Apathy and striatal dopamine transporter levels in de-novo, untreated Parkinson's disease patients (347 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2015 May; 21(5): 489-493.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.794, 5-year impact factor: 3.899
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928587429&partnerID=40&md5=c570b0e07294ba61a94ee19c704d23f2
Keywords: Apathy, Behavioral Disorders, Dopamine, Non-Motor Symptoms, Parkinson, S Disease, [123] Fp-Cit Spect, Dopamine Transporter, Ioflupane I 123, Adult, Article, Caudate Nucleus, Clinical Article, Corpus Striatum, Depression, Dopamine Brain Level, Dopamine Uptake, Female, Human, Motor Dysfunction, Parkinson Disease, Priority Journal, Single Photon Emission Computer Tomography, Aged, Cohort Analysis, Metabolism, Middle Aged, Physiology, Procedures, Retrospective Study, Scintiscanning, Cohort Studies, Dopamine Plasma Membrane Transport Proteins, Retrospective Studies, Emission-Computed, Single-Photon, Apathy Physiology , Corpus Striatum Diagnostic Imaging Metabolism , Dopamine Plasma Membrane Transport Proteins Metabolism , Parkinson Disease Diagnostic Imaging Metabolism , Single-Photon Methods,
Affiliations:
*** IBB - CNR ***
Department of Psychology, Second University of Naples, Caserta, Italy
IDC-Hermitage-Capodimonte, Naples, Italy
University Parthenope, Naples, Italy
Neurodegenerative Diseases Center, Department of Medicine and Surgery, University of Salerno, Salerno, Italy
Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy
Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL) Institute of Neurology, London, United Kingdom
Institute of Biostructure and Bioimaging, CNR, Naples, Italy
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
References:
Marin, R.S., Apathy: a neuropsychiatric syndrome (1991) JNeuropsychiatr Clin Neurosci, 3, pp. 243-25
Levy, R., Dubois, B., Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits (2006) Cereb Cortex, 16, pp. 916-928
Santangelo, G., Trojano, L., Barone, P., Errico, D., Grossi, D., Vitale, C., Apathy in Parkinson's disease: diagnosis, neuropsychological correlates, pathophysiology and treatment (2013) Behav Neurol, 27, pp. 501-513
Santangelo, G., Vitale, C., Trojano, L., Errico, D., Amboni, M., Barbarulo, A.M., Neuropsychological correlates of theory of mind in patients with early Parkinson's disease (2012) Mov Disord, 27, pp. 98-105
Benito-León, J., Cubo, E., Coronell, C., Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: the ANIMO study (2012) Mov Disord, 27, pp. 211-218. , ANIMO Study Group
Benoit, M., Robert, P.H., Imaging correlates of apathy and depression in Parkinson's disease (2011) JNeurol Sci, 310, pp. 58-60
Poletti, M., Bonuccelli, U., Acute and chronic cognitive effects of levodopa and dopamine agonists on patients with Parkinson's disease: a review (2013) Ther Adv Psychopharmacol, 3, pp. 101-113
Robert, P., Onyike, C.U., Leentjens, A.F., Dujardin, K., Aalten, P., Starkstein, S., Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders (2009) Eur Psychiatry, 24, pp. 98-104
Santangelo, G., Barone, P., Cuoco, S., Raimo, S., Pezzella, D., Picillo, M., Apathy in untreated, de novo patients with Parkinson's disease: validation study of apathy evaluation scale (2014) JNeurol, 261, pp. 2319-2328
Booij, J., Hemelaar, T.G., Speelman, J.D., de Bruin, K., Janssen, A.G., van Royen, E.A., One-day protocol for imaging of the nigrostriatal dopaminergic pathway in Parkinson's disease by [123]FPCIT SPECT (1999) JNucl Med, 40, pp. 753-761
Booij, J., Speelman, J.D., Horstink, M.W., Wolters, E.C., The clinical benefit of imaging striatal dopamine transporters with [123I]FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism (2001) Eur J Nucl Med, 28, pp. 266-272
Laruelle, M.1., Wallace, E., Seibyl, J.P., Baldwin, R.M., Zea-Ponce, Y., Zoghbi, S.S., Graphical, kinetic, and equilibrium analyses of invivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects (1994) JCereb Blood Flow, 14, pp. 982-994
Antonelli, F., Strafella, A.P., Behavioral disorders in Parkinson's disease: the role of dopamine (2014) Park Relat Disord, 20, pp. S10-S12
Roselli, F., Pisciotta, N.M., Perneczky, R., Pennelli, M., Aniello, M.S., De Caro, M.F., Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with lewy bodies: a 123I-FP-CIT SPECT study (2009) Mov Disord, 24, pp. 2097-2103
David, R., Koulibaly, M., Benoit, M., Garcia, R., Caci, H., Darcourt, J., Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases A SPECT study with partial volume effect correction (2008) Clin Neurol Neurosurg, 110, pp. 19-24
Eslinger, P.J., Moore, P., Antani, S., Anderson, C., Grossman, M., Apathy in frontotemporal dementia: behavioral and neuroimaging correlates (2012) Behav Neurol, 25, pp. 127-136
Benoit, M., Clairet, S., Koulibaly, P.M., Darcourt, J., Robert, P.H., Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease (2004) Int J Geriatr Psychiatry, 19, pp. 864-869
Robert, G., Le Jeune, F., Lozachmeur, C., Drapier, S., Dondaine, T., Péron, J., Apathy in patients with Parkinson disease without dementia or depression: a PET study (2012) Neurology, 79, pp. 1155-1160
Reijnders, J.S., Scholtissen, B., Weber, W.E., Aalten, P., Verhey, F.R., Leentjens, A.F., Neuroanatomical correlates of apathy in Parkinson's disease: a magnetic resonance imaging study using voxel-based morphometry (2010) Mov Disord, 25, pp. 2318-2325
Botvinick, M.M., Cohen, J.D., Carter, C.S., Conflict monitoring and anterior cingulate cortex: an update (2004) Trends Cogn Sci, 8, pp. 539-546
Remy, P., Doder, M., Lees, A., Turjanski, N., Brooks, D., Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system (2005) Brain, 128, pp. 1314-1322
Grahn, J.A., Parkinson, J.A., Owen, A.M., The role of the basal ganglia in learning and memory: neuropsychological studies (2009) Behav Brain Res, 199, pp. 53-60
Djaldetti, R., Ziv, I., Melamed, E., The mystery of motor asymmetry in Parkinson's disease (2006) Lancet Neurol, 5, pp. 796-802
Cronin-Golomb, A., Parkinson's disease as a disconnection syndrome (2010) Neuropsychol Rev, 20, pp. 191-208
Harris, E., McNamara, P., Durso, R., Apathy in patients with Parkinson disease as a function of side of onset (2013) JGeriatr Psychiatry Neurol, 26, pp. 95-104
Cubo, E., Benito-Leon, J., Coronell, C., Armesto, D., Clinical correlates of apathy in patients recently diagnosed with Parkinson's disease: the ANIMO study (2012) Neuroepidemiology, 38, pp. 48-55
Aarsland, D., Larsen, J.P., Lim, N.G., Janvin, C., Karlsen, K., Tandberg, E., Range of neuropsychiatric disturbances in patients with Parkinson's disease (1999) JNeurol Neurosurg Psychiatry, 67, pp. 492-496
Robert, G.H., Le Jeune, F., Lozachmeur, C., Drapier, S., Dondaine, T., Péron, J., Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study (2014) Neurology, 83, pp. 1620-1626
Dujardin, K., Sockeel, P., Delliaux, M., Destée, A., Defebvre, L., Apathy may herald cognitive decline and dementia in Parkinson's disease (2009) Mov Disord, 24, pp. 2391-2397
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2015 May; 21(5): 489-493.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.794, 5-year impact factor: 3.899
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928587429&partnerID=40&md5=c570b0e07294ba61a94ee19c704d23f2
Keywords: Apathy, Behavioral Disorders, Dopamine, Non-Motor Symptoms, Parkinson, S Disease, [123] Fp-Cit Spect, Dopamine Transporter, Ioflupane I 123, Adult, Article, Caudate Nucleus, Clinical Article, Corpus Striatum, Depression, Dopamine Brain Level, Dopamine Uptake, Female, Human, Motor Dysfunction, Parkinson Disease, Priority Journal, Single Photon Emission Computer Tomography, Aged, Cohort Analysis, Metabolism, Middle Aged, Physiology, Procedures, Retrospective Study, Scintiscanning, Cohort Studies, Dopamine Plasma Membrane Transport Proteins, Retrospective Studies, Emission-Computed, Single-Photon, Apathy Physiology , Corpus Striatum Diagnostic Imaging Metabolism , Dopamine Plasma Membrane Transport Proteins Metabolism , Parkinson Disease Diagnostic Imaging Metabolism , Single-Photon Methods,
Affiliations:
*** IBB - CNR ***
Department of Psychology, Second University of Naples, Caserta, Italy
IDC-Hermitage-Capodimonte, Naples, Italy
University Parthenope, Naples, Italy
Neurodegenerative Diseases Center, Department of Medicine and Surgery, University of Salerno, Salerno, Italy
Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy
Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL) Institute of Neurology, London, United Kingdom
Institute of Biostructure and Bioimaging, CNR, Naples, Italy
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
References:
Marin, R.S., Apathy: a neuropsychiatric syndrome (1991) JNeuropsychiatr Clin Neurosci, 3, pp. 243-25
Levy, R., Dubois, B., Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits (2006) Cereb Cortex, 16, pp. 916-928
Santangelo, G., Trojano, L., Barone, P., Errico, D., Grossi, D., Vitale, C., Apathy in Parkinson's disease: diagnosis, neuropsychological correlates, pathophysiology and treatment (2013) Behav Neurol, 27, pp. 501-513
Santangelo, G., Vitale, C., Trojano, L., Errico, D., Amboni, M., Barbarulo, A.M., Neuropsychological correlates of theory of mind in patients with early Parkinson's disease (2012) Mov Disord, 27, pp. 98-105
Benito-León, J., Cubo, E., Coronell, C., Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: the ANIMO study (2012) Mov Disord, 27, pp. 211-218. , ANIMO Study Group
Benoit, M., Robert, P.H., Imaging correlates of apathy and depression in Parkinson's disease (2011) JNeurol Sci, 310, pp. 58-60
Poletti, M., Bonuccelli, U., Acute and chronic cognitive effects of levodopa and dopamine agonists on patients with Parkinson's disease: a review (2013) Ther Adv Psychopharmacol, 3, pp. 101-113
Robert, P., Onyike, C.U., Leentjens, A.F., Dujardin, K., Aalten, P., Starkstein, S., Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders (2009) Eur Psychiatry, 24, pp. 98-104
Santangelo, G., Barone, P., Cuoco, S., Raimo, S., Pezzella, D., Picillo, M., Apathy in untreated, de novo patients with Parkinson's disease: validation study of apathy evaluation scale (2014) JNeurol, 261, pp. 2319-2328
Booij, J., Hemelaar, T.G., Speelman, J.D., de Bruin, K., Janssen, A.G., van Royen, E.A., One-day protocol for imaging of the nigrostriatal dopaminergic pathway in Parkinson's disease by [123]FPCIT SPECT (1999) JNucl Med, 40, pp. 753-761
Booij, J., Speelman, J.D., Horstink, M.W., Wolters, E.C., The clinical benefit of imaging striatal dopamine transporters with [123I]FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism (2001) Eur J Nucl Med, 28, pp. 266-272
Laruelle, M.1., Wallace, E., Seibyl, J.P., Baldwin, R.M., Zea-Ponce, Y., Zoghbi, S.S., Graphical, kinetic, and equilibrium analyses of invivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects (1994) JCereb Blood Flow, 14, pp. 982-994
Antonelli, F., Strafella, A.P., Behavioral disorders in Parkinson's disease: the role of dopamine (2014) Park Relat Disord, 20, pp. S10-S12
Roselli, F., Pisciotta, N.M., Perneczky, R., Pennelli, M., Aniello, M.S., De Caro, M.F., Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with lewy bodies: a 123I-FP-CIT SPECT study (2009) Mov Disord, 24, pp. 2097-2103
David, R., Koulibaly, M., Benoit, M., Garcia, R., Caci, H., Darcourt, J., Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases A SPECT study with partial volume effect correction (2008) Clin Neurol Neurosurg, 110, pp. 19-24
Eslinger, P.J., Moore, P., Antani, S., Anderson, C., Grossman, M., Apathy in frontotemporal dementia: behavioral and neuroimaging correlates (2012) Behav Neurol, 25, pp. 127-136
Benoit, M., Clairet, S., Koulibaly, P.M., Darcourt, J., Robert, P.H., Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease (2004) Int J Geriatr Psychiatry, 19, pp. 864-869
Robert, G., Le Jeune, F., Lozachmeur, C., Drapier, S., Dondaine, T., Péron, J., Apathy in patients with Parkinson disease without dementia or depression: a PET study (2012) Neurology, 79, pp. 1155-1160
Reijnders, J.S., Scholtissen, B., Weber, W.E., Aalten, P., Verhey, F.R., Leentjens, A.F., Neuroanatomical correlates of apathy in Parkinson's disease: a magnetic resonance imaging study using voxel-based morphometry (2010) Mov Disord, 25, pp. 2318-2325
Botvinick, M.M., Cohen, J.D., Carter, C.S., Conflict monitoring and anterior cingulate cortex: an update (2004) Trends Cogn Sci, 8, pp. 539-546
Remy, P., Doder, M., Lees, A., Turjanski, N., Brooks, D., Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system (2005) Brain, 128, pp. 1314-1322
Grahn, J.A., Parkinson, J.A., Owen, A.M., The role of the basal ganglia in learning and memory: neuropsychological studies (2009) Behav Brain Res, 199, pp. 53-60
Djaldetti, R., Ziv, I., Melamed, E., The mystery of motor asymmetry in Parkinson's disease (2006) Lancet Neurol, 5, pp. 796-802
Cronin-Golomb, A., Parkinson's disease as a disconnection syndrome (2010) Neuropsychol Rev, 20, pp. 191-208
Harris, E., McNamara, P., Durso, R., Apathy in patients with Parkinson disease as a function of side of onset (2013) JGeriatr Psychiatry Neurol, 26, pp. 95-104
Cubo, E., Benito-Leon, J., Coronell, C., Armesto, D., Clinical correlates of apathy in patients recently diagnosed with Parkinson's disease: the ANIMO study (2012) Neuroepidemiology, 38, pp. 48-55
Aarsland, D., Larsen, J.P., Lim, N.G., Janvin, C., Karlsen, K., Tandberg, E., Range of neuropsychiatric disturbances in patients with Parkinson's disease (1999) JNeurol Neurosurg Psychiatry, 67, pp. 492-496
Robert, G.H., Le Jeune, F., Lozachmeur, C., Drapier, S., Dondaine, T., Péron, J., Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study (2014) Neurology, 83, pp. 1620-1626
Dujardin, K., Sockeel, P., Delliaux, M., Destée, A., Defebvre, L., Apathy may herald cognitive decline and dementia in Parkinson's disease (2009) Mov Disord, 24, pp. 2391-2397
Apathy and striatal dopamine transporter levels in de-novo, untreated Parkinson's disease patients
Introduction: Apathy is a neuropsychiatric symptom in Parkinson's Disease (PD) which has a negative impact on quality of life and might be related in part to damage of presynaptic dopaminergic system. Little is known about relationship between striatal dopamine levels and apathy in PD patients without dementia and/or depression. The aim of the present study was to investigate the relationship between "pure apathy" and striatal dopamine uptake in untreated, drug-naïve PD patients without clinically significant dementia and/or depression. Methods: Fourteen PD patients with pure apathy and 14 PD patients without apathy, matched for age, side of motor symptoms