Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts(528 views) Margotta V, Fonti R, Palladini G, Filoni S, Lauro GM
Affiliations: Dipartimento di Biologia animale e dell'Uomo (Facolta' di Scienze), Universita' di Roma La Sapienza, Italy.
References: Not available.
Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts
In the homeotherms the presence of glial-fibrillary acidic protein (GFAP) and that of neurofilaments (NF) are used as specific molecular markers associated with intermediate filaments (IF) of the glial and neuronal elements respectively. On this basis a comparison was made between trends in the immunohistochemical response to these markers of the ependyma of a both a normal and a regenerating spinal cord in Triturus carnifex (Urodele Amphibian) adults, whose high spinal cord regenerative capacity is due to the ependymal epithelium cells. Under normal conditions, the ependymal cells are vimentin positive and negative for GFAP and the IF, respectively, while GFAP and NF positivity is found in the grey and white matter. During regeneration, by about day 10, vimentin positivity begins to decrease in the ependymal epithelium of the caudal stump and GFAP positive elements appear (subsequently, this was observed also in the ependymal epithelium of the cephalic stump). High GFAP positivity is found also in the newly formed apical ampullae. From day 20 to after day 30 these patterns develop both in the stumps and in the regenerating spinal cord. NF positivity is always restricted to the grey matter alone and to the axonal processes of the white matter. At about day 60, by which time the regenerative processes may be considered as having terminated and the spinal cord has virtually regained its original structure, the immunohistochemical features typical of the rest state are restored in the ependymal epithelium.(ABSTRACT TRUNCATED AT 250 WORDS)
Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts
No results.
Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(513 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote