The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin(430 views)(PDF restricted219 views) GrassoG, Lanza V, Malgieri G, Fattorusso R, Pietropaolo A, Rizzarelli E, Milardi D
G. Grasso, E. Rizzarelli
Dipartimento di Scienze Chimiche, Universita` degli Studi di Catania, V.le A. Doria 6, 95125 Catania, Ita
References: Not available.
The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin
We report an ATP-dependent ubiquitin conjugation with IDE which, in turn, promotes Ub-Ub linkages in tube tests. We propose a novel function for IDE as a non-canonical ubiquitin activating enzyme.
The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin