Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor (678 views)
Diabetesdiabetes (ISSN: 0012-1797), 2012; 61(3): 692-701.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.895, 5-year impact factor: 8.611
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857393446&partnerID=40&md5=21bfc25ba07cf3af5c626629ad5d0da8
Keywords: Beta 2 Adrenergic Receptor, Glucose Transporter 2, Peroxisome Proliferator Activated Receptor Gamma, Transcription Factor Pdx 1, Adenovirus, Aging, Animal Cell, Animal Cell Culture, Animal Experiment, Animal Model, Animal Tissue, Article, Assay, Controlled Study, Ex Vivo Study, Gene Transfer, Glucose Homeostasis, Glucose Intolerance, Glucose Metabolism, In Vivo Study, Insulin Release, Insulinoma, Mouse, Nonhuman, Pancreas Islet Beta Cell, Phenotype, Priority Journal, Protein Expression, Wild Type, Age Factors, Glucose Tolerance Test, Glucose Transporter Type 2, Homeodomain Proteins, Mice, Inbred C57bl, Ppar Gamma, Trans-Activators,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy
Columbia-Presbyterian Medical Center, College of Physicians and Surgeons, Columbia University, New York, NY, United States
Columbia University Medical Center, Columbia University, New York, NY, United States
Department of Cellular and Molecular Biology and Pathology, Institute of Experimental Endocrinology and Oncology Gaetano Salvatore, Federico II University of Naples, Naples, Italy
School of Medicine, University of Salerno, Salerno, Italy
References:
Defronzo, R.A., Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus (2009) Diabetes, 58, pp. 773-79
Basu, R., Breda, E., Oberg, A.L., Powell, C.C., Man, C.D., Basu, A., Vittone, J.L., Rizza, R.A., Mechanisms of the age-associated deterioration in glucose tolerance: Contribution of alterations in insulin secretion, action, and clearance (2003) Diabetes, 52 (7), pp. 1738-1748
Gumbiner, B., Polonsky, K.S., Beltz, W.F., Wallace, P., Brechtel, G., Fink, R.I., Effects of Aging on Insulin Secretion (1989) Diabetes, 38 (12), pp. 1549-1556
Ma, X., Becker, D., Arena, V.C., Vicini, P., Greenbaum, C., The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: A population analysis (2009) J Clin Endocrinol Metab, 94, pp. 2446-2451
Reaven, E., Wright, D., Mondon, C.E., Effect of age and diet on insulin secretion and insulin action in the rat (1983) Diabetes, 32 (2), pp. 175-180
Perfetti, R., Rafizadeh, C.M., Liotta, A.S., Egan, J.M., Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats (1995) Am J Physiol, 269, pp. E983-E990
Ihm, S.-H., Matsumoto, I., Sawada, T., Nakano, M., Zhang, H.J., Ansite, J.D., Sutherland, D.E.R., Hering, B.J., Effect of donor age on function of isolated human islets (2006) Diabetes, 55 (5), pp. 1361-1368. , http://diabetes.diabetesjournals.org/cgi/content/full/55/5/1361, DOI 10.2337/db05-1333
Iozzo, P., Beck-Nielsen, H., Laakso, M., Smith, U., Yki-Jarvinen, H., Ferrannini, E., Independent influence of age on basal insulin secretion in nondiabetic humans (1999) Journal of Clinical Endocrinology and Metabolism, 84 (3), pp. 863-868
Rosengren, A.H., Jokubka, R., Tojjar, D., Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes (2010) Science, 327, pp. 217-220
Doyle, M.E., Egan, J.M., Pharmacological agents that directly modulate insulin secretion (2003) Pharmacological Reviews, 55 (1), pp. 105-131. , DOI 10.1124/pr.55.1.7
Lembo, G., Napoli, R., Capaldo, B., Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension (1992) J Clin Invest, 90, pp. 24-29
Seals, D.R., Esler, M.D., Human ageing and the sympathoadrenal system (2000) J Physiol, 528, pp. 407-417
Lembo, G., Capaldo, B., Rendina, V., Acute noradrenergic activation induces insulin resistance in human skeletal muscle (1994) Am J Physiol, 266, pp. E242-E247
Asensio, C., Jimenez, M., Kuhne, F., Rohner-Jeanrenaud, F., Muzzin, P., The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intolerance (2005) Diabetes, 54 (12), pp. 3490-3495. , http://diabetes.diabetesjournals.org/cgi/reprint/54/12/3490, DOI 10.2337/diabetes.54.12.3490
Haffner, C.A., Kendall, M.J., Metabolic effects of beta 2-agonists (1992) J Clin Pharm Ther, 17, pp. 155-164
Ikarashi, T., Hanyu, O., Maruyama, S., Souda, S., Kobayashi, C., Abe, E., Ukisu, J., Aizawa, Y., Genotype Gly/Gly of the Arg16Gly polymorphism of the beta 2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients (2004) Diabetes Research and Clinical Practice, 63 (1), pp. 11-18. , DOI 10.1016/j.diabres.2003.08.010
Scarpace, P.J., Mooradian, A.D., Morley, J.E., Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue (1988) J Gerontol, 43, pp. B65-B70
Xiao, R.-P., Tomhave, E.D., Wang, D.-J., Ji, X., Boluyt, M.O., Cheng, H., Lakatta, E.G., Koch, W.J., Age-associated reductions in cardiac beta 1- and beta 2-adrenergic responses without changes in inhibitory G proteins or receptor kinases (1998) Journal of Clinical Investigation, 101 (6), pp. 1273-1282
Schocken, D.D., Roth, G.S., Reduced beta adrenergic receptor concentrations in ageing man (1977) Nature, 267 (5614), pp. 856-858
Feldman, R.D., Limbird, L.E., Nadeau, J., Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly (1984) New England Journal of Medicine, 310 (13), pp. 815-819
Bao, X., Mills, P.J., Rana, B.K., Dimsdale, J.E., Schork, N.J., Smith, D.W., Rao, F., Ziegler, M.G., Interactive effects of common beta 2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function (2005) Hypertension, 46 (2), pp. 301-307. , DOI 10.1161/01.HYP.0000175842.19266.95
Kang, K.B., Rajanayagam, M.A.S., Van Der, Z.A., Majewski, H., A role for cyclooxygenase in aging-related changes of beta-adrenoceptor- mediated relaxation in rat aortas (2007) Naunyn-Schmiedeberg's Archives of Pharmacology, 375 (4), pp. 273-281. , DOI 10.1007/s00210-007-0153-y
Ryall, J.G., Plant, D.R., Gregorevic, P., Sillence, M.N., Lynch, G.S., Beta2-agonist administration reverses muscle wasting and improves muscle function in aged rats (2004) Journal of Physiology, 555 (1), pp. 175-188. , DOI 10.1113/jphysiol.2003.056770
White, M., Roden, R., Minobe, W., Khan, M.F., Larrabee, P., Wollmering, M., Port, J.D., Bristow, M.R., Age-related changes in beta-adrenergic neuroeffector systems in the human heart (1994) Circulation, 90 (3), pp. 1225-1238
Chruscinski, A.J., Rohrer, D.K., Schauble, E., Desai, K.H., Bernstein, D., Kobilka, B.K., Targeted disruption of the beta2 adrenergic receptor gene (1999) J Biol Chem, 274, pp. 16694-16700
Evans-Molina, C., Robbins, R.D., Kono, T., Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure (2009) Mol Cell Biol, 29, pp. 2053-2067
Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Molecular and Cellular Biology, 24 (11), pp. 5005-5015. , DOI 10.1128/MCB.24.11.5005-5015.2004
Santulli, G., Basilicata, M.F., De Simone, M., Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit (2011) J Transl Med, 9, p. 7
Sorriento, D., Santulli, G., Fusco, A., Anastasio, A., Trimarco, B., Iaccarino, G., Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression (2010) Hypertension, 56, pp. 696-704
Xie, T., Chen, M., Zhang, Q.H., Ma, Z., Weinstein, L.S., Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes (2007) Proc Natl Acad Sci USA, 104, pp. 19601-19606
Lombardi, A., Ulianich, L., Treglia, A.S., Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway (2012) Diabetologia, 55, pp. 141-153
Fiory, F., Lombardi, A., Miele, C., Giudicelli, J., Béguinot, F., Van Obberghen, E., Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E (2011) Diabetologia, 54, pp. 2941-2952
McGraw, D.W., Forbes, S.L., Mak, J.C., Transgenic overexpression of beta (2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction (2000) Am J Physiol Lung Cell Mol Physiol, 279, pp. L379-L389
Mutlu, G.M., Dumasius, V., Burhop, J., McShane, P.J., Meng, F.J., Welch, L., Dumasius, A., Factor, P., Upregulation of Alveolar Epithelial Active Na + Transport Is Dependent on beta 2-Adrenergic Receptor Signaling (2004) Circulation Research, 94 (8), pp. 1091-1100. , DOI 10.1161/01.RES.0000125623.56442.20
Ciccarelli, M., Sorriento, D., Cipolletta, E., Impaired neoangiogenesis in β 2-adrenoceptor gene-deficient mice: Restoration by intravascular human β 2- adrenoceptor gene transfer and role of NFκB and CREB transcription factors (2011) Br J Pharmacol, 162, pp. 712-721
Iaccarino, G., Ciccarelli, M., Sorriento, D., Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (2005) Circ Res, 97, pp. 1182-1189
Sorriento, D., Ciccarelli, M., Santulli, G., The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha (2008) Proc Natl Acad Sci USA, 105, pp. 17818-17823
Perino, A., Ghigo, A., Ferrero, E., Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110g (2011) Mol Cell, 42, pp. 84-95
Oriente, F., Iovino, S., Cassese, A., Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression (2009) Diabetologia, 52, pp. 2642-2652
Mauvais-Jarvis, F., Virkamaki, A., Michael, M.D., A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes (2000) Diabetes, 49, pp. 2126-2134
Faisy, C., Pinto, F.M., Blouquit-Laye, S., Beta2-Agonist modulates epithelial gene expression involved in the T- and B-cell chemotaxis and induces airway sensitization in human isolated bronchi (2010) Pharmacol Res, 61, pp. 121-128
Blalock, E.M., Phelps, J.T., Pancani, T., Effects of long-term pioglitazone treatment on peripheral and central markers of aging (2010) PLoS ONE, 5, pp. e10405
Rosen, E.D., Kulkarni, R.N., Sarraf, P., Ozcan, U., Okada, T., Hsu, C.-H., Eisenman, D., Spiegelman, B.M., Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis (2003) Molecular and Cellular Biology, 23 (20), pp. 7222-7229. , DOI 10.1128/MCB.23.20.7222-7229.2003
Collins, S., Yehuda-Shnaidman, E., Wang, H., Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks (2010) Int J Obes, 34 (SUPPL. 1), pp. S28-S33. , Lond
Fogli, S., Pellegrini, S., Adinolfi, B., Rosiglitazone reverses salbutamol-induced β(2) -adrenoceptor tolerance in airway smooth muscle (2011) Br J Pharmacol, 162, pp. 378-391
Tadaishi, M., Miura, S., Kai, Y., Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: A role of β 2- adrenergic receptor activation (2011) Am J Physiol Endocrinol Metab, 300, pp. E341-E349
Sung, B., Park, S., Byung, P.Y., Hae, Y.C., Modulation of PPAR in aging, inflammation, and calorie restriction (2004) Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 59 (10), pp. 997-1006
Guri, A.J., Hontecillas, R., Bassaganya-Riera, J., Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR γ axis (2010) Clin Nutr, 29, pp. 646-653
Kim, S.P., Ha, J.M., Yun, S.J., Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation (2010) Biochem Biophys Res Commun, 399, pp. 55-59
Diabetesdiabetes (ISSN: 0012-1797), 2012; 61(3): 692-701.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.895, 5-year impact factor: 8.611
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857393446&partnerID=40&md5=21bfc25ba07cf3af5c626629ad5d0da8
Keywords: Beta 2 Adrenergic Receptor, Glucose Transporter 2, Peroxisome Proliferator Activated Receptor Gamma, Transcription Factor Pdx 1, Adenovirus, Aging, Animal Cell, Animal Cell Culture, Animal Experiment, Animal Model, Animal Tissue, Article, Assay, Controlled Study, Ex Vivo Study, Gene Transfer, Glucose Homeostasis, Glucose Intolerance, Glucose Metabolism, In Vivo Study, Insulin Release, Insulinoma, Mouse, Nonhuman, Pancreas Islet Beta Cell, Phenotype, Priority Journal, Protein Expression, Wild Type, Age Factors, Glucose Tolerance Test, Glucose Transporter Type 2, Homeodomain Proteins, Mice, Inbred C57bl, Ppar Gamma, Trans-Activators,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy
Columbia-Presbyterian Medical Center, College of Physicians and Surgeons, Columbia University, New York, NY, United States
Columbia University Medical Center, Columbia University, New York, NY, United States
Department of Cellular and Molecular Biology and Pathology, Institute of Experimental Endocrinology and Oncology Gaetano Salvatore, Federico II University of Naples, Naples, Italy
School of Medicine, University of Salerno, Salerno, Italy
References:
Defronzo, R.A., Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus (2009) Diabetes, 58, pp. 773-79
Basu, R., Breda, E., Oberg, A.L., Powell, C.C., Man, C.D., Basu, A., Vittone, J.L., Rizza, R.A., Mechanisms of the age-associated deterioration in glucose tolerance: Contribution of alterations in insulin secretion, action, and clearance (2003) Diabetes, 52 (7), pp. 1738-1748
Gumbiner, B., Polonsky, K.S., Beltz, W.F., Wallace, P., Brechtel, G., Fink, R.I., Effects of Aging on Insulin Secretion (1989) Diabetes, 38 (12), pp. 1549-1556
Ma, X., Becker, D., Arena, V.C., Vicini, P., Greenbaum, C., The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: A population analysis (2009) J Clin Endocrinol Metab, 94, pp. 2446-2451
Reaven, E., Wright, D., Mondon, C.E., Effect of age and diet on insulin secretion and insulin action in the rat (1983) Diabetes, 32 (2), pp. 175-180
Perfetti, R., Rafizadeh, C.M., Liotta, A.S., Egan, J.M., Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats (1995) Am J Physiol, 269, pp. E983-E990
Ihm, S.-H., Matsumoto, I., Sawada, T., Nakano, M., Zhang, H.J., Ansite, J.D., Sutherland, D.E.R., Hering, B.J., Effect of donor age on function of isolated human islets (2006) Diabetes, 55 (5), pp. 1361-1368. , http://diabetes.diabetesjournals.org/cgi/content/full/55/5/1361, DOI 10.2337/db05-1333
Iozzo, P., Beck-Nielsen, H., Laakso, M., Smith, U., Yki-Jarvinen, H., Ferrannini, E., Independent influence of age on basal insulin secretion in nondiabetic humans (1999) Journal of Clinical Endocrinology and Metabolism, 84 (3), pp. 863-868
Rosengren, A.H., Jokubka, R., Tojjar, D., Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes (2010) Science, 327, pp. 217-220
Doyle, M.E., Egan, J.M., Pharmacological agents that directly modulate insulin secretion (2003) Pharmacological Reviews, 55 (1), pp. 105-131. , DOI 10.1124/pr.55.1.7
Lembo, G., Napoli, R., Capaldo, B., Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension (1992) J Clin Invest, 90, pp. 24-29
Seals, D.R., Esler, M.D., Human ageing and the sympathoadrenal system (2000) J Physiol, 528, pp. 407-417
Lembo, G., Capaldo, B., Rendina, V., Acute noradrenergic activation induces insulin resistance in human skeletal muscle (1994) Am J Physiol, 266, pp. E242-E247
Asensio, C., Jimenez, M., Kuhne, F., Rohner-Jeanrenaud, F., Muzzin, P., The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intolerance (2005) Diabetes, 54 (12), pp. 3490-3495. , http://diabetes.diabetesjournals.org/cgi/reprint/54/12/3490, DOI 10.2337/diabetes.54.12.3490
Haffner, C.A., Kendall, M.J., Metabolic effects of beta 2-agonists (1992) J Clin Pharm Ther, 17, pp. 155-164
Ikarashi, T., Hanyu, O., Maruyama, S., Souda, S., Kobayashi, C., Abe, E., Ukisu, J., Aizawa, Y., Genotype Gly/Gly of the Arg16Gly polymorphism of the beta 2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients (2004) Diabetes Research and Clinical Practice, 63 (1), pp. 11-18. , DOI 10.1016/j.diabres.2003.08.010
Scarpace, P.J., Mooradian, A.D., Morley, J.E., Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue (1988) J Gerontol, 43, pp. B65-B70
