Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (508 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 13.958, 5-year impact factor: 14.708
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937630298&partnerID=40&md5=a3419da71197a64904a4486caa54de4e
Keywords: Small Interfering Rna, Thiol Oxidase, Apoptosis, Article, Biogenesis, Breathing, Cell Death, Deletion Mutant, Depletion, Embryo Development, Escherichia Coli, Image Analysis, Immunoprecipitation, Inner Membrane, Isothermal Titration Calorimetry, Membrane Potential, Mitochondrial Targeting Signal, Morphogenesis, Phenotype, Protein Expression, Protein Protein Interaction, Respiratory Chain, Respiratory Function, Stable Transfection,
Affiliations:
*** IBB - CNR ***
Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
INSERM, UMRS 1138, Paris, France
Gustave Roussy Comprehensive Cancer Center, Villejuif, France
Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France
Université Pierre et Marie Curie, Paris, France
Université Paris Sud/Paris XI, Kremlin Bicêtre, France
INSERM U935, Villejuif, France
ESTeam Paris Sud, Stem Cell Core Facility, Institut André Lwoff, Villejuif, France
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases IRCCS L. Spallanzani, Rome, Italy
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy
Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
INSERM U1009, Villejuif, France
Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom
INSERM UMR1141, Hôpital Robert Debré, Paris, France
Faculté de Médecine Denis Diderot, Université Paris 7, Paris, France
Cell Death and Aging Team, Gustave Roussy, Villejuif, France
INSERM U1030, Gustave Roussy, Villejuif, France
Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France
Laboratoire d'Hématologie, Hôpital Paul Brousse AP-HP, Villejuif, France
Animal and Veterinary Resources, Villejuif, France
Department of Pediatrics, University of Gothenburg, The Queen Silvia Children's Hospital, Gothenburg, Sweden
Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden
Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
1Equipe 11 labellise´ e par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, Fra
References:
Allen, S., Balabanidou, V., Sideris, D.P., Lisowsky, T., Tokatlidis, K., Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c (2005) J. Mol. Biol., 353, pp. 937-94
Baker, M.J., Mooga, V.P., Guiard, B., Langer, T., Ryan, M.T., Stojanovski, D., Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease (2012) J. Mol. Biol., 424, pp. 227-239
Banci, L., Bertini, I., Cefaro, C., Ciofi-Baffoni, S., Gallo, A., Martinelli, M., Sideris, D.P., Tokatlidis, K., MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria (2009) Nat. Struct. Mol. Biol., 16, pp. 198-206
Bénit, P., Goncalves, S., Dassa, E.P., Brière, J.J., Rustin, P., The variability of the harlequin mouse phenotype resembles that of human mitochondrial-complex I-deficiency syndromes (2008) PLoS ONE, 3, p. e3208
Berger, I., Ben-Neriah, Z., Dor-Wolman, T., Shaag, A., Saada, A., Zenvirt, S., Raas-Rothschild, A., Elpeleg, O., Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing (2011) Mol. Genet. Metab., 104, pp. 517-520
Bihlmaier, K., Mesecke, N., Terziyska, N., Bien, M., Hell, K., Herrmann, J.M., The disulfide relay system of mitochondria is connected to the respiratory chain (2007) J. Cell Biol., 179, pp. 389-395
Brown, D., Yu, B.D., Joza, N., Bénit, P., Meneses, J., Firpo, M., Rustin, P., Martin, G.R., Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 9918-9923
Chacinska, A., Pfannschmidt, S., Wiedemann, N., Kozjak, V., Sanjuán Szklarz, L.K., Schulze-Specking, A., Truscott, K.N., Pfanner, N., Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins (2004) EMBO J., 23, pp. 3735-3746
