Export to BibTeX Export to EndNote
Messori L, Cinellu MA, Merlino A
* Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c) (324 views)
Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875linking), 2014 Jul 31; 5(10): 1110-1113.
Impact Factor: 3.12
View Export to BibTeX Export to EndNote
Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
View Export to BibTeX Export to EndNote
Russo Krauss I, Messori L, Cinellu MA, Marasco D, Sirignano R, Merlino A
* Interactions of gold-based drugs with proteins: the structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold(III) compound Auoxo3 (339 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2014; 43(46): 17483-17488.
Impact Factor: 4.197
View Export to BibTeX Export to EndNote
Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
* The mode of action of anticancer gold-based drugs: a structural perspective (366 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
Impact Factor: 6.718
View Export to BibTeX Export to EndNote
12 Records (12 excluding Abstracts).
Total impact factor: 62.099 (62.099 excluding Abstracts).
Total 5 year impact factor: 60.459 (60.459 excluding Abstracts).
Total impact factor: 62.099 (62.099 excluding Abstracts).
Total 5 year impact factor: 60.459 (60.459 excluding Abstracts).
360 views. Last view on Sunday 12 March 2023, 5:40:04
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