Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (583 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.782, 5-year impact factor: 3.67
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-29244470231&partnerID=40&md5=2d35430a993bef9415a2b220a3bf1830
Keywords: Akt, Calcium, Heart, Oxygen Consumption, Adenosine Triphosphatase (calcium), Adenovirus Vector, Adenylate Cyclase, Aequorin, Beta Adrenergic Receptor, Buffer, Calsequestrin, Dobutamine, Messenger Rna, Phospholamban, Protein Kinase B, Ryanodine Receptor, Animal Experiment, Animal Tissue, Aorta Clamping, Article, Binding Affinity, Body Weight, Calcium Cell Level, Calcium Transport, Catheter, Cell Energy, Controlled Study, Documentation, Enzyme Activity, Gene Transfer, Heart Hypertrophy, Heart Left Ventricle, Heart Left Ventricle Contractility, Heart Left Ventricle Mass, Heart Muscle Contractility, Heart Muscle Oxygen Consumption, Heart Perfusion, Heart Ventricle Pressure, Inotropism, Isolated Heart, Myofilament, Nonhuman, Postoperative Period, Pressure Gradient, Priority Journal, Protein Content, Rat Strain, Receptor Density, Sarcoplasmic Reticulum, Steady State, Systole, Tetany, Titrimetry, Viral Gene Delivery System, Wild Type, Adenoviridae, Adrenergic Beta-Agonists, Calcium-Transporting Atpases, Echocardiography, Gene Therapy, Genetic Vectors, Heart Failure, Congestive, Myocardial Contraction, Myocardial Reperfusion Injury, Ng-Nitroarginine Methyl Ester, Nitric Oxide Synthase, Proto-Oncogene Proteins C-Akt, Sprague-Dawley, Transduction,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine and Cardiovascular Sciences, University 'Federico II', Via S Pansini 5, Naples 80131, Italy
Molecular Oncology Research Institute, New England Medical Center, Boston, MA, United States
Medizinische Universitätsklinik, Würzburg, Germany
Instituto Superiore Sanita', Rome, Italy
San Raffaele Biomedical Science Park, Rome-Multimedica Hospital, Milan, Italy
Institute of Molecular Medicine, University of California, San Diego, CA, United States
References:
Testa, J.R., Bellacosa, A., Akt plays a central role in tumorigenesis (2001) Proc Natl Acad Sci USA, 98, pp. 10983-1098
Oh, H., Fujio, Y., Kunisada, K., Hirota, H., Matsui, H., Kishimoto, T., Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes (1998) J Biol Chem, 273, pp. 9703-9710
Morisco, C., Zebrowski, D.C., Vatner, D.E., Vatner, S.F., Sadoshima, J., The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes (2000) J Biol Chem, 275, pp. 14466-14475
Matsui, T., Nagoshi, T., Rosenzweig, A., Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival (2003) Cell Cycle, 2, pp. 220-223
Shioi, T., McMullen, J.R., Kang, P.M., Douglas, P.S., Obata, T., Franke, T.F., Akt/protein kinase B promotes organ growth in transgenic mice (2002) Mol Cell Biol, 22, pp. 2799-2809
Yamashita, K., Kajstura, J., Discher, D.J., Wasserlauf, B.J., Bishopric, N.H., Anversa, P., Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1 (2001) Circ Res, 88, pp. 609-614
Miao, W., Luo, Z., Kitsis, R.N., Walsh, K., Intracoronary adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo (2000) J Mol Cell Cardiol, 32, pp. 2397-2402
Matsui, T., Tao, J., del Monte, F., Lee, K.H., Li, L., Picard, M., Akt preserves cardiac function and prevents injury after transient cardiac ischemia in vivo (2001) Circulation, 104, pp. 330-335
Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R.N., Walsh, K., Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart (2000) Circulation, 101, pp. 660-667
Condorelli, G., Drusco, A., Stassi, G., Bellacosa, A., Roncarati, R., Iaccarino, G., Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice (2002) Proc Natl Acad Sci USA, 99, pp. 12333-12338
Kim, Y.K., Kim, S.J., Yatani, A., Huang, Y., Castelli, G., Vatner, D.E., Mechanisms of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt (2003) J Biol Chem, 278, pp. 47622-47628
Bonci, D., Cittadini, A., Latronico, M.V., Borello, U., Aycock, J.K., Drusco, A., 'Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo (2003) Gene Therapy, 10, pp. 630-636
Hajjar, R.J., Schmidt, U., Matsui, T., Guerrero, J.L., Lee, K.H., Gwathmey, J.K., Modulation of ventricular function through gene transfer in vivo (1998) Proc Natl Acad Sci USA, 95, pp. 5251-5256
