β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (659 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
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Paper type: Journal Article,
Impact factor: 8.066, 5-year impact factor: 6.461
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845385712&partnerID=40&md5=64a765c0e5eda79a106e544fab86345f
Keywords: Atenolol, Atrial Natriuretic Factor, Beta 2 Adrenergic Receptor, Calcium Channel Blocking Agent, Carrier Protein, Diuretic Agent, Enalapril, Glutamine, Glycine, Isoprenaline, Mitogen Activated Protein Kinase 1, Synaptophysin, Threonine, Antihypertensive Agent, Adult, Article, Blood Pressure Measurement, Clinical Trial, Controlled Clinical Trial, Controlled Study, Correlation Analysis, Drug Dose Increase, Embryo, Female, Gene Overexpression, Genetic Linkage, Genetic Polymorphism, Genetic Variability, Heart Left Ventricle Hypertrophy, Human, Human Cell, Major Clinical Study, Pharmacogenomics, Priority Journal, Prospective Study, Randomized Controlled Trial, Remission, Signal Transduction, Treatment Outcome, Genotype, Heterozygote, Middle Aged, Left Ventricular, Prospective Studies,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Dipartimento di Neuroscienze e Scienze del Comportamento, Università Federico II di Napoli, Italy
References:
Not available.
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 8.066, 5-year impact factor: 6.461
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845385712&partnerID=40&md5=64a765c0e5eda79a106e544fab86345f
Keywords: Atenolol, Atrial Natriuretic Factor, Beta 2 Adrenergic Receptor, Calcium Channel Blocking Agent, Carrier Protein, Diuretic Agent, Enalapril, Glutamine, Glycine, Isoprenaline, Mitogen Activated Protein Kinase 1, Synaptophysin, Threonine, Antihypertensive Agent, Adult, Article, Blood Pressure Measurement, Clinical Trial, Controlled Clinical Trial, Controlled Study, Correlation Analysis, Drug Dose Increase, Embryo, Female, Gene Overexpression, Genetic Linkage, Genetic Polymorphism, Genetic Variability, Heart Left Ventricle Hypertrophy, Human, Human Cell, Major Clinical Study, Pharmacogenomics, Priority Journal, Prospective Study, Randomized Controlled Trial, Remission, Signal Transduction, Treatment Outcome, Genotype, Heterozygote, Middle Aged, Left Ventricular, Prospective Studies,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Dipartimento di Neuroscienze e Scienze del Comportamento, Università Federico II di Napoli, Italy
References:
Not available.
β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension
Objectives: Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication. β 2-Adrenergic receptors (β 2ARs) are up-regulated in hypertension and largely polymorphic within the human population. Recently, we have shown that the Glu27 β 2AR variant is strongly associated with cardiac hypertrophy in hypertension. The objective of this study is to verify whether this polymorphism also affects hypertrophy regression in response to antihypertensive therapy. Methods: In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile β 2AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. Results were stratified according to treatment and the Glu27Gln polymorphism of the β 2AR. In cells with stable overexpression of the Glu27 or Gln27 variant of β 2AR, we also explored the implications of this polymorphism on hypertrophy-related intracellular signal transduction. Results: Among hypertensive patients, the Gly16 allele was found in 63% of patients and the Glu27 allele was found in 40.6%. Both polymorphisms were in linkage disequilibrium, as expected. Four hundred forty-one hypertrophic hypertensive patients completed the 2-year follow-up. At baseline, patients carrying at least 1 allele of the Glu27 variant presented with a larger cardiac size despite similar blood pressure levels (142.9 ± 22.5 g/m 2 in Glu27 carriers versus 138.2 ± 18.4 g/m 2 in Gln27 carriers, P < .02). Blood pressure normalization was achieved by both drugs. At follow-up, compared with the Gln27 patients, the Glu27 patients showed a larger reduction in hypertrophy when treated with enalapril (percent change in left ventricular mass, -6.3% ± 7.7% in Glu27 carriers versus -2.18% ± 7.9% in Gln27 carriers; P < .05) but not with atenolol therapy (-2.8% ± 8.9% in Glu27 carriers versus -2.4% ± 8.8% in Gln27 carriers, P = not significant). In in vitro studies the activation of p38 and extracellular signal-regulated kinase (ERK-) 1/2 (data not shown) and the activity of the atrial natriuretic factor (ANF) promoter after isoproterenol (INN, isoprenaline) stimulation were larger in Glu27 β 2AR overexpressing cells than in Gln27 β 2AR overexpressing cells (fold difference compared with unstimulated cells, 9.7 ± 2.9 for Glu27 β 2AR versus 4.2 ± 0.3 for Gln27 β 2AR; P < .05). Conclusions: The Glu27 variant of β 2AR enhances hypertension-induced left ventricular hypertrophy. In these patients angiotensin-converting enzyme inhibitors are more efficient than β-blockers in reducing cardiac size. © 2006 American Society for Clinical Pharmacology and Therapeutics.
Objectives: Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication. β 2-Adrenergic receptors (β 2ARs) are up-regulated in hypertension and largely polymorphic within the human population. Recently, we have shown that the Glu27 β 2AR variant is strongly associated with cardiac hypertrophy in hypertension. The objective of this study is to verify whether this polymorphism also affects hypertrophy regression in response to antihypertensive therapy. Methods: In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile β 2AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. Results were stratified according to treatment and the Glu27Gln polymorphism of the β 2AR. In cells with stable overexpression of the Glu27 or Gln27 variant of β 2AR, we also explored the implications of this polymorphism on hypertrophy-related intracellular signal transduction. Results: Among hypertensive patients, the Gly16 allele was found in 63% of patients and the Glu27 allele was found in 40.6%. Both polymorphisms were in linkage disequilibrium, as expected. Four hundred forty-one hypertrophic hypertensive patients completed the 2-year follow-up. At baseline, patients carrying at least 1 allele of the Glu27 variant presented with a larger cardiac size despite similar blood pressure levels (142.9 ± 22.5 g/m 2 in Glu27 carriers versus 138.2 ± 18.4 g/m 2 in Gln27 carriers, P < .02). Blood pressure normalization was achieved by both drugs. At follow-up, compared with the Gln27 patients, the Glu27 patients showed a larger reduction in hypertrophy when treated with enalapril (percent change in left ventricular mass, -6.3% ± 7.7% in Glu27 carriers versus -2.18% ± 7.9% in Gln27 carriers; P < .05) but not with atenolol therapy (-2.8% ± 8.9% in Glu27 carriers versus -2.4% ± 8.8% in Gln27 carriers, P = not significant). In in vitro studies the activation of p38 and extracellular signal-regulated kinase (ERK-) 1/2 (data not shown) and the activity of the atrial natriuretic factor (ANF) promoter after isoproterenol (INN, isoprenaline) stimulation were larger in Glu27 β 2AR overexpressing cells than in Gln27 β 2AR overexpressing cells (fold difference compared with unstimulated cells, 9.7 ± 2.9 for Glu27 β 2AR versus 4.2 ± 0.3 for Gln27 β 2AR; P < .05). Conclusions: The Glu27 variant of β 2AR enhances hypertension-induced left ventricular hypertrophy. In these patients angiotensin-converting enzyme inhibitors are more efficient than β-blockers in reducing cardiac size. © 2006 American Society for Clinical Pharmacology and Therapeutics.
β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension
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β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension
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Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G
* Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor (979 views)
Diabetesdiabetes (ISSN: 0012-1797), 2012; 61(3): 692-701.
Impact Factor: 7.895
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (644 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (1038 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Nov 1; 67(11): 1462-1465.
Impact Factor: 0.506
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
* Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ (844 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2011 Jun 16; 117(24): 6520-6531.
Impact Factor: 9.898
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (807 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Kowalczyk L, Ratera M, Paladino A, Bartoccioni P, Errasti-murugarren E, Valencia E, Portella G, Bial S, Zorzano A, Fita I, Orozco M, Carpena X, Vázquez-ibar JL, Palacín M
Molecular basis of substrate-induced permeation by an amino acid antiporter (239 views)
Proc Natl Acad Sci U S A (ISSN: 0027-8424linking), 2011 Mar 8; 108 (10 ): 3935-3940.
Impact Factor:
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (812 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (915 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (1435 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (934 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (662 views)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
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Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
* Lung structure abnormalities, but normal lung function in pediatric bronchiectasis (666 views)
Chest (ISSN: 0012-3692), 2006 Sep; 130(2): 480-486.
Impact Factor: 3.924
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Perrone-Filardi P, Cuocolo A, Brevetti G, Silvestro A, Storto G, Dellegrottaglie S, Corrado L, Cafiero M, Camerino R, Polimeno M, Zarrilli A, Caiazzo G, Maglione A, Petretta A, Chiariello M
* Sodium and diseases in the aged (766 views)
Clin Ter, 2005 Nov 1; 138(5-6): 199-205.
Impact Factor: 0.329
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Acampa W, Petretta M, Spinelli L, Ibello F, De Lauro F, Sansone V, Salvatore M, Cuocolo A
* Survival benefit after revascularization is independent of left ventricular ejection fraction improvement in patients with previous myocardial infarction and viable myocardium (1260 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Apr; 32(4): 430-437.
Impact Factor: 3.883
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (744 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (1083 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
Crystal Structure Of A Collagen-Like Polypeptide With Repeating Sequence Pro-Hyp-Gly At 1. 4 Ang Resolution: Implications For Collagen Hydration (944 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 8-13.
Impact Factor: 2.405
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (736 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Russo R, Rao MA, Romano M, Scotto Di Santolo M, Cardei S, Giunta A, Cuocolo A, Volpe M
Prospects of pharmacologic treatment of post-ischemic heart failure (439 views)
Cardiologia (ISSN: 0393-1978), 1995 Dec; 40(12Suppl1): 533-537.
Impact Factor: 0
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (726 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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31 Records (30 excluding Abstracts).
Total impact factor: 142.114 (137.036 excluding Abstracts).
Total 5 year impact factor: 149.345 (144.267 excluding Abstracts).
Total impact factor: 142.114 (137.036 excluding Abstracts).
Total 5 year impact factor: 149.345 (144.267 excluding Abstracts).
659 views. Last view on Sunday 20 April 2025, 17:13:32
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