Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (647 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
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Paper type: Journal Article,
Impact factor: 3.432, 5-year impact factor: 4.071
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884612383&partnerID=40&md5=063cc3be44019c0b56a4b4f89b7435ab
Keywords: Cardiovascular System, Cyclic Peptides, Grk2 Inhibitors, Nmr Conformational Analysis, Cyclopeptide, G Protein Coupled Receptor Kinase 2, G Protein Coupled Receptor Kinase 2 Inhibitor, Lactam Derivative, Protein Serine Threonine Kinase Inhibitor, Unclassified Drug, Article, Controlled Study, Drug Conformation, Drug Design, Drug Efficacy, Drug Potency, Drug Selectivity, Drug Synthesis, Enzyme Inhibition, Enzyme Structure, Human, Human Cell, Nuclear Magnetic Resonance Spectroscopy, Nuclear Overhauser Effect, Peptide Library, Protein Structure, 7-Pentamethyldihydro Benzofuran-5-Sulfonyl, 2-(1h-Benzotriazole-1-Yl)-1, 3-Tetramethyluronium Hexafluoro-Phosphate, 9-Fluorenyl-Methoxycarbonyl, Adenosine Triphosphate, Cyclic Adenosine Monophosphate, Dichloromethane, Dipea, Dodecylphosphocholine, Egta, Electrospray Ionization, Ethylene Diamine Tetraacetic Acid, Ethylene Glycol Tetraacetic Acid, Fmoc, Hbtu, Liquid Chromatography Quadrupole Mass Spectrometry, N-Diisopropylethyl-Amine, N-Dimethylformamide, N-Hydroxy-Benzotriazole, Pr(3)sih Or Tis, Reversed-Phase High Performance Liquid Chromatography, Rp-Hplc, Structure-Activity Relationship, Trifluoroacetic Acid, Triisopropylsilane, Trityl, Dose-Response Relationship, G-Protein-Coupled Receptor Kinase 2, Models, Molecular, Protein Kinase Inhibitors,
Affiliations:
*** IBB - CNR ***
Dipartimento di Farmacia Federico II, University of Naples, Italy
Dipartimento di Scienze Biomediche Avanzate Federico II, University of Naples, Italy
Dipartimento di Medicina e Chirurgia, University of Salerno, Italy
IRCCS Multimedica, Milano, Italy
Pharmaceutical Science, University of Salerno, Salerno, Italy
References:
Not available.
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.432, 5-year impact factor: 4.071
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884612383&partnerID=40&md5=063cc3be44019c0b56a4b4f89b7435ab
Keywords: Cardiovascular System, Cyclic Peptides, Grk2 Inhibitors, Nmr Conformational Analysis, Cyclopeptide, G Protein Coupled Receptor Kinase 2, G Protein Coupled Receptor Kinase 2 Inhibitor, Lactam Derivative, Protein Serine Threonine Kinase Inhibitor, Unclassified Drug, Article, Controlled Study, Drug Conformation, Drug Design, Drug Efficacy, Drug Potency, Drug Selectivity, Drug Synthesis, Enzyme Inhibition, Enzyme Structure, Human, Human Cell, Nuclear Magnetic Resonance Spectroscopy, Nuclear Overhauser Effect, Peptide Library, Protein Structure, 7-Pentamethyldihydro Benzofuran-5-Sulfonyl, 2-(1h-Benzotriazole-1-Yl)-1, 3-Tetramethyluronium Hexafluoro-Phosphate, 9-Fluorenyl-Methoxycarbonyl, Adenosine Triphosphate, Cyclic Adenosine Monophosphate, Dichloromethane, Dipea, Dodecylphosphocholine, Egta, Electrospray Ionization, Ethylene Diamine Tetraacetic Acid, Ethylene Glycol Tetraacetic Acid, Fmoc, Hbtu, Liquid Chromatography Quadrupole Mass Spectrometry, N-Diisopropylethyl-Amine, N-Dimethylformamide, N-Hydroxy-Benzotriazole, Pr(3)sih Or Tis, Reversed-Phase High Performance Liquid Chromatography, Rp-Hplc, Structure-Activity Relationship, Trifluoroacetic Acid, Triisopropylsilane, Trityl, Dose-Response Relationship, G-Protein-Coupled Receptor Kinase 2, Models, Molecular, Protein Kinase Inhibitors,
Affiliations:
*** IBB - CNR ***
Dipartimento di Farmacia Federico II, University of Naples, Italy
Dipartimento di Scienze Biomediche Avanzate Federico II, University of Naples, Italy
Dipartimento di Medicina e Chirurgia, University of Salerno, Italy
IRCCS Multimedica, Milano, Italy
Pharmaceutical Science, University of Salerno, Salerno, Italy
References:
Not available.
Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors
G protein-coupled receptor kinase 2 (GRK2) is a relevant signaling node of the cellular transduction network, playing major roles in the physiology of various organs/tissues including the heart and blood vessels. Emerging evidence suggests that GRK2 is up regulated in pathological situations such as heart failure, hypertrophy and hypertension, and its inhibition offers a potential therapeutic solution to these diseases. We explored the GRK2 inhibitory activity of a library of cyclic peptides derived from the HJ loop of G protein-coupled receptor kinases 2 (GRK2). The design of these cyclic compounds was based on the conformation of the HJ loop within the X-ray structure of GRK2. One of these compounds, the cyclic peptide 7, inhibited potently and selectively the GRK2 activity, being more active than its linear precursor. In a cellular system, this peptide confirms the beneficial signaling properties of a potent GRK2 inhibitor. Preferred conformations of the most potent analog were investigated by NMR spectroscopy. © 2013 Published by Elsevier Masson SAS.
G protein-coupled receptor kinase 2 (GRK2) is a relevant signaling node of the cellular transduction network, playing major roles in the physiology of various organs/tissues including the heart and blood vessels. Emerging evidence suggests that GRK2 is up regulated in pathological situations such as heart failure, hypertrophy and hypertension, and its inhibition offers a potential therapeutic solution to these diseases. We explored the GRK2 inhibitory activity of a library of cyclic peptides derived from the HJ loop of G protein-coupled receptor kinases 2 (GRK2). The design of these cyclic compounds was based on the conformation of the HJ loop within the X-ray structure of GRK2. One of these compounds, the cyclic peptide 7, inhibited potently and selectively the GRK2 activity, being more active than its linear precursor. In a cellular system, this peptide confirms the beneficial signaling properties of a potent GRK2 inhibitor. Preferred conformations of the most potent analog were investigated by NMR spectroscopy. © 2013 Published by Elsevier Masson SAS.
Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors
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Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors
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Impact Factor: 2.425
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Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Non-Covalent Interactions in Cyclopeptide Proton Complex Formation in Aqueous Solution (308 views)
Thermochim Acta, 1989; 154: 97-106.
Impact Factor: 0
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Betocchi S, Cuocolo A, Pace L, Chiariello M, Trimarco B, Alfano B, Ricciardelli B, Salvatore M, Condorelli M
Effects of intravenous verapamil administration on left ventricular diastolic function in systemic hypertension (795 views)
Am J Cardiol (ISSN: 0002-9149), 1987 Mar 1; 59(6): 624-629.
Impact Factor: 2.402
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Ferrara LA, Mancini M, Marotta T, Pasanisi F, Fasano ML
Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol (943 views)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1986; 29(6): 717-719.
Impact Factor: 1.219
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Ferrara LA, Strazzullo P, Scillitani A, Mancini M, Gagliardi R
Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients (736 views)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1985; 28(3): 241-244.
Impact Factor: 1.219
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Vosa C, Lapenta L, Caianiello G, Esposito V, de LucaL, D'Angelo TS, Salvatore M
Pre- and postoperative Tc 99m scanning in monitoring pulmonary perfusion in the tetralogy of Fallot (716 views)
Ital J Surg Sci (ISSN: 0392-3525), 1984; 14(1): 21-24.
Impact Factor: 0
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* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (270 views)
Chembiochem (ISSN: 1439-4227linking, 1439-7633), 2020 Mar 2; 21(5): 702-711.
Impact Factor: 2.641
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Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (885 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* Conformational stabilization of a beta-hairpin through a triazole-tryptophan interaction (365 views)
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
Impact Factor: 3.451
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Calvanese L, Caporale A, Focà G, Iaccarino E, Sandomenico A, Doti N, Apicella I, Incisivo GM, De Falco S, Falcigno L, D’auria G, Ruvo M
* Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications (586 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2017 Dec 2; 50(2): 321-329.
Impact Factor: 2.906
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Greco A, Coda ARD, Albanese S, Ragucci M, Liuzzi R, Auletta L, Gargiulo S, Lamagna F, Salvatore M, Mancini M
* High-Frequency Ultrasound for the Study of Early Mouse Embryonic Cardiovascular System (352 views)
Reprod Sci (ISSN: 1933-7191), 2015 Dec; 22(12): 1649-1655.
