Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (334 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.658, 5-year impact factor: 4.046
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-17644434970&partnerID=40&md5=7be520972b84b443a30cc041dbcb19b7
Keywords: Aging, Beta-Adrenergic Receptor, Exercise, Acetylcholine, Alpha 2 Adrenergic Receptor Stimulating Agent, Beta Adrenergic Receptor Stimulating Agent, Brimonidine, G Protein Coupled Receptor Kinase, Isoprenaline, Muscarinic Agent, N(g) Methylarginine, Nitroprusside Sodium, Phenylephrine, Adrenergic System, Animal Experiment, Article, Blood Vessel Reactivity, Carotid Artery, Controlled Study, Desensitization, Enzyme Activity, Nonhuman, Priority Journal, Receptor Down Regulation, Signal Transduction, Vasodilatation, Adrenergic Beta-Agonists, Blotting, Western, Body Weight, Carotid Arteries, Cells, Cultured, Cytosol, Endothelium, Vascular, Enzyme Inhibitors, Isoproterenol, Muscle Relaxation, Smooth, Nitric Oxide Synthase, Nitric Oxide Synthase Type Iii, Omega-N-Methylarginine, Organ Size, Physical Conditioning, Quinoxalines, Inbred Wky, Vasodilator Agents,
Affiliations:
*** IBB - CNR ***
Department of Geriatrics, University of Naples Federico II, 80131 Naples, Italy
Department of Internal Medicine, University of Naples Federico II, 80131 Naples, Italy
Department of Gerontology, II University of Naples, 80131 Naples, Italy
Cattedra di Geriatria, Univ. degli Studi Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
References:
Bohm, M., Dorner, H., Htun, P., Lensche, H., Platt, D., Erdmann, E., Effects of exercise on myocardial adenylate cyclase and Giα expression in senescence (1993) Am J Physiol Heart Circ Physiol, 264, pp. H805-H81
Bohm, M., Gierschik, P., Knorr, A., Larisch, K., Weismann, K., Erdmann, E., Desensitization of adenylate cyclase and increase of Giα in cardiac hypertrophy due to acquired hypertension (1992) Hypertension, 20, pp. 103-112
Budd, D.C., Challiss, R.A., Young, K.W., Tobin, A.B., Cross talk between m3-muscarinic and β2-adrenergic receptors at the level of receptor phosphorylation and desensitization (1999) Mol Pharmacol, 56, pp. 813-823
Chapman, J., Schutzer, W.E., Watts, V.J., Mader, S.L., Impaired cholera toxin relaxation with age in rat aorta (1999) J Gerontol A Biol Sci Med Sci, 54, pp. B154-B159
Chen, Y., Collins, H.L., DiCarlo, S.E., Daily exercise enhances acetylcholine-induced dilation in mesenteric and hindlimb vasculature of hypertensive rats (1999) Clin Exp Hypertens, 21, pp. 353-376
Choi, D.J., Rockman, H.A., β-adrenergic receptor desensitization in cardiac hypertrophy and heart failure (1999) Cell Biochem Biophys, 31, pp. 321-329
Cohn, J.N., Sympathetic nervous system activity and the heart (1989) Am J Hypertens, 2, pp. 353S-356S
Davies, C.H., Ferrara, N., Harding, S.E., β-adrenoceptor function changes with age of subject in myocytes from nonfailing human ventricle (1996) Cardiovasc Res, 31, pp. 152-156
Dawes, M., Chowienczyk, P.J., Ritter, J.M., Effects of inhibition of the L-arginine/nitric oxide pathway on vasodilation caused by β-adrenergic agonists in human forearm (1997) Circulation, 95, pp. 2293-2297
Eckhart, A.D., Ozaki, T., Tevaearai, H., Rockman, H.A., Koch, W.J., Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates β-adrenergic receptor signaling and increases resting blood pressure (2002) Mol Pharmacol, 61, pp. 749-758
Ehsani, A.A., Cardiovascular adaptations to exercise training in the elderly (1987) Fed Proc, 46, pp. 1840-1843
Gardiner, S.M., Kemp, P.A., Bennett, T., Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to adrenaline or BRL 38227 in conscious rats (1991) Br J Pharmacol, 104, pp. 731-737
Gros, R., Benovic, J.L., Tan, C.M., Feldman, R.D., G-protein-coupled receptor kinase activity is increased in hypertension (1997) J Clin Invest, 99, pp. 2087-2093
