A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity(359 views) Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Keywords: Adenovirus Vector, Antineoplastic Agent, I Kappa B, Immunoglobulin Enhancer Binding Protein, Transactivator Rh Protein, Unclassified Drug, G Protein Coupled Receptor Kinase 5, Grk5 Protein, Human, Lipocortin 5, Recombinant Protein, Transactivator Protein, Animal Experiment, Animal Model, Animal Tissue, Antineoplastic Activity, Apoptosis, Article, Cancer Cell Culture, Cancer Growth, Cancer Inhibition, Cell Survival, Controlled Study, Drug Dose Comparison, Gene Overexpression, Human Cell, In Vitro Study, Mouse, Nonhuman, Transcription Initiation, Transcription Regulation, Viral Gene Delivery System, Bagg Albino Mouse, Cell Proliferation, Chemistry, Drug Effect, Drug Screening, Genetics, Inflammation, Isolation And Purification, Metabolism, Neovascularization (pathology), Protein Tertiary Structure, Staining, Tumor Cell Line, Adenoviridae, Mus Musculus, Annexin A5, G-Protein-Coupled Receptor Kinase 5, Gene Products, Inbred Balb C, Nf-Kappa B, Protein Structure, Staining And Labeling, Xenograft Model Antitumor Assays,
Affiliations: *** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Napoli, Italy
CEINGE-Biotecnologie Avanzate, Napoli, Italy
Dipartimento di Biochimica e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Napoli, Italy
References: Gilmore, T.D., Introduction to NF-kappaB: players, pathways, perspectives (2006) Oncogene, 25, pp. 6680-6684. , 10.1038/sj.onc.1209954, 1707232
Brasier, A.R., The NF-kappaB regulatory network (2006) Cardiovasc Toxicol, 6, pp. 111-130. , 10.1385/CT:6:2:111, 17303919
Perkins, N.D., Integrating cell-signalling pathways with NF-kappaB and IKK function (2007) Nat Rev Mol Cell Biol, 8, pp. 49-62. , 10.1038/nrm2083, 17183360
Gilmore, T.D., The Rel/NF-kappaB signal transduction pathway: introduction (1999) Oncogene, 18, pp. 6842-6844. , 10.1038/sj.onc.1203237, 10602459
Tian, B., Brasier, A.R., Identification of a nuclear factor kappa B-dependent gene network (2003) Recent Prog Horm Res, 58, pp. 95-130. , 10.1210/rp.58.1.95, 12795416
Jacobs, M.D., Harrison, S.C., Structure of an IkappaBalpha/NF-kappaB complex (1998) Cell, 95, pp. 749-758. , 10.1016/S0092-8674(00)81698-0, 9865693
Baldwin, A.S., Series introduction: the transcription factor NF-kappaB and human disease (2001) J Clin Invest, 107, pp. 3-6. , 198555, 11134170, 10.1172/JCI11891
Kumar, A., Takada, Y., Boriek, A.M., Aggarwal, B.B., Nuclear factor-kappaB: its role in health and disease (2004) J Mol Med, 82, pp. 434-448. , 10.1007/s00109-004-0555-y, 15175863
Yamamoto, Y., Gaynor, R.B., Role of the NF-kappaB pathway in the pathogenesis of human disease states (2001) Curr Mol Med, 1, pp. 287-296. , 10.2174/1566524013363816, 11899077
Brown, K., Park, S., Kanno, T., Franzoso, G., Siebenlist, U., Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha (1993) Proc Natl Acad Sci USA, 90, pp. 2532-2536. , 46122, 8460169, 10.1073/pnas.90.6.2532
Shibata, A., Nagaya, T., Imai, T., Funahashi, H., Nakao, A., Seo, H., Inhibition of NF-kappaB activity decreases the VEGF mRNA expression in MDA-MB-231 breast cancer cells (2002) Breast Cancer Res Treat, 73, pp. 237-243. , 10.1023/A:1015872531675, 12160329
Freund, C., Schmidt-Ullrich, R., Baurand, A., Dunger, S., Schneider, W., Loser, P., El-Jamali, A., Bergmann, M.W., Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo (2005) Circulation, 111, pp. 2319-2325. , 10.1161/01.CIR.0000164237.58200.5A, 15870116
Ross, J.S., Stagliano, N.E., Donovan, M.J., Breitbart, R.E., Ginsburg, G.S., Atherosclerosis: a cancer of the blood vessels? (2001) Am J Clin Pathol, 116 (SUPPL), pp. S97-107
