Keywords: Bric A Brac Tramtrack And Broad Complex Protein, Cullin, Histone Deacetylase 1, Hydrocarbon, Membrane Protein, Peptides And Proteins, Protein Kctd11, Stapled Peptide, Unclassified Drug, Alpha Helix, Article, Binding Affinity, Circular Dichroism, Controlled Study, Human, Molecular Dynamics, Molecular Model, Nuclear Magnetic Resonance Spectroscopy, Protein Analysis, Protein Binding, Protein Conformation, Protein Degradation, Protein Domain, Protein Expression, Protein Protein Interaction, Protein Stability, Protein Targeting, Theoretical Study, Cullin Proteins, Chemistry, Metabolism, Protein Structure, Secondary, Tertiary,
Affiliations: *** IBB - CNR ***
Institute of Biostructures and Bioimaging, C.N.R, Napoli, Italy
Institute of Crystallography, C.N.R, Bari, Italy
Second University of Napoli, Caserta, Italy
Interuniversity Centre for Research on Bioactive Peptides (CIRPEB), Napoli, Italy
Department of Molecular Medicine, La Sapienza University, Roma, Italy
References: Blackwell, H.E., Grubbs, R.H., Highly efficient synthesis of covalently cross-linked peptide helices by ringclosing metathesis (1998) Angew Chem Int Edit, 37 (23), pp. 3281-3284. , PubMed PMID: ISI:000077806300017. Englis
Verdine, G.L., Hilinski, G.J., Stapled peptides for intracellular drug targets (2012) Methods in Enzymology: Protein Engineering for Therapeutics, 203 (503 PART B), pp. 3-33. , PubMed PMID: ISI:000300198000001. English
Bird, G.H., Gavathiotis, E., Labelle, J.L., Katz, S.G., Walensky, L.D., Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies (2014) ACS Chem Biol, 9 (3), pp. 831-837. , Mar 21 PMID: 24358963. Epub 2013/12/24. eng
Joseph, T.L., Lane, D.P., Verma, C.S., Stapled BH3 peptides against MCL-1: Mechanism and design using atomistic simulations (2012) PLoS One, 7 (8). , Aug 31 PubMed PMID: ISI:000308221300039. English
Bernal, F., Tyler, A.F., Korsmeyer, S.J., Walensky, L.D., Verdine, G.L., Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide (2007) J Am Chem Soc, 129 (16), p. 5298. , Apr 25 PubMed PMID: ISI:000245782800073. English
Moellering, R.E., Cornejo, M., Davis, T.N., Del Bianco, C., Aster, J.C., Blacklow, S.C., Direct inhibition of the NOTCH transcription factor complex (2009) Nature, 462 (7270), pp. 182-188. , Nov 12 PMID: 19907488. PMCID: 2951323. Epub 2009/11/13. eng
Walensky, L.D., Kung, A.L., Escher, I., Malia, T.J., Barbuto, S., Wright, R.D., Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix (2004) Science, 305 (5689), pp. 1466-1470. , Sep 3 PMID: 15353804. PMCID: 1360987. Epub 2004/09/09. eng
Phillips, C., Roberts, L.R., Schade, M., Bazin, R., Bent, A., Davies, N.L., Design and structure of stapled peptides binding to estrogen receptors (2011) J Am Chem Soc, 133 (25), pp. 9696-9699. , Jun 29 PMID: 21612236. Epub 2011/05/27. eng
Sviridov, D.O., Ikpot, I.Z., Stonik, J., Drake, S.K., Amar, M., Osei-Hwedieh, D.O., Helix stabilization of amphipathic peptides by hydrocarbon stapling increases cholesterol efflux by the ABCA1 transporter (2011) Biochem Biophys Res Commun, 410 (3), pp. 446-451. , Jul 8 PMID: 21672528. PMCID: 3253552. Epub 2011/06/16. eng
Bhattacharya, S., Zhang, H., Debnath, A.K., Cowburn, D., Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid (2008) J Biol Chem, 283 (24), pp. 16274-16278. , Jun 13 PMID: 18417468. PMCID: 2423268. Epub 2008/04/18. eng
Pintard, L., Willems, A., Peter, M., Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family (2004) Embo J, 23 (8), pp. 1681-1687. , Apr 21 PMID: 15071497. PMCID: 394240. Epub 2004/04/09. eng
Errington, W.J., Khan, M.Q., Bueler, S.A., Rubinstein, J.L., Chakrabartty, A., Prive, G.G., Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase (2012) Structure, 20 (7), pp. 1141-1153. , Jul 3 PMID: 22632832. Epub 2012/05/29. eng
Genschik, P., Sumara, I., Lechner, E., The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): Cellular functions and disease implications (2013) Embo J, 32 (17), pp. 2307-2320. , Aug 28 PMID: 23912815. PMCID: 3770339. Epub 2013/08/06. eng
Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K., Prive, G.G., Sequence and structural analysis of BTB domain proteins (2005) Genome Biol, 6 (10), p. R82. , PMID: 16207353. PMCID: 1257465. Epub 2005/10/07. eng
Canettieri, G., Di Marcotullio, L., Greco, A., Coni, S., Antonucci, L., Infante, P., Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (2010) Nat Cell Biol, 12 (2), pp. 132-142. , Feb PMID: 20081843. Epub 2010/01/19. eng
Pirone, L., Correale, S., De Paola, I., Zaccaro, L., De Simone, G., Vitagliano, L., Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: Implications for KCTD-cullin 3 recognition (2011) J Pept Sci, 17 (5), pp. 373-376. , May PMID: 21438081. Epub 2011/03/26. eng
Correale, S., Pirone, L., Di Marcotullio, L., De Smaele, E., Greco, A., Mazza, D., Molecular organization of the cullin E3 ligase adaptor KCTD11 (2011) Biochimie, 93 (4), pp. 715-724. , Apr PMID: 21237243. Epub 2011/01/18. eng
Azizieh, R., Orduz, D., Van Bogaert, P., Bouschet, T., Rodriguez, W., Schiffmann, S.N., Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons (2011) Mol Neurobiol, 44 (1), pp. 111-121. , Aug PMID: 21710140. Epub 2011/06/29. eng
Williams, M.J., Almen, M.S., Fredriksson, R., Schioth, H.B., What model organisms and interactomics can reveal about the genetics of human obesity (2012) Cell Mol Life Sci, 69 (22), pp. 3819-3834. , Nov PMID: 22618246. Epub 2012/05/24. eng
Golzio, C., Willer, J., Talkowski, M.E., Oh, E.C., Taniguchi, Y., Jacquemont, S., KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant (2012) Nature, 485 (7398), pp. 363-367. , May 17 PMID: 22596160. PMCID: 3366115. Epub 2012/05/19. eng
Dementieva, I.S., Tereshko, V., McCrossan, Z.A., Solomaha, E., Araki, D., Xu, C., Pentameric assembly of potassium channel tetramerization domain-containing protein 5 (2009) J Mol Biol, 387 (1), pp. 175-191. , Mar 20 PubMed PMID: ISI:000264610000014. English PMID: 19361449
Bayon, Y., Trinidad, A.G., De La Puerta, M.L., Del Carmen Rodriguez, M., Bogetz, J., Rojas, A., KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases (2008) Febs J, 275 (15), pp. 3900-3910. , Aug PMID: 18573101. Epub 2008/06/25. eng
Chen, Y., Yang, Z., Meng, M., Zhao, Y., Dong, N., Yan, H., Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement (2009) Mol Cell, 35 (6), pp. 841-855. , Sep 24 PMID: 19782033. Epub 2009/09/29. eng
De Smaele, E., Di Marcotullio, L., Moretti, M., Pelloni, M., Occhione, M.A., Infante, P., Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma (2011) Neoplasia, 13 (4), pp. 374-385. , Apr PMID: 21472142. PMCID: 3071086. Epub 2011/04/08. eng
Hu, X., Yan, F., Wang, F., Yang, Z., Xiao, L., Li, L., TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-kappaB and AP-1 (2012) Mol Biol Rep, 39 (11), pp. 9911-9919. , Nov PMID: 22810651. Epub 2012/07/20. eng
Huang, T., Xu, J., Xiang, J., Lu, Y., Chen, R., Huang, L., PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP(51-136) region containing octapeptide repeats (2012) Biochem Biophys Res Commun, 417 (1), pp. 182-186. , Jan 6 PMID: 22138399. Epub 2011/12/06. eng
Bixby, K.A., Nanao, M.H., Shen, N.V., Kreusch, A., Bellamy, H., Pfaffinger, P.J., Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels (1999) Nat Struct Biol, 6 (1), pp. 38-43. , Jan PMID: 9886290. Epub 1999/01/14. eng
Amadei, A., Linssen, A.B., Berendsen, H.J., Essential dynamics of proteins (1993) Proteins, 17 (4), pp. 412-425. , Dec PMID: 8108382. Epub 1993/12/01. eng
Amadei, A., Ceruso, M.A., Di Nola, A., On the convergence of the conformational coordinates basis set obtained by the essential dynamics analysis of proteins' molecular dynamics simulations (1999) Proteins, 36 (4), pp. 419-424. , Sep 1 PMID: 10450083. Epub 1999/08/18. eng