Gros, R., Chorazyczewski, J., Meek, M.D., Benovic, J.L., Ferguson, S.S., Feldman, R.D., G-protein-coupled receptor kinase activity in hypertension: Increased vascular and lymphocyte G-protein receptor kinase-2 protein expression (2000) Hypertension, 35, pp. 38-42
Gurdal, H., Friedman, E., Johnson, M.D., β-adrenoceptor-GαS coupling decreases with age in rat aorta (1995) Mol Pharmacol, 47, pp. 772-778
Heijenbrok, F.J., Mathy, M.J., Pfaffendorf, M., Van Zwieten, P.A., The influence of chronic inhibition of nitric oxide synthesis on contractile and relaxant properties of rat carotid and mesenteric arteries (2000) Naunyn Schmiedebergs Arch Pharmacol, 362, pp. 504-511
Higashi, Y., Sasaki, S., Kurisu, S., Yoshimizu, A., Sasaki, N., Matsuura, H., Kajiyama, G., Oshima, T., Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: Role of endothelium-derived nitric oxide (1999) Circulation, 100, pp. 1194-1202
Hosey, M.M., Benovic, J.L., DebBurman, S.K., Richardson, R.M., Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors (1995) Life Sci, 56, pp. 951-955
Iaccarino, G., Barbato, E., Cipolleta, E., Esposito, A., Fiorillo, A., Koch, W.J., Trimarco, B., Cardiac βARK 1 upregulation induced by chronic salt deprivation in rats (2001) Hypertension, 38, pp. 255-260
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Koch, W.J., Trimarco, B., β2-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension (2002) Circulation, 106, pp. 349-355
Johnson, L.R., Parker, J.L., Laughlin, M.H., Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs (2000) J Appl Physiol, 88, pp. 443-451
Koch, W.J., Rockman, H.A., Samama, P., Hamilton, R.A., Bond, R.A., Milano, C.A., Lefkowitz, R.J., Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor (1995) Science, 268, pp. 1350-1353
Lembo, G., Iaccarino, G., Vecchione, C., Barbato, E., Izzo, R., Fontana, D., Trimarco, B., Insulin modulation of an endothelial nitric oxide component present in the α2- and β-adrenergic responses in human forearm (1997) J Clin Invest, 100, pp. 2007-2014
Marin, J., Age-related changes in vascular responses: A review (1995) Mech Ageing Dev, 79, pp. 71-114
Orenstein, T.L., Parker, T.G., Butany, J.W., Goodman, J.M., Dawood, F., Wen, W.H., Wee, L., Liu, P.P., Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression (1995) J Clin Invest, 96, pp. 858-866
Pan, H.Y., Hoffman, B.B., Pershe, R.A., Blaschke, T.F., Decline in β adrenergic receptor-mediated vascular relaxation with aging in man (1986) J Pharmacol Exp Ther, 239, pp. 802-807
Parent, R., Al-Obaidi, M., Lavallee, M., Nitric oxide formation contributes to β-adrenergic dilation of resistance coronary vessels in conscious dogs (1993) Circ Res, 73, pp. 241-251
Rebich, S., Devine, J.O., Armstead, W.M., Role of nitric oxide and cAMP in β-adrenoceptor-induced pial artery vasodilation (1995) Am J Physiol Heart Circ Physiol, 268, pp. H1071-H1076
Roth, D.A., White, C.D., Podolin, D.A., Mazzeo, R.S., Alterations in myocardial signal transduction due to aging and chronic dynamic exercise (1998) J Appl Physiol, 84, pp. 177-184
Schutzer, W.E., Reed, J.F., Bliziotes, M., Mader, S.L., Upregulation of G protein-linked receptor kinases with advancing age in rat aorta (2001) Am J Physiol Regul Integr Comp Physiol, 280, pp. R897-R903
Spina, R.J., Turner, M.J., Ehsani, A.A., β-adrenergic-mediated improvement in left ventricular function by exercise training in older men (1998) Am J Physiol Heart Circ Physiol, 274, pp. H397-H404
Spurgeon, H.A., Steinbach, M.F., Lakatta, E.G., Chronic exercise prevents characteristic age-related changes in rat cardiac contraction (1983) Am J Physiol Heart Circ Physiol, 244, pp. H513-H518
