Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (466 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.069, 5-year impact factor: 5.941
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-70449413985&partnerID=40&md5=5a19412420c320303f8e34e4e71ecf4e
Keywords: Carotid Arteries, Endothelium, Igf-1, Nitric Oxide Synthase, Restenosis, Endothelial Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Protein Kinase B, Somatomedin C, Angiogenesis, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Artery Media, Article, Carotid Artery Injury, Carotid Artery Obstruction, Cell Proliferation, Controlled Study, Drug Activity, Drug Blood Level, Drug Potency, Endothelium Cell, Heart Protection, Histopathology, Intima, Mitosis Inhibition, Neovascularization (pathology), Nonhuman, Priority Journal, Protein Phosphorylation, Reendothelialization, Signal Transduction, Smooth Muscle Fiber, Stem Cell Mobilization, Balloon Dilatation, Carotid Artery Injuries, Carotid Stenosis, Disease Models, Insulin-Like Growth Factor I, Protective Agents, Regeneration, Tunica Intima, Tunica Media,
Affiliations:
*** IBB - CNR ***
Department of Internal Medicine, University Federico II, Naples, Italy
References:
Hayashi, K., Shibata, K., Morita, T., Iwasaki, K., Watanabe, M., Sobue, K., Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells (2004) J Biol Chem, 279, pp. 40807-4081
Bay, H.B., Pollman, M., Inishi, Y., Gibbons, G.H., Regulation of vascular smooth muscle cell apoptosis: modulation of Bad by a phosphatidylinositol 3-kinase-dependent pathway (1999) Circ Res, 85, pp. 229-237
Delafontaine, P., Song, Y.-.H., Li, Y., Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels (2004) Arterioscler Thromb Vasc Biol, 24, pp. 435-444
Michell, B.J., Griffiths, J.E., Mitchelhill, K.I., Rodriguez-Crespo, I., Tiganis, T., Bozinovski, S., Ortiz de Montellano, P.R., Pearson, R.B., The Akt kinase signals directly to endothelial nitric oxide synthase (1999) Curr Biol, 9, pp. 845-848
Isenovic, E.R., Divald, A., Milivojevic, N., Grgurevic, T., Fisher, S.E., Sowers, J.R., Interactive effects of insulin-like Growth Factor-1 and β-estradiol on endothelial nitric oxide synthase activity in rat aortic endothelial cells (2003) Metabolism, 52, pp. 482-487
Repetto, S., Salani, B., Maggi, D., Cordera, R., Insulin and IGF-I phosphorylate eNOS in HUVECs by a caveolin-1 mechanism (2005) Biochem Biophys Res Commun, 337, pp. 849-852
Griendling, K.K., Fitzgerald, G.A., Oxidative stress and cardiovascular injury: part II: animal and human studies (2003) Circulation, 108, pp. 2034-2040
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Rosen, T., Eden, S., Larson, G., Wilhelmsen, L., Bengtsson, B.A., Cardiovascular risk factors in adult patients with growth hormone deficiency (1993) Acta Endocrinol, 129, pp. 195-200
Lanes, R., Soros, A., Flores, K., Gunczler, P., Carrillo, E., Bandel, J., Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue, and left ventricular mass and function in growth hormone-deficient adolescents: apparent effects of growth hormone treatment on these parameters (2005) J Clin Endocrinol Metab, 90, pp. 3978-3982
Galasso, G., Sciekofer, S., Sato, K., Shibata, R., Handy, D.E., Ouchi, N., Leopold, J.A., Walsh, K., Imaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction (2006) Circ Res, 98, pp. 254-261
Thum, T., Hoeber, S., Froese, S., Klink, I., Stichtenoth, D.O., Galuppo, P., Jakob, M., Bauersachs, J., Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1 (2007) Circ Res, 100, pp. 434-443
Cercek, B., Fishbein, M.C., Forrester, J.S., Helfant, R.H., Fagin, J.A., Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation (1990) Circ Res, 66, pp. 1755-1760
Khorsandi, M.J., Fagin, J.A., Giannella-Neto, D., Forrester, J.S., Cercek, B., Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity (1992) J Clin Invest, 90, pp. 1926-1931
Clowes, A.W., Reidy, M.A., Clowes, M.M., Kinetics of cellular proliferation after arterial injury (1983) Lab Invest, 49, pp. 327-333
Aloke, V., Finnb Herman, K., Tanga, G.B., Deena, K., Webera, T.N., Wightc, A., Clermontb, R., Kolodgiea, D., A novel rat model of carotid artery stenting for the understanding of restenosis in metabolic diseases (2002) J Vasc Res, 39, pp. 414-425
Walter, D.H., Rittig, K., Bahlmann, F.H., Kirchmair, R., Silver, M., Murayama, T., Nishimura, H., Isner, J.M., Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells (2002) Circulation, 105, pp. 3017-3024
Tulis, D.A., Histological and morphometric analyses for rat carotid balloon injury model (2007) Methods Mol Med, 139, pp. 31-36
Grant, M.B., Wargovich, T.J., Bush, D., Player, D.W., Caballero, S., Foegh, M., Spoerri, P.E., Expression of IGF-1, IGF-1 receptor and TGF-β following balloon angioplasty in atherosclerotic and normal rabbit iliac arteries: an immunocytochemical study (1999) Regul Pept, 79, pp. 47-53
Zhu, B., Zhao, G., Witte, D.P., Hui, D.Y., Fagin, J.A., Targeted overexpression of IGF-1 in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intrarterial injury (2001) Endocrinology, 142, pp. 3598-3606
Lim, H.J., Park, H.Y., Ko, Y.G., Lee, S.H., Cho, S.Y., Lee, E.J., Jameson, J.L., Jang, Y., Dominant negative insulin-like growth factor-1 receptor inhibits neointimal formation trough suppression of vascular smooth muscle cell migration and proliferation and induction of apoptosis (2004) Biochem Biophys Res Commun, 325, pp. 1106-1114
Santoian, E.D., Schneider, J., Gravanis, M., Foegh, M., Tarazona, N., Cipolla, G., King, S.B., Angiopeptin inhibits intimal hyperplasia after angioplasty in porcine coronary arteries (1993) Circulation, 88, pp. 11-14
Emanuelsson, H., Beart, K.J., Bagger, J.P., Balcon, R., Heikkilä, J., Piessens, J., Schaeffer, M., Foegh, M.L., Long-term effect of angiopeptin treatment in coronary angioplasty: reduction of clinical events but not angiographic restenosis (1995) Circulation, 91, pp. 1689-1696
Kursaklioglu, S.H., Iyisoy, A., Amasyali, B., Barcin, C., Kose, S., Celik, T., Kilic, A., Demirtas, E., Long-term effects of octreotide therapy on in-stent restenosis (2003) Heart Vessels, 18, pp. 130-135
von Essen, R., Ostermaier, R., Grube, E., Maurer, W., Tebbe, U., Erbel, R., Roth, M., Weidinger, G., Effects of octreotide on restenosis after coronary angioplasty: results of the VERAS study (1997) Circulation, 96, pp. 1482-1487
Capaldo, B., Guardasole, V., Pardo, F., Matarazzo, M., Di Rella, F., Numis, F., Merola, B., Saccà, L., Abnormal vascular reactivity in growth hormone deficiency (2001) Circulation, 103, pp. 520-524
Borson-Chazot, F., Serusclat, A., Kalfallah, Y., Ducottet, X., Sassolas, G., Bernard, S., Labrousse, F., Berthezene, F., Decrease in carotid intima-media thickness in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1329-1333
Capaldo, B., Patti, L., Oliviero, U., Longobardi, S., Pardo, F., Vitale, F., Fazio, S., Saccà, L., Increased arterial intima-media thickness in childhood-onset growth hormone deficiency (1997) J Clin Endocrinol Metab, 82, pp. 1378-1381
DeBoer, H., Blok, G.J., van der Veen, E.A., Clinical aspects of growth hormone deficiency in adults (1995) Endocr Rev, 16, pp. 63-86
Bengtsson, B.A., Gudmundur, J., Effect of growth-hormone therapy on early atherosclerotic changes in GH-deficient adults (1999) Lancet, 353, pp. 1898-1899
Tsukahara, R.H., Gordienko, D.V., Tonshoff, B., Gelato, M.C., Goligorscky, M.S., Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells (1994) Kidney Int, 45, pp. 598-604
