Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.609, 5-year impact factor: 4.522
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84940192193&partnerID=40&md5=7ba2c4d7c6b85e0a1ad8704a1f2f6b26
Keywords: Alzheimer, S Disease, Glut3, Igf-Ir, Glucose, Ss-Amyloid, Alzheimer’s Disease, ß-Amyloid, 4 Diamino 1, 4 Bis(2 Aminophenylthio) 2, 3 Dicyanobutadiene, 2 Morpholino 8 Phenylchromone, 3 Bromo 5 Tert Butyl 4 Hydroxybenzylidenemalononitrile, Amyloid Beta Protein, Amyloid Precursor Protein, Gamma Secretase Inhibitor, Glucose Transporter 3, Monomer, Pentapeptide, Somatomedin C Receptor, Thioflavine, Adult, Aged, Alzheimer Disease, Animal Cell, Animal Experiment, Article, Brain Depth Stimulation, Cell Energy, Cerebrospinal Fluid Analysis, Clinical Article, Confocal Laser Microscopy, Controlled Study, Cytofluorometry, Depolarization, Energy Resource, Enzyme Linked Immunosorbent Assay, Female, Gene Translocation, Glucose Intake, Glucose Tolerance Test, Human, Immunofluorescence, Insulin Release, Middle Aged, Mild Cognitive Impairment, Mouse Mutant, Nerve Cell Culture, Nerve Cell Stimulation, Nonhuman, Pancreas Islet Beta Cell, Protein Phosphorylation, Protein Protein Interaction, Western Blotting,
Affiliations:
*** IBB - CNR ***
National Research Council, Institute of Biostructure and Bioimaging Catania, Italy., National Research Council, Institute of Biostructure and Bioimaging Catania, Italy ; PhD Program in Neuropharmacology, University of Catania Catania, Italy., National Research Council, Institute of Biostructure and Bioimaging Catania, Italy ; Department of Clinical and Molecular Biomedicine, University of Catania Catania, Italy., Department of Drug Sciences, University of Catania Catania, Italy ; IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging Troina, Italy., Department of Molecular Pathology, Neuropharmacology Unit, IRCCS Neuromed Pozzilli, Italy., Department of Drug Sciences, University of Catania Catania, Italy., NEUROFARBA, University of Florence Florence, Italy., Department of Molecular Pathology, Neuropharmacology Unit, IRCCS Neuromed Pozzilli, Italy ; Department of Human Physiology and Pharmacology, University "La Sapienza" Rome, Italy., National Research Council, Institute of Biostructure and Bioimaging Catania, Italy ; Department of Drug Sciences, University of Catania Catania, Italy.,
References:
Beguinot, F., Kahn, C.R., Moses, A.C., Smith, R.J., Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells (1985) J. Biol. Chem, 260, pp. 15892-1589
Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., Vigneri, R., Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease (2009) Endocr. Rev, 30, pp. 586-623
Bilan, P.J., Mitsumoto, Y., Maher, F., Simpson, I.A., Klip, A., Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells: Regulation by cellular differentiation, insulin and insulin-like growth factor-I (1992) Biochem. Biophys. Res. Commun, 186, pp. 1129-1137
Bilic, E., Rudan, I., Kusec, V., Zurak, N., Delimar, D., Zagar, M., Comparison of of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls (2006) Eur. J. Neurol, 13, pp. 1340-1345
Bondy, C.A., Cheng, C.M., Signaling by insulin growht factor-1 in brain (2004) Eur. J. Pharmacol, 490, pp. 25-31
Caselli, R.J., Chen, K., Lee, W., Alexander, G.E., Reiman, E.M., Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment (2008) Arch. Neurol, 65, pp. 1231-1236
Chalifour, R.J., McLaughlin, R.W., Lavoie, L., Morissette, C., Tremblay, N., Boulé, M., Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide (2003) J. Biol. Chem, 278, pp. 34874-34881
Cheng, C.M., Reinhardt, R.R., Lee, W.H., Joncas, G., Patel, S.C., Bondy, C.A., Insulin-like growth factor 1 regulates developing brain glucose metabolism (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 10236-10241
Chishti, M.A., Yang, D.S., Janus, C., Phinney, A.L., Horne, P., Pearson, J., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695 (2001) J. Biol. Chem, 276, pp. 21562-21570
Cirrito, J.R., May, P.C., O'Dell, M.A., Taylor, J.W., Parsadanian, M., Cramer, J.W., In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life (2003) J. Neurosci, 23, pp. 8844-8853
Cirrito, J.R., Yamada, K.A., Finn, M.B., Sloviter, R.S., Bales, K.R., May, P.C., Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo (2005) Neuron, 48, pp. 913-922
de la Monte, S.M., Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease (2012) Front. Biosci. (Elite. Ed), 4, pp. 1582-1605
De smet, F., Christoupouls, A., Carmeliet, P., Allostering targeting of receptor tyrosine kinases (2014) Nat. Biotechnol, 32, pp. 1113-1120
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Beta-amyloid monomers are neuroprotective (2009) J. Neurosci, 29, pp. 10582-10587
Hanna, A., Iremonger, K., Das, P., Dickson, D., Golde, T., Janus, C., Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis (2012) Alzheimers Res. Ther, 4, pp. 21-31
Higgins, L.S., Murphy, G.M., Jr., Forno, L.S., Catalano, R., Cordell, B., P3 beta-amyloid peptide has a unique and potentially pathogenic immunohistochemical profile in Alzheimer's disease brain (1996) Am. J. Pathol, 149, pp. 585-596
Hohmeier, H.E., Mulder, H., Chen, G., Henkel-Rieger, R., Prentki, M., Newgard, C.B., Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion (2000) Diabetes, 49, pp. 424-430
Ivanov, A.I., Malkov, A.E., Waseem, T., Mukhtarov, M., Buldakova, S., Gubkina, O., Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices (2014) J. Cereb. Blood Flow Metab, 34, pp. 397-407
Jayaraman, A., Pike, C.J., Alzheimer's disease and type 2 diabetes: Multiple mechanisms contribute to interactions (2014) Curr. Diab. Rep, 14, p. 476
Karran, E., Hardy, J., A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease (2014) Ann. Neurol, 76, pp. 185-205
Kelleher, R.J., III, Bear, M.F., The autistic neurons: Troubled translation? (2008) Cell, 135, pp. 401-406
Kessler, J., Herholz, K., Grond, M., Heiss, W.D., Impaired metabolic activation in Alzheimer's disease: A PET study during continuous visual recognition (1991) Neuropsychologia, 29, pp. 229-243
Lucignani, G., Namba, H., Nehlig, A., Porrino, L.J., Kennedy, C., Sokoloff, L., Effects of insulin on local cerebral glucose utilization in the rat (1987) J. Cereb. Blood Flow Metab, 7, pp. 309-314
McEwen, B.S., Reagan, L.P., Glucose transporter expression in the central nervous system: Relationship to synaptic function (2004) Eur. J. Pharmacol, 490, pp. 13-24
Mosconi, L., Sorbi, S., de Leon, M.J., Li, Y., Nacmias, B., Myoung, P.S., Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease (2006) J. Nucl. Med, 47, pp. 1778-1786
Nag, S., Sarkar, B., Bandyopadhyay, A., Sahoo, B., Sreenivasan, V.K., Kombrabail, M., Nature of the amyloid-beta monomer and the monomer-oligomer equilibrium (2011) J. Biol. Chem, 286, pp. 13827-13833
Nutu, M., Bourgeois, P., Zetterberg, H., Portelius, E., Andreasson, U., Parent, S., Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases (2013) Neuromolecular Med, 15, pp. 169-179
Oksbjerg, N., Gondret, F., Vestergaard, M., Basic principles of muscle development and growth in meat-producing mammals as affected by the insulin-like growth factor (IGF) system (2004) Domest. Anim. Endocrinol, 27, pp. 219-240
Pandini, G., Frasca, F., Mineo, R., Sciacca, L., Vigneri, R., Belfiore, A., Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved (2002) J. Biol. Chem, 277, pp. 39684-39695
Petersen, R.C., Stevens, J.C., Ganguli, M., Tangalos, E.G., Cummings, J.L., DeKosky, S.T., Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the quality standards subcommittee of the American Academy of Neurology (2001) Neurology, 56, pp. 1133-1142
Pike, C.J., Overman, M.J., Cotman, C.W., Amino-terminal deletions enhance aggregation of beta-amyloid peptidesin vitro (1995) J. Biol. Chem, 270, pp. 23895-23898
Piriz, J., Muller, A., Trejo, J.L., Torres-Aleman, I., IGF-I and the aging mammalian brain (2011) Exp. Gerontol, 46, pp. 96-99
Reed, M.N., Hofmeister, J.J., Jungbauer, L., Welzel, A.T., Yu, C., Sherman, M.A., Cognitive effects of cell-derived and synthetically derived Aβ oligomers (2011) Neurobiol. Aging, 32, pp. 1784-1794
Reiman, E.M., Chen, K., Alexander, G.E., Caselli, R.J., Bandy, D., Osborne, D., Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia (2004) Proc. Natl. Acad. Sci. U.S.A, 101, pp. 284-289
Reiman, E.M., Uecker, A., Gonzalez-Lima, F., Minear, D., Chen, K., Callaway, N.L., Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography (2000) Neuroreport, 11, pp. 987-991
Selkoe, D.J., Resolving controversies on the path to Alzheimer's therapeutichs (2011) Nat. Med, 17, pp. 1060-1065
Shivers, B.D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K., Seeburg, P.H., Alzheimer's disease amyloidogenic glycoprotein: Expression pattern in rat brain suggests a role in cell contact (1998) EMBO J, 7, pp. 1365-1370
Simpson, I.A., Dwyer, D., Malide, D., Moley, K.H., Travis, A., Vannucci, S.J., The facilitative glucose transporter GLUT3: 20 years of distinction (2008) Am. J. Physiol. Endocrinol. Metab, 295, pp. E242-E245
Stranahan, A.M., Mattson, M.P., Metabolic reserve as a determinant of cognitive aging (2012) J. Alzheimers. Dis, 30, pp. S5-S13
Taha, C., Tsakiridis, T., McCall, A., Klip, A., Glucose transporter expression in L6 muscle cells: Regulation through insulin- and stress-activated pathways (1997) Am. J. Physiol, 273, pp. E68-E76
Talbot, K., Wang, H.Y., Kazi, H., Han, L.Y., Bakshi, K.P., Stucky, A., Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline (2012) J. Clin. Invest, 122, pp. 1316-1338
Tampellini, D., Rahman, N., Lin, M.T., Capetillo-Zarate, E., Gouras, G.K., Impaired β-amyloid secretion in Alzheimer's disease pathogenesis (2011) J. Neurosci, 26, pp. 15384-15390
Tjemberg, L.O., Arrest of beta-amyloid fibril formation by a pentapeptide ligand (1996) J. Biol. Chem, 271, pp. 8545-8548
Toye, A.A., Lippiat, J.D., Proks, P., Shimomura, K., Bentley, L., Hugill, A., A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice (2005) Diabetologia, 48, pp. 675-686
Uemura, E., Greenlee, H.W., Insulin regulates glucose uptake by promoting traslocation of glucose transporter GLUT3 (2006) Exp. Neurol, 198, pp. 48-53
Van Schravendijk, C.F., Heylen, L., Van den Brande, J.L., Pipeleers, D.G., Direct effect of insulin and insulin-like growth factor-I on the secretory activity of rat pancreatic beta cells (1990) Diabetologia, 33, pp. 649-653
Yang, Q., Yamagata, K., Fukui, K., Cao, Y., Nammo, T., Iwahashi, H., Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells (2002) Diabetes, 51, pp. 785-792
Zhang, B., Tang, X.C., Zhang, H.Y., Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models (2013) J. Neurosci. Res, 91, pp. 717-725
Zhao, W.Q., De Felice, F.G., Fernandez, S., Chen, H., Lambert, M.P., Quon, M.J., Amyloid beta oligomers induce impairment of neuronal insulin receptors (2008) FASEB J, 22, pp. 246-260
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.609, 5-year impact factor: 4.522
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84940192193&partnerID=40&md5=7ba2c4d7c6b85e0a1ad8704a1f2f6b26
