Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (423 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.873, 5-year impact factor: 6.984
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865816275&partnerID=40&md5=d6010fc4507eee0ca2e5b179d71383a5
Keywords: Angiogenesis, Catecholamines, Endothelium, Ischemia, Adrenalin, Aromatic Levo Amino Acid Decarboxylase, Cyclic Amp, Cyclic Amp Dependent Protein Kinase, Dopamine Beta Monooxygenase, Noradrenalin, Phenylethanolamine N Methyltransferase, Tyrosine 3 Monooxygenase, 3 Isopropylamino 1 (7 Methyl 4 Indanyloxy) 2 Butanol, Beta 2 Adrenergic Receptor, Beta Adrenergic Receptor Blocking Agent, Cyclic Amp Responsive Element Binding Protein, Isoquinoline Derivative, N (2 (4 Bromocinnamylamino)ethyl) 5 Isoquinolinesulfonamide, N-(2-(4-Bromocinnamylamino)ethyl)-5-Isoquinolinesulfonamide, Propanolamine Derivative, Animal Cell, Animal Experiment, Article, Controlled Study, Endothelium Cell, Enzyme Synthesis, Hypoxia, Immunohistochemistry, In Vitro Study, In Vivo Study, Mouse, Nonhuman, Priority Journal, Protein Expression, Signal Transduction, Biosynthesis, C57bl Mouse, Cattle, Cell Culture, Cell Hypoxia, Drug Antagonism, Femoral Artery, Genetics, Hindlimb, Metabolism, Reverse Transcription Polymerase Chain Reaction, Secretion, Vascular Endothelium, Vascularization, Western Blotting, Adrenergic Beta-Antagonists, Cyclic Amp Response Element-Binding Protein, Cyclic Amp-Dependent Protein Kinases, Dopa Decarboxylase, Dopamine Beta-Hydroxylase, Endothelial Cells, Inbred C57bl, Reverse Transcriptase Polymerase Chain Reaction, Tyrosine 3-Monooxygenase,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Naples, Italy
Università degli Studi di Salerno, Salerno, Italy
Istituto Di Ricovero e Cura a Carattere Scientifico Multimedica, Milan, Italy
References:
Aird, W.C., Phenotypic heterogeneity of the endothelium: I-structure, function, and mechanisms (2007) Circ Res., 100, pp. 158-17
Cook-Mills, J.M., Deem, T.L., Active participation of endothelial cells in inflammation (2005) J Leukoc Biol., 77, pp. 487-495
Lamalice, L., Le Boeuf, F., Huot, J., Endothelial cell migration during angiogenesis (2007) Circ Res., 100, pp. 782-794
Vanhoutte, P.M., Endothelial dysfunction and atherosclerosis (1997) Eur Heart J., 18 (SUPPL. E), pp. E19-E29
Carmeliet, P., Jain, R.K., Molecular mechanisms and clinical applications of angiogenesis (2011) Nature, 473, pp. 298-307
Sumpio, B.E., Riley, J.T., Dardik, A., Cells in focus: Endothelial cell (2002) Int J Biochem Cell Biol., 34, pp. 1508-1512
Bowen-Pope, D.F., Hart, C.E., Seifert, R.A., Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor (1989) J Biol Chem., 264, pp. 2502-2508
Gellai, M., De Wolf, R., Fletcher, T., Nambi, P., Contribution of endogenous endothelin-1 to the maintenance of vascular tone: Role of nitric oxide (1997) Pharmacology, 55, pp. 299-308
Haynes, W.G., Webb, D.J., Endothelin as a regulator of cardiovascular function in health and disease (1998) J Hypertens, 16, pp. 1081-1098
Iadecola, C., Pelligrino, D.A., Moskowitz, M.A., Lassen, N.A., Nitric oxide synthase inhibition and cerebrovascular regulation (1994) J Cereb Blood Flow Metab., 14, pp. 175-192
Masaki, T., Endothelin in vascular biology (1994) Ann NY Acad Sci., 714, pp. 101-108
Moncada, S., Palmer, R.M., Higgs, E.A., Nitric oxide: Physiology, pathophysiology, and pharmacology (1991) Pharmacol Rev., 43, pp. 109-142
Rubanyi, G.M., Polokoff, M.A., Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology (1994) Pharmacol Rev., 46, pp. 325-415
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Masaki, T., A novel potent vasoconstrictor peptide produced by vascular endothelial cells (1988) Nature, 332, pp. 411-415
Ciccarelli, M., Santulli, G., Campanile, A., Galasso, G., Cervero, P., Altobelli, G.G., Cimini, V., Iaccarino, G., Endothelial α 1-adrenoceptors regulate neo-angiogenesis (2008) Br J Pharmacol., 153, pp. 936-946
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Koch, W.J., Trimarco, B., Beta (2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension (2002) Circulation, 106, pp. 349-355
