INCREASED ENDOTHELIN-1 SERUM LEVELS IN PATIENTS WITH MULTIPLE SCLEROSIS(467 views) Cianflone A, Criscuolo C, Lanzillo R, Liuzzi R, Mancini M, Tedeschi E, Postiglione E, Vacca G, Vacchiano V, Moccia M, VastoLa M, Puorro G, Marsili A, Incoronato M, Salvatore M, Brescia-Morra V
Veins And Lymphatics (ISSN: 2279-7483), 2015; 4(s1): 22-22.
1Neurosciences, Reproductive and Odontostomatological Sciences,University Federico II, Naples;2Institute of Biostructure and Bioimaging, National Research Council, Naples;Biomedical Sciences, University Federico II, Naples;Foundation, Naples, Italy
References: Not available.
INCREASED ENDOTHELIN-1 SERUM LEVELS IN PATIENTS WITH MULTIPLE SCLEROSIS
Background
:Clinical and experimental evidence suggests that endothelin-1 (ET-1) plays a role in cardiac and vascular disease.Patients with multiple sclerosis (MS) show global cerebral hypoperfusion.The widespread decrease in perfusion in normal-appearing white matter and grey matter in MS seems to be secondary to increased blood concentrations of ET-1.
Objectives:
To evaluate ET-1 in MS patients vs healthy subjects (HS) in the context of a larger study on the association among MS, amyotrophic lateral sclerosis (ALS), and vascular changes at molecular,genetic, anatomic and functional level.
Methods:
ET-1 will be measured in 300 MS patients, 50 ALS patients, and 300 healthy subjects (HS) recruited over 3 years. Serum ET-1 levels were coded and assayed with a commercially available ELISA kit in blinded fashion by a laboratory assistant (detection range 0.39-25 pg/mL; R&D Systems).
Results
: After two years we recruited 300 MS patients, 46 ALS patients and 178 HS. ET-1 levels were performed i
n 120 MS patients(79 females, 41 males) and in 125 HS (68 females, 57 males). ET-1 median were significantly higher in MS compared to HS (1.59 vs 1.50 pg/mL, P=0.03) at Mann-Whitney test. When stratified for gender,median ET-1 levels were significantly higher in females MS vs HS (1.58 vs 1.44 pg/mL, P=0.03). ET-1 levels positively correlated with age in female MS vs HS (P<0.05) but not in males. ET-1 median were significantly higher in 23 SP vs 97 RR MS subtype (2.10 vs 1.57 pg/mL, P=0.003).
Conclusions
: We confirm that serum ET-1 levels are significantly increased in MS patients, especially in women. This finding could help to explain the higher incidence of MS in females and the sexassociated
differences in susceptibility to cardiovascular diseases.Correlation of ET-1 levels with SP subtype of disease opens new insights in MS pathogenesis.
INCREASED ENDOTHELIN-1 SERUM LEVELS IN PATIENTS WITH MULTIPLE SCLEROSIS