Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (487 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
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Paper type: Journal Article,
Impact factor: 6.908, 5-year impact factor: 6.949
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957229688&partnerID=40&md5=84c05697411fe27cfd7b59fd9fb3c0b7
Keywords: Cardiac Hypertrophy, Intracardiac Injection, Nf-κb, Spontaneously Hypertensive Rats, Transcription Factors, Adenovirus Vector, Atrial Natriuretic Factor, G Protein Coupled Receptor Kinase 5, Immunoglobulin Enhancer Binding Protein, Phenylephrine, Amino Terminal Sequence, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Gene Expression, Heart Left Ventricle Hypertrophy, Heart Muscle Cell, Heart Ventricle Hypertrophy, Nonhuman, Priority Journal, Wistar Kyoto Rat, Adenoviridae, Apoptosis, Blood Pressure, Blotting, Western, Cell Line, Echocardiography, Genetic Vectors, Left Ventricular, I-Kappa B Proteins, Myoblasts, Myocardium, Nf-Kappa B, Protein Binding, Inbred Shr, Inbred Wky,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
References:
Akira, S., Uematsu, S., Takeuchi, O., Pathogen recognition and innate immunity (2006) Cell, 124 (4), pp. 783-801. , DOI 10.1016/j.cell.2006.02.015, PII S009286740600190
Baldwin Jr., A.S., Series introduction: The transcription factor NF-B and human disease (2001) J Clin Invest, 107, pp. 3-6
Karin, M., Cao, Y., Greten, F.R., Li, Z.-W., NF-κB in cancer: From innocent bystander to major culprit (2002) Nature Reviews Cancer, 2 (4), pp. 301-310
Li, Q., Verma, I.M., Nf-B regulation in the immune system (2002) Nat Rev Immunol, 2, pp. 725-734
Cao, S., Zhang, X., Edwards, J.P., Mosser, D.M., NF-κB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages (2006) Journal of Biological Chemistry, 281 (36), pp. 26041-26050. , http://www.jbc.org/cgi/reprint/281/36/26041, DOI 10.1074/jbc.M602222200
Purcell, N.H., Tang, G., Yu, C., Mercurio, F., DiDonato, J.A., Lin, A., Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (12), pp. 6668-6673. , DOI 10.1073/pnas.111155798
Hirotani, S., Otsu, K., Nishida, K., Higuchi, Y., Morita, T., Nakayama, H., Yamaguchi, O., Hori, M., Involvement of nuclear factor-κB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy (2002) Circulation, 105 (4), pp. 509-515. , DOI 10.1161/hc0402.102863
Li, Y., Ha, T., Gao, X., Kelley, J., Williams, D.L., Browder, I.W., Kao, R.L., Li, C., NF-κ activation is required for the development of cardiac hypertrophy in vivo (2004) American Journal of Physiology - Heart and Circulatory Physiology, 287 (4), pp. H1712-H1720. , DOI 10.1152/ajpheart.00124.2004, 56-4
Kawano, S., Kubota, T., Monden, Y., Kawamura, N., Tsutsui, H., Takeshita, A., Sunagawa, K., Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II (2005) Cardiovascular Research, 67 (4), pp. 689-698. , DOI 10.1016/j.cardiores.2005.04.030, PII S0008636305002142
Parameswaran, N., Pao, C.S., Leonhard, K.S., Dong, S.K., Kratz, M., Ley, S.C., Benovic, J.L., Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFκB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages (2006) Journal of Biological Chemistry, 281 (45), pp. 34159-34170. , http://www.jbc.org/cgi/reprint/281/45/34159, DOI 10.1074/jbc.M605376200
Sorriento, D., Ciccarelli, M., Santulli, G., Campanile, A., Altobelli, G.G., Cimini, V., Galasso, G., Iaccarino, G., The G-protein-coupled receptor kinase 5 inhibits NF-B transcriptional activity by inducing nuclear accumulation of I-B (2008) Proc Natl Acad Sci U S A, 105, pp. 17818-17823
Sorriento, D., Campanile, A., Santulli, G., Leggiero, E., Pastore, L., Trimarco, B., Iaccarino, G., A new synthetic protein, Tat-rh, inhibits tumor growth through the regulation of NF-B activity (2009) Mol Cancer, 8, p. 97
Pleger, S.T., Remppis, A., Heidt, B., Volkers, M., Chuprun, J.K., Kuhn, M., Zhou, R.-H., Most, P., S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction (2005) Molecular Therapy, 12 (6), pp. 1120-1129. , DOI 10.1016/j.ymthe.2005.08.002, PII S1525001605015534
Iaccarino, G., Keys, J.R., Rapacciuolo, A., Shotwell, K.F., Lefkowitz, R.J., Rockman, H.A., Koch, W.J., Regulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-- adrenergic receptors (2001) Journal of the American College of Cardiology, 38 (2), pp. 534-540. , DOI 10.1016/S0735-1097(01)01396-1, PII S0735109701013961
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., Altobelli, G.G., Iaccarino, G., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 41
Watson, L.E., Sheth, M., Denyer, R.F., Dostal, D.E., Baseline echocardiographic values for adult male rats (2004) Journal of the American Society of Echocardiography, 17 (2), pp. 161-167. , DOI 10.1016/j.echo.2003.10.010
Oriente, F., Iovino, S., Cassese, A., Romano, C., Miele, C., Troncone, G., Balletta, M., Formisano, P., Overproduction of phosphoprotein enriched in diabetes (ped) induces mesangial expansion and upregulates protein kinase C- activity and TGF-1 expression (2009) Diabetologia, 52, pp. 2642-2652
Ogata, T., Miyauchi, T., Sakai, S., Takanashi, M., Irukayama-Tomobe, Y., Yamaguchi, I., Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway (2004) Journal of the American College of Cardiology, 43 (8), pp. 1481-1488. , DOI 10.1016/j.jacc.2003.11.043, PII S0735109704001901
Schellings, M.W.M., Baumann, M., Van Leeuwen, R.E.W., Duisters, R.F.J.J., Janssen, S.H.P., Schroen, B., Peutz-Kootstra, C.J., Pinto, Y.M., Imatinib attenuates end-organ damage in hypertensive homozygous TGR(mRen2)27 rats (2006) Hypertension, 47 (3), pp. 467-474. , DOI 10.1161/01.HYP.0000202487.68969.f7, PII 0000426820060300000034
Santulli, G., Cipolletta, E., Campanile, A., Maione, S., Trimarco, V., Marino, M., Trimarco, B., Iaccarino, G., Deletion of the camk4 gene in mice determines a hypertensive phenotype (2009) Circulation, 120, pp. S613-S613
Abramoff, M.D., Magelhaes, P.J., Ram, S.J., Image processing with Imagej (2004) Biophotonics Int, 11, pp. 36-42
Wang, S., Kotamraju, S., Konorev, E., Kalivendi, S., Joseph, J., Kalyanaraman, B., Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: The role of hydrogen peroxide (2002) Biochemical Journal, 367 (3), pp. 729-740. , DOI 10.1042/BJ20020752
Martini, J.S., Raake, P., Vinge, L.E., DeGeorge Jr., B.R., Chuprun, J.K., Harris, D.M., Gao, E., Koch, W.J., Uncovering G proteincoupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes (2008) Proc Natl Acad Sci U S A, 105, pp. 12457-12462
Gupta, S., Young, D., Sen, S., Inhibition of NF-κB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats (2005) American Journal of Physiology - Heart and Circulatory Physiology, 289 (1), pp. H20-H29. , DOI 10.1152/ajpheart.00082.2005, 58-1
Bing, O.H., Brooks, W.W., Robinson, K.G., Slawsky, M.T., Hayes, J.A., Litwin, S.E., Sen, S., Conrad, C.H., The spontaneously hypertensive rat as a model of the transition from compensated left ventricular hypertrophy to failure (1995) J Mol Cell Cardiol, 27, pp. 383-396
Capasso, J.M., Palackal, T., Olivetti, G., Anversa, P., Left ventricular failure induced by long-term hypertension in rats (1990) Circulation Research, 66 (5), pp. 1400-1412
Ayobe, M.H., Tarazi, R.C., Reversal of changes in myocardial-receptors and inotropic responsiveness with regression of cardiac hypertrophy in renal hypertensive rats (RHR) (1984) Circ Res, 54, pp. 125-134
Barkett, M., Gilmore, T.D., Control of apoptosis by rel/NF-B transcription factors (1999) Oncogene, 18, pp. 6910-6924
Pacifico, F., Leonardi, A., NF-B in solid tumors (2006) Biochem Pharmacol, 72, pp. 1142-1152
Dorn, I.I.G.W., The fuzzy logic of physiological cardiac hypertrophy (2007) Hypertension, 49, pp. 962-970
Dash, R., Schmidt, A.G., Pathak, A., Gerst, M.J., Biniakiewicz, D., Kadambi, V.J., Hoit, B.D., Kranias, E.G., Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy (2003) Cardiovascular Research, 57 (3), pp. 704-714. , DOI 10.1016/S0008-6363(02)00772-1
Harada, K., Pressure overload induces cardiac hypertrophy in angiotensin II type 1a receptor knockout mice (1998) Circulation, 97 (19), pp. 1952-1959
Aikawa, R., Nagai, T., Tanaka, M., Zou, Y., Ishihara, T., Takano, H., Hasegawa, H., Komuro, I., Reactive oxygen species in mechanical stress-induced cardiac hypertrophy (2001) Biochemical and Biophysical Research Communications, 289 (4), pp. 901-907. , DOI 10.1006/bbrc.2001.6068
De Windt, L.J., Lim, H.W., Bueno, O.F., Liang, Q., Delling, U., Braz, J.C., Glascock, B.J., Molkentin, J.D., Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (6), pp. 3322-3327. , DOI 10.1073/pnas.031371998
Liang, Q., Molkentin, J.D., Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression (2002) Journal of Molecular and Cellular Cardiology, 34 (6), pp. 611-616. , DOI 10.1006/jmcc.2002.2011
Dorn II, G.W., Force, T., Protein kinase cascades in the regulation of cardiac hypertrophy (2005) Journal of Clinical Investigation, 115 (3), pp. 527-537. , DOI 10.1172/JCI200524178
Sands, W.A., Palmer, T.M., Regulating gene transcription in response to cyclic amp elevation (2008) Cell Signal, 20, pp. 460-466
Cowen, R.L., Williams, J.C., Emery, S., Blakey, D., Darling, J.L., Lowenstein, P.R., Castro, M.G., Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane (2002) Cancer Gene Therapy, 9 (11), pp. 897-907. , DOI 10.1038/sj.cgt.7700514
Leor, J., Quinones, M.J., Patterson, M., Kedes, L., Kloner, R.A., Adenovirus-mediated gene transfer into infarcted myocardium: Feasibility, timing, and location of expression (1996) Journal of Molecular and Cellular Cardiology, 28 (10), pp. 2057-2067. , DOI 10.1006/jmcc.1996.0199
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.908, 5-year impact factor: 6.949
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957229688&partnerID=40&md5=84c05697411fe27cfd7b59fd9fb3c0b7
Keywords: Cardiac Hypertrophy, Intracardiac Injection, Nf-κb, Spontaneously Hypertensive Rats, Transcription Factors, Adenovirus Vector, Atrial Natriuretic Factor, G Protein Coupled Receptor Kinase 5, Immunoglobulin Enhancer Binding Protein, Phenylephrine, Amino Terminal Sequence, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Gene Expression, Heart Left Ventricle Hypertrophy, Heart Muscle Cell, Heart Ventricle Hypertrophy, Nonhuman, Priority Journal, Wistar Kyoto Rat, Adenoviridae, Apoptosis, Blood Pressure, Blotting, Western, Cell Line, Echocardiography, Genetic Vectors, Left Ventricular, I-Kappa B Proteins, Myoblasts, Myocardium, Nf-Kappa B, Protein Binding, Inbred Shr, Inbred Wky,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