Oswald, J., Boxberger, S., Jorgensen, B., Feldmann, S., Ehninger, G., Bornhauser, M., Werner, C., Mesenchymal stem cells can be differentiated into endothelial cells in vitro (2004) Stem Cells, 22, pp. 377-384
Bailey, A.S., Willenbring, H., Jiang, S., Anderson, D.A., Schroeder, D.A., Wong, M.H., Grompe, M., Fleming, W.H., Myeloid lineage progenitors give rise to vascular endothelium (2006) Proc Natl Acad Sci USA, 103, pp. 13156-13161
Elsheikh, E., Uzunel, M., He, Z., Holgersson, J., Nowak, G., Sumitran-Holgersson, S., Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity (2005) Blood, 106, pp. 2347-2355
Fujiyama, S., Amano, K., Uehira, K., Yoshida, M., Nishiwaki, Y., Nozawa, Y., Jin, D., Matsubara, H., Bone marrow monocyte lineage cells adhere on injured endothelium in a monocyte chemoattractant protein-1-dependent manner and accelerate reendothelialization as endothelial progenitor cells (2003) Circ Res., 93, pp. 980-989
Rehman, J., Li, J., Orschell, C.M., March, K.L., Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors (2003) Circulation, 107, pp. 1164-1169
Zhang, R., Yang, H., Li, M., Yao, Q., Chen, C., Acceleration of endothelial-like cell differentiation from CD14 + monocytes in vitro (2005) Exp Hematol., 33, pp. 1554-1563
Christenson, J.G., Dairman, W., Udenfriend, S., Preparation and properties of a homogeneous aromatic l-amino acid decarboxylase from hog kidney (1970) Arch Biochem Biophys., 141, pp. 356-367
Connett, R.J., Kirshner, N., Purification and properties of bovine phenylethanolamine n-methyltransferase (1970) J Biol Chem., 245, pp. 329-334
Craine, J.E., Daniels, G.H., Kaufman, S., Dopamine-β-hydroxylase: The subunit structure and anion activation of the bovine adrenal enzyme (1973) J Biol Chem., 248, pp. 7838-7844
Shiman, R., Akino, M., Kaufman, S., Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla (1971) J Biol Chem., 246, pp. 1330-1340
Axelrod, J., Weinshilboum, R., Catecholamines (1972) N Engl J Med., 287, pp. 237-242
Kopin, I.J., Monoamine oxidase and catecholamine metabolism (1994) J Neural Transm Suppl., 41, pp. 57-67
Eisenhofer, G., Kopin, I.J., Goldstein, D.S., Catecholamine metabolism: A contemporary view with implications for physiology and medicine (2004) Pharmacol Rev., 56, pp. 331-349
Josefsson, E., Bergquist, J., Ekman, R., Tarkowski, A., Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis (1996) Immunology, 88, pp. 140-146
Bergquist, J., Silberring, J., Identification of catecholamines in the immune system by electrospray ionization mass spectrometry (1998) Rapid Commun Mass Spectrom., 12, pp. 683-688
Marino, F., Cosentino, M., Bombelli, R., Ferrari, M., Lecchini, S., Frigo, G., Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells (1999) Exp Hematol., 27, pp. 489-495
Musso, N.R., Brenci, S., Setti, M., Indiveri, F., Lotti, G., Catecholamine content and in vitro catecholamine synthesis in peripheral human lymphocytes (1996) J Clin Endocrinol Metab., 81, pp. 3553-3557
Spengler, R.N., Chensue, S.W., Giacherio, D.A., Blenk, N., Kunkel, S.L., Endogenous norepinephrine regulates tumor necrosis factor-a production from macrophages in vitro (1994) J Immunol., 152, pp. 3024-3031
Cosentino, M., Fietta, A.M., Ferrari, M., Rasini, E., Bombelli, R., Carcano, E., Saporiti, F., Lecchini, S., Human CD4+ Cd25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop (2007) Blood, 109, pp. 632-642
Bergquist, J., Tarkowski, A., Ekman, R., Ewing, A., Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop (1994) Proc Natl Acad Sci USA, 91, pp. 12912-12916
Engler, K.L., Rudd, M.L., Ryan, J.J., Stewart, J.K., Fischer-Stenger, K., Autocrine actions of macrophage-derived catecholamines on interleukin-1β (2005) J Neuroimmunol., 160, pp. 87-91
Sorriento, D., Ciccarelli, M., Santulli, G., Campanile, A., Altobelli, G.G., Cimini, V., Galasso, G., Iaccarino, G., The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaBα (2008) Proc Natl Acad Sci USA, 105, pp. 17818-17823
Piech-Dumas, K.M., Tank, A.W., CREB mediates the camp-responsiveness of the tyrosine hydroxylase gene: Use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines (1999) Brain Res Mol Brain Res., 70, pp. 219-230
