Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis(271 views) Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Department of Medicine and Surgery, University of Salerno, Salerno, Italy
Department of Clinical and Translational Medicine, Federico II University, Napoli, Italy
IBB, CNR, Napoli, Italy
IOS e Coleman, Napoli, Italy
References: Not available.
Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
Cancer is a multistep process encompassing the transformation of normal epithelial cells to thestromal invasion and metastasis, with these last considered the final stage of the disease. Tumorinvasiveness is based on creation of a specific peri-tumoral environment which on turn dependsupon epithelial-stromal interactions, degradation of extracellular matrix and reorganization of fibrillarcomponents. Even though several aspects of the stromal and cellular remodeling have beenelucidated and described, such as the epithelial-mesenchymal transition (EMT) and extracellularmatrix degradation, all the underlying molecular mechanism are far to be elucidated in their complexity.In this review we focused on new actors such as microRNAs, G protein coupled receptorkinases (GRKs) and Calcium/calmodulin-dependent protein kinase (CaMKs) known to be involvedin several important physiological processes like development, cell differentiation and cell signaling,and more recently linked to tumor progression and invasion.
Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
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