References:
Akira, S., Uematsu, S., Takeuchi, O., Pathogen recognition and innate immunity (2006) Cell, 124 (4), pp. 783-801. , DOI 10.1016/j.cell.2006.02.015, PII S009286740600190
Baldwin Jr., A.S., Series introduction: The transcription factor NF-B and human disease (2001) J Clin Invest, 107, pp. 3-6
Karin, M., Cao, Y., Greten, F.R., Li, Z.-W., NF-κB in cancer: From innocent bystander to major culprit (2002) Nature Reviews Cancer, 2 (4), pp. 301-310
Li, Q., Verma, I.M., Nf-B regulation in the immune system (2002) Nat Rev Immunol, 2, pp. 725-734
Cao, S., Zhang, X., Edwards, J.P., Mosser, D.M., NF-κB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages (2006) Journal of Biological Chemistry, 281 (36), pp. 26041-26050. , http://www.jbc.org/cgi/reprint/281/36/26041, DOI 10.1074/jbc.M602222200
Purcell, N.H., Tang, G., Yu, C., Mercurio, F., DiDonato, J.A., Lin, A., Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (12), pp. 6668-6673. , DOI 10.1073/pnas.111155798
Hirotani, S., Otsu, K., Nishida, K., Higuchi, Y., Morita, T., Nakayama, H., Yamaguchi, O., Hori, M., Involvement of nuclear factor-κB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy (2002) Circulation, 105 (4), pp. 509-515. , DOI 10.1161/hc0402.102863
Li, Y., Ha, T., Gao, X., Kelley, J., Williams, D.L., Browder, I.W., Kao, R.L., Li, C., NF-κ activation is required for the development of cardiac hypertrophy in vivo (2004) American Journal of Physiology - Heart and Circulatory Physiology, 287 (4), pp. H1712-H1720. , DOI 10.1152/ajpheart.00124.2004, 56-4
Kawano, S., Kubota, T., Monden, Y., Kawamura, N., Tsutsui, H., Takeshita, A., Sunagawa, K., Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II (2005) Cardiovascular Research, 67 (4), pp. 689-698. , DOI 10.1016/j.cardiores.2005.04.030, PII S0008636305002142
Parameswaran, N., Pao, C.S., Leonhard, K.S., Dong, S.K., Kratz, M., Ley, S.C., Benovic, J.L., Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFκB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages (2006) Journal of Biological Chemistry, 281 (45), pp. 34159-34170. , http://www.jbc.org/cgi/reprint/281/45/34159, DOI 10.1074/jbc.M605376200
Sorriento, D., Ciccarelli, M., Santulli, G., Campanile, A., Altobelli, G.G., Cimini, V., Galasso, G., Iaccarino, G., The G-protein-coupled receptor kinase 5 inhibits NF-B transcriptional activity by inducing nuclear accumulation of I-B (2008) Proc Natl Acad Sci U S A, 105, pp. 17818-17823
Sorriento, D., Campanile, A., Santulli, G., Leggiero, E., Pastore, L., Trimarco, B., Iaccarino, G., A new synthetic protein, Tat-rh, inhibits tumor growth through the regulation of NF-B activity (2009) Mol Cancer, 8, p. 97
Pleger, S.T., Remppis, A., Heidt, B., Volkers, M., Chuprun, J.K., Kuhn, M., Zhou, R.-H., Most, P., S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction (2005) Molecular Therapy, 12 (6), pp. 1120-1129. , DOI 10.1016/j.ymthe.2005.08.002, PII S1525001605015534
Iaccarino, G., Keys, J.R., Rapacciuolo, A., Shotwell, K.F., Lefkowitz, R.J., Rockman, H.A., Koch, W.J., Regulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-- adrenergic receptors (2001) Journal of the American College of Cardiology, 38 (2), pp. 534-540. , DOI 10.1016/S0735-1097(01)01396-1, PII S0735109701013961