Lim, J., Yang, C., Hong, S.J., Kim, K.S., Regulation of tyrosine hydroxylase gene transcription by the cAMP-signaling pathway: Involvement of multiple transcription factors (2000) Mol Cell Biochem., 212, pp. 51-60
Ciccarelli, M., Sorriento, D., Cipolletta, E., Santulli, G., Fusco, A., Zhou, R.H., Eckhart, A.D., Iaccarino, G., Impaired neoangiogenesis in β-adrenoceptor gene-deficient mice: Restoration by intravascular human β-adrenoceptor gene transfer and role of NFkappaB and CREB transcription factors Br J Pharmacol., 162, pp. 712-721
Min, J., Jin, Y.M., Moon, J.S., Sung, M.S., Jo, S.A., Jo, I., Hypoxia-induced endothelial NO synthase gene transcriptional activation is mediated through the TAX-responsive element in endothelial cells (2006) Hypertension, 47, pp. 1189-1196
Gillbro, J.M., Marles, L.K., Hibberts, N.A., Schallreuter, K.U., Autocrine catecholamine biosynthesis and the β-adrenoceptor signal promote pigmentation in human epidermal melanocytes (2004) J Invest Dermatol., 123, pp. 346-353
Bayer, V.E., Pickel, V.M., Ultrastructural localization of tyrosine hydroxylase in the rat ventral tegmental area: Relationship between immunolabeling density and neuronal associations (1990) J Neurosci., 10, pp. 2996-3013
Isermann, B., Hendrickson, S.B., Zogg, M., Wing, M., Cummiskey, M., Kisanuki, Y.Y., Yanagisawa, M., Weiler, H., Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis (2001) J Clin Invest., 108, pp. 537-546
Nathan, C., Points of control in inflammation (2002) Nature, 420, pp. 846-852
Pearson, J.D., Endothelial cell function and thrombosis (1999) Baillieres Best Pract Res Clin Haematol., 12, pp. 329-341
Sidelmann, J.J., Gram, J., Jespersen, J., Kluft, C., Fibrin clot formation and lysis: Basic mechanisms (2000) Semin Thromb Hemost., 26, pp. 605-618
Yancopoulos, G.D., Davis, S., Gale, N.W., Rudge, J.S., Wiegand, S.J., Holash, J., Vascular-specific growth factors and blood vessel formation (2000) Nature, 407, pp. 242-248
Folkman, J., Endothelial cells and angiogenic growth factors in cancer growth and metastasis: Introduction (1990) Cancer Metastasis Rev., 9, pp. 171-174
Palmer, R.M., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327, pp. 524-526
Barry, O.P., Pratico, D., Lawson, J.A., Fitz Gerald, G.A., Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles (1997) J Clin Invest., 99, pp. 2118-2127
Borovsky, V., Herman, M., Dunphy, G., Caplea, A., Ely, D., Co2 asphyxia increases plasma norepinephrine in rats via sympathetic nerves (1998) Am J Physiol., 274, pp. R19-R22
Chalothorn, D., Zhang, H., Clayton, J.A., Thomas, S.A., Faber, J.E., Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia (2005) Am J Physiol Heart Circ Physiol., 289, pp. H947-H959
Candipan, R.C., Hsiun, P.T., Pratt, R., Cooke, J.P., Vascular injury augments adrenergic neurotransmission (1994) Circulation, 89, pp. 777-784
Baranczyk-Kuzma, A., Audus, K.L., Borchardt, R.T., Catecholaminemetabolizing enzymes of bovine brain microvessel endothelial cell monolayers (1986) J Neurochem., 46, pp. 1956-1960
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.873, 5-year impact factor: 6.984
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865816275&partnerID=40&md5=d6010fc4507eee0ca2e5b179d71383a5
Keywords: Angiogenesis, Catecholamines, Endothelium, Ischemia, Adrenalin, Aromatic Levo Amino Acid Decarboxylase, Cyclic Amp, Cyclic Amp Dependent Protein Kinase, Dopamine Beta Monooxygenase, Noradrenalin, Phenylethanolamine N Methyltransferase, Tyrosine 3 Monooxygenase, 3 Isopropylamino 1 (7 Methyl 4 Indanyloxy) 2 Butanol, Beta 2 Adrenergic Receptor, Beta Adrenergic Receptor Blocking Agent, Cyclic Amp Responsive Element Binding Protein, Isoquinoline Derivative, N (2 (4 Bromocinnamylamino)ethyl) 5 Isoquinolinesulfonamide, N-(2-(4-Bromocinnamylamino)ethyl)-5-Isoquinolinesulfonamide, Propanolamine Derivative, Animal Cell, Animal Experiment, Article, Controlled Study, Endothelium Cell, Enzyme Synthesis, Hypoxia, Immunohistochemistry, In Vitro Study, In Vivo Study, Mouse, Nonhuman, Priority Journal, Protein Expression, Signal Transduction, Biosynthesis, C57bl Mouse, Cattle, Cell Culture, Cell Hypoxia, Drug Antagonism, Femoral Artery, Genetics, Hindlimb, Metabolism, Reverse Transcription Polymerase Chain Reaction, Secretion, Vascular Endothelium, Vascularization, Western Blotting, Adrenergic Beta-Antagonists, Cyclic Amp Response Element-Binding Protein, Cyclic Amp-Dependent Protein Kinases, Dopa Decarboxylase, Dopamine Beta-Hydroxylase, Endothelial Cells, Inbred C57bl, Reverse Transcriptase Polymerase Chain Reaction, Tyrosine 3-Monooxygenase,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Naples, Italy