Impact Factor: 2.429
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di Villa Bianca R, Mitidieri E, Donnarumma E, Fusco F, Longo N, Rosa GD, Novellino E, Grieco P, Mirone V, Cirino G, Sorrentino R
* A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands (492 views)
Asian J Androl (ISSN: 1008-682x), 2015 Jan; 17(1): 81-85.
Impact Factor: 2.644
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (535 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (584 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (513 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Saviano M, Del Gatto A, De Simone M, De Paola I, Saviano M, Zaccaro L
* Investigation of the Best Conditions to Obtain c(RGDfK) Peptide on Solid Phase (530 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2011 Mar; 17(1): 39-45.
Impact Factor: 0.986
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (510 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (524 views)
J Transl Med (ISSN: 1479-5876electronic, 1479-5876linking), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2202 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (583 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Amodeo P, Castello G, De Luca S, Scala S, Siani A, Vitale RM
* CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES (488 views)
Patent, 2010; PctWo2011092575: Pct-Pct.
Impact Factor: 0
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (489 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (1244 views)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (425 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (594 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (458 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Benedetti E, Pedone C
* Cyclolinopeptide A: inhibitor, immunosuppressor or other? (578 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2005 May; 11(5): 268-272.
Impact Factor: 1.803
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (564 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (403 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Clemente F, D'Avino E, Guaragno M, Menichetti A
* An on line technique to detect cardiac output variations and cardiovascular performances during abdominal aortic surgery (549 views)
Journal Of Clinical Monitoring And Computing (ISSN: 1387-1307), 2004 Apr; 18(2): 81-87.
Impact Factor: 0.888
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Kozarski M, Ferrari G, Clemente F, Gorczynska K, De Lazzari C, Darowski M, Mimmo R, Tosti G, Guaragno M
* A hybrid mock circulatory system: development and testing of an electro-hydraulic impedance simulator (356 views)
Int J Artif Organs (ISSN: 0391-3988, 0391-3988print), 2003 Jan; 26(1): 53-63.
Impact Factor: 0.964
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Biondi B, Palmieri EA, Pagano L, Klain M, Scherillo G, Salvatore M, Fenzi G, Lombardi G, Fazio S
* Cardiovascular safety of acute recombinant human thyrotropin administration to patients monitored for differentiated thyroid cancer (413 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Jan; 88(1): 211-214.
Impact Factor: 5.873
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Ferrari G, De Lazzari C, Kozarski M, Clemente F, Górczy ska K, Mimmo R, Monnanni E, Tosti G, Guaragno M
* A hybrid mock circulatory system: Testing a prototype under physiologic and pathological conditions (252 views)
Asaio Journal (ISSN: 1058-2916), 2002 Sep; 48(5): 487-494.
Impact Factor: 1.043
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (457 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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De Lazzari C, Darowski M, Ferrari G, Clemente F, Guaragno M
* Energetic parameter changes with mechanical ventilation in conjunction with BVAD assistance (573 views)
J Med Eng Technol (ISSN: 0309-1902), 2002 Mar; 26(2): 63-70.
Impact Factor: 0.538
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Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (466 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001 Mar 16; 7(6): 1176-1183.
Impact Factor: 4.614
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Monti SM, Gallo M, Ferracane R, Borrelli RC, Ritieni A, Greco ML, Graniti A, Fogliano V
* Analysis of bacterial lipodepsipeptides by matrix-assisted laser desorption/ionisation time-of-flight and high-performance liquid chromatography with electrospray mass spectrometry (437 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic), 2001; 15(8): 623-628.
Impact Factor: 2.478
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (394 views)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
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Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (738 views)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
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Lombardi A, D'Agostino B, Nastri F, D'Andrea LD, Filippelli A, Falciani M, Rossi F, Pavone V
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine (495 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894xprint, 0960-894xlinking), 1998 May 19; 8(10): 1153-1156.
Impact Factor: 1.5
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Lombardi A, D'Auria G, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
A novel rigid β-turn molecular scaffold (472 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1998; 120(24): 5879-5886.
Impact Factor: 5.725
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Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (454 views)
Journal Of The Chemical Society Dalton Transactions (ISSN: 0300-9246), 1998; (22): 3851-3857.
Impact Factor: 2.507
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D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (382 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
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Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
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Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (518 views)
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
Impact Factor: 0
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Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A
Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide (406 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1995 Oct; 26(12): 453-460.
