Potential role of intensity modulated proton beams in prostate cancer radiotherapy (624 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
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Paper type: Journal Article,
Impact factor: 3.327, 5-year impact factor: 4.441
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035169882&partnerID=40&md5=0882cd3861265f97234a14b4cc2a55eb
Keywords: Conformal Radiotherapy, Dose Escalation, Intensity Modulated Radiotherapy, Prostate Cancer, Proton Therapy, Prostate Specific Antigen, Article, Bladder, Cancer Control, Cancer Radiotherapy, Case Report, Computer Assisted Radiotherapy, Computer Assisted Tomography, Controlled Study, Femur Head, Human, Intermethod Comparison, Morbidity, Prediction, Priority Journal, Probability, Proton Radiation, Radiation Dose, Radiation Dose Distribution, Radiation Injury, Rectum, Standard, Technique, Treatment Planning, Volumetry, X Irradiation, Prostatic Neoplasms, Radiation Dosage, Radiotherapy Dosage, X-Ray Computed, Urinary Bladder,
Affiliations:
*** IBB - CNR ***
Radiation Oncology Department, University Hospital, Geneva, Switzerland
Division of Radiation Medicine, Paul Scherrer Institute, Villigen, Switzerland
Hospital Cantonal, Division de Radio-Oncologie, 1211 Genve 14, Switzerland
References:
Not available.
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.327, 5-year impact factor: 4.441
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035169882&partnerID=40&md5=0882cd3861265f97234a14b4cc2a55eb
Keywords: Conformal Radiotherapy, Dose Escalation, Intensity Modulated Radiotherapy, Prostate Cancer, Proton Therapy, Prostate Specific Antigen, Article, Bladder, Cancer Control, Cancer Radiotherapy, Case Report, Computer Assisted Radiotherapy, Computer Assisted Tomography, Controlled Study, Femur Head, Human, Intermethod Comparison, Morbidity, Prediction, Priority Journal, Probability, Proton Radiation, Radiation Dose, Radiation Dose Distribution, Radiation Injury, Rectum, Standard, Technique, Treatment Planning, Volumetry, X Irradiation, Prostatic Neoplasms, Radiation Dosage, Radiotherapy Dosage, X-Ray Computed, Urinary Bladder,
Affiliations:
*** IBB - CNR ***
Radiation Oncology Department, University Hospital, Geneva, Switzerland
Division of Radiation Medicine, Paul Scherrer Institute, Villigen, Switzerland
Hospital Cantonal, Division de Radio-Oncologie, 1211 Genve 14, Switzerland
References:
Not available.
Potential role of intensity modulated proton beams in prostate cancer radiotherapy
Purpose: The present study was undertaken to assess the potential benefit of intensity modulated (IM) proton beams in optimizing the dose distribution to safely escalate the tumor dose in prostate cancer radiotherapy. Methods and Materials: Four treatment plans were compared in a prostate cancer patient aiming to deliver 81 Gy to the target: 1) conformal 18 MV X-rays, 6-fields; 2) 214 MeV protons, 2-fields; 3) IM 15 MV X-rays, 5-fields; and 4) 177-200 Mev IM protons, 5-fields as in Plan 3. In addition, IM methods were used to further escalate the tumor dose to 99 Gy. Dose-volume histograms (DVH) were used to physically compare the treatment plans. DVH data were also used to obtain normal tissue complication probabilities (NTCP) for the rectum, bladder, femoral heads, and tumor control probabilities. Results: Although the planning target volume dose distribution was satisfactory with the four treatment plans, the homogeneity was slightly reduced in both X-ray plans (IM and standard) and the low-to-medium doses delivered to all organs at risk, and other normal tissues were significantly reduced by both proton plans. For a prescribed dose of 81 Gy, only the IM X-ray and IM proton plans both succeeded in predicting an acceptably low NTCP for the rectum (
Purpose: The present study was undertaken to assess the potential benefit of intensity modulated (IM) proton beams in optimizing the dose distribution to safely escalate the tumor dose in prostate cancer radiotherapy. Methods and Materials: Four treatment plans were compared in a prostate cancer patient aiming to deliver 81 Gy to the target: 1) conformal 18 MV X-rays, 6-fields; 2) 214 MeV protons, 2-fields; 3) IM 15 MV X-rays, 5-fields; and 4) 177-200 Mev IM protons, 5-fields as in Plan 3. In addition, IM methods were used to further escalate the tumor dose to 99 Gy. Dose-volume histograms (DVH) were used to physically compare the treatment plans. DVH data were also used to obtain normal tissue complication probabilities (NTCP) for the rectum, bladder, femoral heads, and tumor control probabilities. Results: Although the planning target volume dose distribution was satisfactory with the four treatment plans, the homogeneity was slightly reduced in both X-ray plans (IM and standard) and the low-to-medium doses delivered to all organs at risk, and other normal tissues were significantly reduced by both proton plans. For a prescribed dose of 81 Gy, only the IM X-ray and IM proton plans both succeeded in predicting an acceptably low NTCP for the rectum (
Potential role of intensity modulated proton beams in prostate cancer radiotherapy
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Potential role of intensity modulated proton beams in prostate cancer radiotherapy
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Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (694 views) (PDF 71 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (1388 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Cella L, Conson M, Pressello MC, Molinelli S, Schneider U, Donato V, Orecchia R, Salvatore M, Pacelli R
* Hodgkin's lymphoma emerging radiation treatment techniques: Trade-offs between late radio-induced toxicities and secondary malignant neoplasms (713 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2013 Jan 30; 8(1): 22-22.
Impact Factor: 2.36
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (601 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (1582 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (729 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (956 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (718 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (677 views)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (699 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
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Cella L, Lomax A, Miralbell R
* New techniques in hadrontherapy: Intensity modulated proton beams (467 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
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33 Records (32 excluding Abstracts).
Total impact factor: 96.227 (93.819 excluding Abstracts).
Total 5 year impact factor: 86.011 (83.553 excluding Abstracts).
Total impact factor: 96.227 (93.819 excluding Abstracts).
Total 5 year impact factor: 86.011 (83.553 excluding Abstracts).
624 views. Last view on Saturday 26 April 2025, 17:22:46
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