Radiation Oncology Department, University Hospital, Geneva, Switzerland
Division of Radiation Medicine, Paul Scherrer Institute, Villigen, Switzerland
Hospital Cantonal, Division de Radio-Oncologie, 1211 Genve 14, Switzerland
References: Zietman, A.L., Coen, J., Shipley, W.U., Radical radiation therapy in the management of prostatic adenocarcinoma. The initial prostate specific antigen value as a predictor of treatment outcome (1994) J Urol, 151, pp. 640-64
Zagars, G.K., Pollack, A., von Eschenbach, A.C., Prognostic factors for clinically localized prostate carcinoma. Analysis of 938 patients irradiated in the prostate specific antigen era (1997) Cancer, 79, pp. 1370-1380
Hanks, G.E., Martz, K.L., Diamond, J.J., The effect of dose on local control of prostate cancer (1988) Int J Radiat Oncol Biol Phys, 15, pp. 1299-1306
Shipley, W.U., Verhey, L.J., Munzenrider, J.E., Advanced prostate cancer
The results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional dose irradiation using photons alone (1995) Int J Radiat Oncol Biol Phys, 32, pp. 3-12
Schultheiss, T.E., Lee, W.R., Hunt, M.A., Late GI and GU complications in the treatment of prostate cancer (1997) Int J Radiat Oncol Biol Phys, 37, pp. 3-11
Sandler, H.M., McShan, D.L., Lichter, A.S., Potential improvement in the results of irradiation for prostate carcinoma using improved dose distribution (1991) Int J Radiat Oncol Biol Phys, 22, pp. 361-367
Dearnaley, D.P., Khoo, V.S., Norma, A.R., Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer
A randomised trial (1999) Lancet, 353, pp. 267-272
Bortfeld, T., Buerkelbach, J., Boesecke, R., Schlegel, W., Three-dimensional solution of the inverse problem in conformation radiotherapy (1992), pp. 503-508. , Breit A. (Ed.), Advanced radiation therapy
Tumor response monitoring and treatment planning, Berlin: Springer VerlagBrahme, A., Optimization of radiation therapy (1994) Int J Radiat Oncol Biol Phys, 28, pp. 785-787
Lomax, A., Intensity modulation methods for proton radiotherapy (1999) Phys Med Biol, 44, pp. 185-205
Bieri, S., Miralbell, R., Nouet, P., Reproducibility of conformal radiation therapy in localized carcinoma of the prostate without rigid immobilization (1996) Radiother Oncol, 38, pp. 223-230
Slater, J.D., Yonemoto, L.T., Rossi, C.J., Conformal proton therapy for prostate carcinoma (1998) Int J Radiat Oncol Biol Phys, 42, pp. 299-304
Burman, C., Chui, C.S., Kutcher, G., Planning delivery, and quality assurance of intensity modulated radiotherapy using dynamic multileaf collimator
A strategy for large-scale implementation for the treatment of carcinoma of the prostate (1997) Int J Radiat Oncol Biol Phys, 39, pp. 863-873
Lomax, A., Logean, M., Volken, W., The exchange of radiotherapy data as part of an electronic patient referral system (2000) Int J Radiat Oncol Biol Phys, 47, pp. 1449-1456
Lomax, A., Pedroni, E., Schaffner, B., A 3D treatment planning for conformal proton therapy by spot scanning (1996), pp. 67-71. , Faulkner K., Carey B., Crellin A., Harrison R.M. (Eds.), Quantitative imaging in oncology, London: British Institute of RadiologyLomax A, Scheib S, Munkel G
et al. The comparison of spot scanning proton radiotherapy with conventional photon therapies. In: Hounsell AR, Willkinson JM, Williams PC, editors. XI International Conference on the Use of Computers in Radiation Therapy. Manchester: 20-24 March, 1994. p. 366-367Lyman, J.T., Complication probability as assessed from dose-volume histograms (1985) Radiat Res, 104, pp. 513-519
Kutcher, G.J., Burman, C., Brewster, L., Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations (1991) Int J Radiat Oncol Biol Phys, 21, pp. 137-146
Goitein, M., The probability of controlling an inhomogeneously irradiated tumor (1987), Report of the working groups on the Evaluation of Treatment Planning for Particle Beam Radiotherapy, Bethesda, MD: National Cancer InstituteZelefsky, M.J., Leibel, S.A., Gaudin, P.B., Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer (1998) Int J Radiat Oncol Biol Phys, 41, pp. 491-500
Anderson, P.R., Hanlon, A.L., Patchefsky, A., Perineural invasion and Gleason 7-10 tumors predict increased failure in prostate cancer patients with pretreatment PSA <10 ng/ml treated with conformal external beam radiation therapy (1998) Int J Radiat Oncol Biol Phys, 41, pp. 1087-1092
Marks, L.B., Anscher, M.S., Radiotherapy for prostate cancer
Should the seminal vesicles be considered target? (1992) Int J Radiat Oncol Biol Phys, 24, pp. 435-440
Pisansky, T.M., Blute, M.L., Suman, V.J., Correlation of pretherapy prostate cancer chacteristics with seminal vesicle invasion in radical prostatectomy specimens (1996) Int J Radiat Oncol Biol Phys, 36, pp. 585-591
Zelefsky, M.J., Happersett, L., Leibel, S.A., The effect of treatment positioning on normal tissue dose in patients with prostate cancer treated with three-dimensional conformal radiotherapy (1997) Int J Radiat Oncol Biol Phys, 37, pp. 13-19
Weber, D.C., Nouet, P., Rouzaud, M., Miralbell, R., Patient positioning in prostate radiotherapy. Is prone better than supine? (2000) Int J Radiat Oncol Biol Phys, 47, pp. 365-371
Reinstein, L.E., Wang, X.H., Burman, C.M., A feasability study of automated inverse treatment planning for cancer of the prostate (1998) Int J Radiat Oncol Biol Phys, 40, pp. 207-214
Benk, V.A., Adams, J.A., Shipley, W.U., Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma (1993) Int J Radiat Oncol Biol Phys, 26, pp. 551-557
Jackson, A., Value of DVH assessments
Can they accurately predict for toxicity? (2000) Int J Radiat Oncol Biol Phys, 46, p. 702. , (abstract)
Neugut, A.I., Ahsan, H., Robinson, E., Bladder carcinoma and other second malignancies after radiotherapy for prostate carcinoma (1997) Cancer, 79, pp. 1600-1604
Potential role of intensity modulated proton beams in prostate cancer radiotherapy
Purpose: The present study was undertaken to assess the potential benefit of intensity modulated (IM) proton beams in optimizing the dose distribution to safely escalate the tumor dose in prostate cancer radiotherapy. Methods and Materials: Four treatment plans were compared in a prostate cancer patient aiming to deliver 81 Gy to the target: 1) conformal 18 MV X-rays, 6-fields; 2) 214 MeV protons, 2-fields; 3) IM 15 MV X-rays, 5-fields; and 4) 177-200 Mev IM protons, 5-fields as in Plan 3. In addition, IM methods were used to further escalate the tumor dose to 99 Gy. Dose-volume histograms (DVH) were used to physically compare the treatment plans. DVH data were also used to obtain normal tissue complication probabilities (NTCP) for the rectum, bladder, femoral heads, and tumor control probabilities. Results: Although the planning target volume dose distribution was satisfactory with the four treatment plans, the homogeneity was slightly reduced in both X-ray plans (IM and standard) and the low-to-medium doses delivered to all organs at risk, and other normal tissues were significantly reduced by both proton plans. For a prescribed dose of 81 Gy, only the IM X-ray and IM proton plans both succeeded in predicting an acceptably low NTCP for the rectum (
Potential role of intensity modulated proton beams in prostate cancer radiotherapy
No results.
Potential role of intensity modulated proton beams in prostate cancer radiotherapy