Chacinska, A., Guiard, B., Müller, J.M., Schulze-Specking, A., Gabriel, K., Kutik, S., Pfanner, N., Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40 (2008) J. Biol. Chem., 283, pp. 29723-29729
Churbanova, I.Y., Sevrioukova, I.F., Redox-dependent changes in molecular properties of mitochondrial apoptosis-inducing factor (2008) J. Biol. Chem., 283, pp. 5622-5631
Dabir, D.V., Leverich, E.P., Kim, S.K., Tsai, F.D., Hirasawa, M., Knaff, D.B., Koehler, C.M., A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1 (2007) EMBO J., 26, pp. 4801-4811
Darshi, M., Trinh, K.N., Murphy, A.N., Taylor, S.S., Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space (2012) J. Biol. Chem., 287, pp. 39480-39491
de Boer, E., Rodriguez, P., Bonte, E., Krijgsveld, J., Katsantoni, E., Heck, A., Grosveld, F., Strouboulis, J., Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 7480-7485
de Felipe, P., Luke, G.A., Hughes, L.E., Gani, D., Halpin, C., Ryan, M.D., E unum pluribus: multiple proteins from a self-processing polyprotein (2006) Trends Biotechnol., 24, pp. 68-75
Di Fonzo, A., Ronchi, D., Lodi, T., Fassone, E., Tigano, M., Lamperti, C., Corti, S., Nizzardo, M., The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency (2009) Am. J. Hum. Genet., 84, pp. 594-604
Feraud, O., Debili, N., Penninger, J.M., Kroemer, G., Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF (2007) Cell Death Differ., 14, pp. 385-387
Fischer, M., Horn, S., Belkacemi, A., Kojer, K., Petrungaro, C., Habich, M., Ali, M., Kauff, F., Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells (2013) Mol. Biol. Cell, 24, pp. 2160-2170
Fraga, H., Bech-Serra, J.J., Canals, F., Ortega, G., Millet, O., Ventura, S., The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19 (2014) J. Biol. Chem., 289, pp. 9852-9864
Ghezzi, D., Sevrioukova, I., Invernizzi, F., Lamperti, C., Mora, M., D'Adamo, P., Novara, F., Zeviani, M., Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor (2010) Am. J. Hum. Genet., 86, pp. 639-649
Hangen, E., Blomgren, K., Bénit, P., Kroemer, G., Modjtahedi, N., Life with or without AIF (2010) Trends Biochem. Sci., 35, pp. 278-287
Hangen, E., De Zio, D., Bordi, M., Zhu, C., Dessen, P., Caffin, F., Lachkar, S., Benard, J., A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2 (2010) Cell Death Differ., 17, pp. 1155-1166
Hofmann, S., Rothbauer, U., Mühlenbein, N., Baiker, K., Hell, K., Bauer, M.F., Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space (2005) J. Mol. Biol., 353, pp. 517-528
Jensen, M.B., Jasper, H., Mitochondrial proteostasis in the control of aging and longevity (2014) Cell Metab., 20, pp. 214-225
Joza, N., Susin, S.A., Daugas, E., Stanford, W.L., Cho, S.K., Li, C.Y., Sasaki, T., Ravagnan, L., Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death (2001) Nature, 410, pp. 549-554
Klein, J.A., Longo-Guess, C.M., Rossmann, M.P., Seburn, K.L., Hurd, R.E., Frankel, W.N., Bronson, R.T., Ackerman, S.L., The harlequin mouse mutation downregulates apoptosis-inducing factor (2002) Nature, 419, pp. 367-374
Koch, J.R., Schmid, F.X., Mia40 targets cysteines in a hydrophobic environment to direct oxidative protein folding in the mitochondria (2014) Nat. Commun., 5, p. 3041
Li, X., Zhao, X., Fang, Y., Jiang, X., Duong, T., Fan, C., Huang, C.C., Kain, S.R., Generation of destabilized green fluorescent protein as a transcription reporter (1998) J. Biol. Chem., 273, pp. 34970-34975
Maté, M.J., Ortiz-Lombardía, M., Boitel, B., Haouz, A., Tello, D., Susin, S.A., Penninger, J., Alzari, P.M., The crystal structure of the mouse apoptosis-inducing factor AIF (2002) Nat. Struct. Biol., 9, pp. 442-446
