A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF restricted 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 7.36, 5-year impact factor: 5.174
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84949455030&partnerID=40&md5=63010eee90601e58d27b20329e347084
Keywords: Bone Marrow-Derived Mesenchymal Stem Cells (bm-Mscs), Chemokine Receptor Type 4 (cxcr4), Novel Cxcr4 Inhibitor, Tumor Invasion, Chemokine Receptor Cxcr4, Chemokine Receptor Cxcr4 Antagonist, Mitogen Activated Protein Kinase, Peptide R, Plerixafor, Unclassified Drug, Antineoplastic Activity, Article, Bone Marrow Derived Mesenchymal Stem Cell, Cancer Growth, Carcinogenesis, Cell Function, Cell Interaction, Cell Invasion, Cell Proliferation, Controlled Study, Hepatocellular Carcinoma Cell Line, Human, Human Cell, In Vitro Study, Liver Cell Carcinoma, Metastasis Potential, Migration Inhibition, Osteosarcoma, Priority Journal, Protein Phosphorylation, Signal Transduction, Snu 398 Cell Line, U2os Cell Line, Bone Neoplasms, Drug Therapy, Pathology, Cell Movement, Epithelial-Mesenchymal Transition, Extracellular Signal-Regulated Map Kinases, Metabolism, Liver Neoplasms, Mesenchymal Stromal Cells, Physiology, Neoplasm Invasiveness, Proto-Oncogene Proteins C-Akt, Wound Healing,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy; Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Naples, Italy., Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Naples, Italy., Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", CNR, Naples, Italy., Istituto Ortopedico Rizzoli, Bologna, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy. Electronic address: antonella.zannetti@cnr.it.,
References:
Quail, D.F., Joyce, J.A., Microenvironmental regulation of tumor progression and metastasis (2013) Nat. Med, 19, pp. 1423-143
Quante, M., Tu, S.P., Tomita, H., Gonda, T., Wang, S.S., Takashi, S., Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth (2011) Cancer Cell, 19, pp. 257-272
Barcellos-de-Souza, P., Gori, V., Bambi, F., Chiarugi, P., Tumor microenvironment: bone marrow-mesenchymal stem cells as key players (1836) Biochim. Biophys. Acta, 2013, pp. 321-335
Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation (2011) Cell, 144, pp. 646-674
Worthley, D.L., Si, Y., Quante, M., Churchill, M., Mukherjee, S., Wang, T.C., Bone marrow cells as precursors of the tumor stroma (2013) Exp. Cell Res, 319, pp. 1650-1656
Liu, S., Ginestier, C., Ou, S.J., Clouthier, S.G., Patel, S.H., Monville, F., Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks (2011) Cancer Res, 15, pp. 614-624
Luo, J., Ok Lee, S., Liang, L., Huang, C.K., Li, L., Wen, S., Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling (2014) Oncogene, 22, pp. 2768-2778
Chaturvedi, P., Gilkes, D.M., Wong, C.C., Kshitiz, W., Luo, W., Zhang, H., Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (2013) J. Clin. Invest, 123, pp. 189-205
Suzuki, K., Sun, R., Origuchi, M., Kanehira, M., Takahata, T., Itoh, J., Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization (2011) Mol. Med, 17, pp. 579-587
Jung, Y., Kim, J.K., Shiozawa, Y., Wang, J., Mishra, A., Joseph, J., Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis (2013) Nat. Commun, 4, p. 1795
Shinagawa, K., Kitadai, Y., Tanaka, M., Sumida, T., Kodama, M., Higashi, Y., Mesenchymal stem cells enhance growth and metastasis of colon cancer (2010) Int. J. Cancer, 127, pp. 2323-2333
Halpern, J.L., Kilbarger, A., Lynch, C.C., Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor (2011) Cancer Lett, 308, pp. 91-99
Teicher, B.A., Fricker, S.P., CXCL12 (SDF-1)/CXCR4 pathway in cancer (2010) Clin. Cancer Res, 16, pp. 2927-2931
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410, pp. 50-56
Scala, S., Ottaiano, A., Ascierto, P.A., Cavalli, M., Simeone, E., Giuliano, P., Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma (2005) Clin. Cancer Res, 11, pp. 1835-1841