Università degli Studi di Salerno, Salerno, Italy
Istituto Di Ricovero e Cura a Carattere Scientifico Multimedica, Milan, Italy
References:
Aird, W.C., Phenotypic heterogeneity of the endothelium: I-structure, function, and mechanisms (2007) Circ Res., 100, pp. 158-17
Cook-Mills, J.M., Deem, T.L., Active participation of endothelial cells in inflammation (2005) J Leukoc Biol., 77, pp. 487-495
Lamalice, L., Le Boeuf, F., Huot, J., Endothelial cell migration during angiogenesis (2007) Circ Res., 100, pp. 782-794
Vanhoutte, P.M., Endothelial dysfunction and atherosclerosis (1997) Eur Heart J., 18 (SUPPL. E), pp. E19-E29
Carmeliet, P., Jain, R.K., Molecular mechanisms and clinical applications of angiogenesis (2011) Nature, 473, pp. 298-307
Sumpio, B.E., Riley, J.T., Dardik, A., Cells in focus: Endothelial cell (2002) Int J Biochem Cell Biol., 34, pp. 1508-1512
Bowen-Pope, D.F., Hart, C.E., Seifert, R.A., Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor (1989) J Biol Chem., 264, pp. 2502-2508
Gellai, M., De Wolf, R., Fletcher, T., Nambi, P., Contribution of endogenous endothelin-1 to the maintenance of vascular tone: Role of nitric oxide (1997) Pharmacology, 55, pp. 299-308
Haynes, W.G., Webb, D.J., Endothelin as a regulator of cardiovascular function in health and disease (1998) J Hypertens, 16, pp. 1081-1098
Iadecola, C., Pelligrino, D.A., Moskowitz, M.A., Lassen, N.A., Nitric oxide synthase inhibition and cerebrovascular regulation (1994) J Cereb Blood Flow Metab., 14, pp. 175-192
Masaki, T., Endothelin in vascular biology (1994) Ann NY Acad Sci., 714, pp. 101-108
Moncada, S., Palmer, R.M., Higgs, E.A., Nitric oxide: Physiology, pathophysiology, and pharmacology (1991) Pharmacol Rev., 43, pp. 109-142
Rubanyi, G.M., Polokoff, M.A., Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology (1994) Pharmacol Rev., 46, pp. 325-415
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Masaki, T., A novel potent vasoconstrictor peptide produced by vascular endothelial cells (1988) Nature, 332, pp. 411-415
Ciccarelli, M., Santulli, G., Campanile, A., Galasso, G., Cervero, P., Altobelli, G.G., Cimini, V., Iaccarino, G., Endothelial α 1-adrenoceptors regulate neo-angiogenesis (2008) Br J Pharmacol., 153, pp. 936-946
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Koch, W.J., Trimarco, B., Beta (2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension (2002) Circulation, 106, pp. 349-355
Oswald, J., Boxberger, S., Jorgensen, B., Feldmann, S., Ehninger, G., Bornhauser, M., Werner, C., Mesenchymal stem cells can be differentiated into endothelial cells in vitro (2004) Stem Cells, 22, pp. 377-384
Bailey, A.S., Willenbring, H., Jiang, S., Anderson, D.A., Schroeder, D.A., Wong, M.H., Grompe, M., Fleming, W.H., Myeloid lineage progenitors give rise to vascular endothelium (2006) Proc Natl Acad Sci USA, 103, pp. 13156-13161
Elsheikh, E., Uzunel, M., He, Z., Holgersson, J., Nowak, G., Sumitran-Holgersson, S., Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity (2005) Blood, 106, pp. 2347-2355
Fujiyama, S., Amano, K., Uehira, K., Yoshida, M., Nishiwaki, Y., Nozawa, Y., Jin, D., Matsubara, H., Bone marrow monocyte lineage cells adhere on injured endothelium in a monocyte chemoattractant protein-1-dependent manner and accelerate reendothelialization as endothelial progenitor cells (2003) Circ Res., 93, pp. 980-989
Rehman, J., Li, J., Orschell, C.M., March, K.L., Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors (2003) Circulation, 107, pp. 1164-1169
Zhang, R., Yang, H., Li, M., Yao, Q., Chen, C., Acceleration of endothelial-like cell differentiation from CD14 + monocytes in vitro (2005) Exp Hematol., 33, pp. 1554-1563
Christenson, J.G., Dairman, W., Udenfriend, S., Preparation and properties of a homogeneous aromatic l-amino acid decarboxylase from hog kidney (1970) Arch Biochem Biophys., 141, pp. 356-367
Connett, R.J., Kirshner, N., Purification and properties of bovine phenylethanolamine n-methyltransferase (1970) J Biol Chem., 245, pp. 329-334
Craine, J.E., Daniels, G.H., Kaufman, S., Dopamine-β-hydroxylase: The subunit structure and anion activation of the bovine adrenal enzyme (1973) J Biol Chem., 248, pp. 7838-7844
Shiman, R., Akino, M., Kaufman, S., Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla (1971) J Biol Chem., 246, pp. 1330-1340
Axelrod, J., Weinshilboum, R., Catecholamines (1972) N Engl J Med., 287, pp. 237-242
Kopin, I.J., Monoamine oxidase and catecholamine metabolism (1994) J Neural Transm Suppl., 41, pp. 57-67
Eisenhofer, G., Kopin, I.J., Goldstein, D.S., Catecholamine metabolism: A contemporary view with implications for physiology and medicine (2004) Pharmacol Rev., 56, pp. 331-349
Josefsson, E., Bergquist, J., Ekman, R., Tarkowski, A., Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis (1996) Immunology, 88, pp. 140-146
Bergquist, J., Silberring, J., Identification of catecholamines in the immune system by electrospray ionization mass spectrometry (1998) Rapid Commun Mass Spectrom., 12, pp. 683-688
Marino, F., Cosentino, M., Bombelli, R., Ferrari, M., Lecchini, S., Frigo, G., Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells (1999) Exp Hematol., 27, pp. 489-495
Musso, N.R., Brenci, S., Setti, M., Indiveri, F., Lotti, G., Catecholamine content and in vitro catecholamine synthesis in peripheral human lymphocytes (1996) J Clin Endocrinol Metab., 81, pp. 3553-3557
Spengler, R.N., Chensue, S.W., Giacherio, D.A., Blenk, N., Kunkel, S.L., Endogenous norepinephrine regulates tumor necrosis factor-a production from macrophages in vitro (1994) J Immunol., 152, pp. 3024-3031
Cosentino, M., Fietta, A.M., Ferrari, M., Rasini, E., Bombelli, R., Carcano, E., Saporiti, F., Lecchini, S., Human CD4+ Cd25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop (2007) Blood, 109, pp. 632-642
Bergquist, J., Tarkowski, A., Ekman, R., Ewing, A., Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop (1994) Proc Natl Acad Sci USA, 91, pp. 12912-12916
Engler, K.L., Rudd, M.L., Ryan, J.J., Stewart, J.K., Fischer-Stenger, K., Autocrine actions of macrophage-derived catecholamines on interleukin-1β (2005) J Neuroimmunol., 160, pp. 87-91
Sorriento, D., Ciccarelli, M., Santulli, G., Campanile, A., Altobelli, G.G., Cimini, V., Galasso, G., Iaccarino, G., The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaBα (2008) Proc Natl Acad Sci USA, 105, pp. 17818-17823
Piech-Dumas, K.M., Tank, A.W., CREB mediates the camp-responsiveness of the tyrosine hydroxylase gene: Use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines (1999) Brain Res Mol Brain Res., 70, pp. 219-230
Lim, J., Yang, C., Hong, S.J., Kim, K.S., Regulation of tyrosine hydroxylase gene transcription by the cAMP-signaling pathway: Involvement of multiple transcription factors (2000) Mol Cell Biochem., 212, pp. 51-60
Ciccarelli, M., Sorriento, D., Cipolletta, E., Santulli, G., Fusco, A., Zhou, R.H., Eckhart, A.D., Iaccarino, G., Impaired neoangiogenesis in β-adrenoceptor gene-deficient mice: Restoration by intravascular human β-adrenoceptor gene transfer and role of NFkappaB and CREB transcription factors Br J Pharmacol., 162, pp. 712-721
Min, J., Jin, Y.M., Moon, J.S., Sung, M.S., Jo, S.A., Jo, I., Hypoxia-induced endothelial NO synthase gene transcriptional activation is mediated through the TAX-responsive element in endothelial cells (2006) Hypertension, 47, pp. 1189-1196
Gillbro, J.M., Marles, L.K., Hibberts, N.A., Schallreuter, K.U., Autocrine catecholamine biosynthesis and the β-adrenoceptor signal promote pigmentation in human epidermal melanocytes (2004) J Invest Dermatol., 123, pp. 346-353
Bayer, V.E., Pickel, V.M., Ultrastructural localization of tyrosine hydroxylase in the rat ventral tegmental area: Relationship between immunolabeling density and neuronal associations (1990) J Neurosci., 10, pp. 2996-3013
Isermann, B., Hendrickson, S.B., Zogg, M., Wing, M., Cummiskey, M., Kisanuki, Y.Y., Yanagisawa, M., Weiler, H., Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis (2001) J Clin Invest., 108, pp. 537-546
Nathan, C., Points of control in inflammation (2002) Nature, 420, pp. 846-852
Pearson, J.D., Endothelial cell function and thrombosis (1999) Baillieres Best Pract Res Clin Haematol., 12, pp. 329-341
Sidelmann, J.J., Gram, J., Jespersen, J., Kluft, C., Fibrin clot formation and lysis: Basic mechanisms (2000) Semin Thromb Hemost., 26, pp. 605-618
Yancopoulos, G.D., Davis, S., Gale, N.W., Rudge, J.S., Wiegand, S.J., Holash, J., Vascular-specific growth factors and blood vessel formation (2000) Nature, 407, pp. 242-248
Folkman, J., Endothelial cells and angiogenic growth factors in cancer growth and metastasis: Introduction (1990) Cancer Metastasis Rev., 9, pp. 171-174
Palmer, R.M., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327, pp. 524-526
Barry, O.P., Pratico, D., Lawson, J.A., Fitz Gerald, G.A., Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles (1997) J Clin Invest., 99, pp. 2118-2127
Borovsky, V., Herman, M., Dunphy, G., Caplea, A., Ely, D., Co2 asphyxia increases plasma norepinephrine in rats via sympathetic nerves (1998) Am J Physiol., 274, pp. R19-R22
Chalothorn, D., Zhang, H., Clayton, J.A., Thomas, S.A., Faber, J.E., Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia (2005) Am J Physiol Heart Circ Physiol., 289, pp. H947-H959
Candipan, R.C., Hsiun, P.T., Pratt, R., Cooke, J.P., Vascular injury augments adrenergic neurotransmission (1994) Circulation, 89, pp. 777-784
Baranczyk-Kuzma, A., Audus, K.L., Borchardt, R.T., Catecholaminemetabolizing enzymes of bovine brain microvessel endothelial cell monolayers (1986) J Neurochem., 46, pp. 1956-1960
Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo
Recently it has been demonstrated that catecholamines are produced and used by macrophages and mediate immune response. The aim of this study is to verify whether endothelial cells (ECs), which are of myeloid origin, can produce catecholamines. We demonstrated that genes coding for tyrosine hydroxylase, Dopa decarboxylase, dopamine β hydroxylase (DβH), and phenylethanolamine- iV-methyl transferase, enzymes involved in the synthesis of catecholamines, are all expressed in basal conditions in bovine aorta ECs, and their expression is enhanced in response to hypoxia. Moreover, hypoxia enhances catecholamine release. To evaluate the signal transduction pathway that regulates catecholamine synthesis in ECs, we overexpressed in bovine aorta ECs either protein kinase A (PKA) or the transcription factor cAMP response element binding, because PKA/cAMP response element binding activation induces tyrosine hydroxylase transcription and activity in response to stress. Both cAMP response element binding and PKA overexpression enhance DβH and phenylethanolamine-iV-methyl transferase gene expression and catecholamine release, whereas H89, inhibitor of PKA, exerts the opposite effect, evidencing the role of PKA/cAMP response element binding transduction pathway in the regulation of catecholamine release in bovine aorta ECs. We then evaluated by immunohistochemistry the expression of tyrosine hydroxylase, Dopa decarboxylase, DβH, and phenylethanolamine-iV-methyl transferase in femoral arteries from hindlimbs of C57Bl/6 mice 3 days after removal of the common femoral artery to induce chronic ischemia. Ischemia evokes tyrosine hydroxylase, Dopa decarboxylase, DβH, and phenylethanolamine-iV-methyl transferase expression in the endothelium. Finally, the pharmacological inhibition of catecholamine release by fusaric acid, an inhibitor of DβH, reduces the ability of ECs to form network-like structures on Matrigel matrix. In conclusion, our study demonstrates for the first time that ECs are able to synthesize and release catecholamines in response to ischemia. © 2012 American Heart Association, Inc.