Impact Factor: 2.572
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Mazzeo M, Isernia C, Rossi F, Saviano M, Pedone C, Paolillo L, Benedetti E, Pavone V
Conformational Behaviour of a Cyclolinopeptide A Analogue: Two-dimensional NMR study of cyclo(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-ala-Val(8)) (320 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1995 Sep; 1(5): 330-340.
Impact Factor: 1.311
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (484 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C
[Aib5, 6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture (325 views)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1995 Apr 15; 51: Pt-Pt.
Impact Factor: 0.459
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (618 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
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Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (464 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
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Rossi F, Saviano M, Di Blasio B, Zanotti G, Maione AM, Tancredi T, Pedone C
BIOACTIVE PEPTIDES - SOLID-STATE, SOLUTION AND MOLECULAR-DYNAMICS STUDIES OF A CYCLOLINOPEPTIDE-A RELATED CYSTINYL CYCLOPENTAPEPTIDE (458 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Feb; 34(2): 273-284.
Impact Factor: 2.425
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Di Blasio B, Lombardi A, D'Auria G, Saviano M, Isernia C, Maglio O, Paolillo L, Pedone C, Pavone V
Beta-Alanine Containing Peptides: Gamma-Turns In Cyclotetrapeptides (561 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Apr; 31(10): 621-631.
Impact Factor: 2.425
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DIBLASIO B, ROSSI F, BENEDETTI E, PAVONE V, SAVIANO M, PEDONE C, ZANOTTI G, TANCREDI T
BIOACTIVE PEPTIDES - X-RAY AND NMR CONFORMATIONAL STUDY OF [AIB(5, 6)-D-ALA(8)]CYCLOLINOPEPTIDE-A (443 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1992 Oct 7; 114(21): 8277-8283.
Impact Factor: 5.65
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Tancredi T, Benedetti E, Grimaldi M, Pedone C, Rossi F, Saviano M, Temussi PA, Zanotti G
Ion binding of cyclolinopeptide A: An NMR and CD conformational study (634 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1991 May; 31(6): 761-767.
Impact Factor: 2.425
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Cucinotta V, D'Alessandro F, Impellizzeri G, Pappalardo G, Rizzarelli E, Vecchio G
Cyclopeptide Functionalized beta-Cyclodextrin. A New Class of Potentially Enzyme Mimicking Compound with Two Recognition Sites (268 views)
Chem Commun, 1991; N/D: 293-294.
Impact Factor: 0
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Tancredi T, Zanotti G, Rossi F, Benedetti E, Pedone C, Temussi PA
Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (423 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 513-523.
Impact Factor: 2.425
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Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Non-Covalent Interactions in Cyclopeptide Proton Complex Formation in Aqueous Solution (308 views)
Thermochim Acta, 1989; 154: 97-106.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Betocchi S, Cuocolo A, Pace L, Chiariello M, Trimarco B, Alfano B, Ricciardelli B, Salvatore M, Condorelli M
Effects of intravenous verapamil administration on left ventricular diastolic function in systemic hypertension (795 views)
Am J Cardiol (ISSN: 0002-9149), 1987 Mar 1; 59(6): 624-629.
Impact Factor: 2.402
View Export to BibTeX Export to EndNote
Ferrara LA, Mancini M, Marotta T, Pasanisi F, Fasano ML
Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol (943 views)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1986; 29(6): 717-719.
Impact Factor: 1.219
View Export to BibTeX Export to EndNote
Ferrara LA, Strazzullo P, Scillitani A, Mancini M, Gagliardi R
Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients (736 views)
Eur J Clin Pharmacol Springer Verlag (ISSN: 0031-6970, 1432-1041), 1985; 28(3): 241-244.
Impact Factor: 1.219
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Vosa C, Lapenta L, Caianiello G, Esposito V, de LucaL, D'Angelo TS, Salvatore M
Pre- and postoperative Tc 99m scanning in monitoring pulmonary perfusion in the tetralogy of Fallot (716 views)
Ital J Surg Sci (ISSN: 0392-3525), 1984; 14(1): 21-24.
Impact Factor: 0
View Export to BibTeX Export to EndNote
57 Records (55 excluding Abstracts).
Total impact factor: 156.967 (152.974 excluding Abstracts).
Total 5 year impact factor: 161.75 (157.083 excluding Abstracts).
Total impact factor: 156.967 (152.974 excluding Abstracts).
Total 5 year impact factor: 161.75 (157.083 excluding Abstracts).
647 views. Last view on Friday 15 September 2023, 0:30:01
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