Vose, J.M., Ho, A.D., Coiffier, B., Corradini, P., Khouri, I., Sureda, A., Advance in mobilization for the optimization of autologous stem cell transplantation (2009) Leuk. Lymphoma, 50, pp. 1412-1421
Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska-Wieczorek, A., Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis (2005) Stem Cells, 23, pp. 879-894
De Clercq, E., The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil) (2009) Biochem. Pharmacol, 77, pp. 1655-1664
Hendrix, C.W., Collier, A.C., Lederman, M.M., Schols, D., Pollard, R.B., Brown, S., Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection (2004) J. Acquir. Immune Defic. Syndr, 37, pp. 1253-1262
Portella, L., Vitale, R., De Luca, S., D'Alterio, C., Ieranò, C., Napolitano, M., Preclinical development of a novel class of CXCR4 antagonist impairing solid tumors growth and metastases (2013) PLoS ONE, 8, p. 9
Tu, B., Du, L., Fan, Q.M., Tang, Z., Tang, T.T., STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma (2012) Cancer Lett, 325, pp. 80-88
Xu, W.T., Bian, Z.Y., Fan, Q.M., Li, G., Tang, T.T., Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis (2009) Cancer Lett, 281, pp. 32-41
Zhang, P., Dong, L., Yan, K., Long, H., Yang, T.T., Dong, M.Q., CXCR4-mediated osteosarcoma growth and pulmonary metastasis is promoted by mesenchymal stem cells through VEGF (2013) Oncol. Rep, 30, pp. 1753-1761
Yu, F.X., Hu, W.J., He, B., Zheng, Y.H., Zhang, Q.Y., Chen, L., Bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion (2015) World J. Surg. Oncol, 13, p. 52
Li, X., Luo, Q., Sun, J., Song, G., Conditioned medium from mesenchymal stem cells enhances the migration of hepatoma cells through CXCR4 up-regulation and F-actin remodeling (2015) Biotechnol. Lett, 37, pp. 511-521
Li, T., Zhao, S., Song, B., Wei, Z., Lu, G., Zhou, J., Effects of transforming growth factor β-1 infected human bone marrow mesenchymal stem cells on high- and low-metastatic potential hepatocellular carcinoma (2015) Eur. J. Med. Res, 20, p. 56
Clark, J.C., Dass, C.R., Choong, P.F., A review of clinical and molecular prognostic factors in osteosarcoma (2008) J. Cancer Res. Clin. Oncol, 134, pp. 281-297
Ghanem, I., Riveiro, M.E., Paradis, V., Faivre, S., de Parga, P.M., Raymond, E., Insights on the CXCL12-CXCR4 axis in hepatocellular carcinoma carcinogenesis (2014) Am. J. Transl. Res, 6, pp. 340-352
Pierini, M., Dozza, B., Lucarelli, E., Tazzari, P.L., Ricci, F., Remondini, D., Efficient isolation and enrichment of mesenchymal stem cells from bone marrow (2012) Cytotherapy, 14, pp. 686-693
Zannetti, A., Iommelli, F., Fonti, R., Papaccioli, A., Sommella, J., Lettieri, A., Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type 3 (2008) Clin. Cancer Res, 15, pp. 5209-5219
Zannetti, A., Del Vecchio, S., Carriero, M.W., Fonti, R., Franco, P., Botti, G., Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (2000) Cancer Res, 15, pp. 1546-1551
Scala, S., Molecular pathways: targeting the CXCR4-CXCL12 axis-untapped potential in the tumor microenvironment (2015) Clin. Cancer Res, 21, pp. 4278-4285
Ieranò, C., Santagata, S., Napolitano, M., Guardia, F., Grimaldi, A., Antignani, E., CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells (2014) Cell Death Dis, 5, p. e1310
Koh, B.I., Kang, Y., The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells (2012) EMBO Rep, 13, pp. 412-422
Bergfeld, S.A., DeClerck, Y.A., Bone marrow-derived mesenchymal stem cells and the tumor microenvironment (2010) Cancer Metastasis Rev, 29, pp. 249-261
Zhang, T., Lee, Y.W., Rui, Y.F., Cheng, T.Y., Jiang, X.H., Li, G., Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors (2013) Stem Cell Res. Ther, 13, p. 70
Karnoub, A.E., Dash, A.B., Vo, A.P., Sullivan, A., Brooks, M.W., Bell, G.W., Mesenchymal stem cells within tumour stroma promote breast cancer metastasis (2007) Nature, 4, pp. 557-563