Recently it has been demonstrated that catecholamines are produced and used by macrophages and mediate immune response. The aim of this study is to verify whether endothelial cells (ECs), which are of myeloid origin, can produce catecholamines. We demonstrated that genes coding for tyrosine hydroxylase, Dopa decarboxylase, dopamine β hydroxylase (DβH), and phenylethanolamine- iV-methyl transferase, enzymes involved in the synthesis of catecholamines, are all expressed in basal conditions in bovine aorta ECs, and their expression is enhanced in response to hypoxia. Moreover, hypoxia enhances catecholamine release. To evaluate the signal transduction pathway that regulates catecholamine synthesis in ECs, we overexpressed in bovine aorta ECs either protein kinase A (PKA) or the transcription factor cAMP response element binding, because PKA/cAMP response element binding activation induces tyrosine hydroxylase transcription and activity in response to stress. Both cAMP response element binding and PKA overexpression enhance DβH and phenylethanolamine-iV-methyl transferase gene expression and catecholamine release, whereas H89, inhibitor of PKA, exerts the opposite effect, evidencing the role of PKA/cAMP response element binding transduction pathway in the regulation of catecholamine release in bovine aorta ECs. We then evaluated by immunohistochemistry the expression of tyrosine hydroxylase, Dopa decarboxylase, DβH, and phenylethanolamine-iV-methyl transferase in femoral arteries from hindlimbs of C57Bl/6 mice 3 days after removal of the common femoral artery to induce chronic ischemia. Ischemia evokes tyrosine hydroxylase, Dopa decarboxylase, DβH, and phenylethanolamine-iV-methyl transferase expression in the endothelium. Finally, the pharmacological inhibition of catecholamine release by fusaric acid, an inhibitor of DβH, reduces the ability of ECs to form network-like structures on Matrigel matrix. In conclusion, our study demonstrates for the first time that ECs are able to synthesize and release catecholamines in response to ischemia. © 2012 American Heart Association, Inc.
Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo
Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (820 views)
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14494 views)
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Impact Factor: 4.414
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
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Impact Factor: 3.407
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
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Impact Factor: 9.432
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (536 views)
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
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Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
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Impact Factor: 1.654
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Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
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Impact Factor: 1.654
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (323 views)
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Impact Factor: 2.801
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
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Impact Factor: 9.38
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Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (720 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
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Impact Factor: 1.148
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
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Impact Factor: 2.507
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Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
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Impact Factor: 2.405
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Perrone-Filardi P, Cuocolo A, Brevetti G, Silvestro A, Storto G, Dellegrottaglie S, Corrado L, Cafiero M, Camerino R, Polimeno M, Zarrilli A, Caiazzo G, Maglione A, Petretta A, Chiariello M
* Sodium and diseases in the aged (260 views)
Clin Ter, 2005 Nov 1; 138(5-6): 199-205.