Milenkovic, D., Ramming, T., Müller, J.M., Wenz, L.S., Gebert, N., Schulze-Specking, A., Stojanovski, D., Chacinska, A., Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria (2009) Mol. Biol. Cell, 20, pp. 2530-2539
Murray, P., Edgar, D., The regulation of embryonic stem cell differentiation by leukaemia inhibitory factor (LIF) (2001) Differentiation, 68, pp. 227-234
Naoé, M., Ohwa, Y., Ishikawa, D., Ohshima, C., Nishikawa, S., Yamamoto, H., Endo, T., Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space (2004) J. Biol. Chem., 279, pp. 47815-47821
Norberg, E., Karlsson, M., Korenovska, O., Szydlowski, S., Silberberg, G., Uhlén, P., Orrenius, S., Zhivotovsky, B., Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis (2010) EMBO J., 29, pp. 3869-3878
Otera, H., Ohsakaya, S., Nagaura, Z., Ishihara, N., Mihara, K., Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space (2005) EMBO J., 24, pp. 1375-1386
Parrish, J.Z., Xue, D., Functional genomic analysis of apoptotic DNA degradation in C. elegans (2003) Mol. Cell, 11, pp. 987-996
Pfanner, N., van der Laan, M., Amati, P., Capaldi, R.A., Caudy, A.A., Chacinska, A., Darshi, M., Icho, T., Uniform nomenclature for the mitochondrial contact site and cristae organizing system (2014) J. Cell Biol., 204, pp. 1083-1086
Pospisilik, J.A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P.D., Ebersberger, I., Neely, G., Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes (2007) Cell, 131, pp. 476-491
Qi, Y., Tian, X., Liu, J., Han, Y., Graham, A.M., Simon, M.C., Penninger, J.M., Li, S., Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis (2012) J. Cell Biol., 198, pp. 103-114
Rinaldi, C., Grunseich, C., Sevrioukova, I.F., Schindler, A., Horkayne-Szakaly, I., Lamperti, C., Landouré, G., Bönnemann, C., Cowchock syndrome is associated with a mutation in apoptosis-inducing factor (2012) Am. J. Hum. Genet., 91, pp. 1095-1102
Sideris, D.P., Petrakis, N., Katrakili, N., Mikropoulou, D., Gallo, A., Ciofi-Baffoni, S., Banci, L., Tokatlidis, K., A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding (2009) J. Cell Biol., 187, pp. 1007-1022
Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Mangion, J., Loeffler, M., Molecular characterization of mitochondrial apoptosis-inducing factor (1999) Nature, 397, pp. 441-446
Szklarczyk, R., Wanschers, B.F., Nabuurs, S.B., Nouws, J., Nijtmans, L.G., Huynen, M.A., NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I (2011) FEBS Lett., 585, pp. 737-743
Vahsen, N., Candé, C., Brière, J.J., Bénit, P., Joza, N., Larochette, N., Mastroberardino, P.G., Lazar, V., AIF deficiency compromises oxidative phosphorylation (2004) EMBO J., 23, pp. 4679-4689
Weis, B.L., Schleiff, E., Zerges, W., Protein targeting to subcellular organelles via MRNA localization (2013) Biochim. Biophys. Acta, 1833, pp. 260-273
Yang, J., Staples, O., Thomas, L.W., Briston, T., Robson, M., Poon, E., Simões, M.L., Ahmed, A., Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression (2012) J. Clin. Invest., 122, pp. 600-611
Ye, H., Cande, C., Stephanou, N.C., Jiang, S., Gurbuxani, S., Larochette, N., Daugas, E., Wu, H., DNA binding is required for the apoptogenic action of apoptosis inducing factor (2002) Nat. Struct. Biol., 9, pp. 680-684
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 13.958, 5-year impact factor: 14.708
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937630298&partnerID=40&md5=a3419da71197a64904a4486caa54de4e
Keywords: Small Interfering Rna, Thiol Oxidase, Apoptosis, Article, Biogenesis, Breathing, Cell Death, Deletion Mutant, Depletion, Embryo Development, Escherichia Coli, Image Analysis, Immunoprecipitation, Inner Membrane, Isothermal Titration Calorimetry, Membrane Potential, Mitochondrial Targeting Signal, Morphogenesis, Phenotype, Protein Expression, Protein Protein Interaction, Respiratory Chain, Respiratory Function, Stable Transfection,
Affiliations:
*** IBB - CNR ***
Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
INSERM, UMRS 1138, Paris, France
Gustave Roussy Comprehensive Cancer Center, Villejuif, France
Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France
Université Pierre et Marie Curie, Paris, France
Université Paris Sud/Paris XI, Kremlin Bicêtre, France
INSERM U935, Villejuif, France
ESTeam Paris Sud, Stem Cell Core Facility, Institut André Lwoff, Villejuif, France
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases IRCCS L. Spallanzani, Rome, Italy
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy
Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
INSERM U1009, Villejuif, France
Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom
INSERM UMR1141, Hôpital Robert Debré, Paris, France
Faculté de Médecine Denis Diderot, Université Paris 7, Paris, France
Cell Death and Aging Team, Gustave Roussy, Villejuif, France
INSERM U1030, Gustave Roussy, Villejuif, France
Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France
Laboratoire d'Hématologie, Hôpital Paul Brousse AP-HP, Villejuif, France
Animal and Veterinary Resources, Villejuif, France
Department of Pediatrics, University of Gothenburg, The Queen Silvia Children's Hospital, Gothenburg, Sweden
Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden
Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
1Equipe 11 labellise´ e par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, Fra
References:
Allen, S., Balabanidou, V., Sideris, D.P., Lisowsky, T., Tokatlidis, K., Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c (2005) J. Mol. Biol., 353, pp. 937-94
Baker, M.J., Mooga, V.P., Guiard, B., Langer, T., Ryan, M.T., Stojanovski, D., Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease (2012) J. Mol. Biol., 424, pp. 227-239
Banci, L., Bertini, I., Cefaro, C., Ciofi-Baffoni, S., Gallo, A., Martinelli, M., Sideris, D.P., Tokatlidis, K., MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria (2009) Nat. Struct. Mol. Biol., 16, pp. 198-206
Bénit, P., Goncalves, S., Dassa, E.P., Brière, J.J., Rustin, P., The variability of the harlequin mouse phenotype resembles that of human mitochondrial-complex I-deficiency syndromes (2008) PLoS ONE, 3, p. e3208
Berger, I., Ben-Neriah, Z., Dor-Wolman, T., Shaag, A., Saada, A., Zenvirt, S., Raas-Rothschild, A., Elpeleg, O., Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing (2011) Mol. Genet. Metab., 104, pp. 517-520
Bihlmaier, K., Mesecke, N., Terziyska, N., Bien, M., Hell, K., Herrmann, J.M., The disulfide relay system of mitochondria is connected to the respiratory chain (2007) J. Cell Biol., 179, pp. 389-395
Brown, D., Yu, B.D., Joza, N., Bénit, P., Meneses, J., Firpo, M., Rustin, P., Martin, G.R., Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 9918-9923
Chacinska, A., Pfannschmidt, S., Wiedemann, N., Kozjak, V., Sanjuán Szklarz, L.K., Schulze-Specking, A., Truscott, K.N., Pfanner, N., Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins (2004) EMBO J., 23, pp. 3735-3746
Chacinska, A., Guiard, B., Müller, J.M., Schulze-Specking, A., Gabriel, K., Kutik, S., Pfanner, N., Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40 (2008) J. Biol. Chem., 283, pp. 29723-29729
Churbanova, I.Y., Sevrioukova, I.F., Redox-dependent changes in molecular properties of mitochondrial apoptosis-inducing factor (2008) J. Biol. Chem., 283, pp. 5622-5631