Keywords: Alzheimer, S Disease, Glut3, Igf-Ir, Glucose, Ss-Amyloid, Alzheimer’s Disease, ß-Amyloid, 4 Diamino 1, 4 Bis(2 Aminophenylthio) 2, 3 Dicyanobutadiene, 2 Morpholino 8 Phenylchromone, 3 Bromo 5 Tert Butyl 4 Hydroxybenzylidenemalononitrile, Amyloid Beta Protein, Amyloid Precursor Protein, Gamma Secretase Inhibitor, Glucose Transporter 3, Monomer, Pentapeptide, Somatomedin C Receptor, Thioflavine, Adult, Aged, Alzheimer Disease, Animal Cell, Animal Experiment, Article, Brain Depth Stimulation, Cell Energy, Cerebrospinal Fluid Analysis, Clinical Article, Confocal Laser Microscopy, Controlled Study, Cytofluorometry, Depolarization, Energy Resource, Enzyme Linked Immunosorbent Assay, Female, Gene Translocation, Glucose Intake, Glucose Tolerance Test, Human, Immunofluorescence, Insulin Release, Middle Aged, Mild Cognitive Impairment, Mouse Mutant, Nerve Cell Culture, Nerve Cell Stimulation, Nonhuman, Pancreas Islet Beta Cell, Protein Phosphorylation, Protein Protein Interaction, Western Blotting,
Affiliations:
*** IBB - CNR ***
National Research Council, Institute of Biostructure and Bioimaging Catania, Italy., National Research Council, Institute of Biostructure and Bioimaging Catania, Italy ; PhD Program in Neuropharmacology, University of Catania Catania, Italy., National Research Council, Institute of Biostructure and Bioimaging Catania, Italy ; Department of Clinical and Molecular Biomedicine, University of Catania Catania, Italy., Department of Drug Sciences, University of Catania Catania, Italy ; IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging Troina, Italy., Department of Molecular Pathology, Neuropharmacology Unit, IRCCS Neuromed Pozzilli, Italy., Department of Drug Sciences, University of Catania Catania, Italy., NEUROFARBA, University of Florence Florence, Italy., Department of Molecular Pathology, Neuropharmacology Unit, IRCCS Neuromed Pozzilli, Italy ; Department of Human Physiology and Pharmacology, University "La Sapienza" Rome, Italy., National Research Council, Institute of Biostructure and Bioimaging Catania, Italy ; Department of Drug Sciences, University of Catania Catania, Italy.,
References:
Beguinot, F., Kahn, C.R., Moses, A.C., Smith, R.J., Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells (1985) J. Biol. Chem, 260, pp. 15892-1589
Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., Vigneri, R., Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease (2009) Endocr. Rev, 30, pp. 586-623
Bilan, P.J., Mitsumoto, Y., Maher, F., Simpson, I.A., Klip, A., Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells: Regulation by cellular differentiation, insulin and insulin-like growth factor-I (1992) Biochem. Biophys. Res. Commun, 186, pp. 1129-1137
Bilic, E., Rudan, I., Kusec, V., Zurak, N., Delimar, D., Zagar, M., Comparison of of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls (2006) Eur. J. Neurol, 13, pp. 1340-1345
Bondy, C.A., Cheng, C.M., Signaling by insulin growht factor-1 in brain (2004) Eur. J. Pharmacol, 490, pp. 25-31
Caselli, R.J., Chen, K., Lee, W., Alexander, G.E., Reiman, E.M., Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment (2008) Arch. Neurol, 65, pp. 1231-1236
Chalifour, R.J., McLaughlin, R.W., Lavoie, L., Morissette, C., Tremblay, N., Boulé, M., Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide (2003) J. Biol. Chem, 278, pp. 34874-34881
Cheng, C.M., Reinhardt, R.R., Lee, W.H., Joncas, G., Patel, S.C., Bondy, C.A., Insulin-like growth factor 1 regulates developing brain glucose metabolism (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 10236-10241
Chishti, M.A., Yang, D.S., Janus, C., Phinney, A.L., Horne, P., Pearson, J., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695 (2001) J. Biol. Chem, 276, pp. 21562-21570