Frantz, S., Fraccarollo, D., Wagner, H., Behr, T.M., Jung, P., Angermann, C.E., Ertl, G., Bauersachs, J., Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure (2003) Cardiovasc Res, 57, pp. 749-756. , 10.1016/S0008-6363(02)00723-X, 12618236
Karin, M., Cao, Y., Greten, F.R., Li, Z.W., NF-kappaB in cancer: from innocent bystander to major culprit (2002) Nat Rev Cancer, 2, pp. 301-310. , 10.1038/nrc780, 12001991
Hanahan, D., Weinberg, R.A., The hallmarks of cancer (2000) Cell, 100, pp. 57-70. , 10.1016/S0092-8674(00)81683-9, 10647931
Aggarwal, B., Nuclear factor-kappaB: the enemy within (2004) cancer cell, 6, pp. 203-208. , 10.1016/j.ccr.2004.09.003, 15380510
Shattuck-Brandt, R.L., Richmond, A., Enhanced degradation of I-kappaB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cells (1997) Cancer Res, 57, pp. 3032-3039
Amiri, K.I., Richmond, A., Role of nuclear factor-kappa B in melanoma (2005) Cancer Metastasis Rev, 24, pp. 301-313. , 2668255, 15986139, 10.1007/s10555-005-1579-7
Visconti, R., Cerutti, J., Battista, S., Fedele, M., Trapasso, F., Zeki, K., Miano, M.P., Curcio, F., Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression (1997) Oncogene, 15, pp. 1987-1994. , 10.1038/sj.onc.1201373, 9365245
Pacifico, F., Mauro, C., Barone, C., Crescenzi, E., Mellone, S., Monaco, M., Chiappetta, G., Vito, P., Oncogenic and anti-apoptotic activity of NF-kappa B in human thyroid carcinomas (2004) J Biol Chem, 279, pp. 54610-54619. , 10.1074/jbc.M403492200, 15475567
Kojima, M., Morisaki, T., Sasaki, N., Nakano, K., Mibu, R., Tanaka, M., Katano, M., Increased nuclear factor-kB activation in human colorectal carcinoma and its correlation with tumor progression (2004) Anticancer Res, 24, pp. 675-681
Kane, R.C., Bross, P.F., Farrell, A.T., Pazdur, R., Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy (2003) Oncologist, 8, pp. 508-513. , 10.1634/theoncologist.8-6-508, 14657528
Jimi, E., Aoki, K., Saito, H., D'Acquisto, F., May, M.J., Nakamura, I., Sudo, T., Fukushima, H., Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo (2004) Nat Med, 10, pp. 617-624. , 10.1038/nm1054, 15156202
Dewan, M.Z., Terashima, K., Taruishi, M., Hasegawa, H., Ito, M., Tanaka, Y., Mori, N., Maeda, M., Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB (2003) J Virol, 77, pp. 5286-5294. , 153944, 12692230, 10.1128/JVI.77.9.5286-5294.2003
Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R., Verma, I.M., Suppression of TNF-alpha-induced apoptosis by NF-kappaB (1996) Science, 274, pp. 787-789. , 10.1126/science.274.5288.787, 8864120
Wang, C.Y., Mayo, M.W., Baldwin, A.S., TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB (1996) Science, 274, pp. 784-787. , 10.1126/science.274.5288.784, 8864119
Sorriento, D., Ciccarelli, M., Santulli, G., Campanile, A., Altobelli, G.G., Cimini, V., Galasso, G., Pastore, L., The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha (2008) Proc Natl Acad Sci USA, 105, pp. 17818-17823. , 2584738, 19008357, 10.1073/pnas.0804446105
Schweppe, R.E., Klopper, J.P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J.A., Fagin, J.A., Haugen, B.R., Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification (2008) J Clin Endocrinol Metab, 93, pp. 4331-4341. , 2582569, 18713817, 10.1210/jc.2008-1102
Becker-Hapak, M., McAllister, S.S., Dowdy, S.F., TAT-mediated protein transduction into mammalian cells (2001) Methods, 24, pp. 247-256. , 10.1006/meth.2001.1186, 11403574
Bargou, R.C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M.Y., Arnold, W., Royer, H.D., Dorken, B., Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells (1997) J Clin Invest, 100, pp. 2961-2969. , 508507, 9399941, 10.1172/JCI119849
Sovak, M.A., Bellas, R.E., Kim, D.W., Zanieski, G.J., Rogers, A.E., Traish, A.M., Sonenshein, G.E., Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer (1997) J Clin Invest, 100, pp. 2952-2960. , 508506, 9399940, 10.1172/JCI119848
Suh, J., Payvandi, F., Edelstein, L.C., Amenta, P.S., Zong, W.X., Gelinas, C., Rabson, A.B., Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells (2002) Prostate, 52, pp. 183-200. , 10.1002/pros.10082, 12111695
Mukhopadhyay, T., Roth, J.A., Maxwell, S.A., Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma (1995) Oncogene, 11, pp. 999-1003
Wang, W., Abbruzzese, J.L., Evans, D.B., Larry, L., Cleary, K.R., Chiao, P.J., The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells (1999) Clin Cancer Res, 5, pp. 119-127
Ondrey, F.G., Dong, G., Sunwoo, J., Chen, Z., Wolf, J.S., Crowl-Bancroft, C.V., Mukaida, N., Van Waes, C., Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines (1999) Mol Carcinog, 26, pp. 119-129. , 10.1002/(SICI)1098-2744(199910)26:2<119::AID-MC6>
3.0.CO
Nair, A., Venkatraman, M., Maliekal, T.T., Nair, B., Karunagaran, D., NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix (2003) Oncogene, 22, pp. 50-58. , 10.1038/sj.onc.1206043, 12527907
Demeter, J.G., De Jong, S.A., Lawrence, A.M., Paloyan, E., Anaplastic thyroid carcinoma: risk factors and outcome (1991) Surgery, 110, pp. 956-961
Cho, S., Urata, Y., Iida, T., Goto, S., Yamaguchi, M., Sumikawa, K., Kondo, T., Glutathione downregulates the phosphorylation of I kappa B: autoloop regulation of the NF-kappa B-mediated expression of NF-kappa B subunits by TNF-alpha in mouse vascular endothelial cells (1998) Biochem Biophys Res Commun, 253, pp. 104-108. , 10.1006/bbrc.1998.9697, 9875227
Schreck, R., Meier, B., Mannel, D.N., Droge, W., Baeuerle, P.A., Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells (1992) J Exp Med, 175, pp. 1181-1194. , 2119220, 1314883, 10.1084/jem.175.5.1181
Higgins, K.A., Perez, J.R., Coleman, T.A., Dorshkind, K., McComas, W.A., Sarmiento, U.M., Rosen, C.A., Narayanan, R., Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression (1993) Proc Natl Acad Sci USA, 90, pp. 9901-9905. , 47680, 8234333, 10.1073/pnas.90.21.9901
Snyder, E.L., Dowdy, S.F., Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo (2005) Expert Opin Drug Deliv, 2, pp. 43-51. , 10.1517/17425247.2.1.43, 16296734
Wadia, J.S., Dowdy, S.F., Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer (2005) Adv Drug Deliv Rev, 57, pp. 579-596. , 10.1016/j.addr.2004.10.005, 15722165
Arlt, A., Gehrz, A., Muerkoster, S., Vorndamm, J., Kruse, M.L., Folsch, U.R., Schafer, H., Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death (2003) Oncogene, 22, pp. 3243-3251. , 10.1038/sj.onc.1206390, 12761494
Brach, M.A., Hass, R., Sherman, M.L., Gunji, H., Weichselbaum, R., Kufe, D., Ionizing radiation induces expression and binding activity of the nuclear factor kappa B (1991) J Clin Invest, 88, pp. 691-695. , 295415, 1864978, 10.1172/JCI115354
Hwang, S., Ding, A., Activation of NF-kappa B in murine macrophages by taxol (1995) Cancer Biochem Biophys, 14, pp. 265-272
Huang, S., DeGuzman, A., Bucana, C.D., Fidler, I.J., Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice (2000) Clin Cancer Res, 6, pp. 2573-2581
Chilov, D., Kukk, E., Taira, S., Jeltsch, M., Kaukonen, J., Palotie, A., Joukov, V., Alitalo, K., Genomic organization of human and mouse genes for vascular endothelial growth factor C (1997) J Biol Chem, 272, pp. 25176-25183. , 10.1074/jbc.272.40.25176, 9312130
A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(288 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S * Fusion in Coq(481 views) Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596. Impact Factor:0.415 ViewExport to BibTeXExport to EndNote