β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (382 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 8.066, 5-year impact factor: 6.461
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845385712&partnerID=40&md5=64a765c0e5eda79a106e544fab86345f
Keywords: Atenolol, Atrial Natriuretic Factor, Beta 2 Adrenergic Receptor, Calcium Channel Blocking Agent, Carrier Protein, Diuretic Agent, Enalapril, Glutamine, Glycine, Isoprenaline, Mitogen Activated Protein Kinase 1, Synaptophysin, Threonine, Antihypertensive Agent, Adult, Article, Blood Pressure Measurement, Clinical Trial, Controlled Clinical Trial, Controlled Study, Correlation Analysis, Drug Dose Increase, Embryo, Female, Gene Overexpression, Genetic Linkage, Genetic Polymorphism, Genetic Variability, Heart Left Ventricle Hypertrophy, Human, Human Cell, Major Clinical Study, Pharmacogenomics, Priority Journal, Prospective Study, Randomized Controlled Trial, Remission, Signal Transduction, Treatment Outcome, Genotype, Heterozygote, Middle Aged, Left Ventricular, Prospective Studies,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Dipartimento di Neuroscienze e Scienze del Comportamento, Università Federico II di Napoli, Italy
References:
2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension (2003) J Hypertens, 21, pp. 1011-105
Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo Jr., J.L., The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report (2003) JAMA, 289, pp. 2560-2572
Frohlich, E.D., Apstein, C., Chobanian, A.V., Devereux, R.B., Dustan, H.P., Dzau, V., The heart in hypertension (1992) N Engl J Med, 327, pp. 998-1008
Adams, T.D., Yanowitz, F.G., Fisher, A.G., Ridges, J.D., Nelson, A.G., Hagan, A.D., Heritability of cardiac size: an echocardiographic and electrocardiographic study of monozygotic and dizygotic twins (1985) Circulation, 71, pp. 39-44
Harshfield, G.A., Grim, C.E., Hwang, C., Savage, D.D., Anderson, S.J., Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins (1990) Am J Hypertens, 3, pp. 538-543
Post, W.S., Larson, M.G., Myers, R.H., Galderisi, M., Levy, D., Heritability of left ventricular mass: the Framingham Heart Study (1997) Hypertension, 30, pp. 1025-1028
Turner, S.T., Boerwinkle, E., Genetics of hypertension, target-organ complications, and response to therapy (2000) Circulation, 102 (SUPPL. 4), pp. IV40-IV45
Iaccarino, G., Barbato, E., Cipoletta, E., Fiorillo, A., Trimarco, B., Role of the sympathetic nervous system in cardiac remodeling in hypertension (2001) Clin Exp Hypertens, 23, pp. 35-43
Akhter, S.A., Milano, C.A., Shotwell, K.F., Cho, M.C., Rockman, H.A., Lefkowitz, R.J., Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling (1997) J Biol Chem, 272, pp. 21253-21259
Engelhardt, S., Hein, L., Wiesmann, F., Lohse, M.J., Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice (1999) Proc Natl Acad Sci U S A, 96, pp. 7059-7064
Liggett, S.B., Tepe, N.M., Lorenz, J.N., Canning, A.M., Jantz, T.D., Mitarai, S., Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level (2000) Circulation, 101, pp. 1707-1714
Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., Koch, W.J., Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade (1998) Circulation, 98, pp. 1783-1789
Bono, M., Cases, A., Calls, J., Gaya, J., Jimenez, W., Carretero, J., Effect of antihypertensive treatment on the increased beta 2-adrenoceptor density in patients with essential hypertension (1995) Am J Hypertens, 8 (PART 1), pp. 487-493
Laflamme, K.A., Oster, L., Cardinal, R., de Champlain, J., Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat (1997) Hypertension, 30 (PART 1), pp. 278-287
Eisenach, J.H., Barnes, S.A., Pike, T.L., Sokolnicki, L.A., Masuki, S., Dietz, N.M., Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise (2005) J Appl Physiol, 99, pp. 1776-1781
Liggett, S.B., Molecular and genetic basis of beta2-adrenergic receptor function (1999) J Allergy Clin Immunol, 104 (PART 2), pp. S42-S46
Bengtsson, K., Orho-Melander, M., Melander, O., Lindblad, U., Ranstam, J., Rastam, L., Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes (2001) Hypertension, 37, pp. 1303-1308
Bray, M.S., Boerwinkle, E., The role of beta(2)-adrenergic receptor variation in human hypertension (2000) Curr Hypertens Rep, 2, pp. 39-43
Gratze, G., Fortin, J., Labugger, R., Binder, A., Kotanko, P., Timmermann, B., beta-2 Adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians (1999) Hypertension, 33, pp. 1425-1430
Kotanko, P., Binder, A., Tasker, J., DeFreitas, P., Kamdar, S., Clark, A.J., Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor (1997) Hypertension, 30, pp. 773-776
Tomaszewski, M., Brain, N.J., Charchar, F.J., Wang, W.Y., Lacka, B., Padmanabahn, S., Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis (2002) Hypertension, 40, pp. 286-291
Iaccarino, G., Lanni, F., Cipolletta, E., Trimarco, V., Izzo, R., Iovino, G.L., The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension (2004) J Hypertens, 22, pp. 2117-2122
Bruck, H., Leineweber, K., Beilfuss, A., Weber, M., Heusch, G., Philipp, T., Genotype-dependent time course of lymphocyte beta 2-adrenergic receptor down-regulation (2003) Clin Pharmacol Ther, 74, pp. 255-263
Green, S.A., Turki, J., Bejarano, P., Hall, I.P., Liggett, S.B., Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells (1995) Am J Respir Cell Mol Biol, 13, pp. 25-33
Dishy, V., Sofowora, G.G., Xie, H.G., Kim, R.B., Byrne, D.W., Stein, C.M., The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization (2001) N Engl J Med, 345, pp. 1030-1035
Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., Lohse, M.J., Klotz, K.N., Comparative pharmacology of human beta-adrenergic receptor subtypes-characterization of stably transfected receptors in CHO cells (2004) Naunyn Schmiedebergs Arch Pharmacol, 369, pp. 151-159
Bohm, M., Grabel, C., Knorr, A., Erdmann, E., Treatment in hypertensive cardiac hypertrophy, I. Neuropeptide Y and beta-adrenoceptors (1995) Hypertension, 25, pp. 954-961
Zechner, D., Thuerauf, D.J., Hanford, D.S., McDonough, P.M., Glembotski, C.C., A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression (1997) J Cell Biol, 139, pp. 115-127
Sugden, P.H., Signalling pathways in cardiac myocyte hypertrophy (2001) Ann Med, 33, pp. 611-622
McDonald, P.H., Lefkowitz, R.J., Beta-Arrestins: new roles in regulating heptahelical receptors' functions (2001) Cell Signal, 13, pp. 683-689
De Luca, N., Izzo, R., Iaccarino, G., Malini, P.L., Morisco, C., Rozza, F., The use of a telematic connection for the follow-up of hypertensive patients improves the cardiovascular prognosis (2005) J Hypertens, 23, pp. 1417-1423
1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee (1999) J Hypertens, 17, pp. 151-183
Devereux, R.B., Alonso, D.R., Lutas, E.M., Gottlieb, G.J., Campo, E., Sachs, I., Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings (1986) Am J Cardiol, 57, pp. 450-458
Devereux, R.B., Reichek, N., Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method (1977) Circulation, 55, pp. 613-618
Large, V., Hellstrom, L., Reynisdottir, S., Lonnqvist, F., Eriksson, P., Lannfelt, L., Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function (1997) J Clin Invest, 100, pp. 3005-3013
Sahn, D.J., DeMaria, A., Kisslo, J., Weyman, A., Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements (1978) Circulation, 58, pp. 1072-1083
Ganau, A., Devereux, R.B., Roman, M.J., de Simone, G., Pickering, T.G., Saba, P.S., Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension (1992) J Am Coll Cardiol, 19, pp. 1550-1558
