CaMKII protects MKP-1 from proteasome degradation in endothelial cells (259 views)
Cell Signal (ISSN: 0898-6568), 2014; 26(10): 2167-2174.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.315, 5-year impact factor: 4.154
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904469075&partnerID=40&md5=9f4acaacd6c8d441ecf4c2e1e6ef1bff
Keywords: Camkii, Endothelial Cell, Phosphatases,
Affiliations:
*** IBB - CNR ***
Department of Medicine, University of Salerno, Italy
Department of Translational Science, Federico II University of Naples, Italy
Department of Advanced Biomedical Science, Federico II University of Naples, Italy
Department of Pharmacology, University of Salerno, Italy
IRCCS Multimedica, Milan, Italy
References:
Iaccarino, G., Ciccarelli, M., Sorriento, D., Galasso, G., Campanile, A., Santulli, G., Cipolletta, E., Trimarco, B., (2005) Circ. Res., 97 (11), pp. 1182-118
Cobb, M.H., Goldsmith, E.J., (1995) J. Biol. Chem., 270 (25), pp. 14843-14846
Seger, R., Krebs, E.G., (1995) FASEB J., 9 (9), pp. 726-735
Marshall, C.J., (1995) Cell, 80 (2), pp. 179-185
Chen, R.H., Sarnecki, C., Blenis, J., (1992) Mol. Cell. Biol., 12 (3), pp. 915-927
Gonzalez, F.A., Seth, A., Raden, D.L., Bowman, D.S., Fay, F.S., Davis, R.J., (1993) J. Cell Biol., 122 (5), pp. 1089-1101
Lenormand, P., Sardet, C., Pages, G., L'Allemain, G., Brunet, A., Pouyssegur, J., (1993) J. Cell Biol., 122 (5), pp. 1079-1088
Rusciano, M.R., Maione, A.S., Illario, M., (2012) Transl. Med. UniSa, 4, pp. 66-72
Illario, M., Cavallo, A.L., Bayer, K.U., Di Matola, T., Fenzi, G., Rossi, G., Vitale, M., (2003) J. Biol. Chem., 278 (46), pp. 45101-45108
Farooq, A., Plotnikova, O., Chaturvedi, G., Yan, S., Zeng, L., Zhang, Q., Zhou, M.M., (2003) Structure, 11 (2), pp. 155-164
Farooq, A., Zhou, M.M., (2004) Cell. Signal., 16 (7), pp. 769-779
Brondello, J.M., Brunet, A., Pouyssegur, J., McKenzie, F.R., (1997) J. Biol. Chem., 272 (2), pp. 1368-1376
Vinals, F., Pouyssegur, J., (1999) Mol. Cell. Biol., 19 (4), pp. 2763-2772
Kent, K.C., Mii, S., Harrington, E.O., Chang, J.D., Mallette, S., Ware, J.A., (1995) Circ. Res., 77 (2), pp. 231-238
Camps, M., Nichols, A., Arkinstall, S., (2000) Faseb J., 14 (1), pp. 6-16
Keyse, S.M., (1995) Biochim. Biophys. Acta, 1265 (2-3), pp. 152-160
Sun, H., Charles, C.H., Lau, L.F., Tonks, N.K., (1993) Cell, 75 (3), pp. 487-493
Scimeca, J.C., Servant, M.J., Dyer, J.O., Meloche, S., (1997) Oncogene, 15 (6), pp. 717-725
Durham, P.L., Russo, A.F., (2000) Mol. Endocrinol., 14 (10), pp. 1570-1582
Ryser, S., Massiha, A., Piuz, I., Schlegel, W., (2004) Biochem. J., 378 (PART 2), pp. 473-484
Takeshita, S., Toda, M., Yamagishi, H., (1989) EMBO J., 8 (11), pp. 3261-3270
Katagiri, C., Masuda, K., Urano, T., Yamashita, K., Araki, Y., Kikuchi, K., Shima, H., (2005) J. Biol. Chem., 280 (15), pp. 14716-14722
Brondello, J.M., Pouyssegur, J., McKenzie, F.R., (1999) Science, 286 (5449), pp. 2514-2517
Chen, P., Li, J., Barnes, J., Kokkonen, G.C., Lee, J.C., Liu, Y., (2002) J. Immunol., 169 (11), pp. 6408-6416
Marchetti, S., Gimond, C., Chambard, J.C., Touboul, T., Roux, D., Pouyssegur, J., Pages, G., (2005) Mol. Cell. Biol., 25 (2), pp. 854-864
Kucharska, A., Rushworth, L.K., Staples, C., Morrice, N.A., Keyse, S.M., (2009) Cell. Signal., 21 (12), pp. 1794-1805
Liu, R., Zheng, H.Q., Zhou, Z., Dong, J.T., Chen, C., (2009) J. Biol. Chem., 284 (25), pp. 16791-16798
Liang, D., Zeng, Q., Xu, Z., Zhang, H., Gui, L., Xu, C., Chen, S., Chen, L., (2014) Biochem. Pharmacol., 87 (2), pp. 332-343
Takahashi, K., Suzuki, K., (2006) J. Cell. Physiol., 208 (1), pp. 213-219
Yamashita, T., Inui, S., Maeda, K., Hua, D.R., Takagi, K., Fukunaga, K., Sakaguchi, N., (2006) Brain Res., 1082 (1), pp. 1-10
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Koch, W.J., Trimarco, B., (2002) Circulation, 106 (3), pp. 349-355
Ciccarelli, M., Cipolletta, E., Santulli, G., Campanile, A., Pumiglia, K., Cervero, P., Pastore, L., Iaccarino, G., (2007) Cell. Signal., 19 (9), pp. 1949-1955
Iaccarino, G., Dolber, P.C., Lefkowitz, R.J., Koch, W.J., (1999) Hypertension, 33 (1 PART 2), pp. 396-401
Gomez-Monterrey, I., Sala, M., Rusciano, M.R., Monaco, S., Maione, A.S., Iaccarino, G., Tortorella, P., Campiglia, P., (2013) Eur. J. Med. Chem., 62, pp. 425-434
Coultrap, S.J., Barcomb, K., Bayer, K.U., (2012) PLoS One, 7 (5), pp. e37176
Wang, Z., Ginnan, R., Abdullaev, I.F., Trebak, M., Vincent, P.A., Singer, H.A., (2010) J. Biol. Chem., 285 (28), pp. 21303-21312
Stefan, M.I., Edelstein, S.J., Le Novere, N., (2008) Proc. Natl. Acad. Sci. U. S. A., 105 (31), pp. 10768-10773
Keyse, S.M., Emslie, E.A., (1992) Nature, 359 (6396), pp. 644-647
Noguchi, T., Metz, R., Chen, L., Mattei, M.G., Carrasco, D., Bravo, R., (1993) Mol. Cell. Biol., 13 (9), pp. 5195-5205
Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J., Davis, R.J., (1995) J. Biol. Chem., 270 (13), pp. 7420-7426
Brunet, A., Roux, D., Lenormand, P., Dowd, S., Keyse, S., Pouyssegur, J., (1999) Embo J., 18 (3), pp. 664-674
Hutter, D., Chen, P., Barnes, J., Liu, Y., (2000) Biochem. J., 352 (PART 1), pp. 155-163
Slack, D.N., Seternes, O.M., Gabrielsen, M., Keyse, S.M., (2001) J. Biol. Chem., 276 (19), pp. 16491-16500
Keyse, S.M., (2000) Curr. Opin. Cell Biol., 12 (2), pp. 186-192
Charles, C.H., Abler, A.S., Lau, L.F., (1992) Oncogene, 7 (1), pp. 187-190
Kwak, S.P., Hakes, D.J., Martell, K.J., Dixon, J.E., (1994) J. Biol. Chem., 269 (5), pp. 3596-3604
Xu, Q., Fawcett, T.W., Gorospe, M., Guyton, K.Z., Liu, Y., Holbrook, N.J., (1997) Hypertension, 30 (1 PART 1), pp. 106-111
Short, M.D., Fox, S.M., Lam, C.F., Stenmark, K.R., Das, M., (2006) Mol. Biol. Cell, 17 (4), pp. 1995-2008
Moutzouris, J.P., Che, W., Ramsay, E.E., Manetsch, M., Alkhouri, H., Bjorkman, A.M., Schuster, F., Ammit, A.J., (2010) Biochim. Biophys. Acta, 1803 (3), pp. 416-423
Min, L.J., Mogi, M., Li, J.M., Iwanami, J., Iwai, M., Horiuchi, M., (2005) Circ. Res., 97 (5), pp. 434-442
Shields, K.M., Panzhinskiy, E., Burns, N., Zawada, W.M., Das, M., (2011) Am. J. Pathol., 178 (1), pp. 98-109
Imaizumi, S., Grijalva, V., Priceman, S., Wu, L., Su, F., Farias-Eisner, R., Hama, S., Reddy, S.T., (2010) Mol. Genet. Metab., 101 (1), pp. 66-75
Cell Signal (ISSN: 0898-6568), 2014; 26(10): 2167-2174.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.315, 5-year impact factor: 4.154
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904469075&partnerID=40&md5=9f4acaacd6c8d441ecf4c2e1e6ef1bff
Keywords: Camkii, Endothelial Cell, Phosphatases,
Affiliations:
*** IBB - CNR ***
Department of Medicine, University of Salerno, Italy
Department of Translational Science, Federico II University of Naples, Italy
Department of Advanced Biomedical Science, Federico II University of Naples, Italy
Department of Pharmacology, University of Salerno, Italy
IRCCS Multimedica, Milan, Italy
References:
Iaccarino, G., Ciccarelli, M., Sorriento, D., Galasso, G., Campanile, A., Santulli, G., Cipolletta, E., Trimarco, B., (2005) Circ. Res., 97 (11), pp. 1182-118
Cobb, M.H., Goldsmith, E.J., (1995) J. Biol. Chem., 270 (25), pp. 14843-14846
Seger, R., Krebs, E.G., (1995) FASEB J., 9 (9), pp. 726-735
Marshall, C.J., (1995) Cell, 80 (2), pp. 179-185
Chen, R.H., Sarnecki, C., Blenis, J., (1992) Mol. Cell. Biol., 12 (3), pp. 915-927
Gonzalez, F.A., Seth, A., Raden, D.L., Bowman, D.S., Fay, F.S., Davis, R.J., (1993) J. Cell Biol., 122 (5), pp. 1089-1101
Lenormand, P., Sardet, C., Pages, G., L'Allemain, G., Brunet, A., Pouyssegur, J., (1993) J. Cell Biol., 122 (5), pp. 1079-1088
Rusciano, M.R., Maione, A.S., Illario, M., (2012) Transl. Med. UniSa, 4, pp. 66-72
Illario, M., Cavallo, A.L., Bayer, K.U., Di Matola, T., Fenzi, G., Rossi, G., Vitale, M., (2003) J. Biol. Chem., 278 (46), pp. 45101-45108
Farooq, A., Plotnikova, O., Chaturvedi, G., Yan, S., Zeng, L., Zhang, Q., Zhou, M.M., (2003) Structure, 11 (2), pp. 155-164
Farooq, A., Zhou, M.M., (2004) Cell. Signal., 16 (7), pp. 769-779
Brondello, J.M., Brunet, A., Pouyssegur, J., McKenzie, F.R., (1997) J. Biol. Chem., 272 (2), pp. 1368-1376
Vinals, F., Pouyssegur, J., (1999) Mol. Cell. Biol., 19 (4), pp. 2763-2772
Kent, K.C., Mii, S., Harrington, E.O., Chang, J.D., Mallette, S., Ware, J.A., (1995) Circ. Res., 77 (2), pp. 231-238
Camps, M., Nichols, A., Arkinstall, S., (2000) Faseb J., 14 (1), pp. 6-16
Keyse, S.M., (1995) Biochim. Biophys. Acta, 1265 (2-3), pp. 152-160
Sun, H., Charles, C.H., Lau, L.F., Tonks, N.K., (1993) Cell, 75 (3), pp. 487-493
Scimeca, J.C., Servant, M.J., Dyer, J.O., Meloche, S., (1997) Oncogene, 15 (6), pp. 717-725
Durham, P.L., Russo, A.F., (2000) Mol. Endocrinol., 14 (10), pp. 1570-1582
Ryser, S., Massiha, A., Piuz, I., Schlegel, W., (2004) Biochem. J., 378 (PART 2), pp. 473-484
Takeshita, S., Toda, M., Yamagishi, H., (1989) EMBO J., 8 (11), pp. 3261-3270
Katagiri, C., Masuda, K., Urano, T., Yamashita, K., Araki, Y., Kikuchi, K., Shima, H., (2005) J. Biol. Chem., 280 (15), pp. 14716-14722
Brondello, J.M., Pouyssegur, J., McKenzie, F.R., (1999) Science, 286 (5449), pp. 2514-2517
Chen, P., Li, J., Barnes, J., Kokkonen, G.C., Lee, J.C., Liu, Y., (2002) J. Immunol., 169 (11), pp. 6408-6416
Marchetti, S., Gimond, C., Chambard, J.C., Touboul, T., Roux, D., Pouyssegur, J., Pages, G., (2005) Mol. Cell. Biol., 25 (2), pp. 854-864
Kucharska, A., Rushworth, L.K., Staples, C., Morrice, N.A., Keyse, S.M., (2009) Cell. Signal., 21 (12), pp. 1794-1805
Liu, R., Zheng, H.Q., Zhou, Z., Dong, J.T., Chen, C., (2009) J. Biol. Chem., 284 (25), pp. 16791-16798
Liang, D., Zeng, Q., Xu, Z., Zhang, H., Gui, L., Xu, C., Chen, S., Chen, L., (2014) Biochem. Pharmacol., 87 (2), pp. 332-343
Takahashi, K., Suzuki, K., (2006) J. Cell. Physiol., 208 (1), pp. 213-219
Yamashita, T., Inui, S., Maeda, K., Hua, D.R., Takagi, K., Fukunaga, K., Sakaguchi, N., (2006) Brain Res., 1082 (1), pp. 1-10
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Koch, W.J., Trimarco, B., (2002) Circulation, 106 (3), pp. 349-355
Ciccarelli, M., Cipolletta, E., Santulli, G., Campanile, A., Pumiglia, K., Cervero, P., Pastore, L., Iaccarino, G., (2007) Cell. Signal., 19 (9), pp. 1949-1955
Iaccarino, G., Dolber, P.C., Lefkowitz, R.J., Koch, W.J., (1999) Hypertension, 33 (1 PART 2), pp. 396-401
Gomez-Monterrey, I., Sala, M., Rusciano, M.R., Monaco, S., Maione, A.S., Iaccarino, G., Tortorella, P., Campiglia, P., (2013) Eur. J. Med. Chem., 62, pp. 425-434