Cirrito, J.R., May, P.C., O'Dell, M.A., Taylor, J.W., Parsadanian, M., Cramer, J.W., In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life (2003) J. Neurosci, 23, pp. 8844-8853
Cirrito, J.R., Yamada, K.A., Finn, M.B., Sloviter, R.S., Bales, K.R., May, P.C., Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo (2005) Neuron, 48, pp. 913-922
de la Monte, S.M., Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease (2012) Front. Biosci. (Elite. Ed), 4, pp. 1582-1605
De smet, F., Christoupouls, A., Carmeliet, P., Allostering targeting of receptor tyrosine kinases (2014) Nat. Biotechnol, 32, pp. 1113-1120
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Beta-amyloid monomers are neuroprotective (2009) J. Neurosci, 29, pp. 10582-10587
Hanna, A., Iremonger, K., Das, P., Dickson, D., Golde, T., Janus, C., Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis (2012) Alzheimers Res. Ther, 4, pp. 21-31
Higgins, L.S., Murphy, G.M., Jr., Forno, L.S., Catalano, R., Cordell, B., P3 beta-amyloid peptide has a unique and potentially pathogenic immunohistochemical profile in Alzheimer's disease brain (1996) Am. J. Pathol, 149, pp. 585-596
Hohmeier, H.E., Mulder, H., Chen, G., Henkel-Rieger, R., Prentki, M., Newgard, C.B., Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion (2000) Diabetes, 49, pp. 424-430
Ivanov, A.I., Malkov, A.E., Waseem, T., Mukhtarov, M., Buldakova, S., Gubkina, O., Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices (2014) J. Cereb. Blood Flow Metab, 34, pp. 397-407
Jayaraman, A., Pike, C.J., Alzheimer's disease and type 2 diabetes: Multiple mechanisms contribute to interactions (2014) Curr. Diab. Rep, 14, p. 476
Karran, E., Hardy, J., A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease (2014) Ann. Neurol, 76, pp. 185-205
Kelleher, R.J., III, Bear, M.F., The autistic neurons: Troubled translation? (2008) Cell, 135, pp. 401-406
Kessler, J., Herholz, K., Grond, M., Heiss, W.D., Impaired metabolic activation in Alzheimer's disease: A PET study during continuous visual recognition (1991) Neuropsychologia, 29, pp. 229-243
Lucignani, G., Namba, H., Nehlig, A., Porrino, L.J., Kennedy, C., Sokoloff, L., Effects of insulin on local cerebral glucose utilization in the rat (1987) J. Cereb. Blood Flow Metab, 7, pp. 309-314
McEwen, B.S., Reagan, L.P., Glucose transporter expression in the central nervous system: Relationship to synaptic function (2004) Eur. J. Pharmacol, 490, pp. 13-24
Mosconi, L., Sorbi, S., de Leon, M.J., Li, Y., Nacmias, B., Myoung, P.S., Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease (2006) J. Nucl. Med, 47, pp. 1778-1786
Nag, S., Sarkar, B., Bandyopadhyay, A., Sahoo, B., Sreenivasan, V.K., Kombrabail, M., Nature of the amyloid-beta monomer and the monomer-oligomer equilibrium (2011) J. Biol. Chem, 286, pp. 13827-13833
Nutu, M., Bourgeois, P., Zetterberg, H., Portelius, E., Andreasson, U., Parent, S., Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases (2013) Neuromolecular Med, 15, pp. 169-179
Oksbjerg, N., Gondret, F., Vestergaard, M., Basic principles of muscle development and growth in meat-producing mammals as affected by the insulin-like growth factor (IGF) system (2004) Domest. Anim. Endocrinol, 27, pp. 219-240
Pandini, G., Frasca, F., Mineo, R., Sciacca, L., Vigneri, R., Belfiore, A., Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved (2002) J. Biol. Chem, 277, pp. 39684-39695
Petersen, R.C., Stevens, J.C., Ganguli, M., Tangalos, E.G., Cummings, J.L., DeKosky, S.T., Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the quality standards subcommittee of the American Academy of Neurology (2001) Neurology, 56, pp. 1133-1142