Liu, Y., Han, Z.P., Zhang, S.S., Jing, Y.Y., Bu, X.X., Wang, C.Y., Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer (2011) J. Biol. Chem, 15, pp. 25007-25015
Hogan, N.M., Joyce, M.R., Murphy, J.M., Barry, F.P., O'Brien, T., Kerin, M.J., Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation (2013) Biochem. Biophys. Res. Commun, 14, pp. 574-579
Ho, I.A., Toh, H.C., Ng, W.H., Teo, Y.L., Guo, C.M., Hui, K.M., Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis (2013) Stem Cells, 31, pp. 146-1455
Cuiffo, B.G., Campagne, A., Bell, G.W., Lembo, A., Orso, F., Lien, E.C., MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis (2014) Cell Stem Cell, 15, pp. 762-774
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 7.36, 5-year impact factor: 5.174
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84949455030&partnerID=40&md5=63010eee90601e58d27b20329e347084
Keywords: Bone Marrow-Derived Mesenchymal Stem Cells (bm-Mscs), Chemokine Receptor Type 4 (cxcr4), Novel Cxcr4 Inhibitor, Tumor Invasion, Chemokine Receptor Cxcr4, Chemokine Receptor Cxcr4 Antagonist, Mitogen Activated Protein Kinase, Peptide R, Plerixafor, Unclassified Drug, Antineoplastic Activity, Article, Bone Marrow Derived Mesenchymal Stem Cell, Cancer Growth, Carcinogenesis, Cell Function, Cell Interaction, Cell Invasion, Cell Proliferation, Controlled Study, Hepatocellular Carcinoma Cell Line, Human, Human Cell, In Vitro Study, Liver Cell Carcinoma, Metastasis Potential, Migration Inhibition, Osteosarcoma, Priority Journal, Protein Phosphorylation, Signal Transduction, Snu 398 Cell Line, U2os Cell Line, Bone Neoplasms, Drug Therapy, Pathology, Cell Movement, Epithelial-Mesenchymal Transition, Extracellular Signal-Regulated Map Kinases, Metabolism, Liver Neoplasms, Mesenchymal Stromal Cells, Physiology, Neoplasm Invasiveness, Proto-Oncogene Proteins C-Akt, Wound Healing,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy; Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Naples, Italy., Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Naples, Italy., Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", CNR, Naples, Italy., Istituto Ortopedico Rizzoli, Bologna, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy. Electronic address: antonella.zannetti@cnr.it.,
References:
Quail, D.F., Joyce, J.A., Microenvironmental regulation of tumor progression and metastasis (2013) Nat. Med, 19, pp. 1423-143
Quante, M., Tu, S.P., Tomita, H., Gonda, T., Wang, S.S., Takashi, S., Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth (2011) Cancer Cell, 19, pp. 257-272
Barcellos-de-Souza, P., Gori, V., Bambi, F., Chiarugi, P., Tumor microenvironment: bone marrow-mesenchymal stem cells as key players (1836) Biochim. Biophys. Acta, 2013, pp. 321-335
Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation (2011) Cell, 144, pp. 646-674
Worthley, D.L., Si, Y., Quante, M., Churchill, M., Mukherjee, S., Wang, T.C., Bone marrow cells as precursors of the tumor stroma (2013) Exp. Cell Res, 319, pp. 1650-1656
Liu, S., Ginestier, C., Ou, S.J., Clouthier, S.G., Patel, S.H., Monville, F., Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks (2011) Cancer Res, 15, pp. 614-624
Luo, J., Ok Lee, S., Liang, L., Huang, C.K., Li, L., Wen, S., Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling (2014) Oncogene, 22, pp. 2768-2778
Chaturvedi, P., Gilkes, D.M., Wong, C.C., Kshitiz, W., Luo, W., Zhang, H., Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (2013) J. Clin. Invest, 123, pp. 189-205
Suzuki, K., Sun, R., Origuchi, M., Kanehira, M., Takahata, T., Itoh, J., Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization (2011) Mol. Med, 17, pp. 579-587
Jung, Y., Kim, J.K., Shiozawa, Y., Wang, J., Mishra, A., Joseph, J., Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis (2013) Nat. Commun, 4, p. 1795
Shinagawa, K., Kitadai, Y., Tanaka, M., Sumida, T., Kodama, M., Higashi, Y., Mesenchymal stem cells enhance growth and metastasis of colon cancer (2010) Int. J. Cancer, 127, pp. 2323-2333
Halpern, J.L., Kilbarger, A., Lynch, C.C., Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor (2011) Cancer Lett, 308, pp. 91-99
Teicher, B.A., Fricker, S.P., CXCL12 (SDF-1)/CXCR4 pathway in cancer (2010) Clin. Cancer Res, 16, pp. 2927-2931
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410, pp. 50-56
Scala, S., Ottaiano, A., Ascierto, P.A., Cavalli, M., Simeone, E., Giuliano, P., Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma (2005) Clin. Cancer Res, 11, pp. 1835-1841
Vose, J.M., Ho, A.D., Coiffier, B., Corradini, P., Khouri, I., Sureda, A., Advance in mobilization for the optimization of autologous stem cell transplantation (2009) Leuk. Lymphoma, 50, pp. 1412-1421
Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska-Wieczorek, A., Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis (2005) Stem Cells, 23, pp. 879-894
De Clercq, E., The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil) (2009) Biochem. Pharmacol, 77, pp. 1655-1664
Hendrix, C.W., Collier, A.C., Lederman, M.M., Schols, D., Pollard, R.B., Brown, S., Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection (2004) J. Acquir. Immune Defic. Syndr, 37, pp. 1253-1262
Portella, L., Vitale, R., De Luca, S., D'Alterio, C., Ieranò, C., Napolitano, M., Preclinical development of a novel class of CXCR4 antagonist impairing solid tumors growth and metastases (2013) PLoS ONE, 8, p. 9
Tu, B., Du, L., Fan, Q.M., Tang, Z., Tang, T.T., STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma (2012) Cancer Lett, 325, pp. 80-88
Xu, W.T., Bian, Z.Y., Fan, Q.M., Li, G., Tang, T.T., Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis (2009) Cancer Lett, 281, pp. 32-41
Zhang, P., Dong, L., Yan, K., Long, H., Yang, T.T., Dong, M.Q., CXCR4-mediated osteosarcoma growth and pulmonary metastasis is promoted by mesenchymal stem cells through VEGF (2013) Oncol. Rep, 30, pp. 1753-1761
Yu, F.X., Hu, W.J., He, B., Zheng, Y.H., Zhang, Q.Y., Chen, L., Bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion (2015) World J. Surg. Oncol, 13, p. 52
Li, X., Luo, Q., Sun, J., Song, G., Conditioned medium from mesenchymal stem cells enhances the migration of hepatoma cells through CXCR4 up-regulation and F-actin remodeling (2015) Biotechnol. Lett, 37, pp. 511-521
Li, T., Zhao, S., Song, B., Wei, Z., Lu, G., Zhou, J., Effects of transforming growth factor β-1 infected human bone marrow mesenchymal stem cells on high- and low-metastatic potential hepatocellular carcinoma (2015) Eur. J. Med. Res, 20, p. 56
Clark, J.C., Dass, C.R., Choong, P.F., A review of clinical and molecular prognostic factors in osteosarcoma (2008) J. Cancer Res. Clin. Oncol, 134, pp. 281-297
Ghanem, I., Riveiro, M.E., Paradis, V., Faivre, S., de Parga, P.M., Raymond, E., Insights on the CXCL12-CXCR4 axis in hepatocellular carcinoma carcinogenesis (2014) Am. J. Transl. Res, 6, pp. 340-352
Pierini, M., Dozza, B., Lucarelli, E., Tazzari, P.L., Ricci, F., Remondini, D., Efficient isolation and enrichment of mesenchymal stem cells from bone marrow (2012) Cytotherapy, 14, pp. 686-693
Zannetti, A., Iommelli, F., Fonti, R., Papaccioli, A., Sommella, J., Lettieri, A., Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type 3 (2008) Clin. Cancer Res, 15, pp. 5209-5219
Zannetti, A., Del Vecchio, S., Carriero, M.W., Fonti, R., Franco, P., Botti, G., Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (2000) Cancer Res, 15, pp. 1546-1551
Scala, S., Molecular pathways: targeting the CXCR4-CXCL12 axis-untapped potential in the tumor microenvironment (2015) Clin. Cancer Res, 21, pp. 4278-4285
Ieranò, C., Santagata, S., Napolitano, M., Guardia, F., Grimaldi, A., Antignani, E., CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells (2014) Cell Death Dis, 5, p. e1310
Koh, B.I., Kang, Y., The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells (2012) EMBO Rep, 13, pp. 412-422