Coultrap, S.J., Barcomb, K., Bayer, K.U., (2012) PLoS One, 7 (5), pp. e37176
Wang, Z., Ginnan, R., Abdullaev, I.F., Trebak, M., Vincent, P.A., Singer, H.A., (2010) J. Biol. Chem., 285 (28), pp. 21303-21312
Stefan, M.I., Edelstein, S.J., Le Novere, N., (2008) Proc. Natl. Acad. Sci. U. S. A., 105 (31), pp. 10768-10773
Keyse, S.M., Emslie, E.A., (1992) Nature, 359 (6396), pp. 644-647
Noguchi, T., Metz, R., Chen, L., Mattei, M.G., Carrasco, D., Bravo, R., (1993) Mol. Cell. Biol., 13 (9), pp. 5195-5205
Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J., Davis, R.J., (1995) J. Biol. Chem., 270 (13), pp. 7420-7426
Brunet, A., Roux, D., Lenormand, P., Dowd, S., Keyse, S., Pouyssegur, J., (1999) Embo J., 18 (3), pp. 664-674
Hutter, D., Chen, P., Barnes, J., Liu, Y., (2000) Biochem. J., 352 (PART 1), pp. 155-163
Slack, D.N., Seternes, O.M., Gabrielsen, M., Keyse, S.M., (2001) J. Biol. Chem., 276 (19), pp. 16491-16500
Keyse, S.M., (2000) Curr. Opin. Cell Biol., 12 (2), pp. 186-192
Charles, C.H., Abler, A.S., Lau, L.F., (1992) Oncogene, 7 (1), pp. 187-190
Kwak, S.P., Hakes, D.J., Martell, K.J., Dixon, J.E., (1994) J. Biol. Chem., 269 (5), pp. 3596-3604
Xu, Q., Fawcett, T.W., Gorospe, M., Guyton, K.Z., Liu, Y., Holbrook, N.J., (1997) Hypertension, 30 (1 PART 1), pp. 106-111
Short, M.D., Fox, S.M., Lam, C.F., Stenmark, K.R., Das, M., (2006) Mol. Biol. Cell, 17 (4), pp. 1995-2008
Moutzouris, J.P., Che, W., Ramsay, E.E., Manetsch, M., Alkhouri, H., Bjorkman, A.M., Schuster, F., Ammit, A.J., (2010) Biochim. Biophys. Acta, 1803 (3), pp. 416-423
Min, L.J., Mogi, M., Li, J.M., Iwanami, J., Iwai, M., Horiuchi, M., (2005) Circ. Res., 97 (5), pp. 434-442
Shields, K.M., Panzhinskiy, E., Burns, N., Zawada, W.M., Das, M., (2011) Am. J. Pathol., 178 (1), pp. 98-109
Imaizumi, S., Grijalva, V., Priceman, S., Wu, L., Su, F., Farias-Eisner, R., Hama, S., Reddy, S.T., (2010) Mol. Genet. Metab., 101 (1), pp. 66-75
CaMKII protects MKP-1 from proteasome degradation in endothelial cells
CaMKs are a widely distributed family of kinases with multiple and often cell specific effects on intracellular signal transduction pathway. In endothelial cells, it has been recognized a role for CamKII in several pathways such as eNOS activation and nitric oxide production. It is not clear though, whether CaMKII interfere with other endothelial cell functions such as ERK activation and cell proliferation. We explored this issue in primary cultured rat endothelial cells and we evaluated the effect on endothelial cell proliferation and DNA synthesis. CaMKII inhibition through Cantide, conducted into the cell through Antoennapedia (ANT-CN), showed positive effects on proliferation and H3-thimdine incorporation similar to insulin stimulation. Accordingly, both CaMKII pharmacological inhibition and silencing through shRNA produced activation of the p44/42 MAPK. These observations leaded to the hypothesis that CamKII could regulate p44/p42 by interfering with specific ERK phosphatases. Indeed, we found that CaMKII interacts and protect the dual specific phosphatase MKP-1 from proteasome mediated degradation while this complex is disrupted by CaMKII inhibitors. This study reveals that CaMKII, besides phosphorylation through the known ras-raf-mek pathway, can regulate also dephosphorylation of p44/p42 by modulation of MKP-1 level. This novel finding opens to a novel scenario in regulation of endothelial cell functions. © 2014.
