Keywords: Article, Brain Mapping, Free Induction Decay Rate, Gray Matter, Image Analysis, Image Processing, Image Quality, Image Reconstruction, Imaging And Display, Longitudinal Rate, Magnetic Field, Mathematical Analysis, Morphology, Multiparametric Approach, Neuroanatomy, Neuroimaging, Nuclear Magnetic Resonance Imaging, Nuclear Magnetic Resonance Scanner, Proton Density, Pure Transverse Rate, Quantitative Analysis, Radiofrequency Inhomogeneity, Radiological Parameters, Reproducibility, Sequence Bloch Equation, Signal Noise Ratio, Steady State, Study Design, Three Dimensional Imaging, White Matter, Adult
, Algorithms
, Brain Pathology
, Feasibility Studies
, Female
, Humans
, Three-Dimensional Methods
, Magnetic Resonance Imaging Methods
, Middle Aged
, Multiple Sclerosis, Relapsing-Remitting Diagnosis
, Signal-To-Noise Ratio,
Affiliations: *** IBB - CNR ***
1 Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
2 Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
3 IRCCS SDN, Naples, Italy,
4 The MRI Institute for Biomedical Research,Waterloo, ON, Canada, 5 Department of Radiology,Wayne State University, Detroit, MI, United States of America, 6 The MRI Institute for Biomedical Research, Detroit, MI, United States of America
Consiglio Nazionale delle Ricerche
Universita degli Studi di Napoli Federico II
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
IRCCS SDN, Naples, Italy.
The MRI Institute for Biomedical Research, Waterloo, ON, Canada.
Department of Radiology, Wayne State University, Detroit, MI, United States of America.
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A Novel Multiparametric Approach to 3D Quantitative MRI of the Brain
Magnetic Resonance properties of tissues can be quantified in several respects: relaxation
processes, density of imaged nuclei, magnetism of environmental molecules, etc. In this
paper, we propose a new comprehensive approach to obtain 3D high resolution quantitative
maps of arbitrary body districts, mainly focusing on the brain. The theory presented makes it
possible to map longitudinal (R1), pure transverse (R2) and free induction decay (R2) rates,
along with proton density (PD) and magnetic susceptibility (χ), from a set of fast acquisition
sequences in steady-state that are highly insensitive to flow phenomena. A novel denoising
scheme is described and applied to the acquired datasets to enhance the signal to noise
ratio of the derived maps and an information theory approach compensates for biases from
radio frequency (RF) inhomogeneities, if no direct measure of the RF field is available.
Finally, the results obtained on sample brain scans of healthy controls and multiple sclerosis
patients are presented and discussed.
A Novel Multiparametric Approach to 3D Quantitative MRI of the Brain
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(726 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote