Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (810 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
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Paper type: Journal Article,
Impact factor: 4.512, 5-year impact factor: 3.905
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78649676137&partnerID=40&md5=34aad93f30140a94a9919d2da80f3a94
Keywords: Heart Failure, Muscle Wasting, Ubiquitin System, Atrogin 1, Messenger Rna, Transcription Factor Fkhrl1, Adult, Aged, Article, Clinical Article, Controlled Study, Female, Gene Activation, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Failure, Heart Muscle, Human, Human Tissue, Linear Regression Analysis, Muscle Atrophy, Priority Journal, Protein Expression, Protein Induction, Protein Phosphorylation, Real Time Polymerase Chain Reaction, Western Blotting, Case-Control Studies, Confidence Intervals, Forkhead Transcription Factors, Linear Models, Middle Aged, Muscle Proteins, Myocardium, Skp Cullin F-Box Protein Ligases, Statistics As Topic, Ventricular Function,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Via S. Pansini, 5, 80131 Naples, Italy
Molecular Cardiology, CVI Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, United States
References:
Not available.
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.512, 5-year impact factor: 3.905
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78649676137&partnerID=40&md5=34aad93f30140a94a9919d2da80f3a94
Keywords: Heart Failure, Muscle Wasting, Ubiquitin System, Atrogin 1, Messenger Rna, Transcription Factor Fkhrl1, Adult, Aged, Article, Clinical Article, Controlled Study, Female, Gene Activation, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Failure, Heart Muscle, Human, Human Tissue, Linear Regression Analysis, Muscle Atrophy, Priority Journal, Protein Expression, Protein Induction, Protein Phosphorylation, Real Time Polymerase Chain Reaction, Western Blotting, Case-Control Studies, Confidence Intervals, Forkhead Transcription Factors, Linear Models, Middle Aged, Muscle Proteins, Myocardium, Skp Cullin F-Box Protein Ligases, Statistics As Topic, Ventricular Function,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Via S. Pansini, 5, 80131 Naples, Italy
Molecular Cardiology, CVI Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, United States
References:
Not available.
Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure
Aims Several studies have shown that muscle mass loss is an important pathogenic issue in heart failure (HF). Atrogin-1 is a F-box protein selectively expressed in cardiac and skeletal muscle tissue, which plays a pivotal role in muscle wasting regulation. The aim of this study was to investigate the expression of Atrogin-1 and the molecular pathway involved in Atrogin-1 regulation in human HF. Methods and results Cardiac tissue from patients with HF (HF group: n = 10) or with normal left ventricular function (control group: n = 9) was studied by western blot and real time-PCR analysis. Linear regression analysis between patients left ventricular ejection fraction (LVEF) and Atrogin1 or its regulator Forkhead box O 3a (Foxo3a) myocardial expression was performed to test correlations between protein expression and LVEF. Western blot analysis revealed that the myocardial expression of Atrogin-1 in the HF group was 2.5-fold increased compared with controls (P = 0.007). Accordingly, Atrogin-1 mRNA was 1.5 higher than in controls (P = 0.003). The expression of Foxo3a and its up-stream regulator AKT were also measured. Western blot analysis demonstrated in the HF group a 2.56-fold reduction of AKT phosphorylation and a 3.32-fold increase of Foxo3a as compared with controls (P = 0.002 and P = 0.001, respectively). Finally, linear regression showed a significant relationship between Foxo3a or Atrogin-1 expression and LVEF (R = 0.976, P < 0.0001 and R = 0.895, P = 0.003, respectively).Conclusion Our results suggest that in human HF, the activity of AKT decreases, with activation of Foxo3a and induction of Atrogin-1, thereby leading to a molecular state that favours heart muscle loss and left ventricular dysfunction. © 2010 Author.