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., Altobelli, G.G., Iaccarino, G., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 41
Watson, L.E., Sheth, M., Denyer, R.F., Dostal, D.E., Baseline echocardiographic values for adult male rats (2004) Journal of the American Society of Echocardiography, 17 (2), pp. 161-167. , DOI 10.1016/j.echo.2003.10.010
Oriente, F., Iovino, S., Cassese, A., Romano, C., Miele, C., Troncone, G., Balletta, M., Formisano, P., Overproduction of phosphoprotein enriched in diabetes (ped) induces mesangial expansion and upregulates protein kinase C- activity and TGF-1 expression (2009) Diabetologia, 52, pp. 2642-2652
Ogata, T., Miyauchi, T., Sakai, S., Takanashi, M., Irukayama-Tomobe, Y., Yamaguchi, I., Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway (2004) Journal of the American College of Cardiology, 43 (8), pp. 1481-1488. , DOI 10.1016/j.jacc.2003.11.043, PII S0735109704001901
Schellings, M.W.M., Baumann, M., Van Leeuwen, R.E.W., Duisters, R.F.J.J., Janssen, S.H.P., Schroen, B., Peutz-Kootstra, C.J., Pinto, Y.M., Imatinib attenuates end-organ damage in hypertensive homozygous TGR(mRen2)27 rats (2006) Hypertension, 47 (3), pp. 467-474. , DOI 10.1161/01.HYP.0000202487.68969.f7, PII 0000426820060300000034
Santulli, G., Cipolletta, E., Campanile, A., Maione, S., Trimarco, V., Marino, M., Trimarco, B., Iaccarino, G., Deletion of the camk4 gene in mice determines a hypertensive phenotype (2009) Circulation, 120, pp. S613-S613
Abramoff, M.D., Magelhaes, P.J., Ram, S.J., Image processing with Imagej (2004) Biophotonics Int, 11, pp. 36-42
Wang, S., Kotamraju, S., Konorev, E., Kalivendi, S., Joseph, J., Kalyanaraman, B., Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: The role of hydrogen peroxide (2002) Biochemical Journal, 367 (3), pp. 729-740. , DOI 10.1042/BJ20020752
Martini, J.S., Raake, P., Vinge, L.E., DeGeorge Jr., B.R., Chuprun, J.K., Harris, D.M., Gao, E., Koch, W.J., Uncovering G proteincoupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes (2008) Proc Natl Acad Sci U S A, 105, pp. 12457-12462
Gupta, S., Young, D., Sen, S., Inhibition of NF-κB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats (2005) American Journal of Physiology - Heart and Circulatory Physiology, 289 (1), pp. H20-H29. , DOI 10.1152/ajpheart.00082.2005, 58-1
Bing, O.H., Brooks, W.W., Robinson, K.G., Slawsky, M.T., Hayes, J.A., Litwin, S.E., Sen, S., Conrad, C.H., The spontaneously hypertensive rat as a model of the transition from compensated left ventricular hypertrophy to failure (1995) J Mol Cell Cardiol, 27, pp. 383-396
Capasso, J.M., Palackal, T., Olivetti, G., Anversa, P., Left ventricular failure induced by long-term hypertension in rats (1990) Circulation Research, 66 (5), pp. 1400-1412
Ayobe, M.H., Tarazi, R.C., Reversal of changes in myocardial-receptors and inotropic responsiveness with regression of cardiac hypertrophy in renal hypertensive rats (RHR) (1984) Circ Res, 54, pp. 125-134
Barkett, M., Gilmore, T.D., Control of apoptosis by rel/NF-B transcription factors (1999) Oncogene, 18, pp. 6910-6924
Pacifico, F., Leonardi, A., NF-B in solid tumors (2006) Biochem Pharmacol, 72, pp. 1142-1152
Dorn, I.I.G.W., The fuzzy logic of physiological cardiac hypertrophy (2007) Hypertension, 49, pp. 962-970