Impact Factor: 0.329
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (651 views)
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Impact Factor: 10.231
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
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Impact Factor: 9.408
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (460 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
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Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
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Impact Factor: 3.658
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (622 views)
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Impact Factor: 5.359
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (455 views)
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Impact Factor: 0.267
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* Thyroid Hormone Enhances Angiogenesis and the Warburg Effect in Squamous Cell Carcinomas (12 views)
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Impact Factor: 6.126
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Capasso D, Del Gatto A, Comegna D, Russo L, Fattorusso R, Saviano M, Di Gaetano S, Zaccaro L
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Impact Factor: 3.267
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Nawaz MI, Rezzola S, Tobia C, Coltrini D, Belleri M, Mitola S, Corsini M, Sandomenico A, Caporale A, Ruvo M, Presta M
* D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor (71 views)
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Impact Factor: 9.78
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Di Stasi R, Diana D, De Rosa L, Fattorusso R, D'Andrea LD
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Impact Factor: 2.275
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Cimmino I, Margheri F, Prisco F, Perruolo G, D'Esposito V, Laurenzana A, Fibbi G, Paciello O, Doti N, Ruvo M, Miele C, Beguinot F, Formisano P, Oriente F
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Impact Factor: 5.391
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (214 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
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Wang L, Coric P, Broussy S, Di Stasi R, Zhou L, D'Andrea LD, Ji L, Vidal M, Bouaziz S, Liu WQ
* Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain "2" (224 views)
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Impact Factor: 2.882
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Di Stasi R, De Rosa L, Diana D, Fattorusso R, D'Andrea LD
* Human Recombinant VEGFR2D4 Biochemical Characterization to Investigate Novel Anti-VEGFR2D4 Antibodies for Allosteric Targeting of VEGFR2 (287 views)
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Impact Factor: 2.275
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De Simone G
* Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350 (225 views)
Expert Opin Ther Pat (ISSN: 1744-7674electronic, 1354-3776linking), 2019 Jan; 29(1): 1-6.
Impact Factor: 3.699
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De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (473 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (337 views)
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Impact Factor: 5.16
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Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E
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Impact Factor: 8
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Crich SG, Terreno E, Aime S
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Adv Drug Deliver Rev (ISSN: 0169-409x), 2017 Sep 15; 119: 61-72.
Impact Factor: 13.66
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Monti M, Iommelli F, De Rosa V, Carriero MV, Miceli R, Camerlingo R, Di Minno G, Del Vecchio S
* Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells (386 views)
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Impact Factor: 2.766
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Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
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Impact Factor: 5.454
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
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Impact Factor: 3.975
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (261 views)
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Impact Factor: 0
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J
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Impact Factor: 0
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Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
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Frontiers In Medicinal Chemistry, 2016; 9: 103-160.
Impact Factor: 0
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Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (432 views)
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Impact Factor: 3.348
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (422 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (237 views)
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Impact Factor: 0.56
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
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Impact Factor: 3.205
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
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Impact Factor: 5.008
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Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
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Impact Factor: 5.683
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
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Impact Factor: 4.922
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
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Impact Factor: 3.447
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
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Impact Factor: 0.983
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Ruggiero D, Paolillo S, Ratta GD, Mariniello A, Formisano T, Pellegrino AM, Filardi PP
* [Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications] (321 views)
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Impact Factor: 7.132
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Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (383 views)
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Impact Factor: 1.862
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
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Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
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Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (471 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (478 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (589 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (367 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
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La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (523 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (554 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (523 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (481 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (480 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
* Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (402 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Impact Factor: 4.67
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (494 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (496 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (489 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (820 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14494 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (415 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (402 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (536 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (771 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (290 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (323 views)
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
Impact Factor: 2.801
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (462 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
Eur J Org Chem (ISSN: 1434-193x), 2007 Nov; (31): 5277-5283.
Impact Factor: 2.914
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (720 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (690 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (827 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Perrone-Filardi P, Cuocolo A, Brevetti G, Silvestro A, Storto G, Dellegrottaglie S, Corrado L, Cafiero M, Camerino R, Polimeno M, Zarrilli A, Caiazzo G, Maglione A, Petretta A, Chiariello M
* Sodium and diseases in the aged (260 views)
Clin Ter, 2005 Nov 1; 138(5-6): 199-205.
Impact Factor: 0.329
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (651 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (460 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (339 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (332 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (622 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (455 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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85 Records (82 excluding Abstracts).
Total impact factor: 381.017 (377.442 excluding Abstracts).
Total 5 year impact factor: 378.082 (373.449 excluding Abstracts).
Total impact factor: 381.017 (377.442 excluding Abstracts).
Total 5 year impact factor: 378.082 (373.449 excluding Abstracts).
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