Sunano, S., Li-Bo, Z., Matsuda, K., Sekiguchi, F., Watanabe, H., Shimamura, K., Endothelium-dependent relaxation by α2-adrenoceptor agonists in spontaneously hypertensive rat aorta (1996) J Cardiovasc Pharmacol, 27, pp. 733-739
Taddei, S., Galetta, F., Virdis, A., Ghiadoni, L., Salvetti, G., Franzoni, F., Giusti, C., Salvetti, A., Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes (2000) Circulation, 101, pp. 2896-2901
Tsuga, H., Okuno, E., Kameyama, K., Haga, T., Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes: Effect of G protein-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6 (1998) J Pharmacol Exp Ther, 284, pp. 1218-1226
Tsujimoto, G., Lee, C.H., Hoffman, B.B., Age-related decrease in β adrenergic receptor-mediated vascular smooth muscle relaxation (1986) J Pharmacol Exp Ther, 239, pp. 411-415
Ungerer, M., Parruti, G., Bohm, M., Puzicha, M., DeBlasi, A., Erdmann, E., Lohse, M.J., Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart (1994) Circ Res, 74, pp. 206-213
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.658, 5-year impact factor: 4.046
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-17644434970&partnerID=40&md5=7be520972b84b443a30cc041dbcb19b7
Keywords: Aging, Beta-Adrenergic Receptor, Exercise, Acetylcholine, Alpha 2 Adrenergic Receptor Stimulating Agent, Beta Adrenergic Receptor Stimulating Agent, Brimonidine, G Protein Coupled Receptor Kinase, Isoprenaline, Muscarinic Agent, N(g) Methylarginine, Nitroprusside Sodium, Phenylephrine, Adrenergic System, Animal Experiment, Article, Blood Vessel Reactivity, Carotid Artery, Controlled Study, Desensitization, Enzyme Activity, Nonhuman, Priority Journal, Receptor Down Regulation, Signal Transduction, Vasodilatation, Adrenergic Beta-Agonists, Blotting, Western, Body Weight, Carotid Arteries, Cells, Cultured, Cytosol, Endothelium, Vascular, Enzyme Inhibitors, Isoproterenol, Muscle Relaxation, Smooth, Nitric Oxide Synthase, Nitric Oxide Synthase Type Iii, Omega-N-Methylarginine, Organ Size, Physical Conditioning, Quinoxalines, Inbred Wky, Vasodilator Agents,
Affiliations:
*** IBB - CNR ***
Department of Geriatrics, University of Naples Federico II, 80131 Naples, Italy
Department of Internal Medicine, University of Naples Federico II, 80131 Naples, Italy
Department of Gerontology, II University of Naples, 80131 Naples, Italy
Cattedra di Geriatria, Univ. degli Studi Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
References:
Bohm, M., Dorner, H., Htun, P., Lensche, H., Platt, D., Erdmann, E., Effects of exercise on myocardial adenylate cyclase and Giα expression in senescence (1993) Am J Physiol Heart Circ Physiol, 264, pp. H805-H81
Bohm, M., Gierschik, P., Knorr, A., Larisch, K., Weismann, K., Erdmann, E., Desensitization of adenylate cyclase and increase of Giα in cardiac hypertrophy due to acquired hypertension (1992) Hypertension, 20, pp. 103-112
Budd, D.C., Challiss, R.A., Young, K.W., Tobin, A.B., Cross talk between m3-muscarinic and β2-adrenergic receptors at the level of receptor phosphorylation and desensitization (1999) Mol Pharmacol, 56, pp. 813-823
Chapman, J., Schutzer, W.E., Watts, V.J., Mader, S.L., Impaired cholera toxin relaxation with age in rat aorta (1999) J Gerontol A Biol Sci Med Sci, 54, pp. B154-B159
Chen, Y., Collins, H.L., DiCarlo, S.E., Daily exercise enhances acetylcholine-induced dilation in mesenteric and hindlimb vasculature of hypertensive rats (1999) Clin Exp Hypertens, 21, pp. 353-376
Choi, D.J., Rockman, H.A., β-adrenergic receptor desensitization in cardiac hypertrophy and heart failure (1999) Cell Biochem Biophys, 31, pp. 321-329
Cohn, J.N., Sympathetic nervous system activity and the heart (1989) Am J Hypertens, 2, pp. 353S-356S
Davies, C.H., Ferrara, N., Harding, S.E., β-adrenoceptor function changes with age of subject in myocytes from nonfailing human ventricle (1996) Cardiovasc Res, 31, pp. 152-156
Dawes, M., Chowienczyk, P.J., Ritter, J.M., Effects of inhibition of the L-arginine/nitric oxide pathway on vasodilation caused by β-adrenergic agonists in human forearm (1997) Circulation, 95, pp. 2293-2297
Eckhart, A.D., Ozaki, T., Tevaearai, H., Rockman, H.A., Koch, W.J., Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates β-adrenergic receptor signaling and increases resting blood pressure (2002) Mol Pharmacol, 61, pp. 749-758
Ehsani, A.A., Cardiovascular adaptations to exercise training in the elderly (1987) Fed Proc, 46, pp. 1840-1843
Gardiner, S.M., Kemp, P.A., Bennett, T., Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to adrenaline or BRL 38227 in conscious rats (1991) Br J Pharmacol, 104, pp. 731-737
Gros, R., Benovic, J.L., Tan, C.M., Feldman, R.D., G-protein-coupled receptor kinase activity is increased in hypertension (1997) J Clin Invest, 99, pp. 2087-2093
Gros, R., Chorazyczewski, J., Meek, M.D., Benovic, J.L., Ferguson, S.S., Feldman, R.D., G-protein-coupled receptor kinase activity in hypertension: Increased vascular and lymphocyte G-protein receptor kinase-2 protein expression (2000) Hypertension, 35, pp. 38-42
Gurdal, H., Friedman, E., Johnson, M.D., β-adrenoceptor-GαS coupling decreases with age in rat aorta (1995) Mol Pharmacol, 47, pp. 772-778
Heijenbrok, F.J., Mathy, M.J., Pfaffendorf, M., Van Zwieten, P.A., The influence of chronic inhibition of nitric oxide synthesis on contractile and relaxant properties of rat carotid and mesenteric arteries (2000) Naunyn Schmiedebergs Arch Pharmacol, 362, pp. 504-511
Higashi, Y., Sasaki, S., Kurisu, S., Yoshimizu, A., Sasaki, N., Matsuura, H., Kajiyama, G., Oshima, T., Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: Role of endothelium-derived nitric oxide (1999) Circulation, 100, pp. 1194-1202
Hosey, M.M., Benovic, J.L., DebBurman, S.K., Richardson, R.M., Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors (1995) Life Sci, 56, pp. 951-955
Iaccarino, G., Barbato, E., Cipolleta, E., Esposito, A., Fiorillo, A., Koch, W.J., Trimarco, B., Cardiac βARK 1 upregulation induced by chronic salt deprivation in rats (2001) Hypertension, 38, pp. 255-260
Iaccarino, G., Cipolletta, E., Fiorillo, A., Annecchiarico, M., Ciccarelli, M., Cimini, V., Koch, W.J., Trimarco, B., β2-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension (2002) Circulation, 106, pp. 349-355
Johnson, L.R., Parker, J.L., Laughlin, M.H., Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs (2000) J Appl Physiol, 88, pp. 443-451
Koch, W.J., Rockman, H.A., Samama, P., Hamilton, R.A., Bond, R.A., Milano, C.A., Lefkowitz, R.J., Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor (1995) Science, 268, pp. 1350-1353
Lembo, G., Iaccarino, G., Vecchione, C., Barbato, E., Izzo, R., Fontana, D., Trimarco, B., Insulin modulation of an endothelial nitric oxide component present in the α2- and β-adrenergic responses in human forearm (1997) J Clin Invest, 100, pp. 2007-2014
Marin, J., Age-related changes in vascular responses: A review (1995) Mech Ageing Dev, 79, pp. 71-114
Orenstein, T.L., Parker, T.G., Butany, J.W., Goodman, J.M., Dawood, F., Wen, W.H., Wee, L., Liu, P.P., Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression (1995) J Clin Invest, 96, pp. 858-866
Pan, H.Y., Hoffman, B.B., Pershe, R.A., Blaschke, T.F., Decline in β adrenergic receptor-mediated vascular relaxation with aging in man (1986) J Pharmacol Exp Ther, 239, pp. 802-807
Parent, R., Al-Obaidi, M., Lavallee, M., Nitric oxide formation contributes to β-adrenergic dilation of resistance coronary vessels in conscious dogs (1993) Circ Res, 73, pp. 241-251
Rebich, S., Devine, J.O., Armstead, W.M., Role of nitric oxide and cAMP in β-adrenoceptor-induced pial artery vasodilation (1995) Am J Physiol Heart Circ Physiol, 268, pp. H1071-H1076
Roth, D.A., White, C.D., Podolin, D.A., Mazzeo, R.S., Alterations in myocardial signal transduction due to aging and chronic dynamic exercise (1998) J Appl Physiol, 84, pp. 177-184
Schutzer, W.E., Reed, J.F., Bliziotes, M., Mader, S.L., Upregulation of G protein-linked receptor kinases with advancing age in rat aorta (2001) Am J Physiol Regul Integr Comp Physiol, 280, pp. R897-R903
Spina, R.J., Turner, M.J., Ehsani, A.A., β-adrenergic-mediated improvement in left ventricular function by exercise training in older men (1998) Am J Physiol Heart Circ Physiol, 274, pp. H397-H404
Spurgeon, H.A., Steinbach, M.F., Lakatta, E.G., Chronic exercise prevents characteristic age-related changes in rat cardiac contraction (1983) Am J Physiol Heart Circ Physiol, 244, pp. H513-H518
Sunano, S., Li-Bo, Z., Matsuda, K., Sekiguchi, F., Watanabe, H., Shimamura, K., Endothelium-dependent relaxation by α2-adrenoceptor agonists in spontaneously hypertensive rat aorta (1996) J Cardiovasc Pharmacol, 27, pp. 733-739
Taddei, S., Galetta, F., Virdis, A., Ghiadoni, L., Salvetti, G., Franzoni, F., Giusti, C., Salvetti, A., Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes (2000) Circulation, 101, pp. 2896-2901
Tsuga, H., Okuno, E., Kameyama, K., Haga, T., Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes: Effect of G protein-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6 (1998) J Pharmacol Exp Ther, 284, pp. 1218-1226
Tsujimoto, G., Lee, C.H., Hoffman, B.B., Age-related decrease in β adrenergic receptor-mediated vascular smooth muscle relaxation (1986) J Pharmacol Exp Ther, 239, pp. 411-415
Ungerer, M., Parruti, G., Bohm, M., Puzicha, M., DeBlasi, A., Erdmann, E., Lohse, M.J., Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart (1994) Circ Res, 74, pp. 206-213
Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries
Aging is associated with alterations in β-adrenergic receptor (β-AR) signaling and reduction in cardiovascular responses to β-AR stimulation. Because exercise can attenuate age-related impairment in myocardial β-AR signaling and function, we tested whether training could also exert favorable effects on vascular β-AR responses. We evaluated common carotid artery responsiveness in isolated vessel ring preparations from 8 aged male Wistar-Kyoto (WKY) rats trained for 6 wk in a 5 days/wk swimming protocol, 10 untrained agematched rats, and 10 young WKY rats. Vessels were preconstricted with phenylephrine (10-6 M), and vasodilation was assessed in response to the β-AR agonist isoproterenol (10-10-3 × 10-8 M), the α2-AR agonist UK-14304 (10-9-10-6 M), the muscarinic receptor agonist ACh (10-9-10-6 M), and nitroprusside (10-8-10-5 M). β-AR density and cytoplasmic β-AR kinase (β-ARK) activity were tested on pooled carotid arteries. β-ARK expression was assessed in two endothelial cell lines from bovine aorta and aorta isolated from a 12-wk WKY rat. β-AR, α2-AR, and muscarinic responses, but not that to nitroprusside, were depressed in untrained aged vs. young animals. Exercise training restored β-AR and muscarinic responses but did not affect vasodilation induced by UK-14304 and nitroprusside. Aged carotid arteries showed reduced β-AR number and increased β-ARK activity. Training counterbalanced these phenomena and restored β-AR density and β-ARK activity to levels observed in young rat carotids. Our data indicate that age impairs β-AR vasorelaxation in rat carotid arteries through β-AR downregulation and desensitization. Exercise restores this response and reverts age-related modification in β-ARs and β-ARK. Our data support an important role for β-ARK in vascular β-AR vasorelaxation.