Dash, R., Schmidt, A.G., Pathak, A., Gerst, M.J., Biniakiewicz, D., Kadambi, V.J., Hoit, B.D., Kranias, E.G., Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy (2003) Cardiovascular Research, 57 (3), pp. 704-714. , DOI 10.1016/S0008-6363(02)00772-1
Harada, K., Pressure overload induces cardiac hypertrophy in angiotensin II type 1a receptor knockout mice (1998) Circulation, 97 (19), pp. 1952-1959
Aikawa, R., Nagai, T., Tanaka, M., Zou, Y., Ishihara, T., Takano, H., Hasegawa, H., Komuro, I., Reactive oxygen species in mechanical stress-induced cardiac hypertrophy (2001) Biochemical and Biophysical Research Communications, 289 (4), pp. 901-907. , DOI 10.1006/bbrc.2001.6068
De Windt, L.J., Lim, H.W., Bueno, O.F., Liang, Q., Delling, U., Braz, J.C., Glascock, B.J., Molkentin, J.D., Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (6), pp. 3322-3327. , DOI 10.1073/pnas.031371998
Liang, Q., Molkentin, J.D., Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression (2002) Journal of Molecular and Cellular Cardiology, 34 (6), pp. 611-616. , DOI 10.1006/jmcc.2002.2011
Dorn II, G.W., Force, T., Protein kinase cascades in the regulation of cardiac hypertrophy (2005) Journal of Clinical Investigation, 115 (3), pp. 527-537. , DOI 10.1172/JCI200524178
Sands, W.A., Palmer, T.M., Regulating gene transcription in response to cyclic amp elevation (2008) Cell Signal, 20, pp. 460-466
Cowen, R.L., Williams, J.C., Emery, S., Blakey, D., Darling, J.L., Lowenstein, P.R., Castro, M.G., Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane (2002) Cancer Gene Therapy, 9 (11), pp. 897-907. , DOI 10.1038/sj.cgt.7700514
Leor, J., Quinones, M.J., Patterson, M., Kedes, L., Kloner, R.A., Adenovirus-mediated gene transfer into infarcted myocardium: Feasibility, timing, and location of expression (1996) Journal of Molecular and Cellular Cardiology, 28 (10), pp. 2057-2067. , DOI 10.1006/jmcc.1996.0199
Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression
Several studies underline the role of the transcription factor NF-κB in the development of left cardiac hypertrophy (LVH). We have demonstrated recently that the RGS homology domain within the amino terminus of GRK5 (GRK5-NT) is able to inhibit NF-κB transcription activity and its associated phenotypes. The aim of this study was to evaluate the ability of GRK5-NT to regulate LVH through the inhibition of NF-κB both in vitro and in vivo. In cardiomyoblasts, GRK5-NT inhibits phenylephrine-induced transcription of both NF-κB and atrial natriuretic factor promoters, assessed by luciferase assay, thus confirming a role for this protein in the regulation of cardiomyocyte hypertrophy. In vivo, we explored 2 rat models of LVH, the spontaneously hypertensive rat and the normotensive Wistar Kyoto rat exposed to chronic administration of phenylephrine. Intracardiac injection of an adenovirus encoding for GRK5-NT reduces cardiac mass in spontaneously hypertensive rats and prevents the development of phenylephrine-induced LVH in Wistar Kyoto rats. This associates with inhibition of NF-κB signaling (assessed by NF-κB levels), transcriptional activity and phenotypes (fibrosis and apoptosis). Such phenomenon is independent from hemodynamic changes, because adenovirus encoding for GRK5-NT did not reduce blood pressure levels in spontaneously hypertensive rats or in Wistar Kyoto rats. In conclusion, our study supports the regulation of LVH based on the GRK5-NT inhibition of the NF-κB transduction signaling. © 2010 American Heart Association, Inc.
Several studies underline the role of the transcription factor NF-κB in the development of left cardiac hypertrophy (LVH). We have demonstrated recently that the RGS homology domain within the amino terminus of GRK5 (GRK5-NT) is able to inhibit NF-κB transcription activity and its associated phenotypes. The aim of this study was to evaluate the ability of GRK5-NT to regulate LVH through the inhibition of NF-κB both in vitro and in vivo. In cardiomyoblasts, GRK5-NT inhibits phenylephrine-induced transcription of both NF-κB and atrial natriuretic factor promoters, assessed by luciferase assay, thus confirming a role for this protein in the regulation of cardiomyocyte hypertrophy. In vivo, we explored 2 rat models of LVH, the spontaneously hypertensive rat and the normotensive Wistar Kyoto rat exposed to chronic administration of phenylephrine. Intracardiac injection of an adenovirus encoding for GRK5-NT reduces cardiac mass in spontaneously hypertensive rats and prevents the development of phenylephrine-induced LVH in Wistar Kyoto rats. This associates with inhibition of NF-κB signaling (assessed by NF-κB levels), transcriptional activity and phenotypes (fibrosis and apoptosis). Such phenomenon is independent from hemodynamic changes, because adenovirus encoding for GRK5-NT did not reduce blood pressure levels in spontaneously hypertensive rats or in Wistar Kyoto rats. In conclusion, our study supports the regulation of LVH based on the GRK5-NT inhibition of the NF-κB transduction signaling. © 2010 American Heart Association, Inc.
Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression
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Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression
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Di Giovannantonio LG, Acampora D, Omodei D, Nigro V, Barba P, Barbieri E, Chambers I, Simeone A
* Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage (11 views)
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Impact Factor: 5.611
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Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (68 views)
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Impact Factor: 2.74
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Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M
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Pirone L, Caldinelli L, Di Lascio S, Di Girolamo R, Di Gaetano S, Fornasari D, Pollegioni L, Benfante R, Pedone E
* Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation (293 views) (PDF 55 views)
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Impact Factor: 3.129
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
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Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, Campiglia P, Trimarco B, Iaccarino G, Ciccarelli M
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Impact Factor: 3.197
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Cipolletta E, Rusciano MR, Maione AS, Santulli G, Sorriento D, Del Giudice C, Ciccarelli M, Franco A, Crola C, Campiglia P, Sala M, Gomez-Monterrey I, De Luca N, Trimarco B, Iaccarino G, Illario M
* Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy (275 views)
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Impact Factor: 3.057
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
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Impact Factor: 2.76
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (508 views)
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Impact Factor: 1.546
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Contursi P, Farina B, Pirone L, Fusco S, Russo L, Bartolucci S, Fattorusso R, Pedone E
* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (383 views)
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Impact Factor: 9.112
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
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Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
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Impact Factor: 4.906
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Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
* Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (393 views)
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Impact Factor: 5.001
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Sorriento D, Illario M, Finelli R, Iaccarino G
* To NFkappaB or not to NFkappaB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator (261 views)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2012 Oct 11; 4: 73-85.
Impact Factor: 2.256
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
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Impact Factor: 2.87
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
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Impact Factor: 4.409
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Amorosi S, Vigliano I, Del Giudice E, Panico L, Maruotti GM, Fusco A, Quarantelli M, Ciccone C, Ursini MV, Martinelli P, Pignata C
* Brain alteration in a Nude/SCID fetus carrying FOXN1 homozygous mutation (401 views)
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Impact Factor: 2.167
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (514 views)
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Impact Factor: 2.572
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (611 views)
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Impact Factor: 19.407
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (301 views)
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Impact Factor: 4.512
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (410 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (490 views)
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Impact Factor: 5.155
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
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Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
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Impact Factor: 2.531
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
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Impact Factor: 4.782
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
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Impact Factor: 1.741
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (438 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
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Impact Factor: 4.104
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
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Impact Factor: 3.19
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
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Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
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Impact Factor: 5.873
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
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Impact Factor: 3.992
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (635 views)
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Impact Factor: 7.051
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
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Impact Factor: 3.542
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
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Impact Factor: 2.849
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (436 views)
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* Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor (10 views)
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Impact Factor: 6.208
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Di Giovannantonio LG, Acampora D, Omodei D, Nigro V, Barba P, Barbieri E, Chambers I, Simeone A
* Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage (11 views)
Development (ISSN: 0950-1991linking), 2021 May 15; 148(10): N/D-N/D.
Impact Factor: 5.611
View Export to BibTeX Export to EndNote
Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (68 views)
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Impact Factor: 2.74
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Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M
* Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2, 1-i]purine Derivatives (98 views)
J Med Chem (ISSN: 0022-2623linking, 0022-2623print), 2020 Mar 12; 63(5): 2035-2050.
Impact Factor: 6.205
View Export to BibTeX Export to EndNote
Pirone L, Caldinelli L, Di Lascio S, Di Girolamo R, Di Gaetano S, Fornasari D, Pollegioni L, Benfante R, Pedone E
* Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation (293 views) (PDF 55 views)
Febs J (ISSN: 1742-464xlinking), 2019 Apr 7; 286(13): 2505-2521.
Impact Factor: 3.129
View Export to BibTeX Export to EndNote
Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, Campiglia P, Trimarco B, Iaccarino G, Ciccarelli M
* Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy (310 views)
J Cardiovasc Transl (ISSN: 1937-5387, 1937-5387linking), 2015 Jul 30; 8(8): 493-502.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Cipolletta E, Rusciano MR, Maione AS, Santulli G, Sorriento D, Del Giudice C, Ciccarelli M, Franco A, Crola C, Campiglia P, Sala M, Gomez-Monterrey I, De Luca N, Trimarco B, Iaccarino G, Illario M
* Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy (275 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Jun 25; 10(6): e0130477-e0130477.
Impact Factor: 3.057
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
View Export to BibTeX Export to EndNote
Contursi P, Farina B, Pirone L, Fusco S, Russo L, Bartolucci S, Fattorusso R, Pedone E
* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (383 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2014; 42(9): 5993-6011.
Impact Factor: 9.112
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
* Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (393 views)
J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
Impact Factor: 5.001
View Export to BibTeX Export to EndNote
Sorriento D, Illario M, Finelli R, Iaccarino G
* To NFkappaB or not to NFkappaB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator (261 views)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2012 Oct 11; 4: 73-85.
Impact Factor: 2.256
View Export to BibTeX Export to EndNote
Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Amorosi S, Vigliano I, Del Giudice E, Panico L, Maruotti GM, Fusco A, Quarantelli M, Ciccone C, Ursini MV, Martinelli P, Pignata C
* Brain alteration in a Nude/SCID fetus carrying FOXN1 homozygous mutation (401 views)
J Neurol Sci (ISSN: 0022-510x), 2010 Nov 15; 298(1-2): 121-123.
Impact Factor: 2.167
View Export to BibTeX Export to EndNote
Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
View Export to BibTeX Export to EndNote
Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (514 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (611 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (301 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (410 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (490 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (565 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
J Pept Res (ISSN: 1397-002x), 2005 Feb; 65(2): 200-208.
Impact Factor: 1.741
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (438 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (478 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (339 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (429 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (635 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (401 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (436 views)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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40 Records (39 excluding Abstracts).
Total impact factor: 181.486 (177.135 excluding Abstracts).
Total 5 year impact factor: 169.424 (165.041 excluding Abstracts).
Total impact factor: 181.486 (177.135 excluding Abstracts).
Total 5 year impact factor: 169.424 (165.041 excluding Abstracts).
487 views. Last view on Sunday 26 March 2023, 17:58:13
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