at onset, motor disability and disease duration, underwent both neuropsychological and behavioral examination including self-rated version of the Apathy Evaluation Scale (AES-S). All patients underwent 123 I-FP-CIT (DaT-SCAN) SPECT to assess dopamine transporter (DAT) striatal uptake. Results: PD patients with apathy showed lower DAT levels in the striatum than non-apathetic patients. After Bonferroni correction the difference between groups was significant in the right caudate. Conclusions: Apathy is associated with reduced striatal dopamine transporter levels, independent of motor disability and depression in non-demented PD patients. These findings suggest that dysfunction of dopaminergic innervation in the striatum and particularly in the right caudate may contribute to development of apathy in early PD. © 2015 Elsevier Ltd.
Introduction: Apathy is a neuropsychiatric symptom in Parkinson's Disease (PD) which has a negative impact on quality of life and might be related in part to damage of presynaptic dopaminergic system. Little is known about relationship between striatal dopamine levels and apathy in PD patients without dementia and/or depression. The aim of the present study was to investigate the relationship between "pure apathy" and striatal dopamine uptake in untreated, drug-naïve PD patients without clinically significant dementia and/or depression. Methods: Fourteen PD patients with pure apathy and 14 PD patients without apathy, matched for age, side of motor symptoms at onset, motor disability and disease duration, underwent both neuropsychological and behavioral examination including self-rated version of the Apathy Evaluation Scale (AES-S). All patients underwent 123 I-FP-CIT (DaT-SCAN) SPECT to assess dopamine transporter (DAT) striatal uptake. Results: PD patients with apathy showed lower DAT levels in the striatum than non-apathetic patients. After Bonferroni correction the difference between groups was significant in the right caudate. Conclusions: Apathy is associated with reduced striatal dopamine transporter levels, independent of motor disability and depression in non-demented PD patients. These findings suggest that dysfunction of dopaminergic innervation in the striatum and particularly in the right caudate may contribute to development of apathy in early PD. © 2015 Elsevier Ltd.
Apathy and striatal dopamine transporter levels in de-novo, untreated Parkinson's disease patients
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Apathy and striatal dopamine transporter levels in de-novo, untreated Parkinson's disease patients
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (341 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
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Pellecchia MT, Varrone A, Annesi G, Amboni M, Cicarelli G, Sansone V, Annesi F, Rocca FE, Vitale C, Pappata S, Quattrone A, Barone P
* Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: An FP-CIT SPECT study (318 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2007 Mar 15; 22(4): 559-563.
Impact Factor: 3.207
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Vitale C, Salvatore E, De Michele G, Garavaglia B, Annesi G, Brice A, Pappata S, Barone P, Salvatore M
* Longitudinal changes of dopamine transporter density in early-onset parkin disease measured with [I-123]FP-CIT SPECT (221 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Salvatore E, Varrone A, Sansone V, Nolano M, Bruni AC, De Rosa A, Santoro L, Pappata S, Filla A, De Michele G
* Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17 (297 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2006 Jun; 21(6): 872-875.