Dabir, D.V., Leverich, E.P., Kim, S.K., Tsai, F.D., Hirasawa, M., Knaff, D.B., Koehler, C.M., A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1 (2007) EMBO J., 26, pp. 4801-4811
Darshi, M., Trinh, K.N., Murphy, A.N., Taylor, S.S., Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space (2012) J. Biol. Chem., 287, pp. 39480-39491
de Boer, E., Rodriguez, P., Bonte, E., Krijgsveld, J., Katsantoni, E., Heck, A., Grosveld, F., Strouboulis, J., Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 7480-7485
de Felipe, P., Luke, G.A., Hughes, L.E., Gani, D., Halpin, C., Ryan, M.D., E unum pluribus: multiple proteins from a self-processing polyprotein (2006) Trends Biotechnol., 24, pp. 68-75
Di Fonzo, A., Ronchi, D., Lodi, T., Fassone, E., Tigano, M., Lamperti, C., Corti, S., Nizzardo, M., The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency (2009) Am. J. Hum. Genet., 84, pp. 594-604
Feraud, O., Debili, N., Penninger, J.M., Kroemer, G., Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF (2007) Cell Death Differ., 14, pp. 385-387
Fischer, M., Horn, S., Belkacemi, A., Kojer, K., Petrungaro, C., Habich, M., Ali, M., Kauff, F., Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells (2013) Mol. Biol. Cell, 24, pp. 2160-2170
Fraga, H., Bech-Serra, J.J., Canals, F., Ortega, G., Millet, O., Ventura, S., The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19 (2014) J. Biol. Chem., 289, pp. 9852-9864
Ghezzi, D., Sevrioukova, I., Invernizzi, F., Lamperti, C., Mora, M., D'Adamo, P., Novara, F., Zeviani, M., Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor (2010) Am. J. Hum. Genet., 86, pp. 639-649
Hangen, E., Blomgren, K., Bénit, P., Kroemer, G., Modjtahedi, N., Life with or without AIF (2010) Trends Biochem. Sci., 35, pp. 278-287
Hangen, E., De Zio, D., Bordi, M., Zhu, C., Dessen, P., Caffin, F., Lachkar, S., Benard, J., A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2 (2010) Cell Death Differ., 17, pp. 1155-1166
Hofmann, S., Rothbauer, U., Mühlenbein, N., Baiker, K., Hell, K., Bauer, M.F., Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space (2005) J. Mol. Biol., 353, pp. 517-528
Jensen, M.B., Jasper, H., Mitochondrial proteostasis in the control of aging and longevity (2014) Cell Metab., 20, pp. 214-225
Joza, N., Susin, S.A., Daugas, E., Stanford, W.L., Cho, S.K., Li, C.Y., Sasaki, T., Ravagnan, L., Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death (2001) Nature, 410, pp. 549-554
Klein, J.A., Longo-Guess, C.M., Rossmann, M.P., Seburn, K.L., Hurd, R.E., Frankel, W.N., Bronson, R.T., Ackerman, S.L., The harlequin mouse mutation downregulates apoptosis-inducing factor (2002) Nature, 419, pp. 367-374
Koch, J.R., Schmid, F.X., Mia40 targets cysteines in a hydrophobic environment to direct oxidative protein folding in the mitochondria (2014) Nat. Commun., 5, p. 3041
Li, X., Zhao, X., Fang, Y., Jiang, X., Duong, T., Fan, C., Huang, C.C., Kain, S.R., Generation of destabilized green fluorescent protein as a transcription reporter (1998) J. Biol. Chem., 273, pp. 34970-34975
Maté, M.J., Ortiz-Lombardía, M., Boitel, B., Haouz, A., Tello, D., Susin, S.A., Penninger, J., Alzari, P.M., The crystal structure of the mouse apoptosis-inducing factor AIF (2002) Nat. Struct. Biol., 9, pp. 442-446
Milenkovic, D., Ramming, T., Müller, J.M., Wenz, L.S., Gebert, N., Schulze-Specking, A., Stojanovski, D., Chacinska, A., Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria (2009) Mol. Biol. Cell, 20, pp. 2530-2539
Murray, P., Edgar, D., The regulation of embryonic stem cell differentiation by leukaemia inhibitory factor (LIF) (2001) Differentiation, 68, pp. 227-234
Naoé, M., Ohwa, Y., Ishikawa, D., Ohshima, C., Nishikawa, S., Yamamoto, H., Endo, T., Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space (2004) J. Biol. Chem., 279, pp. 47815-47821