Ikeda, Y., Gu, Y., Iwanaga, Y., Hoshijima, M., Oh, S.S., Giordano, F.J., Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer (2002) Circulation, 105, pp. 502-508
Camacho, S.A., Brandes, R., Figueredo, V.M., Weiner, M.W., Ca2+ transient decline and myocardial relaxation are slowed during low flow ischemia in rat hearts (1994) J Clin Invest, 93, pp. 951-957
Blinks, J.R., Endoh, M., Modification of myofibrillar responsiveness to Ca2+ as an inotropic mechanism (1986) Circulation, 73, pp. III85-III98
Perrault, C.L., Meuse, A.J., Bentivegna, L.A., Morgan, J.P., Abnormal intracellular calcium handling in acute and chronic heart failure: Role in systolic and diastolic dysfunction (1990) Eur Heart J, 11, pp. 8-21
Wisloff, U., Loennechen, J.P., Falck, G., Beisvag, V., Currie, S., Smith, G., Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats (2001) Cardiovasc Res, 50, pp. 495-508
Beanlands, R.S., Bach, D.S., Raylman, R., Armstrong, W.F., Wilson, V., Montieth, M., Acute effects of dobutamine on myocardial oxygen consumption and cardiac efficiency measure using carbon-11 acetate kinetics in patients with dilated cardiomyopathy (1993) J Am Coll, 22, pp. 1389-1398
Hasenfuss, G., Holubarsch, C., Heiss, H.W., Meinertz, T., Bonzel, T., Wais, U., Myocardial energetics in patients with dilated cardiomyopathy: Influence of nitroprusside and enoximone (1989) Circulation, 80, pp. 51-64
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Cittadini, A., Ishiguro, Y., Stromer, H., Spindler, M., Moses, A.C., Clark, R., Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway. Studies in rat and ferret isolated muscles (1998) Circ Res, 83, pp. 50-59
Tajima, M., Weinberg, E.O., Bartunek, J., Jin, H., Yang, R., Paoni, N.F., Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure (1999) Circulation, 99, pp. 127-134
He, H., Giordano, F.J., Hilal-Dandan, R., Choi, D.J., Rockman, H.A., McDonough, P.M., Overexpression of the rat sarcoplasmic reticulum Ca2+-ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation (1997) J Clin Invest, 100, pp. 380-389
Baker, D.L., Hashimoto, K., Grupp, I.L., Ji, Y., Reed, T., Loukianov, E., Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts (1998) Circ Res, 83, pp. 1205-1214
Duan, J., Zhang, H.Y., Adkins, S.D., Ren, B.H., Norby, F.L., Zhang, X., Impaired cardiac function and IGF-I response in myocyte from calmodulin-diabetic mice: Role of Akt and RhoA (2003) Am J Physiol, 284, pp. E366-E376
Haq, S., Choukroun, G., Lim, H., Tymitz, K.M., del Monte, F., Gwathmey, J., Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure (2001) Circulation, 103, pp. 670-677
Taniyama, Y., Walsh, K., Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth (2002) J Moll Cell Cardiol, 34, pp. 1241-1247
Iaccarino, G., Ciccarelli, M., Sorriento, D., Cipolletta, E., Cerullo, V., Iovino, G.L., Akt participates to endothelial dysfunction in hypertension (2004) Circulation, 109, pp. 2587-2593
Claudio, P.P., Fratta, L., Farina, F., Howard, C.M., Stassi, G., Numata, S., Adenoviral RB2/p130 gene transfer inhibits smooth muscle cell proliferation and prevents restenosis after angioplasty (1999) Circ Res, 85, pp. 1032-1039
Cittadini, A., Stromer, H., Katz, S.E., Clark, R., Moses, A.C., Morgan, J.P., Differential cardiac effects of GH and IGF-1 in the rat: A combined in vivo and in vitro evaluation (1996) Circulation, 93, pp. 800-809
Kihara, Y., Grossman, W., Morgan, J.P., Direct measurement of changes in intracellular calcium transients during hypoxia, ischemia and reperfusion of the intact mammalian heart (1989) Circ. Res., 65, pp. 1029-1044
Brooks, W.W., Healey, N.A., Sen, S., Conrad, C.H., Bing, O.H., Oxygen cost of stress development in hypertrophied and failing hearts from the spontaneously hypertensive rat (1993) Hypertension, 21, pp. 56-64
Nelson, G.S., Berger, R.D., Fetics, B.J., Talbot, M., Spinelli, J.C., Hare, J.M., Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block (2000) Circulation, 102, pp. 3053-3059
Callies, F., Stromer, H., Schwinger, R.H., Bolck, B., Hu, K., Frantz, S., Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia (2003) Endocrinology, 144, pp. 4478-4483
Chomczynski, P., Sacchi, N., Single step method of RNA isolation by acidic guanidinium thiocyanate-phenol-chloroform extraction (1987) Anal Biochem, 162, pp. 156-159
Temsah, R.M., Dyck, C., Netticadan, T., Chapman, D., Elimban, V., Dhalla, N.S., Effect of β-adrenoreceptor blockers on sarcoplasmatic reticular function and gene expression in the ischemic reperfused heart (2000) J Pharmacol Exp Ther, 293, pp. 15-23
Iaccarino, G., Barbato, E., Cipolletta, E., Esposito, A., Fiorillo, A., Koch, W.J., Cardiac βARK1 upregulation induced by chronic salt deprivation in rats (2001) Hypertension, 38, pp. 255-260
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.782, 5-year impact factor: 3.67
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-29244470231&partnerID=40&md5=2d35430a993bef9415a2b220a3bf1830
Keywords: Akt, Calcium, Heart, Oxygen Consumption, Adenosine Triphosphatase (calcium), Adenovirus Vector, Adenylate Cyclase, Aequorin, Beta Adrenergic Receptor, Buffer, Calsequestrin, Dobutamine, Messenger Rna, Phospholamban, Protein Kinase B, Ryanodine Receptor, Animal Experiment, Animal Tissue, Aorta Clamping, Article, Binding Affinity, Body Weight, Calcium Cell Level, Calcium Transport, Catheter, Cell Energy, Controlled Study, Documentation, Enzyme Activity, Gene Transfer, Heart Hypertrophy, Heart Left Ventricle, Heart Left Ventricle Contractility, Heart Left Ventricle Mass, Heart Muscle Contractility, Heart Muscle Oxygen Consumption, Heart Perfusion, Heart Ventricle Pressure, Inotropism, Isolated Heart, Myofilament, Nonhuman, Postoperative Period, Pressure Gradient, Priority Journal, Protein Content, Rat Strain, Receptor Density, Sarcoplasmic Reticulum, Steady State, Systole, Tetany, Titrimetry, Viral Gene Delivery System, Wild Type, Adenoviridae, Adrenergic Beta-Agonists, Calcium-Transporting Atpases, Echocardiography, Gene Therapy, Genetic Vectors, Heart Failure, Congestive, Myocardial Contraction, Myocardial Reperfusion Injury, Ng-Nitroarginine Methyl Ester, Nitric Oxide Synthase, Proto-Oncogene Proteins C-Akt, Sprague-Dawley, Transduction,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine and Cardiovascular Sciences, University 'Federico II', Via S Pansini 5, Naples 80131, Italy
Molecular Oncology Research Institute, New England Medical Center, Boston, MA, United States
Medizinische Universitätsklinik, Würzburg, Germany
Instituto Superiore Sanita', Rome, Italy
San Raffaele Biomedical Science Park, Rome-Multimedica Hospital, Milan, Italy
Institute of Molecular Medicine, University of California, San Diego, CA, United States
References:
Testa, J.R., Bellacosa, A., Akt plays a central role in tumorigenesis (2001) Proc Natl Acad Sci USA, 98, pp. 10983-1098
Oh, H., Fujio, Y., Kunisada, K., Hirota, H., Matsui, H., Kishimoto, T., Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes (1998) J Biol Chem, 273, pp. 9703-9710
Morisco, C., Zebrowski, D.C., Vatner, D.E., Vatner, S.F., Sadoshima, J., The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes (2000) J Biol Chem, 275, pp. 14466-14475
Matsui, T., Nagoshi, T., Rosenzweig, A., Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival (2003) Cell Cycle, 2, pp. 220-223
Shioi, T., McMullen, J.R., Kang, P.M., Douglas, P.S., Obata, T., Franke, T.F., Akt/protein kinase B promotes organ growth in transgenic mice (2002) Mol Cell Biol, 22, pp. 2799-2809
Yamashita, K., Kajstura, J., Discher, D.J., Wasserlauf, B.J., Bishopric, N.H., Anversa, P., Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1 (2001) Circ Res, 88, pp. 609-614
Miao, W., Luo, Z., Kitsis, R.N., Walsh, K., Intracoronary adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo (2000) J Mol Cell Cardiol, 32, pp. 2397-2402
Matsui, T., Tao, J., del Monte, F., Lee, K.H., Li, L., Picard, M., Akt preserves cardiac function and prevents injury after transient cardiac ischemia in vivo (2001) Circulation, 104, pp. 330-335
Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R.N., Walsh, K., Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart (2000) Circulation, 101, pp. 660-667