Aging is associated with alterations in β-adrenergic receptor (β-AR) signaling and reduction in cardiovascular responses to β-AR stimulation. Because exercise can attenuate age-related impairment in myocardial β-AR signaling and function, we tested whether training could also exert favorable effects on vascular β-AR responses. We evaluated common carotid artery responsiveness in isolated vessel ring preparations from 8 aged male Wistar-Kyoto (WKY) rats trained for 6 wk in a 5 days/wk swimming protocol, 10 untrained agematched rats, and 10 young WKY rats. Vessels were preconstricted with phenylephrine (10-6 M), and vasodilation was assessed in response to the β-AR agonist isoproterenol (10-10-3 × 10-8 M), the α2-AR agonist UK-14304 (10-9-10-6 M), the muscarinic receptor agonist ACh (10-9-10-6 M), and nitroprusside (10-8-10-5 M). β-AR density and cytoplasmic β-AR kinase (β-ARK) activity were tested on pooled carotid arteries. β-ARK expression was assessed in two endothelial cell lines from bovine aorta and aorta isolated from a 12-wk WKY rat. β-AR, α2-AR, and muscarinic responses, but not that to nitroprusside, were depressed in untrained aged vs. young animals. Exercise training restored β-AR and muscarinic responses but did not affect vasodilation induced by UK-14304 and nitroprusside. Aged carotid arteries showed reduced β-AR number and increased β-ARK activity. Training counterbalanced these phenomena and restored β-AR density and β-ARK activity to levels observed in young rat carotids. Our data indicate that age impairs β-AR vasorelaxation in rat carotid arteries through β-AR downregulation and desensitization. Exercise restores this response and reverts age-related modification in β-ARs and β-ARK. Our data support an important role for β-ARK in vascular β-AR vasorelaxation.
Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries
No results. |
Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries
Other filter: ([btitle,keywords] "Beta-Adrenergic Rece ...
Ruggiero D, Paolillo S, Ratta GD, Mariniello A, Formisano T, Pellegrino AM, Filardi PP
* [Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications] (339 views)
Monaldi Arch Chest Dis Card Ser (ISSN: 1122-0643, 1122-0643print), 2013 Sep; 80(3): 106-110.
Impact Factor: 7.132
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
View Export to BibTeX Export to EndNote
Blomqvist G, Tavitian B, Pappata S, Crouzel C, Jobert A, Doignon I, Di Giamberardino L
* Quantitative measurement of cerebral acetylcholinesterase using (246 views)
Journal Of Cerebral Blood Flow And Metabolism (ISSN: 0271-678x), 2001 Feb; 21(2): 114-131.
Impact Factor: 5.477
View Export to BibTeX Export to EndNote
* [Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications] (339 views)
Monaldi Arch Chest Dis Card Ser (ISSN: 1122-0643, 1122-0643print), 2013 Sep; 80(3): 106-110.
Impact Factor: 7.132
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
View Export to BibTeX Export to EndNote
Blomqvist G, Tavitian B, Pappata S, Crouzel C, Jobert A, Doignon I, Di Giamberardino L
* Quantitative measurement of cerebral acetylcholinesterase using (246 views)
Journal Of Cerebral Blood Flow And Metabolism (ISSN: 0271-678x), 2001 Feb; 21(2): 114-131.
Impact Factor: 5.477
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 25.172 (25.172 excluding Abstracts).
Total 5 year impact factor: 27.615 (27.615 excluding Abstracts).
Total impact factor: 25.172 (25.172 excluding Abstracts).
Total 5 year impact factor: 27.615 (27.615 excluding Abstracts).
334 views. Last view on Friday 26 May 2023, 5:42:34
ibb.cnr.it
