Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (2386 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
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Paper type: Journal Article,
Impact factor: 4.782, 5-year impact factor: 3.67
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-29244470231&partnerID=40&md5=2d35430a993bef9415a2b220a3bf1830
Keywords: Akt, Calcium, Heart, Oxygen Consumption, Adenosine Triphosphatase (calcium), Adenovirus Vector, Adenylate Cyclase, Aequorin, Beta Adrenergic Receptor, Buffer, Calsequestrin, Dobutamine, Messenger Rna, Phospholamban, Protein Kinase B, Ryanodine Receptor, Animal Experiment, Animal Tissue, Aorta Clamping, Article, Binding Affinity, Body Weight, Calcium Cell Level, Calcium Transport, Catheter, Cell Energy, Controlled Study, Documentation, Enzyme Activity, Gene Transfer, Heart Hypertrophy, Heart Left Ventricle, Heart Left Ventricle Contractility, Heart Left Ventricle Mass, Heart Muscle Contractility, Heart Muscle Oxygen Consumption, Heart Perfusion, Heart Ventricle Pressure, Inotropism, Isolated Heart, Myofilament, Nonhuman, Postoperative Period, Pressure Gradient, Priority Journal, Protein Content, Rat Strain, Receptor Density, Sarcoplasmic Reticulum, Steady State, Systole, Tetany, Titrimetry, Viral Gene Delivery System, Wild Type, Adenoviridae, Adrenergic Beta-Agonists, Calcium-Transporting Atpases, Echocardiography, Gene Therapy, Genetic Vectors, Heart Failure, Congestive, Myocardial Contraction, Myocardial Reperfusion Injury, Ng-Nitroarginine Methyl Ester, Nitric Oxide Synthase, Proto-Oncogene Proteins C-Akt, Sprague-Dawley, Transduction,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine and Cardiovascular Sciences, University 'Federico II', Via S Pansini 5, Naples 80131, Italy
Molecular Oncology Research Institute, New England Medical Center, Boston, MA, United States
Medizinische Universitätsklinik, Würzburg, Germany
Instituto Superiore Sanita', Rome, Italy
San Raffaele Biomedical Science Park, Rome-Multimedica Hospital, Milan, Italy
Institute of Molecular Medicine, University of California, San Diego, CA, United States
References:
Not available.
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.782, 5-year impact factor: 3.67
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-29244470231&partnerID=40&md5=2d35430a993bef9415a2b220a3bf1830
Keywords: Akt, Calcium, Heart, Oxygen Consumption, Adenosine Triphosphatase (calcium), Adenovirus Vector, Adenylate Cyclase, Aequorin, Beta Adrenergic Receptor, Buffer, Calsequestrin, Dobutamine, Messenger Rna, Phospholamban, Protein Kinase B, Ryanodine Receptor, Animal Experiment, Animal Tissue, Aorta Clamping, Article, Binding Affinity, Body Weight, Calcium Cell Level, Calcium Transport, Catheter, Cell Energy, Controlled Study, Documentation, Enzyme Activity, Gene Transfer, Heart Hypertrophy, Heart Left Ventricle, Heart Left Ventricle Contractility, Heart Left Ventricle Mass, Heart Muscle Contractility, Heart Muscle Oxygen Consumption, Heart Perfusion, Heart Ventricle Pressure, Inotropism, Isolated Heart, Myofilament, Nonhuman, Postoperative Period, Pressure Gradient, Priority Journal, Protein Content, Rat Strain, Receptor Density, Sarcoplasmic Reticulum, Steady State, Systole, Tetany, Titrimetry, Viral Gene Delivery System, Wild Type, Adenoviridae, Adrenergic Beta-Agonists, Calcium-Transporting Atpases, Echocardiography, Gene Therapy, Genetic Vectors, Heart Failure, Congestive, Myocardial Contraction, Myocardial Reperfusion Injury, Ng-Nitroarginine Methyl Ester, Nitric Oxide Synthase, Proto-Oncogene Proteins C-Akt, Sprague-Dawley, Transduction,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine and Cardiovascular Sciences, University 'Federico II', Via S Pansini 5, Naples 80131, Italy
Molecular Oncology Research Institute, New England Medical Center, Boston, MA, United States
Medizinische Universitätsklinik, Würzburg, Germany
Instituto Superiore Sanita', Rome, Italy
San Raffaele Biomedical Science Park, Rome-Multimedica Hospital, Milan, Italy
Institute of Molecular Medicine, University of California, San Diego, CA, United States
References:
Not available.