Veermeesch, P., Nong, Z., Stabile, E., Varenne, O., Gillijns, H., Pellens, M., van Pelt, N., Janssens, S., L-arginine administration reduces neointima formation after stent injury in rats by a nitric oxide-mediated mechanism (2001) Arterioscler Thromb Vasc Biol, 21, pp. 1604-1609
Janssens, S., Flaherty, D., Nong, Z., Varenne, O., van Pelt, N., Haustermans, C., Zoldhelyi, P., Collen, D., Human endothelial nitric oxide synthase gene transfer inhibits VSMC proliferation and neointima formation after balloon injury in rats (1998) Circulation, 97, pp. 1274-1281
Rudic, R.D., Shesely, E.G., Maeda, N., Smithies, O., Segal, S.S., Sessa, W.C., Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling (1998) J Clin Invest, 101, pp. 731-736
Moroi, M., Zhang, L., Yasuda, T., Virmani, R., Gold, H.K., Fishman, M.C., Huang, P.L., Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice (1998) J Clin Invest, 101, pp. 1225-1232
Holm, A.M., Anderson, C.B., Haunso, S., Hansen, P.R., Effects of L-arginine on vascular smooth muscle cell proliferation and apoptosis after balloon-injury (2000) Scand Cardiovasc J, 34, pp. 28-32
Sata, M., Fukuda, D., Tanaka, K., Kaneda, Y., Yashiro, H., Shirakawa, I., The role of circulating precursors in vascular repair and lesion formation (2005) J Cell Mol Med, 9, pp. 557-568
Bär, H., Wende, P., Watson, L., Denger, S., van Eys, G., Kreuzer, J., Jahn, L., Smoothelin is an indicator reversible phenotype of smooth muscle cells in balloon-injured rat carotid arteries (2001) Basic Res Cardiol, 97, pp. 9-16
Zhou, X., Beck, C., Boren, J., Akyurek, L.M., Diverse origin of vascular smooth cells in the neointima (2005) Anadolu Kardiyol Derg, 5, pp. 216-220
Devin, J.K., Vaughan, D.E., Blevins, L.S., Chen, Q., Covington, J., Verity, D.K., Young, P.P., Low dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults (2008) Growth Horm IGF Res, 18, pp. 253-263
Urao, N., Inomata, H., Razvi, M., Kim, H.W., Wary, K., McKinney, R., Fukai, T., Ushio-Fukai, M., Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia (2008) Circ Res, 103, pp. 212-220
Thum, T., Fleissner, F., Klink, I., Tsikas, D., Jakob, M., Bauersachs, J., Stichtenoth, D.O., Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I (2007) J Clin Endocrinol Metab, 92, pp. 4172-4179
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.069, 5-year impact factor: 5.941
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-70449413985&partnerID=40&md5=5a19412420c320303f8e34e4e71ecf4e
Keywords: Carotid Arteries, Endothelium, Igf-1, Nitric Oxide Synthase, Restenosis, Endothelial Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Protein Kinase B, Somatomedin C, Angiogenesis, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Artery Media, Article, Carotid Artery Injury, Carotid Artery Obstruction, Cell Proliferation, Controlled Study, Drug Activity, Drug Blood Level, Drug Potency, Endothelium Cell, Heart Protection, Histopathology, Intima, Mitosis Inhibition, Neovascularization (pathology), Nonhuman, Priority Journal, Protein Phosphorylation, Reendothelialization, Signal Transduction, Smooth Muscle Fiber, Stem Cell Mobilization, Balloon Dilatation, Carotid Artery Injuries, Carotid Stenosis, Disease Models, Insulin-Like Growth Factor I, Protective Agents, Regeneration, Tunica Intima, Tunica Media,
Affiliations:
*** IBB - CNR ***
Department of Internal Medicine, University Federico II, Naples, Italy
References:
Hayashi, K., Shibata, K., Morita, T., Iwasaki, K., Watanabe, M., Sobue, K., Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells (2004) J Biol Chem, 279, pp. 40807-4081
Bay, H.B., Pollman, M., Inishi, Y., Gibbons, G.H., Regulation of vascular smooth muscle cell apoptosis: modulation of Bad by a phosphatidylinositol 3-kinase-dependent pathway (1999) Circ Res, 85, pp. 229-237
Delafontaine, P., Song, Y.-.H., Li, Y., Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels (2004) Arterioscler Thromb Vasc Biol, 24, pp. 435-444
Michell, B.J., Griffiths, J.E., Mitchelhill, K.I., Rodriguez-Crespo, I., Tiganis, T., Bozinovski, S., Ortiz de Montellano, P.R., Pearson, R.B., The Akt kinase signals directly to endothelial nitric oxide synthase (1999) Curr Biol, 9, pp. 845-848
Isenovic, E.R., Divald, A., Milivojevic, N., Grgurevic, T., Fisher, S.E., Sowers, J.R., Interactive effects of insulin-like Growth Factor-1 and β-estradiol on endothelial nitric oxide synthase activity in rat aortic endothelial cells (2003) Metabolism, 52, pp. 482-487
Repetto, S., Salani, B., Maggi, D., Cordera, R., Insulin and IGF-I phosphorylate eNOS in HUVECs by a caveolin-1 mechanism (2005) Biochem Biophys Res Commun, 337, pp. 849-852
Griendling, K.K., Fitzgerald, G.A., Oxidative stress and cardiovascular injury: part II: animal and human studies (2003) Circulation, 108, pp. 2034-2040
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Rosen, T., Eden, S., Larson, G., Wilhelmsen, L., Bengtsson, B.A., Cardiovascular risk factors in adult patients with growth hormone deficiency (1993) Acta Endocrinol, 129, pp. 195-200
Lanes, R., Soros, A., Flores, K., Gunczler, P., Carrillo, E., Bandel, J., Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue, and left ventricular mass and function in growth hormone-deficient adolescents: apparent effects of growth hormone treatment on these parameters (2005) J Clin Endocrinol Metab, 90, pp. 3978-3982
Galasso, G., Sciekofer, S., Sato, K., Shibata, R., Handy, D.E., Ouchi, N., Leopold, J.A., Walsh, K., Imaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction (2006) Circ Res, 98, pp. 254-261
Thum, T., Hoeber, S., Froese, S., Klink, I., Stichtenoth, D.O., Galuppo, P., Jakob, M., Bauersachs, J., Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1 (2007) Circ Res, 100, pp. 434-443
Cercek, B., Fishbein, M.C., Forrester, J.S., Helfant, R.H., Fagin, J.A., Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation (1990) Circ Res, 66, pp. 1755-1760
Khorsandi, M.J., Fagin, J.A., Giannella-Neto, D., Forrester, J.S., Cercek, B., Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity (1992) J Clin Invest, 90, pp. 1926-1931
Clowes, A.W., Reidy, M.A., Clowes, M.M., Kinetics of cellular proliferation after arterial injury (1983) Lab Invest, 49, pp. 327-333
Aloke, V., Finnb Herman, K., Tanga, G.B., Deena, K., Webera, T.N., Wightc, A., Clermontb, R., Kolodgiea, D., A novel rat model of carotid artery stenting for the understanding of restenosis in metabolic diseases (2002) J Vasc Res, 39, pp. 414-425
Walter, D.H., Rittig, K., Bahlmann, F.H., Kirchmair, R., Silver, M., Murayama, T., Nishimura, H., Isner, J.M., Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells (2002) Circulation, 105, pp. 3017-3024
Tulis, D.A., Histological and morphometric analyses for rat carotid balloon injury model (2007) Methods Mol Med, 139, pp. 31-36
Grant, M.B., Wargovich, T.J., Bush, D., Player, D.W., Caballero, S., Foegh, M., Spoerri, P.E., Expression of IGF-1, IGF-1 receptor and TGF-β following balloon angioplasty in atherosclerotic and normal rabbit iliac arteries: an immunocytochemical study (1999) Regul Pept, 79, pp. 47-53
Zhu, B., Zhao, G., Witte, D.P., Hui, D.Y., Fagin, J.A., Targeted overexpression of IGF-1 in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intrarterial injury (2001) Endocrinology, 142, pp. 3598-3606
Lim, H.J., Park, H.Y., Ko, Y.G., Lee, S.H., Cho, S.Y., Lee, E.J., Jameson, J.L., Jang, Y., Dominant negative insulin-like growth factor-1 receptor inhibits neointimal formation trough suppression of vascular smooth muscle cell migration and proliferation and induction of apoptosis (2004) Biochem Biophys Res Commun, 325, pp. 1106-1114
Santoian, E.D., Schneider, J., Gravanis, M., Foegh, M., Tarazona, N., Cipolla, G., King, S.B., Angiopeptin inhibits intimal hyperplasia after angioplasty in porcine coronary arteries (1993) Circulation, 88, pp. 11-14
Emanuelsson, H., Beart, K.J., Bagger, J.P., Balcon, R., Heikkilä, J., Piessens, J., Schaeffer, M., Foegh, M.L., Long-term effect of angiopeptin treatment in coronary angioplasty: reduction of clinical events but not angiographic restenosis (1995) Circulation, 91, pp. 1689-1696
Kursaklioglu, S.H., Iyisoy, A., Amasyali, B., Barcin, C., Kose, S., Celik, T., Kilic, A., Demirtas, E., Long-term effects of octreotide therapy on in-stent restenosis (2003) Heart Vessels, 18, pp. 130-135
von Essen, R., Ostermaier, R., Grube, E., Maurer, W., Tebbe, U., Erbel, R., Roth, M., Weidinger, G., Effects of octreotide on restenosis after coronary angioplasty: results of the VERAS study (1997) Circulation, 96, pp. 1482-1487
Capaldo, B., Guardasole, V., Pardo, F., Matarazzo, M., Di Rella, F., Numis, F., Merola, B., Saccà, L., Abnormal vascular reactivity in growth hormone deficiency (2001) Circulation, 103, pp. 520-524
Borson-Chazot, F., Serusclat, A., Kalfallah, Y., Ducottet, X., Sassolas, G., Bernard, S., Labrousse, F., Berthezene, F., Decrease in carotid intima-media thickness in adults with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1329-1333
Capaldo, B., Patti, L., Oliviero, U., Longobardi, S., Pardo, F., Vitale, F., Fazio, S., Saccà, L., Increased arterial intima-media thickness in childhood-onset growth hormone deficiency (1997) J Clin Endocrinol Metab, 82, pp. 1378-1381
DeBoer, H., Blok, G.J., van der Veen, E.A., Clinical aspects of growth hormone deficiency in adults (1995) Endocr Rev, 16, pp. 63-86
Bengtsson, B.A., Gudmundur, J., Effect of growth-hormone therapy on early atherosclerotic changes in GH-deficient adults (1999) Lancet, 353, pp. 1898-1899
Tsukahara, R.H., Gordienko, D.V., Tonshoff, B., Gelato, M.C., Goligorscky, M.S., Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells (1994) Kidney Int, 45, pp. 598-604
Veermeesch, P., Nong, Z., Stabile, E., Varenne, O., Gillijns, H., Pellens, M., van Pelt, N., Janssens, S., L-arginine administration reduces neointima formation after stent injury in rats by a nitric oxide-mediated mechanism (2001) Arterioscler Thromb Vasc Biol, 21, pp. 1604-1609
Janssens, S., Flaherty, D., Nong, Z., Varenne, O., van Pelt, N., Haustermans, C., Zoldhelyi, P., Collen, D., Human endothelial nitric oxide synthase gene transfer inhibits VSMC proliferation and neointima formation after balloon injury in rats (1998) Circulation, 97, pp. 1274-1281
Rudic, R.D., Shesely, E.G., Maeda, N., Smithies, O., Segal, S.S., Sessa, W.C., Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling (1998) J Clin Invest, 101, pp. 731-736
Moroi, M., Zhang, L., Yasuda, T., Virmani, R., Gold, H.K., Fishman, M.C., Huang, P.L., Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice (1998) J Clin Invest, 101, pp. 1225-1232
Holm, A.M., Anderson, C.B., Haunso, S., Hansen, P.R., Effects of L-arginine on vascular smooth muscle cell proliferation and apoptosis after balloon-injury (2000) Scand Cardiovasc J, 34, pp. 28-32
Sata, M., Fukuda, D., Tanaka, K., Kaneda, Y., Yashiro, H., Shirakawa, I., The role of circulating precursors in vascular repair and lesion formation (2005) J Cell Mol Med, 9, pp. 557-568
Bär, H., Wende, P., Watson, L., Denger, S., van Eys, G., Kreuzer, J., Jahn, L., Smoothelin is an indicator reversible phenotype of smooth muscle cells in balloon-injured rat carotid arteries (2001) Basic Res Cardiol, 97, pp. 9-16
Zhou, X., Beck, C., Boren, J., Akyurek, L.M., Diverse origin of vascular smooth cells in the neointima (2005) Anadolu Kardiyol Derg, 5, pp. 216-220
Devin, J.K., Vaughan, D.E., Blevins, L.S., Chen, Q., Covington, J., Verity, D.K., Young, P.P., Low dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults (2008) Growth Horm IGF Res, 18, pp. 253-263
Urao, N., Inomata, H., Razvi, M., Kim, H.W., Wary, K., McKinney, R., Fukai, T., Ushio-Fukai, M., Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia (2008) Circ Res, 103, pp. 212-220
Thum, T., Fleissner, F., Klink, I., Tsikas, D., Jakob, M., Bauersachs, J., Stichtenoth, D.O., Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I (2007) J Clin Endocrinol Metab, 92, pp. 4172-4179
Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury
Background: IGF-1 is a potent mitogen for vascular smooth muscle cells, but exerts protective effects on endothelial cells that may trigger antiatherogenic mechanisms. Objectives: This study was designed to test the hypothesis that an IGF-1 excess following arterial injury prevents neointima formation and vascular stenosis. Methods: Rats were subjected to carotid balloon injury and treated with IGF-1 (1.2 mg kg-1 per die) or saline for 10 days. Results: In IGF-1 treated animals, high tissue levels of eNOS, Akt and its phosphorylated form were found, confirming activation of IGF-1-dependent signaling pathways. IGF-1 markedly reduced neointima formation and post-injury arterial stenosis. IGF-1 exerted proliferative and anti-apoptotic effects in the media of injured carotids, but inhibited mitotic activity and induced apoptosis in the neointima. Furthermore, IGF-1 stimulated mobilization of progenitor endothelial cells and re-endothelialization of the injured arteries. L-NAME administration inhibited IGF-1 vasculoprotective effects. Conclusions: IGF-1 attenuates post-injury carotid stenosis by exerting differential effects in the neointima and tunica media with regard to the key components of the response to injury. The data point to a novel role of IGF-1 as a potent vasculoprotective factor. © 2009 International Society on Thrombosis and Haemostasis.
Background: IGF-1 is a potent mitogen for vascular smooth muscle cells, but exerts protective effects on endothelial cells that may trigger antiatherogenic mechanisms. Objectives: This study was designed to test the hypothesis that an IGF-1 excess following arterial injury prevents neointima formation and vascular stenosis. Methods: Rats were subjected to carotid balloon injury and treated with IGF-1 (1.2 mg kg-1 per die) or saline for 10 days. Results: In IGF-1 treated animals, high tissue levels of eNOS, Akt and its phosphorylated form were found, confirming activation of IGF-1-dependent signaling pathways. IGF-1 markedly reduced neointima formation and post-injury arterial stenosis. IGF-1 exerted proliferative and anti-apoptotic effects in the media of injured carotids, but inhibited mitotic activity and induced apoptosis in the neointima. Furthermore, IGF-1 stimulated mobilization of progenitor endothelial cells and re-endothelialization of the injured arteries. L-NAME administration inhibited IGF-1 vasculoprotective effects. Conclusions: IGF-1 attenuates post-injury carotid stenosis by exerting differential effects in the neointima and tunica media with regard to the key components of the response to injury. The data point to a novel role of IGF-1 as a potent vasculoprotective factor. © 2009 International Society on Thrombosis and Haemostasis.
Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury
| ▼ Noninvasive techniques for coronary flow reserve assessment |
Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (487 views)
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Impact Factor: 3.205
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Petretta M, Cuocolo R, Acampa W, Cuocolo A
* Cardiac Radionuclide Imaging After Coronary Artery Revascularization (290 views)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014; 7(3): 1-9.
Impact Factor: 0
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
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Impact Factor: 3.447
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Acampa W, Petretta MP, Daniele S, Perrone-Filardi P, Petretta M, Cuocolo A
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Impact Factor: 5.217
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Ruggiero D, Paolillo S, Ratta GD, Mariniello A, Formisano T, Pellegrino AM, Filardi PP
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Impact Factor: 7.132
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
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Impact Factor: 5.533
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Berisio R
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
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Petretta M, Cuocolo A
In search of a marker of vulnerable carotid plaque: is the key in the heart? (312 views)
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
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Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
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Impact Factor: 4.409
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
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Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
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Impact Factor: 5.207
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
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Impact Factor: 3.407
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
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Impact Factor: 9.432
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
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Impact Factor: 5.52
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (327 views)
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Impact Factor: 2.801
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
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Impact Factor: 9.38
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1014 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
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Impact Factor: 4.214
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
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Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
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Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
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Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (313 views)
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Impact Factor: 2.405
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Perrone-Filardi P, Cuocolo A, Brevetti G, Silvestro A, Storto G, Dellegrottaglie S, Corrado L, Cafiero M, Camerino R, Polimeno M, Zarrilli A, Caiazzo G, Maglione A, Petretta A, Chiariello M
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Clin Ter, 2005 Nov 1; 138(5-6): 199-205.
Impact Factor: 0.329
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
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Impact Factor: 10.231
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
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Impact Factor: 2.478
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
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Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
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Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
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Impact Factor: 3.658
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
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Impact Factor: 2.013
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Cuocolo A, Acampa W, Evangelista L
* Nuclear medicine and positron emission tomography imaging in cardiology (401 views)
Nucl Med Rev (ISSN: 1506-9680), 2003; 6(1): 59-63.
Impact Factor: 0.155
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (570 views)
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Impact Factor: 6.696
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (776 views)
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Impact Factor: 5.082
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (483 views)
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Impact Factor: 2.151
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Iaccarino V, Tedeschi E, Brunetti A, Soricelli A, Salvatore M
Congenital agenesis/aplasia of the internal carotid arteries: MRA and SPECT findings (212 views)
J Comput Assisted Tomogr (ISSN: 0363-8715), 1995 Nov; 19(6): 987-990.
Impact Factor: 1.263
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Ferrara LA, Mancini M, Iannuzzi R, Marotta T, Gaeta I, Pasanisi F, Postiglione A, Guida L
CAROTID DIAMETER AND BLOOD-FLOW VELOCITIES IN CEREBRAL-CIRCULATION IN HYPERTENSIVE PATIENTS (280 views)
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Impact Factor: 4.323
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Ferrara LA, Mancini M, Celentano A, Galderisi M, Iannuzzi R, Marotta T, Gaeta I
Early changes of the arterial carotid wall in uncomplicated primary hypertensive patients: Study by ultrasound high-resolution B-mode imaging (284 views)
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Impact Factor: 5.317
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Miletich RS, Bankiewicz KS, Quarantelli M, Plunkett RJ, Frank J, Kopin IJ, Di Chiro G
MRI detects acute degeneration of the nigrostriatal dopamine system after MPTP exposure in hemiparkinsonian monkeys (335 views)
Ann Neurol (ISSN: 0364-5134), 1994 Jun; 35(6): 689-697.
Impact Factor: 9.513
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* Circadian Rhythms of Endothelial Nitric Oxide Synthase and Toll-like Receptors 2 Production in Females with Rheumatoid Arthritis Depending on NOS3 Gene Polymorphism (44 views)
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Impact Factor: 0.95
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Monti M, Iommelli F, De Rosa V, Carriero MV, Miceli R, Camerlingo R, Di Minno G, Del Vecchio S
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Impact Factor: 2.766
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (273 views)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
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Impact Factor: 3.205
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Petretta M, Cuocolo R, Acampa W, Cuocolo A
* Cardiac Radionuclide Imaging After Coronary Artery Revascularization (290 views)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014; 7(3): 1-9.
Impact Factor: 0
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
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Impact Factor: 3.447
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Acampa W, Petretta MP, Daniele S, Perrone-Filardi P, Petretta M, Cuocolo A
* Myocardial perfusion imaging after coronary revascularization: A clinical appraisal (478 views)
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Impact Factor: 5.217
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Ruggiero D, Paolillo S, Ratta GD, Mariniello A, Formisano T, Pellegrino AM, Filardi PP
* [Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications] (340 views)
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Impact Factor: 7.132
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (439 views)
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Impact Factor: 2.551
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
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Impact Factor: 5.533
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (607 views)
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Impact Factor: 4.576
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Petretta M, Cuocolo A
In search of a marker of vulnerable carotid plaque: is the key in the heart? (312 views)
Atherosclerosis (ISSN: 1879-1484, 0021-9150), 2012 Jul; 223(1): 95-97.
Impact Factor: 3.706
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (476 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (656 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (449 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
* Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (403 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Impact Factor: 4.67
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (574 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1121 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (417 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (421 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (923 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (327 views)
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
Impact Factor: 2.801
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1014 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (721 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (730 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (313 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Perrone-Filardi P, Cuocolo A, Brevetti G, Silvestro A, Storto G, Dellegrottaglie S, Corrado L, Cafiero M, Camerino R, Polimeno M, Zarrilli A, Caiazzo G, Maglione A, Petretta A, Chiariello M
* Sodium and diseases in the aged (296 views)
Clin Ter, 2005 Nov 1; 138(5-6): 199-205.
Impact Factor: 0.329
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (395 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (334 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (735 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Cuocolo A, Acampa W, Evangelista L
* Nuclear medicine and positron emission tomography imaging in cardiology (401 views)
Nucl Med Rev (ISSN: 1506-9680), 2003; 6(1): 59-63.
Impact Factor: 0.155
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (570 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (776 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (483 views)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Iaccarino V, Tedeschi E, Brunetti A, Soricelli A, Salvatore M
Congenital agenesis/aplasia of the internal carotid arteries: MRA and SPECT findings (212 views)
J Comput Assisted Tomogr (ISSN: 0363-8715), 1995 Nov; 19(6): 987-990.
Impact Factor: 1.263
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Ferrara LA, Mancini M, Iannuzzi R, Marotta T, Gaeta I, Pasanisi F, Postiglione A, Guida L
CAROTID DIAMETER AND BLOOD-FLOW VELOCITIES IN CEREBRAL-CIRCULATION IN HYPERTENSIVE PATIENTS (280 views)
Stroke (ISSN: 0039-2499), 1995 Mar; 26(3): 418-421.
Impact Factor: 4.323
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Ferrara LA, Mancini M, Celentano A, Galderisi M, Iannuzzi R, Marotta T, Gaeta I
Early changes of the arterial carotid wall in uncomplicated primary hypertensive patients: Study by ultrasound high-resolution B-mode imaging (284 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 1994 Sep; 14(8): 1290-1296.
Impact Factor: 5.317
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Miletich RS, Bankiewicz KS, Quarantelli M, Plunkett RJ, Frank J, Kopin IJ, Di Chiro G
MRI detects acute degeneration of the nigrostriatal dopamine system after MPTP exposure in hemiparkinsonian monkeys (335 views)
Ann Neurol (ISSN: 0364-5134), 1994 Jun; 35(6): 689-697.
Impact Factor: 9.513
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55 Records (54 excluding Abstracts).
Total impact factor: 261.79 (257.576 excluding Abstracts).
Total 5 year impact factor: 275.998 (271.74 excluding Abstracts).
Total impact factor: 261.79 (257.576 excluding Abstracts).
Total 5 year impact factor: 275.998 (271.74 excluding Abstracts).
466 views. Last view on Monday 22 May 2023, 1:32:29
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