CaMKs are a widely distributed family of kinases with multiple and often cell specific effects on intracellular signal transduction pathway. In endothelial cells, it has been recognized a role for CamKII in several pathways such as eNOS activation and nitric oxide production. It is not clear though, whether CaMKII interfere with other endothelial cell functions such as ERK activation and cell proliferation. We explored this issue in primary cultured rat endothelial cells and we evaluated the effect on endothelial cell proliferation and DNA synthesis. CaMKII inhibition through Cantide, conducted into the cell through Antoennapedia (ANT-CN), showed positive effects on proliferation and H3-thimdine incorporation similar to insulin stimulation. Accordingly, both CaMKII pharmacological inhibition and silencing through shRNA produced activation of the p44/42 MAPK. These observations leaded to the hypothesis that CamKII could regulate p44/p42 by interfering with specific ERK phosphatases. Indeed, we found that CaMKII interacts and protect the dual specific phosphatase MKP-1 from proteasome mediated degradation while this complex is disrupted by CaMKII inhibitors. This study reveals that CaMKII, besides phosphorylation through the known ras-raf-mek pathway, can regulate also dephosphorylation of p44/p42 by modulation of MKP-1 level. This novel finding opens to a novel scenario in regulation of endothelial cell functions. © 2014.
CaMKII protects MKP-1 from proteasome degradation in endothelial cells
| ▼ Biomolecules able to modulate the VEGF-dependent angiogenesis |
| ▼ Design of New FSHR-Specific Peptides for therapeutic and diagnostic applications |
CaMKII protects MKP-1 from proteasome degradation in endothelial cells
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
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Impact Factor: 3.447
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
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Impact Factor: 6.873
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Impact Factor: 3.909
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
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Impact Factor: 4.773
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
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Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
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Impact Factor: 4.409
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Impact Factor: 1.974
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
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Impact Factor: 3.647
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
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Impact Factor: 1.95
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
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Impact Factor: 5.476
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
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Impact Factor: 5.328
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
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Impact Factor: 5.328
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
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Impact Factor: 2.572
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
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Impact Factor: 3.407
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
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Impact Factor: 9.432
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
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Impact Factor: 5.52
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
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Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
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Impact Factor: 4.922
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
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Impact Factor: 3.447
View Export to BibTeX Export to EndNote
Del Giudice I, Limauro D, Pedone E, Bartolucci S, Fiorentino G
* A novel arsenate reductase from the bacterium Thermus thermophilus HB27: Its role in arsenic detoxification (422 views)
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Impact Factor: 3.191
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (620 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
View Export to BibTeX Export to EndNote
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (607 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (307 views)
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
View Export to BibTeX Export to EndNote
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
View Export to BibTeX Export to EndNote
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
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Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (484 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (449 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1135 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
View Export to BibTeX Export to EndNote
Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
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Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (417 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
View Export to BibTeX Export to EndNote
Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (421 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
View Export to BibTeX Export to EndNote
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (395 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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39 Records (39 excluding Abstracts).
Total impact factor: 202.85 (202.85 excluding Abstracts).
Total 5 year impact factor: 210.813 (210.813 excluding Abstracts).
Total impact factor: 202.85 (202.85 excluding Abstracts).
Total 5 year impact factor: 210.813 (210.813 excluding Abstracts).
259 views. Last view on Monday 29 May 2023, 18:56:30
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