Impact Factor: 3.323
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Sansone V, Varrone A, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison Of A Dual-Headed And A Brain-Dedicated SPECT Camera In The Ability To Measure The Loss Of Dopamine Transporters With [123I]FP-CIT (308 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Varrone A, Salvatore E, Sansone V, De Michele G, Filla A, Pappata S, Salvatore M
* [123I]FP-CIT SPECT Study Of The Striatal Dopamine Transporter Density In Patients With Idiopathic Late Onset Cerebellar Ataxia And MSA-C (237 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (4002 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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Varrone A, Salvatore E, De Michele G, Barone P, Sansone V, Pellecchia MT, Castaldo I, Coppola G, Brunetti A, Salvatore M, Pappata S, Filla A
* Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism (425 views)
Annals Of Neurology, 2004 Mar; 55(3): 426-430.
Impact Factor: 11.91
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* Nonvascular Parkinsonism in Fabry Disease: Results From Magnetic Resonance and Dopamine Transporter Imaging (19 views)
J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2021 Apr 16; 80(5): 476-479.
Impact Factor: 2.923
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Erro R, Landolfi A, D , #xagostino G, Pace L, Picillo M, Scarano M, Cuocolo A, Pappata S, Vitale C, Pellecchia MT, Monteleone P, Barone P
* Bipolar Disorder and Parkinson's Disease: A (123)I-Ioflupane Dopamine Transporter SPECT Study (6 views)
Front Neurol (ISSN: 1664-2295linking), 2021 Apr 13; 12: 652375-652375.
Impact Factor: 3.77
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Greco A, Zannetti A, Pappata S, Albanese S, Coda AR, Ragucci M, Nardelli A, Brunetti A, Cuocolo A, Salvatore M
* Measurement of [123I]FP-CIT binding to the dopamine transporter (DAT) in healthy mouse striatum using dedicated small animal SPECT imaging: feasibility, optimization and validation (465 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785linking, 1824-4785print, 1827-1936electronic), 2018 Mar; 62(1): 112-117.
Impact Factor: 2.413
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De Rosa A, Pellegrino T, Pappata S, Lieto M, Bonifati V, Palma V, Topa A, Santoro L, Bilo L, Cuocolo A, De Michele G
* Non-motor symptoms and cardiac innervation in SYNJ1-related parkinsonism (251 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2016 Feb; 23: 102-105.
Impact Factor: 4.484
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Pellecchia MT, Picillo M, Santangelo G, Longo K, Moccia M, Erro R, Amboni M, Vitale C, Vicidomini C, Salvatore M, Barone P, Pappata S
* Cognitive performances and DAT imaging in early Parkinson's disease with mild cognitive impairment: a preliminary study (479 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2015 Feb 3; 131(5): 275-281.
Impact Factor: 2.559
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Moccia M, Pappata S, Erro R, Picillo M, Vitale C, Amboni M, Longo K, Palladino R, Barone P, Pellecchia MT
* Uric Acid Relates To Dopamine Transporter Availability In Parkinson'S Disease (418 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2015; 131(2): 127-131.
Impact Factor: 2.559
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Moccia M, Pappata S, Picillo M, Erro R, Coda ARD, Longo K, Vitale C, Amboni M, Brunetti A, Capo G, Salvatore M, Barone P, Pellecchia MT
* Dopamine transporter availability in motor subtypes of de novo drug-naïve Parkinson's disease (610 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Nov; 261(11): 2112-2118.
Impact Factor: 3.377
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Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
* Park20 Caused By Synj1 Homozygous Arg258gln Mutation In A New Italian Family (476 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753), 2014 Aug; 15(3): 183-188.
Impact Factor: 2.884
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Greco A, Zannetti A, Coda ARD, Albanese S, Nardelli A, Roca A, Pappata S, Brunetti A, Cuocolo A
* Effects of Thyroid Blockade on Brain Imaging of Dopamine Transporter in Normal Mice (347 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Erro R, Pappata S, Picillo M, Rocco M, Santangelo G, Barone P, Vitale C
* Teaching NeuroImages: Pseudo-abnormal DaTscan findings in meningioma-induced parkinsonism (295 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2013 Mar 26; 80(13): e147-e147.