Iaccarino, G., Ciccarelli, M., Sorriento, D., Galasso, G., Campanile, A., Santulli, G., Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system (2005) Circ Res, 97, pp. 1182-1189
Rockman, H.A., Ross, R.S., Harris, A.N., Knowlton, K.U., Steinhelper, M.E., Field, L.J., Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy (1991) Proc Natl Acad Sci U S A, 88, pp. 8277-8281
Morisco, C., Seta, K., Hardt, S.E., Lee, Y., Vatner, S.F., Sadoshima, J., Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes (2001) J Biol Chem, 276, pp. 28586-28597
Xiang, F., Sakata, Y., Cui, L., Youngblood, J.M., Nakagami, H., Liao, J.K., Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4 (2006) Am J Physiol Heart Circ Physiol, 290, pp. H1997-H2006
Kupari, M., Hautanen, A., Lankinen, L., Koskinen, P., Virolainen, J., Nikkila, H., Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function (1998) Circulation, 97, pp. 569-575
Tamaki, S., Iwai, N., Tsujita, Y., Kinoshita, M., Genetic polymorphism of CYP11B2 gene and hypertension in Japanese (1999) Hypertension, 33 (PART 2), pp. 266-270
Schunkert, H., Hengstenberg, C., Holmer, S.R., Broeckel, U., Luchner, A., Muscholl, M.W., Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure (1999) Circulation, 99, pp. 2255-2260
Sasaki, M., Oki, T., Iuchi, A., Tabata, T., Yamada, H., Manabe, K., Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies (1996) J Hypertens, 14, pp. 1403-1408
Hernandez, D., Lacalzada, J., Salido, E., Linares, J., Barragan, A., Lorenzo, V., Regression of left ventricular hypertrophy by lisinopril after renal transplantation: role of ACE gene polymorphism (2000) Kidney Int, 58, pp. 889-897
Kohno, M., Yokokawa, K., Minami, M., Kano, H., Yasunari, K., Hanehira, T., Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors (1999) Am J Med, 106, pp. 544-549
Stella, P., Bigatti, G., Tizzoni, L., Barlassina, C., Lanzani, C., Bianchi, G., Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension (2004) J Am Coll Cardiol, 43, pp. 265-270
Littlejohn, M.D., Taylor, D.R., Miller, A.L., Kennedy, M.A., Determination of beta2-adrenergic receptor (ADRB2) haplotypes by a multiplexed polymerase chain reaction assay (2002) Hum Mutat, 20, p. 479
Taylor, D.R., Epton, M.J., Kennedy, M.A., Smith, A.D., Iles, S., Miller, A.L., Bronchodilator response in relation to beta2-adrenoceptor haplotype in patients with asthma (2005) Am J Respir Crit Care Med, 172, pp. 700-703
Leineweber, K., Buscher, R., Bruck, H., Brodde, O.E., Beta-adrenoceptor polymorphisms (2004) Naunyn Schmiedebergs Arch Pharmacol, 369, pp. 1-22
Arnett, D.K., de las Fuentes, L., Broeckel, U., Genes for left ventricular hypertrophy (2004) Curr Hypertens Rep, 6, pp. 36-41
Fagard, R., Staessen, J., Thijs, L., Amery, A., Multiple standardized clinic blood pressures may predict left ventricular mass as well as ambulatory monitoring. A metaanalysis of comparative studies (1995) Am J Hypertens, 8 (PART 1), pp. 533-540
Wadworth, A.N., Murdoch, D., Brogden, R.N., Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders (1991) Drugs, 42, pp. 468-510
Sakata, K., Shirotani, M., Yoshida, H., Kurata, C., Comparison of effects of enalapril and nitrendipine on cardiac sympathetic nervous system in essential hypertension (1998) J Am Coll Cardiol, 32, pp. 438-443
Dahlof, B., Devereux, R.B., Kjeldsen, S.E., Julius, S., Beevers, G., de Faire, U., Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol (2002) Lancet, 359, pp. 995-1003
Trimarco, B., Ricciardelli, B., De Luca, N., De Simone, A., Cuocolo, A., Galva, M.D., Participation of endogenous catecholamines in the regulation of left ventricular mass in progeny of hypertensive parents (1985) Circulation, 72, pp. 38-46
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 8.066, 5-year impact factor: 6.461
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845385712&partnerID=40&md5=64a765c0e5eda79a106e544fab86345f
Keywords: Atenolol, Atrial Natriuretic Factor, Beta 2 Adrenergic Receptor, Calcium Channel Blocking Agent, Carrier Protein, Diuretic Agent, Enalapril, Glutamine, Glycine, Isoprenaline, Mitogen Activated Protein Kinase 1, Synaptophysin, Threonine, Antihypertensive Agent, Adult, Article, Blood Pressure Measurement, Clinical Trial, Controlled Clinical Trial, Controlled Study, Correlation Analysis, Drug Dose Increase, Embryo, Female, Gene Overexpression, Genetic Linkage, Genetic Polymorphism, Genetic Variability, Heart Left Ventricle Hypertrophy, Human, Human Cell, Major Clinical Study, Pharmacogenomics, Priority Journal, Prospective Study, Randomized Controlled Trial, Remission, Signal Transduction, Treatment Outcome, Genotype, Heterozygote, Middle Aged, Left Ventricular, Prospective Studies,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Dipartimento di Neuroscienze e Scienze del Comportamento, Università Federico II di Napoli, Italy
References:
2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension (2003) J Hypertens, 21, pp. 1011-105
Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo Jr., J.L., The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report (2003) JAMA, 289, pp. 2560-2572
Frohlich, E.D., Apstein, C., Chobanian, A.V., Devereux, R.B., Dustan, H.P., Dzau, V., The heart in hypertension (1992) N Engl J Med, 327, pp. 998-1008
Adams, T.D., Yanowitz, F.G., Fisher, A.G., Ridges, J.D., Nelson, A.G., Hagan, A.D., Heritability of cardiac size: an echocardiographic and electrocardiographic study of monozygotic and dizygotic twins (1985) Circulation, 71, pp. 39-44
Harshfield, G.A., Grim, C.E., Hwang, C., Savage, D.D., Anderson, S.J., Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins (1990) Am J Hypertens, 3, pp. 538-543
Post, W.S., Larson, M.G., Myers, R.H., Galderisi, M., Levy, D., Heritability of left ventricular mass: the Framingham Heart Study (1997) Hypertension, 30, pp. 1025-1028
Turner, S.T., Boerwinkle, E., Genetics of hypertension, target-organ complications, and response to therapy (2000) Circulation, 102 (SUPPL. 4), pp. IV40-IV45
Iaccarino, G., Barbato, E., Cipoletta, E., Fiorillo, A., Trimarco, B., Role of the sympathetic nervous system in cardiac remodeling in hypertension (2001) Clin Exp Hypertens, 23, pp. 35-43
Akhter, S.A., Milano, C.A., Shotwell, K.F., Cho, M.C., Rockman, H.A., Lefkowitz, R.J., Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling (1997) J Biol Chem, 272, pp. 21253-21259
Engelhardt, S., Hein, L., Wiesmann, F., Lohse, M.J., Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice (1999) Proc Natl Acad Sci U S A, 96, pp. 7059-7064
Liggett, S.B., Tepe, N.M., Lorenz, J.N., Canning, A.M., Jantz, T.D., Mitarai, S., Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level (2000) Circulation, 101, pp. 1707-1714
Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., Koch, W.J., Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade (1998) Circulation, 98, pp. 1783-1789
Bono, M., Cases, A., Calls, J., Gaya, J., Jimenez, W., Carretero, J., Effect of antihypertensive treatment on the increased beta 2-adrenoceptor density in patients with essential hypertension (1995) Am J Hypertens, 8 (PART 1), pp. 487-493
Laflamme, K.A., Oster, L., Cardinal, R., de Champlain, J., Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat (1997) Hypertension, 30 (PART 1), pp. 278-287
Eisenach, J.H., Barnes, S.A., Pike, T.L., Sokolnicki, L.A., Masuki, S., Dietz, N.M., Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise (2005) J Appl Physiol, 99, pp. 1776-1781
Liggett, S.B., Molecular and genetic basis of beta2-adrenergic receptor function (1999) J Allergy Clin Immunol, 104 (PART 2), pp. S42-S46
Bengtsson, K., Orho-Melander, M., Melander, O., Lindblad, U., Ranstam, J., Rastam, L., Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes (2001) Hypertension, 37, pp. 1303-1308
Bray, M.S., Boerwinkle, E., The role of beta(2)-adrenergic receptor variation in human hypertension (2000) Curr Hypertens Rep, 2, pp. 39-43
Gratze, G., Fortin, J., Labugger, R., Binder, A., Kotanko, P., Timmermann, B., beta-2 Adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians (1999) Hypertension, 33, pp. 1425-1430
Kotanko, P., Binder, A., Tasker, J., DeFreitas, P., Kamdar, S., Clark, A.J., Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor (1997) Hypertension, 30, pp. 773-776
Tomaszewski, M., Brain, N.J., Charchar, F.J., Wang, W.Y., Lacka, B., Padmanabahn, S., Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis (2002) Hypertension, 40, pp. 286-291
Iaccarino, G., Lanni, F., Cipolletta, E., Trimarco, V., Izzo, R., Iovino, G.L., The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension (2004) J Hypertens, 22, pp. 2117-2122
Bruck, H., Leineweber, K., Beilfuss, A., Weber, M., Heusch, G., Philipp, T., Genotype-dependent time course of lymphocyte beta 2-adrenergic receptor down-regulation (2003) Clin Pharmacol Ther, 74, pp. 255-263
Green, S.A., Turki, J., Bejarano, P., Hall, I.P., Liggett, S.B., Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells (1995) Am J Respir Cell Mol Biol, 13, pp. 25-33
Dishy, V., Sofowora, G.G., Xie, H.G., Kim, R.B., Byrne, D.W., Stein, C.M., The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization (2001) N Engl J Med, 345, pp. 1030-1035
Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., Lohse, M.J., Klotz, K.N., Comparative pharmacology of human beta-adrenergic receptor subtypes-characterization of stably transfected receptors in CHO cells (2004) Naunyn Schmiedebergs Arch Pharmacol, 369, pp. 151-159
Bohm, M., Grabel, C., Knorr, A., Erdmann, E., Treatment in hypertensive cardiac hypertrophy, I. Neuropeptide Y and beta-adrenoceptors (1995) Hypertension, 25, pp. 954-961
Zechner, D., Thuerauf, D.J., Hanford, D.S., McDonough, P.M., Glembotski, C.C., A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression (1997) J Cell Biol, 139, pp. 115-127
Sugden, P.H., Signalling pathways in cardiac myocyte hypertrophy (2001) Ann Med, 33, pp. 611-622
McDonald, P.H., Lefkowitz, R.J., Beta-Arrestins: new roles in regulating heptahelical receptors' functions (2001) Cell Signal, 13, pp. 683-689
De Luca, N., Izzo, R., Iaccarino, G., Malini, P.L., Morisco, C., Rozza, F., The use of a telematic connection for the follow-up of hypertensive patients improves the cardiovascular prognosis (2005) J Hypertens, 23, pp. 1417-1423
1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee (1999) J Hypertens, 17, pp. 151-183
Devereux, R.B., Alonso, D.R., Lutas, E.M., Gottlieb, G.J., Campo, E., Sachs, I., Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings (1986) Am J Cardiol, 57, pp. 450-458
Devereux, R.B., Reichek, N., Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method (1977) Circulation, 55, pp. 613-618
Large, V., Hellstrom, L., Reynisdottir, S., Lonnqvist, F., Eriksson, P., Lannfelt, L., Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function (1997) J Clin Invest, 100, pp. 3005-3013
Sahn, D.J., DeMaria, A., Kisslo, J., Weyman, A., Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements (1978) Circulation, 58, pp. 1072-1083
Ganau, A., Devereux, R.B., Roman, M.J., de Simone, G., Pickering, T.G., Saba, P.S., Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension (1992) J Am Coll Cardiol, 19, pp. 1550-1558
Iaccarino, G., Ciccarelli, M., Sorriento, D., Galasso, G., Campanile, A., Santulli, G., Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system (2005) Circ Res, 97, pp. 1182-1189