Condorelli, G., Drusco, A., Stassi, G., Bellacosa, A., Roncarati, R., Iaccarino, G., Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice (2002) Proc Natl Acad Sci USA, 99, pp. 12333-12338
Kim, Y.K., Kim, S.J., Yatani, A., Huang, Y., Castelli, G., Vatner, D.E., Mechanisms of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt (2003) J Biol Chem, 278, pp. 47622-47628
Bonci, D., Cittadini, A., Latronico, M.V., Borello, U., Aycock, J.K., Drusco, A., 'Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo (2003) Gene Therapy, 10, pp. 630-636
Hajjar, R.J., Schmidt, U., Matsui, T., Guerrero, J.L., Lee, K.H., Gwathmey, J.K., Modulation of ventricular function through gene transfer in vivo (1998) Proc Natl Acad Sci USA, 95, pp. 5251-5256
Ikeda, Y., Gu, Y., Iwanaga, Y., Hoshijima, M., Oh, S.S., Giordano, F.J., Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer (2002) Circulation, 105, pp. 502-508
Camacho, S.A., Brandes, R., Figueredo, V.M., Weiner, M.W., Ca2+ transient decline and myocardial relaxation are slowed during low flow ischemia in rat hearts (1994) J Clin Invest, 93, pp. 951-957
Blinks, J.R., Endoh, M., Modification of myofibrillar responsiveness to Ca2+ as an inotropic mechanism (1986) Circulation, 73, pp. III85-III98
Perrault, C.L., Meuse, A.J., Bentivegna, L.A., Morgan, J.P., Abnormal intracellular calcium handling in acute and chronic heart failure: Role in systolic and diastolic dysfunction (1990) Eur Heart J, 11, pp. 8-21
Wisloff, U., Loennechen, J.P., Falck, G., Beisvag, V., Currie, S., Smith, G., Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats (2001) Cardiovasc Res, 50, pp. 495-508
Beanlands, R.S., Bach, D.S., Raylman, R., Armstrong, W.F., Wilson, V., Montieth, M., Acute effects of dobutamine on myocardial oxygen consumption and cardiac efficiency measure using carbon-11 acetate kinetics in patients with dilated cardiomyopathy (1993) J Am Coll, 22, pp. 1389-1398
Hasenfuss, G., Holubarsch, C., Heiss, H.W., Meinertz, T., Bonzel, T., Wais, U., Myocardial energetics in patients with dilated cardiomyopathy: Influence of nitroprusside and enoximone (1989) Circulation, 80, pp. 51-64
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Cittadini, A., Ishiguro, Y., Stromer, H., Spindler, M., Moses, A.C., Clark, R., Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway. Studies in rat and ferret isolated muscles (1998) Circ Res, 83, pp. 50-59
Tajima, M., Weinberg, E.O., Bartunek, J., Jin, H., Yang, R., Paoni, N.F., Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure (1999) Circulation, 99, pp. 127-134
He, H., Giordano, F.J., Hilal-Dandan, R., Choi, D.J., Rockman, H.A., McDonough, P.M., Overexpression of the rat sarcoplasmic reticulum Ca2+-ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation (1997) J Clin Invest, 100, pp. 380-389
Baker, D.L., Hashimoto, K., Grupp, I.L., Ji, Y., Reed, T., Loukianov, E., Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts (1998) Circ Res, 83, pp. 1205-1214
Duan, J., Zhang, H.Y., Adkins, S.D., Ren, B.H., Norby, F.L., Zhang, X., Impaired cardiac function and IGF-I response in myocyte from calmodulin-diabetic mice: Role of Akt and RhoA (2003) Am J Physiol, 284, pp. E366-E376
Haq, S., Choukroun, G., Lim, H., Tymitz, K.M., del Monte, F., Gwathmey, J., Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure (2001) Circulation, 103, pp. 670-677
Taniyama, Y., Walsh, K., Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth (2002) J Moll Cell Cardiol, 34, pp. 1241-1247
Iaccarino, G., Ciccarelli, M., Sorriento, D., Cipolletta, E., Cerullo, V., Iovino, G.L., Akt participates to endothelial dysfunction in hypertension (2004) Circulation, 109, pp. 2587-2593
Claudio, P.P., Fratta, L., Farina, F., Howard, C.M., Stassi, G., Numata, S., Adenoviral RB2/p130 gene transfer inhibits smooth muscle cell proliferation and prevents restenosis after angioplasty (1999) Circ Res, 85, pp. 1032-1039
Cittadini, A., Stromer, H., Katz, S.E., Clark, R., Moses, A.C., Morgan, J.P., Differential cardiac effects of GH and IGF-1 in the rat: A combined in vivo and in vitro evaluation (1996) Circulation, 93, pp. 800-809
Kihara, Y., Grossman, W., Morgan, J.P., Direct measurement of changes in intracellular calcium transients during hypoxia, ischemia and reperfusion of the intact mammalian heart (1989) Circ. Res., 65, pp. 1029-1044
Brooks, W.W., Healey, N.A., Sen, S., Conrad, C.H., Bing, O.H., Oxygen cost of stress development in hypertrophied and failing hearts from the spontaneously hypertensive rat (1993) Hypertension, 21, pp. 56-64
Nelson, G.S., Berger, R.D., Fetics, B.J., Talbot, M., Spinelli, J.C., Hare, J.M., Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block (2000) Circulation, 102, pp. 3053-3059
Callies, F., Stromer, H., Schwinger, R.H., Bolck, B., Hu, K., Frantz, S., Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia (2003) Endocrinology, 144, pp. 4478-4483
Chomczynski, P., Sacchi, N., Single step method of RNA isolation by acidic guanidinium thiocyanate-phenol-chloroform extraction (1987) Anal Biochem, 162, pp. 156-159
Temsah, R.M., Dyck, C., Netticadan, T., Chapman, D., Elimban, V., Dhalla, N.S., Effect of β-adrenoreceptor blockers on sarcoplasmatic reticular function and gene expression in the ischemic reperfused heart (2000) J Pharmacol Exp Ther, 293, pp. 15-23
Iaccarino, G., Barbato, E., Cipolletta, E., Esposito, A., Fiorillo, A., Koch, W.J., Cardiac βARK1 upregulation induced by chronic salt deprivation in rats (2001) Hypertension, 38, pp. 255-260
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
The serine-threonine kinase Akt/PKB mediates stimuli from different classes of cardiomyocyte receptors, including the growth hormone/insulin like growth factor and the β-adrenergic receptors. Whereas the growth-promoting and antiapoptotic properties of Akt activation are well established, little is known about the effects of Akt on myocardial contractility, intracellular calcium (Ca2+) handling, oxygen consumption, and β-adrenergic pathway. To this aim, Sprague -Dawley rats were subjected to a wild-type Akt in vivo adenoviral gene transfer using a catheter-based technique combined with aortopulmonary crossclamping. Left ventricular (LV) contractility and intracellular Ca2+ handling were evaluated in an isolated isovolumic buffer-perfused, aequorin-loaded whole heart preparations 10 days after the surgery. The Ca2+-force relationship was obtained under steady-state conditions in tetanized muscles. No significant hypertrophy was detected in adenovirus with wild-type Akt (Ad.Akt) versus controls rats (LV-to-body weight ratio 2.6±177;0.2 versus 2.7±177;0.1mg/g, controls versus Ad.Akt, P, NS). LV contractility, measured as developed pressure, increased by 41% in Ad.Akt. This was accounted for by both more systolic Ca2+ available to the contractile machinery (+19% versus controls) and by enhanced myofilament Ca2+ responsiveness, documented by an increased maximal Ca2+-activated pressure (+19% versus controls) and a shift to the left of the Ca2+-force relationship. Such increased contractility was paralleled by a slight increase of myocardial oxygen consumption (14%), while titrated dose of dobutamine providing similar inotropic effect augmented oxygen consumption by 39% (P
The serine-threonine kinase Akt/PKB mediates stimuli from different classes of cardiomyocyte receptors, including the growth hormone/insulin like growth factor and the β-adrenergic receptors. Whereas the growth-promoting and antiapoptotic properties of Akt activation are well established, little is known about the effects of Akt on myocardial contractility, intracellular calcium (Ca2+) handling, oxygen consumption, and β-adrenergic pathway. To this aim, Sprague -Dawley rats were subjected to a wild-type Akt in vivo adenoviral gene transfer using a catheter-based technique combined with aortopulmonary crossclamping. Left ventricular (LV) contractility and intracellular Ca2+ handling were evaluated in an isolated isovolumic buffer-perfused, aequorin-loaded whole heart preparations 10 days after the surgery. The Ca2+-force relationship was obtained under steady-state conditions in tetanized muscles. No significant hypertrophy was detected in adenovirus with wild-type Akt (Ad.Akt) versus controls rats (LV-to-body weight ratio 2.6±177;0.2 versus 2.7±177;0.1mg/g, controls versus Ad.Akt, P, NS). LV contractility, measured as developed pressure, increased by 41% in Ad.Akt. This was accounted for by both more systolic Ca2+ available to the contractile machinery (+19% versus controls) and by enhanced myofilament Ca2+ responsiveness, documented by an increased maximal Ca2+-activated pressure (+19% versus controls) and a shift to the left of the Ca2+-force relationship. Such increased contractility was paralleled by a slight increase of myocardial oxygen consumption (14%), while titrated dose of dobutamine providing similar inotropic effect augmented oxygen consumption by 39% (P
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
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Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
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Impact Factor: 2.871
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Giallauria F, Acampa W, Ricci F, Vitelli A, Torella G, Lucci R, Del Prete G, Zampella E, Assante R, Rengo G, Leosco D, Cuocolo A, Vigorito C
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Impact Factor: 5.217
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Giallauria F, Acampa W, Ricci F, Gallicchio R, Xhoxhi E, Vitelli A, D'Agostino M, Lucci R, Vigorito C, Cuocolo A
* Effects of exercise training started within 2 weeks after acute myocardial infarction on myocardial perfusion and left ventricular function: A gated SPECT imaging study (442 views)
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Impact Factor: 2.675
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Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (483 views)
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
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Impact Factor: 6.873
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Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
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Manganelli F, Spadafora M, Varrella P, Peluso G, Sauro R, Di Lorenzo E, Rosato G, Daniele S, Cuocolo A
* Addition of atropine to submaximal exercise stress testing in patients evaluated for suspected ischaemia with SPECT imaging: a randomized, placebo-controlled trial (402 views)
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Impact Factor: 4.991
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
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Impact Factor: 4.409
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (480 views)
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Impact Factor: 3.317
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
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Impact Factor: 6.908
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Lucignani G, Cuocolo A
Recent advances in the assessment of myocardial viability (396 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2009 Nov; 36(11): 1892-1895.
Impact Factor: 4.531
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
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Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
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Pedone C, Di Pasquale G, Greco C, Gonzini L, Maggioni AP, Pavesi PC, Sabini A, Boccanelli A; In-Acs Outcome Investigators
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Impact Factor: 0
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
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Impact Factor: 4.447
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Ciampi Q, Betocchi S, Losi MA, Ferro A, Cuocolo A, Lombardi R, Villari B, Chiariello M
* Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy (398 views)
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Impact Factor: 2.359
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Ferro A, Pellegrino T, Spinelli L, Acampa W, Petretta M, Cuocolo A
* Comparison Between Dobutamine Echocardiography and Single-Photon Emission Computed Tomography for Interpretive Reproducibility (394 views)
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Impact Factor: 3.603
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (392 views)
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Impact Factor: 3.475
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
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Impact Factor: 0.023
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
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Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (469 views)
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Impact Factor: 5.873
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
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Impact Factor: 3.658
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De Lazzari C, Darowski M, Ferrari G, Clemente F, Guaragno M
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Impact Factor: 0.538
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Pace L, Nappi A, Imbriaco M, Cuocolo A, Varrone A, Romano M, Trimarco B, Salvatore M
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Impact Factor: 1.368
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Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
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Impact Factor: 3.491
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Biondi B, Fazio S, Cuocolo A, Sabatini D, Nicolai E, Lombardi G, Salvatore M, Sacca L
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Impact Factor: 4.575
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
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Impact Factor: 1.342
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
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Imbriaco M, Cuocolo A, Pace L, Nappi A, Nicolai E, Cardei S, Morisco C, Romano M, Salvatore M
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* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
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Petretta M, Cuocolo A
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
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Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (467 views)
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Impact Factor: 2.871
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Giallauria F, Acampa W, Ricci F, Vitelli A, Torella G, Lucci R, Del Prete G, Zampella E, Assante R, Rengo G, Leosco D, Cuocolo A, Vigorito C
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Impact Factor: 5.217
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Giallauria F, Acampa W, Ricci F, Gallicchio R, Xhoxhi E, Vitelli A, D'Agostino M, Lucci R, Vigorito C, Cuocolo A
* Effects of exercise training started within 2 weeks after acute myocardial infarction on myocardial perfusion and left ventricular function: A gated SPECT imaging study (442 views)
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Impact Factor: 2.675
View Export to BibTeX Export to EndNote
Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
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Impact Factor: 3.35
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (483 views)
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Impact Factor: 3.197
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
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Impact Factor: 4.223
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Manganelli F, Spadafora M, Varrella P, Peluso G, Sauro R, Di Lorenzo E, Rosato G, Daniele S, Cuocolo A
* Addition of atropine to submaximal exercise stress testing in patients evaluated for suspected ischaemia with SPECT imaging: a randomized, placebo-controlled trial (402 views)
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Impact Factor: 4.991
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
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Impact Factor: 4.409
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (480 views)
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Impact Factor: 3.317
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
View Export to BibTeX Export to EndNote
Lucignani G, Cuocolo A
Recent advances in the assessment of myocardial viability (396 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2009 Nov; 36(11): 1892-1895.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
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Impact Factor: 6.202
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
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Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (359 views)
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Impact Factor: 4.16
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Pedone C, Di Pasquale G, Greco C, Gonzini L, Maggioni AP, Pavesi PC, Sabini A, Boccanelli A; In-Acs Outcome Investigators
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Impact Factor: 0
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
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Impact Factor: 4.447
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Ciampi Q, Betocchi S, Losi MA, Ferro A, Cuocolo A, Lombardi R, Villari B, Chiariello M
* Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy (398 views)
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Impact Factor: 2.359
View Export to BibTeX Export to EndNote
Ferro A, Pellegrino T, Spinelli L, Acampa W, Petretta M, Cuocolo A
* Comparison Between Dobutamine Echocardiography and Single-Photon Emission Computed Tomography for Interpretive Reproducibility (394 views)
Am J Cardiol (ISSN: 0002-9149), 2007 Oct 15; 100(8): 1239-1244.
Impact Factor: 3.603
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (392 views)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
View Export to BibTeX Export to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (731 views)
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Impact Factor: 0.023
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
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Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (469 views)
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Impact Factor: 5.873
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (334 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
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De Lazzari C, Darowski M, Ferrari G, Clemente F, Guaragno M
* Energetic parameter changes with mechanical ventilation in conjunction with BVAD assistance (563 views)
J Med Eng Technol (ISSN: 0309-1902), 2002 Mar; 26(2): 63-70.
Impact Factor: 0.538
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Pace L, Nappi A, Imbriaco M, Cuocolo A, Varrone A, Romano M, Trimarco B, Salvatore M
Relationship between exercise capacity and left ventricular function at rest in patients with heart failure. An ambulatory left ventricular monitoring study (277 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 100(3): 120-125.
Impact Factor: 1.368
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Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure (413 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jun; 38(6): 948-953.
Impact Factor: 3.491
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Biondi B, Fazio S, Cuocolo A, Sabatini D, Nicolai E, Lombardi G, Salvatore M, Sacca L
Impaired cardiac reserve and exercise capacity in patients receiving long-term thyrotropin suppressive therapy with levothyroxine (336 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1996 Dec; 81(12): 4224-4228.
Impact Factor: 4.575
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (588 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (377 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Imbriaco M, Cuocolo A, Pace L, Nappi A, Nicolai E, Cardei S, Morisco C, Romano M, Salvatore M
AMBULATORY MONITORING OF LEFT-VENTRICULAR FUNCTION DURING CARDIOPULMONARY EXERCISE TESTS IN NORMAL SEDENTARY SUBJECTS (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Apr; 36(4): 564-568.
Impact Factor: 3.491
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38 Records (37 excluding Abstracts).
Total impact factor: 152.289 (147.938 excluding Abstracts).
Total 5 year impact factor: 162.361 (157.978 excluding Abstracts).
Total impact factor: 152.289 (147.938 excluding Abstracts).
Total 5 year impact factor: 162.361 (157.978 excluding Abstracts).
583 views. Last view on Saturday 10 June 2023, 2:26:34
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