Impact Factor: 8.303
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Erro R, Pappata S, Amboni M, Vicidomini C, Longo K, Santangelo G, Picillo M, Vitale C, Moccia M, Giordano F, Brunetti A, Pellecchia MT, Salvatore M, Barone P
* Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients (493 views)
Parkinsonism Relat D (ISSN: 1873-5126, 1353-8020, 1873-5126electronic), 2012 Nov; 18(9): 1034-1038.
Impact Factor: 3.274
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Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (492 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
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Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G
* The relationship between cerebral vascular disease and parkinsonism: The VADO study (496 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780.
Impact Factor: 3.274
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Varrone A, Stepanov V, Nakao R, Toth M, Gulyas B, Emond P, Deloye JB, Vercouillie J, Stabin MG, Jonsson C, Guilloteau D, Halldin C
* Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates (515 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2011 Sep 1; 52(8): 1313-1321.
Impact Factor: 6.381
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Tossici-Bolt L, Dickson JC, Sera T, de Nijs R, Bagnara MC, Jonsson C, Scheepers E, Zito F, Seese A, Koulibaly PM, Kapucu OL, Koole M, Raith M, George J, Lonsdale MN, Munzing W, Tatsch K, Varrone A
* Calibration of gamma camera systems for a multicentre European 123I-FP-CIT SPECT normal database (581 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1529-1540.
Impact Factor: 4.991
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (542 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (723 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (603 views) (PDF 259 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (533 views)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (341 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Pellecchia MT, Varrone A, Annesi G, Amboni M, Cicarelli G, Sansone V, Annesi F, Rocca FE, Vitale C, Pappata S, Quattrone A, Barone P
* Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: An FP-CIT SPECT study (318 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2007 Mar 15; 22(4): 559-563.
Impact Factor: 3.207
View Export to BibTeX Export to EndNote
Varrone A, Sansone V, Pellecchia MT, Amboni M, Vitale C, Salvatore E, De Michele G, Garavaglia B, Annesi G, Brice A, Pappata S, Barone P, Salvatore M
* Longitudinal changes of dopamine transporter density in early-onset parkin disease measured with [I-123]FP-CIT SPECT (221 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Salvatore E, Varrone A, Sansone V, Nolano M, Bruni AC, De Rosa A, Santoro L, Pappata S, Filla A, De Michele G
* Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17 (297 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2006 Jun; 21(6): 872-875.
Impact Factor: 3.323
View Export to BibTeX Export to EndNote
Sansone V, Varrone A, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison Of A Dual-Headed And A Brain-Dedicated SPECT Camera In The Ability To Measure The Loss Of Dopamine Transporters With [123I]FP-CIT (308 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
View Export to BibTeX Export to EndNote
Varrone A, Salvatore E, Sansone V, De Michele G, Filla A, Pappata S, Salvatore M
* [123I]FP-CIT SPECT Study Of The Striatal Dopamine Transporter Density In Patients With Idiopathic Late Onset Cerebellar Ataxia And MSA-C (237 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
View Export to BibTeX Export to EndNote
Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (4002 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
View Export to BibTeX Export to EndNote
Varrone A, Salvatore E, De Michele G, Barone P, Sansone V, Pellecchia MT, Castaldo I, Coppola G, Brunetti A, Salvatore M, Pappata S, Filla A
* Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism (425 views)
Annals Of Neurology, 2004 Mar; 55(3): 426-430.
Impact Factor: 11.91
View Export to BibTeX Export to EndNote
27 Records (21 excluding Abstracts).
Total impact factor: 122.081 (94.195 excluding Abstracts).
Total 5 year impact factor: 124.201 (94.549 excluding Abstracts).
Total impact factor: 122.081 (94.195 excluding Abstracts).
Total 5 year impact factor: 124.201 (94.549 excluding Abstracts).
347 views. Last view on Saturday 14 January 2023, 18:01:40
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