Merlino, A., Vitagliano, L., Ceruso, M.A., Di Nola, A., Mazzarella, L., Global and local motions in ribonuclease A: A molecular dynamics study (2002) Biopolymers, 65 (4), pp. 274-283. , Nov 15 PMID: 12382288. Epub 2002/10/17. eng
Pirone, L., Esposito, C., Correale, S., Graziano, G., Di Gaetano, S., Vitagliano, L., Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization (2013) Biomed Res Int, 2013, p. 162674. , PMID: 24307990. PMCID: 3838848. Epub 2013/12/7. eng
Balasco, N., Pirone, L., Smaldone, G., Di Gaetano, S., Esposito, L., Pedone, E.M., Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (2014) Biochim Biophys Acta, , Apr 18 PMID: 24747150. Epub 2014/04/22. Eng
Kimple, A.J., Yasgar, A., Hughes, M., Jadhav, A., Willard, F.S., Muller, R.E., A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction (2008) Comb Chem High T Scr, 11 (5), pp. 396-409. , Jun PubMed PMID: ISI:000256568700007. English
Griesinger, C., Otting, G., Wuthrich, K., Ernst, R.R., Clean Tocsy for H-1 spin system-identification in macromolecules (1988) J Am Chem Soc, 110 (23), pp. 7870-7872. , Nov 9 PubMed PMID: ISI:A1988Q949000044. English
Kumar, A., Ernst, R.R., Wuthrich, K., A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules (1980) Biochem Biophys Res Commun, 95 (1), pp. 1-6. , Jul 16 PMID: 7417242. Epub 1980/07/6. eng
Bartels, C., Xia, T.H., Billeter, M., Guntert, P., Wuthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J Biomol NMR, 6 (1), pp. 1-10. , Jul PMID: 22911575. Epub 1995/07/01. eng
Schwarzinger, S., Kroon, G.J., Foss, T.R., Wright, P.E., Dyson, H.J., Random coil chemical shifts in acidic 8 M urea: Implementation of random coil shift data in NMRView (2000) J Biomol NMR, 18 (1), pp. 43-48. , Sep PMID: 11061227. Epub 2000/11/04. eng
Guntert, P., Mumenthaler, C., Wuthrich, K., Torsion angle dynamics for NMR structure calculation with the new program DYANA (1997) J Mol Biol, 273 (1), pp. 283-298. , Oct 17 PMID: 9367762. Epub 1997/11/21. eng
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J Mol Graph, 14 (1), pp. 51-55. , Feb 29-32. PMID: 8744573. Epub 1996/02/01. eng
Laskowski, R.A., Macarthur, M.W., Moss, D.S., Thornton, J.M., Procheck - A program to check the stereochemical quality of protein structures (1993) J Appl Crystallogr, 26, pp. 283-291. , Apr 1 PubMed PMID: ISI: A1993KY85100021. English
Berjanskii, M.V., Neal, S., Wishart, D.S., PREDITOR: A web server for predicting protein torsion angle restraints (2006) Nucleic Acids Res, 34 (WEB SERVER ISSUE), pp. W63-W69. , Jul 1 PMID: 16845087. PMCID: 1538894. Epub 2006/07/18. eng
Marsh, J.A., Singh, V.K., Jia, Z.C., Forman-Kay, J.D., Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: Implications for fibrillation (2006) Protein Sci, 15 (12), pp. 2795-2804. , Dec PubMed PMID: ISI:000242373700012. English. PMID: 17088319
Wishart, D.S., Sykes, B.D., Richards, F.M., The chemical-shift index-A fast and simple method for the assignment of protein secondary structure through Nmr-spectroscopy (1992) Biochemistry, 31 (6), pp. 1647-1651. , Feb 18 PubMed PMID: ISI:A1992HE19400010. English. PMID: 1737021
Liu, Z.P., Xiang, Y.Q., Sun, G.H., The KCTD family of proteins: Structure, function, disease relevance (2013) Cell Biosci, 3. , Nov 24 PubMed PMID: ISI:000331967800001. English
Walensky, L.D., Bird, G.H., Hydrocarbon-stapled peptides: Principles, practice, and progress (2014) J Med Chem, , Mar 6 PMID: 24601557. Epub 2014/03/08. Eng
Canning, P., Cooper, C.D., Krojer, T., Murray, J.W., Pike, A.C., Chaikuad, A., Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases (2013) J Biol Chem, 288 (11), pp. 7803-7814. , Mar 15 PMID: 23349464. PMCID: 3597819. Epub 2013/01/26. eng
Cullin3 - BTB interface: A novel target for stapled peptides
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(341 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote