Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.409, 5-year impact factor: 4.635
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651417065&partnerID=40&md5=3e1318073584e662306eda9a6249b952
Keywords: Adrenergic Signaling, Gene Therapy, Ischaemic Hindlimb, Nfkb Activity, Adenovirus Vector, Beta 2 Adrenergic Receptor, Cyclic Amp Responsive Element Binding Protein, I Kappa B Alpha, Immunoglobulin Enhancer Binding Protein, Isoprenaline, Tumor Necrosis Factor Alpha, Vasculotropin, Angiogenesis, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Cytokine Production, Endothelium Cell, Limb Ischemia, Mouse, Nonhuman, Priority Journal, Receptor Density, Signal Transduction, Transcription Regulation, Upregulation, Viral Gene Therapy, Blood Flow Velocity, Cultured, Creb-Binding Protein, Disease Models, Endothelial Cells, Genetic Vectors, Luciferases, Knockout, Neovascularization, Physiologic, Nf-Kappa B, Radioligand Assay, Transfection, Vascular Endothelial Growth Factor A,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari Ed Immunologiche, Università Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, United States
References:
Alexander, S.P.H., Mathie, A., Peters, J.A., Guide to Receptors and Channels (GRAC), 4th Edition (2009) Br J Pharmacol, 158 (SUPPL. 1), pp. 1-25
Chandrasekar, B., Marelli-Berg, F.M., Tone, M., Bysani, S., Prabhu, S.D., Murray, D.R., Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB (2004) Biochem Biophys Res Commun, 319, pp. 304-311
Chruscinski, A.J., Rohrer, D.K., Schauble, E., Desai, K.H., Bernstein, D., Kobilka, B.K., Targeted disruption of the beta2 adrenergic receptor gene (1999) J Biol Chem, 274, pp. 16694-16700
Ciccarelli, M., Cipolletta, E., Santulli, G., Campanile, A., Pumiglia, K., Cervero, P., Endothelial beta2 adrenergic signaling to AKT: Role of Gi and SRC (2007) Cell Signal, 19, pp. 1949-1955
Ciccarelli, M., Santulli, G., Campanile, A., Galasso, G., Cervero, P., Altobelli, G.G., Endothelial alpha1-adrenoceptors regulate neo-angiogenesis (2008) Br J Pharmacol, 153, pp. 936-946
Farmer, P., Pugin, J., Beta-adrenergic agonists exert their 'anti-inflammatory' effects in monocytic cells through the IkappaB/NF-kappaB pathway (2000) Am J Physiol Lung Cell Mol Physiol, 279, pp. 675-L682
Ferro, A., Queen, L.R., Priest, R.M., Xu, B., Ritter, J.M., Poston, L., Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro (1999) Br J Pharmacol, 126, pp. 1872-1880
Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., Koch, W.J., Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade (1998) Circulation, 98, pp. 1783-1789
Iaccarino, G., Barbato, E., Cipoletta, E., Fiorillo, A., Trimarco, B., Role of the sympathetic nervous system in cardiac remodeling in hypertension (2001) Clin Exp Hypertens, 23, pp. 35-43
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension (2002) Circulation, 106, pp. 349-355
Iaccarino, G., Ciccarelli, M., Sorriento, D., Cipolletta, E., Cerullo, V., Iovino, G.L., AKT participates in endothelial dysfunction in hypertension (2004) Circulation, 109, pp. 2587-2593
Kiriakidis, S., Andreakos, E., Monaco, C., Foxwell, B., Feldmann, M., Paleolog, E., VEGF expression in human macrophages is NF-kappaB-dependent: Studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2 (2003) J Cell Sci, 116, pp. 665-674
Lembo, G., Iaccarino, G., Vecchione, C., Barbato, E., Izzo, R., Fontana, D., Insulin modulation of an endothelial nitric oxide component present in the alpha2-and beta-adrenergic responses in human forearm (1997) J Clin Invest, 100, pp. 2007-2014
Marti, H.J., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia (2000) Am J Pathol, 156, pp. 965-976
Newton, G.E., Adelman, A.G., Lima, V.C., Seidelin, P.H., Schampaert, E., Parker, J.D., Cardiac sympathetic activity in response to acute myocardial ischemia (1997) Am J Physiol, 272, pp. 2079-2084
Rohrer, D.K., Chruscinski, A., Schauble, E.H., Bernstein, D., Kobilka, B.K., Cardiovascular and metabolic alterations in mice lacking both beta1-and beta2-adrenergic receptors (1999) J Biol Chem, 274, pp. 16701-16708
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 41
Santulli, G., Cipolletta, E., Campanile, A., Maione, S., Trimarco, V., Marino, M., Deletion of the CaMK4 Gene in Mice Determines a Hypertensive Phenotype (2009) Circulation, 120, pp. 613-S613
Shenoy, S.K., Drake, M.T., Nelson, C.D., Houtz, D.A., Xiao, K., Madabushi, S., Beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor (2006) J Biol Chem, 281, pp. 1261-1273
Sorriento, D., Campanile, A., Santulli, G., Leggiero, E., Pastore, L., Trimarco, B., A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity (2009) Mol Cancer, 8, p. 97
Sorriento, D., Santulli, G., Fusco, A., Anastasio, A., Trimarco, B., Iaccarino, G., Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-{kappa}B-Dependent hypertrophic gene expression (2010) Hypertension, 56, pp. 696-704
Ye, R.D., Regulation of nuclear factor kappaB activation by G-protein-coupled receptors (2001) J Leukoc Biol, 70, pp. 839-848
Zhou, Q.Y., Quaife, C.J., Palmiter, R.D., Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development (1995) Nature, 374, pp. 640-643
Zhou, R.H., Lee, T.S., Tsou, T.C., Rannou, F., Li, Y.S., Chien, S., Stent implantation activates Akt in the vessel wall: Role of mechanical stretch in vascular smooth muscle cells (2003) Arterioscler Thromb Vasc Biol, 23, pp. 2015-2020
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.409, 5-year impact factor: 4.635
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651417065&partnerID=40&md5=3e1318073584e662306eda9a6249b952
Keywords: Adrenergic Signaling, Gene Therapy, Ischaemic Hindlimb, Nfkb Activity, Adenovirus Vector, Beta 2 Adrenergic Receptor, Cyclic Amp Responsive Element Binding Protein, I Kappa B Alpha, Immunoglobulin Enhancer Binding Protein, Isoprenaline, Tumor Necrosis Factor Alpha, Vasculotropin, Angiogenesis, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Cytokine Production, Endothelium Cell, Limb Ischemia, Mouse, Nonhuman, Priority Journal, Receptor Density, Signal Transduction, Transcription Regulation, Upregulation, Viral Gene Therapy, Blood Flow Velocity, Cultured, Creb-Binding Protein, Disease Models, Endothelial Cells, Genetic Vectors, Luciferases, Knockout, Neovascularization, Physiologic, Nf-Kappa B, Radioligand Assay, Transfection, Vascular Endothelial Growth Factor A,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari Ed Immunologiche, Università Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, United States
References:
Alexander, S.P.H., Mathie, A., Peters, J.A., Guide to Receptors and Channels (GRAC), 4th Edition (2009) Br J Pharmacol, 158 (SUPPL. 1), pp. 1-25
Chandrasekar, B., Marelli-Berg, F.M., Tone, M., Bysani, S., Prabhu, S.D., Murray, D.R., Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB (2004) Biochem Biophys Res Commun, 319, pp. 304-311
Chruscinski, A.J., Rohrer, D.K., Schauble, E., Desai, K.H., Bernstein, D., Kobilka, B.K., Targeted disruption of the beta2 adrenergic receptor gene (1999) J Biol Chem, 274, pp. 16694-16700
Ciccarelli, M., Cipolletta, E., Santulli, G., Campanile, A., Pumiglia, K., Cervero, P., Endothelial beta2 adrenergic signaling to AKT: Role of Gi and SRC (2007) Cell Signal, 19, pp. 1949-1955
Ciccarelli, M., Santulli, G., Campanile, A., Galasso, G., Cervero, P., Altobelli, G.G., Endothelial alpha1-adrenoceptors regulate neo-angiogenesis (2008) Br J Pharmacol, 153, pp. 936-946
Farmer, P., Pugin, J., Beta-adrenergic agonists exert their 'anti-inflammatory' effects in monocytic cells through the IkappaB/NF-kappaB pathway (2000) Am J Physiol Lung Cell Mol Physiol, 279, pp. 675-L682
Ferro, A., Queen, L.R., Priest, R.M., Xu, B., Ritter, J.M., Poston, L., Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro (1999) Br J Pharmacol, 126, pp. 1872-1880
Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., Koch, W.J., Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade (1998) Circulation, 98, pp. 1783-1789
Iaccarino, G., Barbato, E., Cipoletta, E., Fiorillo, A., Trimarco, B., Role of the sympathetic nervous system in cardiac remodeling in hypertension (2001) Clin Exp Hypertens, 23, pp. 35-43
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension (2002) Circulation, 106, pp. 349-355
Iaccarino, G., Ciccarelli, M., Sorriento, D., Cipolletta, E., Cerullo, V., Iovino, G.L., AKT participates in endothelial dysfunction in hypertension (2004) Circulation, 109, pp. 2587-2593
Kiriakidis, S., Andreakos, E., Monaco, C., Foxwell, B., Feldmann, M., Paleolog, E., VEGF expression in human macrophages is NF-kappaB-dependent: Studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2 (2003) J Cell Sci, 116, pp. 665-674
Lembo, G., Iaccarino, G., Vecchione, C., Barbato, E., Izzo, R., Fontana, D., Insulin modulation of an endothelial nitric oxide component present in the alpha2-and beta-adrenergic responses in human forearm (1997) J Clin Invest, 100, pp. 2007-2014
Marti, H.J., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia (2000) Am J Pathol, 156, pp. 965-976
Newton, G.E., Adelman, A.G., Lima, V.C., Seidelin, P.H., Schampaert, E., Parker, J.D., Cardiac sympathetic activity in response to acute myocardial ischemia (1997) Am J Physiol, 272, pp. 2079-2084
Rohrer, D.K., Chruscinski, A., Schauble, E.H., Bernstein, D., Kobilka, B.K., Cardiovascular and metabolic alterations in mice lacking both beta1-and beta2-adrenergic receptors (1999) J Biol Chem, 274, pp. 16701-16708
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 41
Santulli, G., Cipolletta, E., Campanile, A., Maione, S., Trimarco, V., Marino, M., Deletion of the CaMK4 Gene in Mice Determines a Hypertensive Phenotype (2009) Circulation, 120, pp. 613-S613
Shenoy, S.K., Drake, M.T., Nelson, C.D., Houtz, D.A., Xiao, K., Madabushi, S., Beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor (2006) J Biol Chem, 281, pp. 1261-1273
Sorriento, D., Campanile, A., Santulli, G., Leggiero, E., Pastore, L., Trimarco, B., A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity (2009) Mol Cancer, 8, p. 97
Sorriento, D., Santulli, G., Fusco, A., Anastasio, A., Trimarco, B., Iaccarino, G., Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-{kappa}B-Dependent hypertrophic gene expression (2010) Hypertension, 56, pp. 696-704
Ye, R.D., Regulation of nuclear factor kappaB activation by G-protein-coupled receptors (2001) J Leukoc Biol, 70, pp. 839-848
Zhou, Q.Y., Quaife, C.J., Palmiter, R.D., Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development (1995) Nature, 374, pp. 640-643
Zhou, R.H., Lee, T.S., Tsou, T.C., Rannou, F., Li, Y.S., Chien, S., Stent implantation activates Akt in the vessel wall: Role of mechanical stretch in vascular smooth muscle cells (2003) Arterioscler Thromb Vasc Biol, 23, pp. 2015-2020
Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors
Background and Purpose: There is much evidence supporting the role of β 2-adrenoceptors (β 2AR) in angiogenesis but the mechanisms underlying their effects have not been elucidated. Hence, we studied post-ischaemic angiogenesis in the hindlimb (HL) of β 2AR knock-out mice (β 2AR-/-) in vivo and explored possible molecular mechanisms in vitro. Experimental Approach: Femoral artery resection (FAR) was performed in wild-type and β 2AR-/-mice and adaptive responses to chronic HL ischaemia were explored; blood flow was measured by ultrasound and perfusion of dyed beads, bone rarefaction, muscle fibrosis and skin thickness were evaluated by immunoflourescence and morphometric analysis. Intrafemoral delivery of an adenovirus encoding the human β 2AR (ADβ 2AR) was used to reinstate β 2ARs in β 2AR-/-mice. Molecular mechanisms were investigated in mouse-derived aortic endothelial cells (EC) in vitro, focusing on NFκB activation and transcriptional activity. RESULTS Angiogenesis was severely impaired in β 2AR-/-mice subjected to FAR, but was restored by gene therapy with ADβ 2AR. The proangiogenic responses to a variety of stimuli were impaired in β 2AR-/-EC in vitro. Moreover, removal of β 2ARs impaired the activation of NFκB, a transcription factor that promotes angiogenesis; neither isoprenaline (stimulates βARs) nor TNFα induced NFκB activation in β 2AR -/-EC. Interestingly, cAMP response element binding protein (CREB), a transcription factor that counter regulates NFκB, was constitutively increased in β 2AR -/-ECs. ADβ 2AR administration restored β 2AR membrane density, reduced CREB activity and reinstated the NFκB response to isoprenaline and TNFα. Conclusions and Implications: Our results suggest that β 2ARs control angiogenesis through the tight regulation of nuclear transcriptional activity. © 2011 The Authors.
Background and Purpose: There is much evidence supporting the role of β 2-adrenoceptors (β 2AR) in angiogenesis but the mechanisms underlying their effects have not been elucidated. Hence, we studied post-ischaemic angiogenesis in the hindlimb (HL) of β 2AR knock-out mice (β 2AR-/-) in vivo and explored possible molecular mechanisms in vitro. Experimental Approach: Femoral artery resection (FAR) was performed in wild-type and β 2AR-/-mice and adaptive responses to chronic HL ischaemia were explored; blood flow was measured by ultrasound and perfusion of dyed beads, bone rarefaction, muscle fibrosis and skin thickness were evaluated by immunoflourescence and morphometric analysis. Intrafemoral delivery of an adenovirus encoding the human β 2AR (ADβ 2AR) was used to reinstate β 2ARs in β 2AR-/-mice. Molecular mechanisms were investigated in mouse-derived aortic endothelial cells (EC) in vitro, focusing on NFκB activation and transcriptional activity. RESULTS Angiogenesis was severely impaired in β 2AR-/-mice subjected to FAR, but was restored by gene therapy with ADβ 2AR. The proangiogenic responses to a variety of stimuli were impaired in β 2AR-/-EC in vitro. Moreover, removal of β 2ARs impaired the activation of NFκB, a transcription factor that promotes angiogenesis; neither isoprenaline (stimulates βARs) nor TNFα induced NFκB activation in β 2AR -/-EC. Interestingly, cAMP response element binding protein (CREB), a transcription factor that counter regulates NFκB, was constitutively increased in β 2AR -/-ECs. ADβ 2AR administration restored β 2AR membrane density, reduced CREB activity and reinstated the NFκB response to isoprenaline and TNFα. Conclusions and Implications: Our results suggest that β 2ARs control angiogenesis through the tight regulation of nuclear transcriptional activity. © 2011 The Authors.
Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors
| ▼ Evaluation of gene expression and test of new therapies by preclinical imaging in murine models |
Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors
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Impact Factor: 2.76
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (510 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (471 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (423 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1162 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (359 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (439 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (395 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (509 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (378 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (468 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (600 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (457 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (270 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (435 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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21 Records (19 excluding Abstracts).
Total impact factor: 96.601 (91.983 excluding Abstracts).
Total 5 year impact factor: 96.824 (91.372 excluding Abstracts).
Total impact factor: 96.601 (91.983 excluding Abstracts).
Total 5 year impact factor: 96.824 (91.372 excluding Abstracts).
370 views. Last view on Thursday 04 May 2023, 6:21:03
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