Xiao, R.-P., Tomhave, E.D., Wang, D.-J., Ji, X., Boluyt, M.O., Cheng, H., Lakatta, E.G., Koch, W.J., Age-associated reductions in cardiac beta 1- and beta 2-adrenergic responses without changes in inhibitory G proteins or receptor kinases (1998) Journal of Clinical Investigation, 101 (6), pp. 1273-1282
Schocken, D.D., Roth, G.S., Reduced beta adrenergic receptor concentrations in ageing man (1977) Nature, 267 (5614), pp. 856-858
Feldman, R.D., Limbird, L.E., Nadeau, J., Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly (1984) New England Journal of Medicine, 310 (13), pp. 815-819
Bao, X., Mills, P.J., Rana, B.K., Dimsdale, J.E., Schork, N.J., Smith, D.W., Rao, F., Ziegler, M.G., Interactive effects of common beta 2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function (2005) Hypertension, 46 (2), pp. 301-307. , DOI 10.1161/01.HYP.0000175842.19266.95
Kang, K.B., Rajanayagam, M.A.S., Van Der, Z.A., Majewski, H., A role for cyclooxygenase in aging-related changes of beta-adrenoceptor- mediated relaxation in rat aortas (2007) Naunyn-Schmiedeberg's Archives of Pharmacology, 375 (4), pp. 273-281. , DOI 10.1007/s00210-007-0153-y
Ryall, J.G., Plant, D.R., Gregorevic, P., Sillence, M.N., Lynch, G.S., Beta2-agonist administration reverses muscle wasting and improves muscle function in aged rats (2004) Journal of Physiology, 555 (1), pp. 175-188. , DOI 10.1113/jphysiol.2003.056770
White, M., Roden, R., Minobe, W., Khan, M.F., Larrabee, P., Wollmering, M., Port, J.D., Bristow, M.R., Age-related changes in beta-adrenergic neuroeffector systems in the human heart (1994) Circulation, 90 (3), pp. 1225-1238
Chruscinski, A.J., Rohrer, D.K., Schauble, E., Desai, K.H., Bernstein, D., Kobilka, B.K., Targeted disruption of the beta2 adrenergic receptor gene (1999) J Biol Chem, 274, pp. 16694-16700
Evans-Molina, C., Robbins, R.D., Kono, T., Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure (2009) Mol Cell Biol, 29, pp. 2053-2067
Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Molecular and Cellular Biology, 24 (11), pp. 5005-5015. , DOI 10.1128/MCB.24.11.5005-5015.2004
Santulli, G., Basilicata, M.F., De Simone, M., Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit (2011) J Transl Med, 9, p. 7
Sorriento, D., Santulli, G., Fusco, A., Anastasio, A., Trimarco, B., Iaccarino, G., Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression (2010) Hypertension, 56, pp. 696-704
Xie, T., Chen, M., Zhang, Q.H., Ma, Z., Weinstein, L.S., Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes (2007) Proc Natl Acad Sci USA, 104, pp. 19601-19606
Lombardi, A., Ulianich, L., Treglia, A.S., Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway (2012) Diabetologia, 55, pp. 141-153
Fiory, F., Lombardi, A., Miele, C., Giudicelli, J., Béguinot, F., Van Obberghen, E., Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E (2011) Diabetologia, 54, pp. 2941-2952
McGraw, D.W., Forbes, S.L., Mak, J.C., Transgenic overexpression of beta (2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction (2000) Am J Physiol Lung Cell Mol Physiol, 279, pp. L379-L389
Mutlu, G.M., Dumasius, V., Burhop, J., McShane, P.J., Meng, F.J., Welch, L., Dumasius, A., Factor, P., Upregulation of Alveolar Epithelial Active Na + Transport Is Dependent on beta 2-Adrenergic Receptor Signaling (2004) Circulation Research, 94 (8), pp. 1091-1100. , DOI 10.1161/01.RES.0000125623.56442.20
Ciccarelli, M., Sorriento, D., Cipolletta, E., Impaired neoangiogenesis in β 2-adrenoceptor gene-deficient mice: Restoration by intravascular human β 2- adrenoceptor gene transfer and role of NFκB and CREB transcription factors (2011) Br J Pharmacol, 162, pp. 712-721
Iaccarino, G., Ciccarelli, M., Sorriento, D., Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (2005) Circ Res, 97, pp. 1182-1189
Sorriento, D., Ciccarelli, M., Santulli, G., The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha (2008) Proc Natl Acad Sci USA, 105, pp. 17818-17823
Perino, A., Ghigo, A., Ferrero, E., Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110g (2011) Mol Cell, 42, pp. 84-95
Oriente, F., Iovino, S., Cassese, A., Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression (2009) Diabetologia, 52, pp. 2642-2652
Mauvais-Jarvis, F., Virkamaki, A., Michael, M.D., A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes (2000) Diabetes, 49, pp. 2126-2134
Faisy, C., Pinto, F.M., Blouquit-Laye, S., Beta2-Agonist modulates epithelial gene expression involved in the T- and B-cell chemotaxis and induces airway sensitization in human isolated bronchi (2010) Pharmacol Res, 61, pp. 121-128
Blalock, E.M., Phelps, J.T., Pancani, T., Effects of long-term pioglitazone treatment on peripheral and central markers of aging (2010) PLoS ONE, 5, pp. e10405
Rosen, E.D., Kulkarni, R.N., Sarraf, P., Ozcan, U., Okada, T., Hsu, C.-H., Eisenman, D., Spiegelman, B.M., Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis (2003) Molecular and Cellular Biology, 23 (20), pp. 7222-7229. , DOI 10.1128/MCB.23.20.7222-7229.2003
Collins, S., Yehuda-Shnaidman, E., Wang, H., Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks (2010) Int J Obes, 34 (SUPPL. 1), pp. S28-S33. , Lond
Fogli, S., Pellegrini, S., Adinolfi, B., Rosiglitazone reverses salbutamol-induced β(2) -adrenoceptor tolerance in airway smooth muscle (2011) Br J Pharmacol, 162, pp. 378-391
Tadaishi, M., Miura, S., Kai, Y., Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: A role of β 2- adrenergic receptor activation (2011) Am J Physiol Endocrinol Metab, 300, pp. E341-E349
Sung, B., Park, S., Byung, P.Y., Hae, Y.C., Modulation of PPAR in aging, inflammation, and calorie restriction (2004) Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 59 (10), pp. 997-1006
Guri, A.J., Hontecillas, R., Bassaganya-Riera, J., Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR γ axis (2010) Clin Nutr, 29, pp. 646-653
Kim, S.P., Ha, J.M., Yun, S.J., Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation (2010) Biochem Biophys Res Commun, 399, pp. 55-59
Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor
In this study, we investigated the significance of β 2- adrenergic receptor (β 2AR) in age-related impaired insulin secretion and glucose homeostasis. We characterized the metabolic phenotype of β 2AR-null C57Bl/6N mice (β 2AR -/-) by performing in vivo and ex vivo experiments. In vitro assays in cultured INS-1E β-cells were carried out in order to clarify the mechanism by which β 2AR deficiency affects glucose metabolism. Adult β 2AR -/- mice featured glucose intolerance, and pancreatic islets isolated from these animals displayed impaired glucose-induced insulin release, accompanied by reduced expression of peroxisome proliferator-activated receptor (PPAR)γ, pancreatic duodenal homeobox-1 (PDX-1), and GLUT2. Adenovirus-mediated gene transfer of human β 2AR rescued these defects. Consistent effects were evoked in vitro both upon β 2AR knockdown and pharmacologic treatment. Interestingly, with aging, wild-type (β 2AR +/+) littermates developed impaired insulin secretion and glucose tolerance. Moreover, islets from 20-month-old β 2AR +/+ mice exhibited reduced density of β 2AR compared with those from younger animals, paralleled by decreased levels of PPARγ, PDX-1, and GLUT2. Overexpression of β 2AR in aged mice rescued glucose intolerance and insulin release both in vivo and ex vivo, restoring PPARγ/PDX-1/GLUT2 levels. Our data indicate that reduced β 2AR expression contributes to the age-related decline of glucose tolerance in mice. © 2012 by the American Diabetes Association.
In this study, we investigated the significance of β 2- adrenergic receptor (β 2AR) in age-related impaired insulin secretion and glucose homeostasis. We characterized the metabolic phenotype of β 2AR-null C57Bl/6N mice (β 2AR -/-) by performing in vivo and ex vivo experiments. In vitro assays in cultured INS-1E β-cells were carried out in order to clarify the mechanism by which β 2AR deficiency affects glucose metabolism. Adult β 2AR -/- mice featured glucose intolerance, and pancreatic islets isolated from these animals displayed impaired glucose-induced insulin release, accompanied by reduced expression of peroxisome proliferator-activated receptor (PPAR)γ, pancreatic duodenal homeobox-1 (PDX-1), and GLUT2. Adenovirus-mediated gene transfer of human β 2AR rescued these defects. Consistent effects were evoked in vitro both upon β 2AR knockdown and pharmacologic treatment. Interestingly, with aging, wild-type (β 2AR +/+) littermates developed impaired insulin secretion and glucose tolerance. Moreover, islets from 20-month-old β 2AR +/+ mice exhibited reduced density of β 2AR compared with those from younger animals, paralleled by decreased levels of PPARγ, PDX-1, and GLUT2. Overexpression of β 2AR in aged mice rescued glucose intolerance and insulin release both in vivo and ex vivo, restoring PPARγ/PDX-1/GLUT2 levels. Our data indicate that reduced β 2AR expression contributes to the age-related decline of glucose tolerance in mice. © 2012 by the American Diabetes Association.
Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor
No results. |
Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor
Other filter: ([btitle,keywords] "Beta 2 Adrenergic Re ...
Leggiero E, Labruna G, Iaffaldano L, Lombardo B, Greco A, Fiorenza D, Gramanzini M, Montanaro D, Baldi A, Cerullo V, Sacchetti L, Pastore L
* Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice (227 views) (PDF 85 views)
Gene Ther (ISSN: 0969-7128linking), 2019 Jan 30; 26(3-4): 121-130.
Impact Factor: 4.782
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (510 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
View Export to BibTeX Export to EndNote
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (502 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (423 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (422 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
View Export to BibTeX Export to EndNote
Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (359 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (478 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
View Export to BibTeX Export to EndNote
Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
* Lung structure abnormalities, but normal lung function in pediatric bronchiectasis (431 views)
Chest (ISSN: 0012-3692), 2006 Sep; 130(2): 480-486.
Impact Factor: 3.924
View Export to BibTeX Export to EndNote
Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
View Export to BibTeX Export to EndNote
Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (382 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
View Export to BibTeX Export to EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (391 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
View Export to BibTeX Export to EndNote
Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (468 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (269 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
* Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice (227 views) (PDF 85 views)
Gene Ther (ISSN: 0969-7128linking), 2019 Jan 30; 26(3-4): 121-130.
Impact Factor: 4.782
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (510 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
View Export to BibTeX Export to EndNote
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (502 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (423 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (422 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
View Export to BibTeX Export to EndNote
Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (359 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (478 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
View Export to BibTeX Export to EndNote
Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
* Lung structure abnormalities, but normal lung function in pediatric bronchiectasis (431 views)
Chest (ISSN: 0012-3692), 2006 Sep; 130(2): 480-486.
Impact Factor: 3.924
View Export to BibTeX Export to EndNote
Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
View Export to BibTeX Export to EndNote
Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (382 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
View Export to BibTeX Export to EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (391 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
View Export to BibTeX Export to EndNote
Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (468 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (269 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
22 Records (21 excluding Abstracts).
Total impact factor: 144.087 (139.736 excluding Abstracts).
Total 5 year impact factor: 140.876 (136.493 excluding Abstracts).
Total impact factor: 144.087 (139.736 excluding Abstracts).
Total 5 year impact factor: 140.876 (136.493 excluding Abstracts).
678 views. Last view on Sunday 28 May 2023, 17:28:12
ibb.cnr.it