Norberg, E., Karlsson, M., Korenovska, O., Szydlowski, S., Silberberg, G., Uhlén, P., Orrenius, S., Zhivotovsky, B., Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis (2010) EMBO J., 29, pp. 3869-3878
Otera, H., Ohsakaya, S., Nagaura, Z., Ishihara, N., Mihara, K., Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space (2005) EMBO J., 24, pp. 1375-1386
Parrish, J.Z., Xue, D., Functional genomic analysis of apoptotic DNA degradation in C. elegans (2003) Mol. Cell, 11, pp. 987-996
Pfanner, N., van der Laan, M., Amati, P., Capaldi, R.A., Caudy, A.A., Chacinska, A., Darshi, M., Icho, T., Uniform nomenclature for the mitochondrial contact site and cristae organizing system (2014) J. Cell Biol., 204, pp. 1083-1086
Pospisilik, J.A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P.D., Ebersberger, I., Neely, G., Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes (2007) Cell, 131, pp. 476-491
Qi, Y., Tian, X., Liu, J., Han, Y., Graham, A.M., Simon, M.C., Penninger, J.M., Li, S., Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis (2012) J. Cell Biol., 198, pp. 103-114
Rinaldi, C., Grunseich, C., Sevrioukova, I.F., Schindler, A., Horkayne-Szakaly, I., Lamperti, C., Landouré, G., Bönnemann, C., Cowchock syndrome is associated with a mutation in apoptosis-inducing factor (2012) Am. J. Hum. Genet., 91, pp. 1095-1102
Sideris, D.P., Petrakis, N., Katrakili, N., Mikropoulou, D., Gallo, A., Ciofi-Baffoni, S., Banci, L., Tokatlidis, K., A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding (2009) J. Cell Biol., 187, pp. 1007-1022
Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Mangion, J., Loeffler, M., Molecular characterization of mitochondrial apoptosis-inducing factor (1999) Nature, 397, pp. 441-446
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Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory chain complexes. Here we identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery. Depletion or hypomorphic mutation of AIF caused a downregulation of CHCHD4 protein by diminishing its mitochondrial import. CHCHD4 depletion sufficed to induce a respiratory defect that mimicked that observed in AIF-deficient cells. CHCHD4 levels could be restored in AIF-deficient cells by enforcing its AIF-independent mitochondrial localization. This modified CHCHD4 protein reestablished respiratory function in AIF-deficient cells and enabled AIF-deficient embryoid bodies to undergo cavitation, a process of programmed cell death required for embryonic morphogenesis. These findings explain how AIF contributes to the biogenesis of respiratory chain complexes, and they establish an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis. © 2015 Elsevier Inc.
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory chain complexes. Here we identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery. Depletion or hypomorphic mutation of AIF caused a downregulation of CHCHD4 protein by diminishing its mitochondrial import. CHCHD4 depletion sufficed to induce a respiratory defect that mimicked that observed in AIF-deficient cells. CHCHD4 levels could be restored in AIF-deficient cells by enforcing its AIF-independent mitochondrial localization. This modified CHCHD4 protein reestablished respiratory function in AIF-deficient cells and enabled AIF-deficient embryoid bodies to undergo cavitation, a process of programmed cell death required for embryonic morphogenesis. These findings explain how AIF contributes to the biogenesis of respiratory chain complexes, and they establish an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis. © 2015 Elsevier Inc.
Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis
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Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis
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* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (419 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (647 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (469 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (447 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
Impact Factor: 4.472
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (508 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (436 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (620 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (622 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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* Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death (11 views)
J Med Chem (ISSN: 0022-2623linking), 2021 Aug 12; 64 (15 ): 11445-11459.
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
* Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy (165 views)
Sci Transl Med (ISSN: 1946-6234linking), 2021 Feb 17; 13(581): N/D-N/D.
Impact Factor: 17.956
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Longo F, Perri F, Caponigro F, Della Vittoria Scarpati G, Guida A, Pavone E, Aversa C, Muto P, Giuliano M, Ionna F, Solla R
* Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck? (55 views)
Cancers (ISSN: 2072-6694linking), 2020 Sep 28; 12(10): N/D-N/D.
Impact Factor: 6.126
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (214 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
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Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L
* RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer (243 views)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jun 15; 24(12): 2886-2900.
Impact Factor: 6.488
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Farina B, Sturlese M, Mascanzoni F, Caporale A, Monti A, Sorbo GD, Fattorusso R, Ruvo M, Doti N
* Binding mode of AIF(370–394) peptide to CypA: insights from NMR, label-free and molecular docking studies (1049 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2018; 475(14): 2377-2393.
Impact Factor: 4.897
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Cutrin JC, Alberti D, Bernacchioni C, Ciambellotti S, Turano P, Luchinat C, Crich SG, Aime S
* Cancer cell death induced by ferritins and the peculiar role of their labile iron pool (210 views)
Oncotarget, 2018; N/D: N/D-N/D.
Impact Factor: 5.168
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (462 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Doti N, Ruvo M
* Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death (365 views)
Neural Regen Res (ISSN: 1673-5374), 2017 Sep; 12(9): 1428-1429.
Impact Factor: 2.234
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Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (409 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0304-4165linking), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.28
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (363 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
Impact Factor: 5.16
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Musumeci D, Platella C, Riccardi C, Moccia F, Montesarchio D
* Fluorescence sensing using DNA Aptamers in cancer research and clinical diagnostics (272 views)
Cancers (ISSN: 2072-6694, 2072-6694linking), 2017; 9(12): N/D-N/D.
Impact Factor: 5.326
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
* Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide (351 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Sep 12; 111(32): 11612-11617.
Impact Factor: 9.674
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (531 views)
Mol Biol Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
Impact Factor: 4.466
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Hayafune M, Berisio R, Marchetti R, Silipo A, Kayama M, Desaki Y, Arima S, Squeglia F, Ruggiero A, Tokuyasu K, Molinaro A, Kaku H, Shibuya N
* Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization (671 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Jan 21; 111(3): E404-E404.
Impact Factor: 9.674
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (768 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
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Chi M-C, Lo Y-H, Chen Y-Y, Lin L-L, Merlino A
* γ-Glutamyl transpeptidase architecture: Effect of extra sequence deletion on autoprocessing, structure and stability of the protein from Bacillus licheniformis (313 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014; 1844(12): 2290-2297.
Impact Factor: 4.882
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (526 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (505 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (428 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (520 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (430 views) (PDF 242 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (672 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (493 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (431 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3437 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (407 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (490 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (480 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (434 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (402 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Doti N, Marasco D, Sabatella M, Monti SM, Dathan N, Viparelli F, Cassese A, Miele C, Pedone C, Ruvo M
* An analysis of deletion mutants of the PLD1 D4 domain defines short regions within the PLD1 interacting with PED/PEA15: implications for the development of peptides-specific antagonist (422 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (321 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (419 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (647 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (469 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (447 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
Impact Factor: 4.472
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (508 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (436 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (620 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (622 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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66 Records (60 excluding Abstracts).
Total impact factor: 311.988 (287.386 excluding Abstracts).
Total 5 year impact factor: 279.857 (258.525 excluding Abstracts).
Total impact factor: 311.988 (287.386 excluding Abstracts).
Total 5 year impact factor: 279.857 (258.525 excluding Abstracts).
508 views. Last view on Friday 24 February 2023, 2:03:20
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