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
The serine-threonine kinase Akt/PKB mediates stimuli from different classes of cardiomyocyte receptors, including the growth hormone/insulin like growth factor and the β-adrenergic receptors. Whereas the growth-promoting and antiapoptotic properties of Akt activation are well established, little is known about the effects of Akt on myocardial contractility, intracellular calcium (Ca2+) handling, oxygen consumption, and β-adrenergic pathway. To this aim, Sprague -Dawley rats were subjected to a wild-type Akt in vivo adenoviral gene transfer using a catheter-based technique combined with aortopulmonary crossclamping. Left ventricular (LV) contractility and intracellular Ca2+ handling were evaluated in an isolated isovolumic buffer-perfused, aequorin-loaded whole heart preparations 10 days after the surgery. The Ca2+-force relationship was obtained under steady-state conditions in tetanized muscles. No significant hypertrophy was detected in adenovirus with wild-type Akt (Ad.Akt) versus controls rats (LV-to-body weight ratio 2.6±177;0.2 versus 2.7±177;0.1mg/g, controls versus Ad.Akt, P, NS). LV contractility, measured as developed pressure, increased by 41% in Ad.Akt. This was accounted for by both more systolic Ca2+ available to the contractile machinery (+19% versus controls) and by enhanced myofilament Ca2+ responsiveness, documented by an increased maximal Ca2+-activated pressure (+19% versus controls) and a shift to the left of the Ca2+-force relationship. Such increased contractility was paralleled by a slight increase of myocardial oxygen consumption (14%), while titrated dose of dobutamine providing similar inotropic effect augmented oxygen consumption by 39% (P
The serine-threonine kinase Akt/PKB mediates stimuli from different classes of cardiomyocyte receptors, including the growth hormone/insulin like growth factor and the β-adrenergic receptors. Whereas the growth-promoting and antiapoptotic properties of Akt activation are well established, little is known about the effects of Akt on myocardial contractility, intracellular calcium (Ca2+) handling, oxygen consumption, and β-adrenergic pathway. To this aim, Sprague -Dawley rats were subjected to a wild-type Akt in vivo adenoviral gene transfer using a catheter-based technique combined with aortopulmonary crossclamping. Left ventricular (LV) contractility and intracellular Ca2+ handling were evaluated in an isolated isovolumic buffer-perfused, aequorin-loaded whole heart preparations 10 days after the surgery. The Ca2+-force relationship was obtained under steady-state conditions in tetanized muscles. No significant hypertrophy was detected in adenovirus with wild-type Akt (Ad.Akt) versus controls rats (LV-to-body weight ratio 2.6±177;0.2 versus 2.7±177;0.1mg/g, controls versus Ad.Akt, P, NS). LV contractility, measured as developed pressure, increased by 41% in Ad.Akt. This was accounted for by both more systolic Ca2+ available to the contractile machinery (+19% versus controls) and by enhanced myofilament Ca2+ responsiveness, documented by an increased maximal Ca2+-activated pressure (+19% versus controls) and a shift to the left of the Ca2+-force relationship. Such increased contractility was paralleled by a slight increase of myocardial oxygen consumption (14%), while titrated dose of dobutamine providing similar inotropic effect augmented oxygen consumption by 39% (P
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
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Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
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Giallauria F, Acampa W, Ricci F, Vitelli A, Torella G, Lucci R, Del Prete G, Zampella E, Assante R, Rengo G, Leosco D, Cuocolo A, Vigorito C
* Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function (1003 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Feb; 40(3): 315-324.
Impact Factor: 5.217
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Giallauria F, Acampa W, Ricci F, Gallicchio R, Xhoxhi E, Vitelli A, D'Agostino M, Lucci R, Vigorito C, Cuocolo A
* Effects of exercise training started within 2 weeks after acute myocardial infarction on myocardial perfusion and left ventricular function: A gated SPECT imaging study (886 views)
Eur J Prev Cardiol (ISSN: 2047-4873, 2047-4881), 2012 Dec; 19(6): 1410-1419.
Impact Factor: 2.675
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Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
* ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (743 views)
Molecular Biosystems (ISSN: 1742-206x), 2012 Oct 30; 8(12): 3295-3304.
Impact Factor: 3.35
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (761 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (789 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (804 views)
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
Impact Factor: 4.223
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Manganelli F, Spadafora M, Varrella P, Peluso G, Sauro R, Di Lorenzo E, Rosato G, Daniele S, Cuocolo A
* Addition of atropine to submaximal exercise stress testing in patients evaluated for suspected ischaemia with SPECT imaging: a randomized, placebo-controlled trial (878 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 Feb; 38(2): 245-251.
Impact Factor: 4.991
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (969 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (1071 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2010 Sep; 104(8): 885-891.
Impact Factor: 3.317
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (960 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Lucignani G, Cuocolo A
Recent advances in the assessment of myocardial viability (829 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2009 Nov; 36(11): 1892-1895.
Impact Factor: 4.531
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (1258 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (737 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (940 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Pedone C, Di Pasquale G, Greco C, Gonzini L, Maggioni AP, Pavesi PC, Sabini A, Boccanelli A; In-Acs Outcome Investigators
* Prescription at discharge of recommended treatments for secondary prevention in patients with ST-segment elevation myocardial infarction according to reperfusion strategies. Results from the IN-ACS outcome study (946 views)
Acute Cardiac Care (ISSN: 1748-295x, 1748-2941), 2009; 11(4): 222-228.
Impact Factor: 0
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (1046 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Ciampi Q, Betocchi S, Losi MA, Ferro A, Cuocolo A, Lombardi R, Villari B, Chiariello M
* Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy (965 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2007 Nov; 14(6): 869-875.
Impact Factor: 2.359
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Ferro A, Pellegrino T, Spinelli L, Acampa W, Petretta M, Cuocolo A
* Comparison Between Dobutamine Echocardiography and Single-Photon Emission Computed Tomography for Interpretive Reproducibility (980 views)
Am J Cardiol (ISSN: 0002-9149), 2007 Oct 15; 100(8): 1239-1244.
Impact Factor: 3.603
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (760 views)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (1438 views)
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812.
Impact Factor: 0.023
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (875 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (851 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (687 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
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De Lazzari C, Darowski M, Ferrari G, Clemente F, Guaragno M
* Energetic parameter changes with mechanical ventilation in conjunction with BVAD assistance (891 views)
J Med Eng Technol (ISSN: 0309-1902), 2002 Mar; 26(2): 63-70.
Impact Factor: 0.538
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Pace L, Nappi A, Imbriaco M, Cuocolo A, Varrone A, Romano M, Trimarco B, Salvatore M
Relationship between exercise capacity and left ventricular function at rest in patients with heart failure. An ambulatory left ventricular monitoring study (676 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 100(3): 120-125.
Impact Factor: 1.368
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Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure (841 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jun; 38(6): 948-953.
Impact Factor: 3.491
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Biondi B, Fazio S, Cuocolo A, Sabatini D, Nicolai E, Lombardi G, Salvatore M, Sacca L
Impaired cardiac reserve and exercise capacity in patients receiving long-term thyrotropin suppressive therapy with levothyroxine (661 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1996 Dec; 81(12): 4224-4228.
Impact Factor: 4.575
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (1058 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (854 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Imbriaco M, Cuocolo A, Pace L, Nappi A, Nicolai E, Cardei S, Morisco C, Romano M, Salvatore M
AMBULATORY MONITORING OF LEFT-VENTRICULAR FUNCTION DURING CARDIOPULMONARY EXERCISE TESTS IN NORMAL SEDENTARY SUBJECTS (723 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Apr; 36(4): 564-568.
Impact Factor: 3.491
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38 Records (37 excluding Abstracts).
Total impact factor: 152.289 (147.938 excluding Abstracts).
Total 5 year impact factor: 162.361 (157.978 excluding Abstracts).
Total impact factor: 152.289 (147.938 excluding Abstracts).
Total 5 year impact factor: 162.361 (157.978 excluding Abstracts).
2386 views. Last view on Wednesday 21 May 2025, 15:43:57
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