Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (608 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
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Paper type: Journal Article,
Impact factor: 3.257, 5-year impact factor: 3.213
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930636141&partnerID=40&md5=3b2345c8b9e709bb01a096a4e4353606
Keywords: Chemokine, Conformational Ensemble, Intrinsically Disordered Protein (id), Intrinsically Disordered Region(idr), Chemokine Receptor Cxcr4, Antigen Binding, Article, Binding Assay, Camp Assay, Cell Migration Assay, Circular Dichroism, Controlled Study, Human, Human Cell, Hydrogen Bond, Mass Spectrometry, Molecular Dynamics, Molecular Recognition, Nuclear Magnetic Resonance Spectroscopy, Peptide Synthesis, Protein Conformation, Receptor Binding, Reversed Phase High Performance Liquid Chromatography, Simulation,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples “Federico II” and CIRPeB, Via Mezzocannone 16, Naples, Italy
Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), Via Mezzocannone 16, Naples, Italy
Oncology Research Center of Mercogliano (CROM), Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Napoli, Italy
Molecular Immunology and Immuneregulation, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Napoli, Italy
Center of Medical Informatics, AOU Second University of Naples, Napoli, Italy
UFR des Sciences Pharmaceutiques—Collège Sciences de la Santé INSERM U869, Laboratoire ARNA, Université de Bordeaux, 146 rue Léo Saignat, Bordeaux cedex, France
References:
Not available.
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.257, 5-year impact factor: 3.213
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84930636141&partnerID=40&md5=3b2345c8b9e709bb01a096a4e4353606
Keywords: Chemokine, Conformational Ensemble, Intrinsically Disordered Protein (id), Intrinsically Disordered Region(idr), Chemokine Receptor Cxcr4, Antigen Binding, Article, Binding Assay, Camp Assay, Cell Migration Assay, Circular Dichroism, Controlled Study, Human, Human Cell, Hydrogen Bond, Mass Spectrometry, Molecular Dynamics, Molecular Recognition, Nuclear Magnetic Resonance Spectroscopy, Peptide Synthesis, Protein Conformation, Receptor Binding, Reversed Phase High Performance Liquid Chromatography, Simulation,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples “Federico II” and CIRPeB, Via Mezzocannone 16, Naples, Italy
Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), Via Mezzocannone 16, Naples, Italy
Oncology Research Center of Mercogliano (CROM), Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Napoli, Italy
Molecular Immunology and Immuneregulation, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Napoli, Italy
Center of Medical Informatics, AOU Second University of Naples, Napoli, Italy
UFR des Sciences Pharmaceutiques—Collège Sciences de la Santé INSERM U869, Laboratoire ARNA, Université de Bordeaux, 146 rue Léo Saignat, Bordeaux cedex, France
References:
Not available.
Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4
This work reports on the design andthe synthesis of two short linear peptides both containing a few amino acids with disorder propensity and an allylic ester group at the C-terminal end. Their structural properties were firstly analyzed by means of experimental techniques in solution such as CD and NMR methodsthat highlighted peptide flexibility. These results were further confirmed by MD simulationsthat demonstrated the ability of the peptides to assume conformational ensembles. Theyrevealed a network of transient and dynamic -bonds and interactions with water molecules. Binding assays with a well-known drug-target, i.e., the CXCR4 receptor, were also carried out in an attempt to verify their biological function and the possibility to use the assays to develop new specific targets for CXCR4. Moreover, our data indicate that these peptides represent useful tools for molecular recognition processes in which a flexible conformation is required in order to obtain an interaction with a specific target. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
This work reports on the design andthe synthesis of two short linear peptides both containing a few amino acids with disorder propensity and an allylic ester group at the C-terminal end. Their structural properties were firstly analyzed by means of experimental techniques in solution such as CD and NMR methodsthat highlighted peptide flexibility. These results were further confirmed by MD simulationsthat demonstrated the ability of the peptides to assume conformational ensembles. Theyrevealed a network of transient and dynamic -bonds and interactions with water molecules. Binding assays with a well-known drug-target, i.e., the CXCR4 receptor, were also carried out in an attempt to verify their biological function and the possibility to use the assays to develop new specific targets for CXCR4. Moreover, our data indicate that these peptides represent useful tools for molecular recognition processes in which a flexible conformation is required in order to obtain an interaction with a specific target. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4
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Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4
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Vincenzi M, Mercurio FA, Leone M
* NMR spectroscopy in the conformational analysis of peptides: an overview (99 views)
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* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (737 views)
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
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* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (643 views)
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
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Sandomenico A, Monti SM, Palumbo R, Ruvo M
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
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Impact Factor: 4.659
View Export to BibTeX Export to EndNote
* NMR spectroscopy in the conformational analysis of peptides: an overview (99 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(14): 2729-2782.
Impact Factor: 4.184
View Export to BibTeX Export to EndNote
Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (737 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
View Export to BibTeX Export to EndNote
Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (1148 views)
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Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (941 views) (PDF 285 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (597 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
View Export to BibTeX Export to EndNote
Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (643 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; 47(8): 1507-1515.
Impact Factor: 3.196
View Export to BibTeX Export to EndNote
Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (702 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
View Export to BibTeX Export to EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (451 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (513 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Russo L, Raiola L, Campitiello MA, Magrì A, Fattorusso R, Malgieri G, Pappalardo G, La Mendola D, Isernia C
* Probing the residual structure in avian prion hexarepeats by CD, NMR and MD techniques (548 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2013 Sep; 18(9): 11467-11484.
Impact Factor: 2.095
View Export to BibTeX Export to EndNote
Sandomenico A, Monti SM, Palumbo R, Ruvo M
* A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells (781 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Sep; 17(9): 604-609.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (605 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
View Export to BibTeX Export to EndNote
Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (408 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (397 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
View Export to BibTeX Export to EndNote
Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (449 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (502 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
View Export to BibTeX Export to EndNote
Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (352 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
View Export to BibTeX Export to EndNote
Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (401 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
View Export to BibTeX Export to EndNote
18 Records (17 excluding Abstracts).
Total impact factor: 72.139 (68.605 excluding Abstracts).
Total 5 year impact factor: 67.217 (63.202 excluding Abstracts).
Total impact factor: 72.139 (68.605 excluding Abstracts).
Total 5 year impact factor: 67.217 (63.202 excluding Abstracts).
608 views. Last view on Sunday 09 July 2023, 4:59:03
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