Pike, C.J., Overman, M.J., Cotman, C.W., Amino-terminal deletions enhance aggregation of beta-amyloid peptidesin vitro (1995) J. Biol. Chem, 270, pp. 23895-23898
Piriz, J., Muller, A., Trejo, J.L., Torres-Aleman, I., IGF-I and the aging mammalian brain (2011) Exp. Gerontol, 46, pp. 96-99
Reed, M.N., Hofmeister, J.J., Jungbauer, L., Welzel, A.T., Yu, C., Sherman, M.A., Cognitive effects of cell-derived and synthetically derived Aβ oligomers (2011) Neurobiol. Aging, 32, pp. 1784-1794
Reiman, E.M., Chen, K., Alexander, G.E., Caselli, R.J., Bandy, D., Osborne, D., Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia (2004) Proc. Natl. Acad. Sci. U.S.A, 101, pp. 284-289
Reiman, E.M., Uecker, A., Gonzalez-Lima, F., Minear, D., Chen, K., Callaway, N.L., Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography (2000) Neuroreport, 11, pp. 987-991
Selkoe, D.J., Resolving controversies on the path to Alzheimer's therapeutichs (2011) Nat. Med, 17, pp. 1060-1065
Shivers, B.D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K., Seeburg, P.H., Alzheimer's disease amyloidogenic glycoprotein: Expression pattern in rat brain suggests a role in cell contact (1998) EMBO J, 7, pp. 1365-1370
Simpson, I.A., Dwyer, D., Malide, D., Moley, K.H., Travis, A., Vannucci, S.J., The facilitative glucose transporter GLUT3: 20 years of distinction (2008) Am. J. Physiol. Endocrinol. Metab, 295, pp. E242-E245
Stranahan, A.M., Mattson, M.P., Metabolic reserve as a determinant of cognitive aging (2012) J. Alzheimers. Dis, 30, pp. S5-S13
Taha, C., Tsakiridis, T., McCall, A., Klip, A., Glucose transporter expression in L6 muscle cells: Regulation through insulin- and stress-activated pathways (1997) Am. J. Physiol, 273, pp. E68-E76
Talbot, K., Wang, H.Y., Kazi, H., Han, L.Y., Bakshi, K.P., Stucky, A., Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline (2012) J. Clin. Invest, 122, pp. 1316-1338
Tampellini, D., Rahman, N., Lin, M.T., Capetillo-Zarate, E., Gouras, G.K., Impaired β-amyloid secretion in Alzheimer's disease pathogenesis (2011) J. Neurosci, 26, pp. 15384-15390
Tjemberg, L.O., Arrest of beta-amyloid fibril formation by a pentapeptide ligand (1996) J. Biol. Chem, 271, pp. 8545-8548
Toye, A.A., Lippiat, J.D., Proks, P., Shimomura, K., Bentley, L., Hugill, A., A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice (2005) Diabetologia, 48, pp. 675-686
Uemura, E., Greenlee, H.W., Insulin regulates glucose uptake by promoting traslocation of glucose transporter GLUT3 (2006) Exp. Neurol, 198, pp. 48-53
Van Schravendijk, C.F., Heylen, L., Van den Brande, J.L., Pipeleers, D.G., Direct effect of insulin and insulin-like growth factor-I on the secretory activity of rat pancreatic beta cells (1990) Diabetologia, 33, pp. 649-653
Yang, Q., Yamagata, K., Fukui, K., Cao, Y., Nammo, T., Iwahashi, H., Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells (2002) Diabetes, 51, pp. 785-792
Zhang, B., Tang, X.C., Zhang, H.Y., Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models (2013) J. Neurosci. Res, 91, pp. 717-725
Zhao, W.Q., De Felice, F.G., Fernandez, S., Chen, H., Lambert, M.P., Quon, M.J., Amyloid beta oligomers induce impairment of neuronal insulin receptors (2008) FASEB J, 22, pp. 246-260
Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons
ß-amyloid (Aß1−42 ) is produced by proteolytic cleavage of the transmembrane type-1 protein, amyloid precursor protein. Under pathological conditions, Aß1−42 self-aggregates into oligomers, which cause synaptic dysfunction and neuronal loss, and are considered the culprit of Alzheimer's disease (AD). However, Aß1−42 is mainly monomeric at physiological concentrations, and the precise role of monomeric Aß1−42 in neuronal function is largely unknown. We report that the monomer of Aß1−42 activates type-1 insulin-like growth factor receptors and enhances glucose uptake in neurons and peripheral cells by promoting the translocation of the Glut3 glucose transporter from the cytosol to the plasma membrane. In neurons, activity-dependent glucose uptake was blunted after blocking endogenous Aß production, and re-established in the presence of cerebrospinal fluid Aß. APP-null neurons failed to enhance depolarization-stimulated glucose uptake unless exogenous monomeric Aß1−42 was added. These data suggest that Aß1−42 monomers were critical for maintaining neuronal glucose homeostasis. Accordingly, exogenous Aß1−42 monomers were able to rescue the low levels of glucose consumption observed in brain slices from AD mutant mice. © 2015 Giuffrida, Tomasello, Pandini, Caraci, Battaglia, Busceti, Di Pietro, Pappalardo, Attanasio, Chiechio, Bagnoli, Nacmias, Sorbi, Vigneri, Rizzarelli, Nicoletti and Copani.
ß-amyloid (Aß
Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons
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Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons
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Guzzardi MA, La Rosa F, Campani D, Collado MC, Monleon D, Cacciato Insilla A, Tripodi M, Zega A, Dattilo A, Brunetto MR, Maffei M, Bonino F, Iozzo P
* Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer’s Disease Mouse Model (5 views)
Metabolites (ISSN: 2218-1989electronic), 2022 Mar 22; 12 (4 ): N/D-N/D.
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Coppola C, Saracino D, Oliva M, Cipriano L, Puoti G, Pappata S, Di Fede G, Catania M, Ricci M, Cimini S, Giaccone G, Bonavita S, Rossi G
* Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances" (70 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2021 May; 42(5): 2021-2029.
Impact Factor: 1.447
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Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A
* Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (350 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Impact Factor: 3.476
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Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 201 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (990 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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* Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer’s Disease Mouse Model (5 views)
Metabolites (ISSN: 2218-1989electronic), 2022 Mar 22; 12 (4 ): N/D-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Coppola C, Saracino D, Oliva M, Cipriano L, Puoti G, Pappata S, Di Fede G, Catania M, Ricci M, Cimini S, Giaccone G, Bonavita S, Rossi G
* Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances" (70 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2021 May; 42(5): 2021-2029.
Impact Factor: 1.447
View Export to BibTeX Export to EndNote
Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A
* Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (350 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Impact Factor: 3.476
View Export to BibTeX Export to EndNote
Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 201 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (990 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
7 Records (7 excluding Abstracts).
Total impact factor: 20.8 (20.8 excluding Abstracts).
Total 5 year impact factor: 18.139 (18.139 excluding Abstracts).
Total impact factor: 20.8 (20.8 excluding Abstracts).
Total 5 year impact factor: 18.139 (18.139 excluding Abstracts).
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