Aims Several studies have shown that muscle mass loss is an important pathogenic issue in heart failure (HF). Atrogin-1 is a F-box protein selectively expressed in cardiac and skeletal muscle tissue, which plays a pivotal role in muscle wasting regulation. The aim of this study was to investigate the expression of Atrogin-1 and the molecular pathway involved in Atrogin-1 regulation in human HF. Methods and results Cardiac tissue from patients with HF (HF group: n = 10) or with normal left ventricular function (control group: n = 9) was studied by western blot and real time-PCR analysis. Linear regression analysis between patients left ventricular ejection fraction (LVEF) and Atrogin1 or its regulator Forkhead box O 3a (Foxo3a) myocardial expression was performed to test correlations between protein expression and LVEF. Western blot analysis revealed that the myocardial expression of Atrogin-1 in the HF group was 2.5-fold increased compared with controls (P = 0.007). Accordingly, Atrogin-1 mRNA was 1.5 higher than in controls (P = 0.003). The expression of Foxo3a and its up-stream regulator AKT were also measured. Western blot analysis demonstrated in the HF group a 2.56-fold reduction of AKT phosphorylation and a 3.32-fold increase of Foxo3a as compared with controls (P = 0.002 and P = 0.001, respectively). Finally, linear regression showed a significant relationship between Foxo3a or Atrogin-1 expression and LVEF (R = 0.976, P < 0.0001 and R = 0.895, P = 0.003, respectively).Conclusion Our results suggest that in human HF, the activity of AKT decreases, with activation of Foxo3a and induction of Atrogin-1, thereby leading to a molecular state that favours heart muscle loss and left ventricular dysfunction. © 2010 Author.
Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure
| ▼ High-resolution positron emission tomography of the ischaemic mouse heart |
Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure
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Curr Med Imaging Rev (ISSN: 1573-4056, 1573-4056linking), 2005 Jan; 1(1): N/D-N/D.
Impact Factor: 1.059
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Santomauro M, Pace L, Duilio C, Ottaviano L, Borrelli A, Ferro A, Monteforte N, Cuocolo A, Salvatore M, Chiariello M
* Left ventricular pacing in patients with heart failure: Evaluation study with Fourier analysis of radionuclide ventriculography (875 views)
Ital Heart J (ISSN: 1129-471x), 2004 Dec; 5(12): 906-911.
Impact Factor: 6.023
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (682 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2004 Jun 1; 567(1): 20-26.
Impact Factor: 3.843
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Petretta M, Vicario ML, Spinelli L, Ferro A, Cuocolo A, Condorelli M, Bonaduce D
* Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy (617 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2002 Dec; 4(6): 727-735.
Impact Factor: 2.134
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (892 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Ferro A, Salvatore M, Cuocolo A
* Radionuclide monitoring of left ventricular function after sublingual nifedipine administration at rest and during moderate physical activity (1261 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001 Sep; 8(6): 669-676.
Impact Factor: 1.868
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Pace L, Nappi A, Imbriaco M, Cuocolo A, Varrone A, Romano M, Trimarco B, Salvatore M
Relationship between exercise capacity and left ventricular function at rest in patients with heart failure. An ambulatory left ventricular monitoring study (618 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 100(3): 120-125.
Impact Factor: 1.368
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
[Effects left ventricle asynchrony on systolic and diastolic function in patients with non-ischemic heart failure] (564 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Jul; 96(1-2): 68-72.
Impact Factor: 0.967
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
Influence of left ventricular asynchrony on systolic and diastolic function in patients with nonischemic heart failure (796 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(1-2): 68-72.
Impact Factor: 0.967
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (1939 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Pasquali D, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA
Retinoic acid receptors α, β and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer (1261 views)
Eur J Endocrinol (ISSN: 0804-4643), 1997 Oct; 137(4): 410-414.
Impact Factor: 1.968
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Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure (821 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jun; 38(6): 948-953.
Impact Factor: 3.491
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Pace L, Nappi A, Cuocolo A, Varrone A, Romano M, Salvatore M
Exercise capacity and left ventricular function at rest in patients with heart failure (870 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B
Influence of digitalis on left ventricular functional response to exercise in congestive heart failure (742 views)
Am J Cardiol (ISSN: 0002-9149), 1996 Mar 1; 77(7): 480-485.
Impact Factor: 2.402
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Russo R, Rao MA, Romano M, Scotto Di Santolo M, Cardei S, Giunta A, Cuocolo A, Volpe M
Prospects of pharmacologic treatment of post-ischemic heart failure (506 views)
Cardiologia (ISSN: 0393-1978), 1995 Dec; 40(12Suppl1): 533-537.
Impact Factor: 0
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Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (685 views)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
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Morisco C, Argenziano L, Sarno D, Cuocolo A, Romano M, Trimarco B
The practical aspects of treatment in heart failure (898 views)
Ann Ital Med Int (ISSN: 0393-9340), 1993 Oct; 8Suppl: 14S-19S.
Impact Factor: 0
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (682 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (854 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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* Significant functional mitral regurgitation affects left atrial function in heart failure patients: haemodynamic correlations and prognostic implications (1003 views)
Eur Heart J-Card Img (ISSN: 2047-2404linking, 2047-2412), 2019 Mar 12; 20(9): 1012-1019.
Impact Factor: 3.669
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (720 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Cocozza S, Costabile T, Tedeschi E, Abate F, Russo C, Liguori A, Del Vecchio W, Paciello F, Quarantelli M, Filla A, Brunetti A, Saccà F
* Cognitive and functional connectivity alterations in Friedreich's ataxia (2027 views)
Ann Clin Transl Neurol (ISSN: 2328-9503linking, 2328-9503electronic), 2018 Apr 14; 5(6): 677-686.
Impact Factor: 4.649
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Rengo G, Pagano G, Vitale DF, Formisano R, Komici K, Petraglia L, Parisi V, Femminella GD, De Lucia C, Paolillo S, Cannavo A, Attena E, Pellegrino T, Dellegrottaglie S, Memmi A, Trimarco B, Cuocolo A, Filardi PP, Leosco D, Ferrara N
* Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure (418 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jun 10; N/D: N/D-N/D.
Impact Factor: 7.277
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Parisi V, Rengo G, Perrone-filardi P, Pagano G, Femminella GD, Paolillo S, Petraglia L, Gambino G, Caruso A, Grimaldi MG, Baldascino F, Nolano M, Elia A, Cannavo A, De Bellis A, Coscioni E, Pellegrino T, Cuocolo A, Ferrara N, Leosco D
* Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure (467 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2016 Apr 15; 118(8): 1244-1253.
Impact Factor: 13.965
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (647 views)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (795 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Pellegrino T, Piscopo V, Petretta M, Cuocolo A
* 123I-Metaiodobenzylguanidine cardiac innervation imaging: methods and interpretation (709 views)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2015; 3(5): 357-363.
Impact Factor: 0
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Leosco D, Parisi V, Pellegrino T, Pagano G, Femminella GD, Bevilacqua A, Paolillo S, Formisano R, Ferro G, de Lucia C, Prastaro M, Filardi PP, Cuocolo A, Rengo G, Ferrara N
* Alterations of left ventricular deformation and cardiac sympathetic derangement in patients with systolic heart failure: a 3D speckle tracking echocardiography and cardiac 123I-MIBG study (668 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42(10): 1601-1611.
Impact Factor: 5.537
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
* α-thalassemia associated with Hb instability: A tale of two features. The case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro (1303 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(3): N/D-N/D.
Impact Factor: 3.057
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Lelli D, Pedone C, Rossi FF, Incalzi RA
* Clinical and echocardiographic characteristics of elderly hospitalized patients with high levels of NT-proBNP without clinical diagnosis of heart failure (470 views)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2014 Dec; 26(6): 607-613.
Impact Factor: 1.215
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (1127 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Petretta M, Pellegrino T, Cuocolo A
* Cardiac Neuronal Imaging With 123i-Meta-Iodobenzylguanidine In Heart Failure: Implications Of Endpoint Selection And Quantitative Analysis On Clinical Decisions (708 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Sep; 41(9): 1663-1665.
Impact Factor: 5.383
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Giua R, Pedone C, Scarlata S, Carrozzo I, Rossi FF, Valiani V, Incalzi RA
* Relationship between respiratory muscle strength and physical performance in elderly hospitalized patients (531 views)
Rejuv Res (ISSN: 1549-1684, 1557-8577), 2014 Sep; 17(4): 366-371.
Impact Factor: 3.311
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Petretta M, Cuocolo A
Letter by Petretta and Cuocolo regarding article, "Four-variable risk model in men and women with heart failure" (573 views)
Circ-Heart Fail (ISSN: 1941-3289), 2014 Mar 1; 7(2): 380-380.
Impact Factor: 5.867
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Petretta M, Petretta A, Pellegrino T, Nappi C, Cantoni V, Cuocolo A
* Nuclear Cardiology in Heart Failure (886 views)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014 Jan; 7(3): 1-7.
Impact Factor: 0
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Petretta M, Pellegrino T, Cuocolo A
* The "gray Zone" For The Heart To Mediastinum Mibg Uptake Ratio (640 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2014; 21(5): 921-924.
Impact Factor: 2.942
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Paolillo S, Rengo G, Pellegrino T, Formisano R, Savarese G, Pagano G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Insulin Resistance is Associated With Impaired Cardiac Sympathetic Innervation in Patients Affected by Heart Failure (576 views)
Amyloid, 2013 Nov 26; 34: N/D-N/D.
Impact Factor: 2.51
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Pellegrino T, Petretta M, Paolillo S, Boemio A, Carotenuto R, Petretta MP, Di Nuzzo C, Perrone-filardi P, Cuocolo A
* Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure (1169 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2013 Oct; 40(10): 1549-1557.
Impact Factor: 5.217
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Pellegrino T, Petretta M, Boemio A, Carotenuto R, Petretta MP, Paolillo S, Filardi PP, Cuocolo A
* Reliability and Agreement of Planar and Single-Photon Emission Computed Tomography 123I-Metaiodobenzylguanidine Cardiac Imaging in Patients with Heart Failure (507 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (517 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992), 2013 Sep; 36(8): 2395-2401.
Impact Factor: 8.57
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (816 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Scala O, Paolillo S, Rengo G, Pagano G, Formisano R, Pellegrino T, De Michele F, Starace A, Cirillo A, Vitagliano A, Formisano T, Leosco D, Cuocolo A, Perrone-Filardi P
* EFFECTS OF SLEEP APNEA ON CARDIAC SYMPATHETIC ACTIVITY IN PATIENTS WITH SEVERE SYSTOLIC HEART FAILURE: A (123)MIBG SCINTIGRAPHIC STUDY (577 views)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2013 Mar 12; 61(10): N/D-N/D.
Impact Factor: 15.343
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* IMPACT OF DIABETES MELLITUS IN IODINE-123 META-IODOBENZYLGUANIDINE (I123MIBG) CARDIAC UPTAKE IN PATIENTS WITH HEART FAILURE (474 views)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2013 Mar 12; 61(10): 2395-2401.
Impact Factor: 15.343
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Camera L, Campanile F, Imbriaco M, Ippolito R, Sirignano C, Santoro C, Galderisi M, Salvatore M
* Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: Chest X-ray, HRCT and multi-detector row CT angiographic findings (745 views) (PDF 62 views)
J Thorac Dis (ISSN: 2072-1439), 2013 Feb; 5(1): 82-86.
Impact Factor: 0.895
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Petretta M, Acampa W, Fiumara G, Cuocolo A
* Cardiovascular risk stratification in diabetic patients (829 views)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2013; 1(5): 325-339.
Impact Factor: 0
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Pellegrino T, Gargiulo P, Rengo G, Pagano G, Tuccillo M, Boemio A, Leosco D, Filardi PP, Cuocolo A
* Diabetes-dependent Cardiac Sympathetic Denervation in Patients with Left Ventricular Dysfunction is Independent from Heart Failure Status (554 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (897 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Gargiulo P, Rengo G, Pagano G, Pellegrino T, Liccardo D, Femminella GD, De Lucia C, Attena E, Leosco D, Cuocolo A, Filardi PP
* DIABETES IS ASSOCIATED WITH HIGHER CARDIAC SYMPATHETIC DENERVATION IN PATIENTS WITH LEFT VENTRICLE DYSFUNCTION INDEPENDENTLY FROM HEART FAILURE STATUS (573 views)
Journal Of The American College Of Cardiology (ISSN: 0735-1097), 2012 Mar 27; 59(13): N/D-N/D.
Impact Factor: 14.086
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (562 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Esposito G, De Falco F, Tinto N, Testa F, Vitagliano L, Tandurella IC, Iannone L, Rossi S, Rinaldi E, Simonelli F, Zagari A, Salvatore F
* Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase (1641 views)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2011 Dec; 32(12): 1460-1469.
Impact Factor: 5.686
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Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (714 views)
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
Impact Factor: 4.223
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (715 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (756 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (849 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (1119 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (1020 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (936 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (1056 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (1151 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Criscuolo C, Filla A, Coppola G, Rinaldi C, Carbone R, Pinto S, Wang Q, De Leva MF, Salvatore E, Banfi S, Brunetti A, Quarantelli M, Geschwind DH, Pappata S, De Michele G
* Two novel CYP7B1 mutations in Italian families with SPG5: A clinical and genetic study (862 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2009 Aug; 256(8): 1252-1257.
Impact Factor: 2.903
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1874 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (613 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (841 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (697 views)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
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Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
* The chemical synthesis of the GstI protein by NCL on a X-Met site (1046 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Dec 5; 83(5): 508-518.
Impact Factor: 2.48
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (2355 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Dellegrottaglie S, Perrone-filardi P, Pace L, Prastaro M, Corrado L, Cafiero M, Della Morte AM, Zarrilli A, Camerino R, Polimeno M, Chiarillo M
* The identification of reversible dysfunctional myocardium is influenced by the severity of contractile dysfunction and by the length of follow-up (590 views)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2005 Apr; 26(4): 337-343.
Impact Factor: 1.097
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Acampa W, Petretta M, Evangelista L, Petretta A, Cuocolo A
* Radionuclide Imaging in Patients with Ischemic Heart Failure (489 views)
Curr Med Imaging Rev (ISSN: 1573-4056, 1573-4056linking), 2005 Jan; 1(1): N/D-N/D.
Impact Factor: 1.059
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Santomauro M, Pace L, Duilio C, Ottaviano L, Borrelli A, Ferro A, Monteforte N, Cuocolo A, Salvatore M, Chiariello M
* Left ventricular pacing in patients with heart failure: Evaluation study with Fourier analysis of radionuclide ventriculography (875 views)
Ital Heart J (ISSN: 1129-471x), 2004 Dec; 5(12): 906-911.
Impact Factor: 6.023
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (682 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2004 Jun 1; 567(1): 20-26.
Impact Factor: 3.843
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Petretta M, Vicario ML, Spinelli L, Ferro A, Cuocolo A, Condorelli M, Bonaduce D
* Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy (617 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2002 Dec; 4(6): 727-735.
Impact Factor: 2.134
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (892 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Ferro A, Salvatore M, Cuocolo A
* Radionuclide monitoring of left ventricular function after sublingual nifedipine administration at rest and during moderate physical activity (1261 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001 Sep; 8(6): 669-676.
Impact Factor: 1.868
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Pace L, Nappi A, Imbriaco M, Cuocolo A, Varrone A, Romano M, Trimarco B, Salvatore M
Relationship between exercise capacity and left ventricular function at rest in patients with heart failure. An ambulatory left ventricular monitoring study (618 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 100(3): 120-125.
Impact Factor: 1.368
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
[Effects left ventricle asynchrony on systolic and diastolic function in patients with non-ischemic heart failure] (564 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Jul; 96(1-2): 68-72.
Impact Factor: 0.967
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Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
Influence of left ventricular asynchrony on systolic and diastolic function in patients with nonischemic heart failure (796 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(1-2): 68-72.
Impact Factor: 0.967
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (1939 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Pasquali D, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA
Retinoic acid receptors α, β and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer (1261 views)
Eur J Endocrinol (ISSN: 0804-4643), 1997 Oct; 137(4): 410-414.
Impact Factor: 1.968
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Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure (821 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jun; 38(6): 948-953.
Impact Factor: 3.491
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Pace L, Nappi A, Cuocolo A, Varrone A, Romano M, Salvatore M
Exercise capacity and left ventricular function at rest in patients with heart failure (870 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B
Influence of digitalis on left ventricular functional response to exercise in congestive heart failure (742 views)
Am J Cardiol (ISSN: 0002-9149), 1996 Mar 1; 77(7): 480-485.
Impact Factor: 2.402
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Russo R, Rao MA, Romano M, Scotto Di Santolo M, Cardei S, Giunta A, Cuocolo A, Volpe M
Prospects of pharmacologic treatment of post-ischemic heart failure (506 views)
Cardiologia (ISSN: 0393-1978), 1995 Dec; 40(12Suppl1): 533-537.
Impact Factor: 0
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Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (685 views)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
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Morisco C, Argenziano L, Sarno D, Cuocolo A, Romano M, Trimarco B
The practical aspects of treatment in heart failure (898 views)
Ann Ital Med Int (ISSN: 0393-9340), 1993 Oct; 8Suppl: 14S-19S.
Impact Factor: 0
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (682 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (854 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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67 Records (57 excluding Abstracts).
Total impact factor: 244.102 (192.4 excluding Abstracts).
Total 5 year impact factor: 252.332 (192.419 excluding Abstracts).
Total impact factor: 244.102 (192.4 excluding Abstracts).
Total 5 year impact factor: 252.332 (192.419 excluding Abstracts).
810 views. Last view on Tuesday 13 May 2025, 18:37:23
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