Rockman, H.A., Ross, R.S., Harris, A.N., Knowlton, K.U., Steinhelper, M.E., Field, L.J., Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy (1991) Proc Natl Acad Sci U S A, 88, pp. 8277-8281
Morisco, C., Seta, K., Hardt, S.E., Lee, Y., Vatner, S.F., Sadoshima, J., Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes (2001) J Biol Chem, 276, pp. 28586-28597
Xiang, F., Sakata, Y., Cui, L., Youngblood, J.M., Nakagami, H., Liao, J.K., Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4 (2006) Am J Physiol Heart Circ Physiol, 290, pp. H1997-H2006
Kupari, M., Hautanen, A., Lankinen, L., Koskinen, P., Virolainen, J., Nikkila, H., Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function (1998) Circulation, 97, pp. 569-575
Tamaki, S., Iwai, N., Tsujita, Y., Kinoshita, M., Genetic polymorphism of CYP11B2 gene and hypertension in Japanese (1999) Hypertension, 33 (PART 2), pp. 266-270
Schunkert, H., Hengstenberg, C., Holmer, S.R., Broeckel, U., Luchner, A., Muscholl, M.W., Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure (1999) Circulation, 99, pp. 2255-2260
Sasaki, M., Oki, T., Iuchi, A., Tabata, T., Yamada, H., Manabe, K., Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies (1996) J Hypertens, 14, pp. 1403-1408
Hernandez, D., Lacalzada, J., Salido, E., Linares, J., Barragan, A., Lorenzo, V., Regression of left ventricular hypertrophy by lisinopril after renal transplantation: role of ACE gene polymorphism (2000) Kidney Int, 58, pp. 889-897
Kohno, M., Yokokawa, K., Minami, M., Kano, H., Yasunari, K., Hanehira, T., Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors (1999) Am J Med, 106, pp. 544-549
Stella, P., Bigatti, G., Tizzoni, L., Barlassina, C., Lanzani, C., Bianchi, G., Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension (2004) J Am Coll Cardiol, 43, pp. 265-270
Littlejohn, M.D., Taylor, D.R., Miller, A.L., Kennedy, M.A., Determination of beta2-adrenergic receptor (ADRB2) haplotypes by a multiplexed polymerase chain reaction assay (2002) Hum Mutat, 20, p. 479
Taylor, D.R., Epton, M.J., Kennedy, M.A., Smith, A.D., Iles, S., Miller, A.L., Bronchodilator response in relation to beta2-adrenoceptor haplotype in patients with asthma (2005) Am J Respir Crit Care Med, 172, pp. 700-703
Leineweber, K., Buscher, R., Bruck, H., Brodde, O.E., Beta-adrenoceptor polymorphisms (2004) Naunyn Schmiedebergs Arch Pharmacol, 369, pp. 1-22
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β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension
Objectives: Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication. β 2-Adrenergic receptors (β 2ARs) are up-regulated in hypertension and largely polymorphic within the human population. Recently, we have shown that the Glu27 β 2AR variant is strongly associated with cardiac hypertrophy in hypertension. The objective of this study is to verify whether this polymorphism also affects hypertrophy regression in response to antihypertensive therapy. Methods: In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile β 2AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. Results were stratified according to treatment and the Glu27Gln polymorphism of the β 2AR. In cells with stable overexpression of the Glu27 or Gln27 variant of β 2AR, we also explored the implications of this polymorphism on hypertrophy-related intracellular signal transduction. Results: Among hypertensive patients, the Gly16 allele was found in 63% of patients and the Glu27 allele was found in 40.6%. Both polymorphisms were in linkage disequilibrium, as expected. Four hundred forty-one hypertrophic hypertensive patients completed the 2-year follow-up. At baseline, patients carrying at least 1 allele of the Glu27 variant presented with a larger cardiac size despite similar blood pressure levels (142.9 ± 22.5 g/m 2 in Glu27 carriers versus 138.2 ± 18.4 g/m 2 in Gln27 carriers, P < .02). Blood pressure normalization was achieved by both drugs. At follow-up, compared with the Gln27 patients, the Glu27 patients showed a larger reduction in hypertrophy when treated with enalapril (percent change in left ventricular mass, -6.3% ± 7.7% in Glu27 carriers versus -2.18% ± 7.9% in Gln27 carriers; P < .05) but not with atenolol therapy (-2.8% ± 8.9% in Glu27 carriers versus -2.4% ± 8.8% in Gln27 carriers, P = not significant). In in vitro studies the activation of p38 and extracellular signal-regulated kinase (ERK-) 1/2 (data not shown) and the activity of the atrial natriuretic factor (ANF) promoter after isoproterenol (INN, isoprenaline) stimulation were larger in Glu27 β 2AR overexpressing cells than in Gln27 β 2AR overexpressing cells (fold difference compared with unstimulated cells, 9.7 ± 2.9 for Glu27 β 2AR versus 4.2 ± 0.3 for Gln27 β 2AR; P < .05). Conclusions: The Glu27 variant of β 2AR enhances hypertension-induced left ventricular hypertrophy. In these patients angiotensin-converting enzyme inhibitors are more efficient than β-blockers in reducing cardiac size. © 2006 American Society for Clinical Pharmacology and Therapeutics.
Objectives: Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication. β 2-Adrenergic receptors (β 2ARs) are up-regulated in hypertension and largely polymorphic within the human population. Recently, we have shown that the Glu27 β 2AR variant is strongly associated with cardiac hypertrophy in hypertension. The objective of this study is to verify whether this polymorphism also affects hypertrophy regression in response to antihypertensive therapy. Methods: In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile β 2AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. Results were stratified according to treatment and the Glu27Gln polymorphism of the β 2AR. In cells with stable overexpression of the Glu27 or Gln27 variant of β 2AR, we also explored the implications of this polymorphism on hypertrophy-related intracellular signal transduction. Results: Among hypertensive patients, the Gly16 allele was found in 63% of patients and the Glu27 allele was found in 40.6%. Both polymorphisms were in linkage disequilibrium, as expected. Four hundred forty-one hypertrophic hypertensive patients completed the 2-year follow-up. At baseline, patients carrying at least 1 allele of the Glu27 variant presented with a larger cardiac size despite similar blood pressure levels (142.9 ± 22.5 g/m 2 in Glu27 carriers versus 138.2 ± 18.4 g/m 2 in Gln27 carriers, P < .02). Blood pressure normalization was achieved by both drugs. At follow-up, compared with the Gln27 patients, the Glu27 patients showed a larger reduction in hypertrophy when treated with enalapril (percent change in left ventricular mass, -6.3% ± 7.7% in Glu27 carriers versus -2.18% ± 7.9% in Gln27 carriers; P < .05) but not with atenolol therapy (-2.8% ± 8.9% in Glu27 carriers versus -2.4% ± 8.8% in Gln27 carriers, P = not significant). In in vitro studies the activation of p38 and extracellular signal-regulated kinase (ERK-) 1/2 (data not shown) and the activity of the atrial natriuretic factor (ANF) promoter after isoproterenol (INN, isoprenaline) stimulation were larger in Glu27 β 2AR overexpressing cells than in Gln27 β 2AR overexpressing cells (fold difference compared with unstimulated cells, 9.7 ± 2.9 for Glu27 β 2AR versus 4.2 ± 0.3 for Gln27 β 2AR; P < .05). Conclusions: The Glu27 variant of β 2AR enhances hypertension-induced left ventricular hypertrophy. In these patients angiotensin-converting enzyme inhibitors are more efficient than β-blockers in reducing cardiac size. © 2006 American Society for Clinical Pharmacology and Therapeutics.
