ASSESSING THE CORRELATION BETWEEN IRON DEPOSIT IN THE BASAL GANGLIA AND FLOW ABNORMALITIES IN THE NECK VEINS WITH MRI: PRELIMINARY EXPERIENCE(362 views) Canna A, Palma G, Tedeschi E, Cocozza S, Lanzillo R, Russo C, Borrelli P, Postiglione E, Liuzzi R, Criscuolo C, Brescia-Morra V, Mancini M, Salvatore M
Veins And Lymphatics (ISSN: 2279-7483), 2015; 4(s1): 20-21.
Keywords: Multiple Sclerosis, Iron Deposition, Jugular Vein, Extracranial Venous Flow,
Affiliations: *** IBB - CNR ***
1Department of Advanced Biomedical Sciences, University Federico II, Naples; 2Institute of Biostructure and Bioimaging,National Research Council, Naples; 3Department of Neurosciences, Reproductive and Odontostomatological Sciences,University Federico II, Naples, Italy
References: Not available.
ASSESSING THE CORRELATION BETWEEN IRON DEPOSIT IN THE BASAL GANGLIA AND FLOW ABNORMALITIES IN THE NECK VEINS WITH MRI: PRELIMINARY EXPERIENCE
Background
: In Multiple Sclerosis (MS), increased iron deposition has been demonstrated in the basal ganglia (BG), possibly related to dysfunction of the intracranial/extracranial venous drainage. Also,ultrasound studies reported blood flow anomalies of the neck veins draining the intracranial compartment.
Objectives
: To correlate BG R2* values, a measure of iron concentration,and the patterns of neck venous blood flow in patients with MS and healthy controls (HC) obtained with a single Magnetic Resonance (MR) study.
Methods
: In 51 MS patients (age: 38±11 years; females: 67%) and 14 HC (age: 39±14 years; females: 70%) brain R2* maps were derived at 3T from a double-echo 3D Spoiled GRE (TR=28 ms,TE=7 and 22 ms, FA=20°) MR sequence. Using the FSL tool FIRST (Oxford, UK), mean R2* values were extracted in automatedly-segmented
BG. In the same MR session, quantitative measures of the blood flow in the main neck arteries and veins were obtained at C2 and C6 levels, using a 2D phase-contrast sequence with peripheral retrospective triggering. Correlations were analyzed through IBM SPSS software among BG R2* values and Internal Jugular Vein (IJV)
flow measures or an index of the activation of venous collaterals between C2 and C6 levels.
Results:
In MS patients and HC, no significant correlations were found between BG iron deposition in any of the brain structures considered (head of caudate nucleus, pallidus, putamen and thalamus) and neither direct measures of IJV flow nor C2/C6 IJV flow mismatch index.
Conclusions
: In this small cohort, the BG iron deposition in MS patients does not seem to be correlated with flow abnormalities in the veins of the neck. Further studies, possibly with quantitative assessment of the intracranial/extracranial flow in larger samples, are needed to investigate the cause of different iron accumulation rates in neurodegenerative disorders.
ASSESSING THE CORRELATION BETWEEN IRON DEPOSIT IN THE BASAL GANGLIA AND FLOW ABNORMALITIES IN THE NECK VEINS WITH MRI: PRELIMINARY EXPERIENCE