β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension
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β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension
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Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
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Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
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Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
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Impact Factor: 4.932
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Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dolle F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappata S
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Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, Campiglia P, Trimarco B, Iaccarino G, Ciccarelli M
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Impact Factor: 3.197
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Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
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Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
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Bartolucci S, Contursi P, Fiorentino G, Limauro D, Pedone E
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Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
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Russo R, Rao MA, Romano M, Scotto Di Santolo M, Cardei S, Giunta A, Cuocolo A, Volpe M
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
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Impact Factor: 2.425
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* Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection (213 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2018 Nov; 119: 758-769.
Impact Factor: 3.909
View Export to BibTeX Export to EndNote
Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (358 views)
Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
Impact Factor: 2.999
View Export to BibTeX Export to EndNote
Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (314 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
View Export to BibTeX Export to EndNote
Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dolle F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappata S
* Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (862 views) (PDF 304 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Impact Factor: 7.277
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, Campiglia P, Trimarco B, Iaccarino G, Ciccarelli M
* Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy (310 views)
J Cardiovasc Transl (ISSN: 1937-5387, 1937-5387linking), 2015 Jul 30; 8(8): 493-502.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (444 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (314 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992), 2013 Sep; 36(8): 2395-2401.
Impact Factor: 8.57
View Export to BibTeX Export to EndNote
Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
* Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (507 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013 Mar 1; 3: 1351-1351.
Impact Factor: 5.078
View Export to BibTeX Export to EndNote
Bartolucci S, Contursi P, Fiorentino G, Limauro D, Pedone E
* Responding to toxic compounds: a genomic and functional overview of Archaea (712 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2013 Jan 1; 18: 165-189.
Impact Factor: 4.249
View Export to BibTeX Export to EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (446 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
View Export to BibTeX Export to EndNote
Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G
* Age-related impairment in insulin release: The essential role of β 2-adrenergic receptor (678 views)
Diabetesdiabetes (ISSN: 0012-1797), 2012; 61(3): 692-701.
Impact Factor: 7.895
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (506 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Nov 1; 67(11): 1462-1465.
Impact Factor: 0.506
View Export to BibTeX Export to EndNote
Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
* Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ (452 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2011 Jun 16; 117(24): 6520-6531.
Impact Factor: 9.898
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (1024 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (440 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (392 views)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
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Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
* Lung structure abnormalities, but normal lung function in pediatric bronchiectasis (431 views)
Chest (ISSN: 0012-3692), 2006 Sep; 130(2): 480-486.
Impact Factor: 3.924
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Perrone-Filardi P, Cuocolo A, Brevetti G, Silvestro A, Storto G, Dellegrottaglie S, Corrado L, Cafiero M, Camerino R, Polimeno M, Zarrilli A, Caiazzo G, Maglione A, Petretta A, Chiariello M
* Sodium and diseases in the aged (296 views)
Clin Ter, 2005 Nov 1; 138(5-6): 199-205.
Impact Factor: 0.329
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Acampa W, Petretta M, Spinelli L, Ibello F, De Lauro F, Sansone V, Salvatore M, Cuocolo A
* Survival benefit after revascularization is independent of left ventricular ejection fraction improvement in patients with previous myocardial infarction and viable myocardium (470 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Apr; 32(4): 430-437.
Impact Factor: 3.883
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (725 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
Crystal Structure Of A Collagen-Like Polypeptide With Repeating Sequence Pro-Hyp-Gly At 1. 4 Ang Resolution: Implications For Collagen Hydration (441 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 8-13.
Impact Factor: 2.405
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (451 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Russo R, Rao MA, Romano M, Scotto Di Santolo M, Cardei S, Giunta A, Cuocolo A, Volpe M
Prospects of pharmacologic treatment of post-ischemic heart failure (198 views)
Cardiologia (ISSN: 0393-1978), 1995 Dec; 40(12Suppl1): 533-537.
Impact Factor: 0
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (484 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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30 Records (29 excluding Abstracts).
Total impact factor: 142.114 (137.036 excluding Abstracts).
Total 5 year impact factor: 149.345 (144.267 excluding Abstracts).
Total impact factor: 142.114 (137.036 excluding Abstracts).
Total 5 year impact factor: 149.345 (144.267 excluding Abstracts).
382 views. Last view on Sunday 09 April 2023, 11:03:53
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