Bergfeld, S.A., DeClerck, Y.A., Bone marrow-derived mesenchymal stem cells and the tumor microenvironment (2010) Cancer Metastasis Rev, 29, pp. 249-261
Zhang, T., Lee, Y.W., Rui, Y.F., Cheng, T.Y., Jiang, X.H., Li, G., Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors (2013) Stem Cell Res. Ther, 13, p. 70
Karnoub, A.E., Dash, A.B., Vo, A.P., Sullivan, A., Brooks, M.W., Bell, G.W., Mesenchymal stem cells within tumour stroma promote breast cancer metastasis (2007) Nature, 4, pp. 557-563
Liu, Y., Han, Z.P., Zhang, S.S., Jing, Y.Y., Bu, X.X., Wang, C.Y., Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer (2011) J. Biol. Chem, 15, pp. 25007-25015
Hogan, N.M., Joyce, M.R., Murphy, J.M., Barry, F.P., O'Brien, T., Kerin, M.J., Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation (2013) Biochem. Biophys. Res. Commun, 14, pp. 574-579
Ho, I.A., Toh, H.C., Ng, W.H., Teo, Y.L., Guo, C.M., Hui, K.M., Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis (2013) Stem Cells, 31, pp. 146-1455
Cuiffo, B.G., Campagne, A., Bell, G.W., Lembo, A., Orso, F., Lien, E.C., MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis (2014) Cell Stem Cell, 15, pp. 762-774
A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
Recent findings suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are recruited into the microenvironment of developing tumors, where they contribute to metastatic processes. The aim of this study was to investigate the role of BM-MSCs in promoting osteosarcoma and hepatocellular carcinoma cell progression in vitro and the possible mechanisms involved in these processes. U2OS and SNU-398 are osteosarcoma and hepatocellular carcinoma cell lines, respectively, that can be induced to proliferate when cultured in the presence of BM-MSCs. To determine the effect of BM-MSCs on U2OS and SNU-398 cells, the AKT and ERK signaling pathways were investigated, and increases were observed in active P-Akt and P-Erk forms. Moreover, BM-MSCs caused an increase in tumor cell migration and invasion that was derived from the enhancement of CXCR4 levels.Thus, when tumor cells were treated with the CXCR4 antagonist AMD3100, a reduction in their migration and invasion was observed. Furthermore, a new CXCR4 inhibitor, Peptide R, which was recently developed as an anticancer agent, was used to inhibit BM-MSC-mediated tumor invasion and to overcome AMD3100 toxicity. Taken together, these results suggest that inhibiting CXCR4 impairs the cross-talk between tumor cells and BM-MSCs, resulting in reduced metastatic potential in osteosarcoma and hepatocellular carcinoma cells. © 2015 Elsevier Ireland Ltd.
Recent findings suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are recruited into the microenvironment of developing tumors, where they contribute to metastatic processes. The aim of this study was to investigate the role of BM-MSCs in promoting osteosarcoma and hepatocellular carcinoma cell progression in vitro and the possible mechanisms involved in these processes. U2OS and SNU-398 are osteosarcoma and hepatocellular carcinoma cell lines, respectively, that can be induced to proliferate when cultured in the presence of BM-MSCs. To determine the effect of BM-MSCs on U2OS and SNU-398 cells, the AKT and ERK signaling pathways were investigated, and increases were observed in active P-Akt and P-Erk forms. Moreover, BM-MSCs caused an increase in tumor cell migration and invasion that was derived from the enhancement of CXCR4 levels.Thus, when tumor cells were treated with the CXCR4 antagonist AMD3100, a reduction in their migration and invasion was observed. Furthermore, a new CXCR4 inhibitor, Peptide R, which was recently developed as an anticancer agent, was used to inhibit BM-MSC-mediated tumor invasion and to overcome AMD3100 toxicity. Taken together, these results suggest that inhibiting CXCR4 impairs the cross-talk between tumor cells and BM-MSCs, resulting in reduced metastatic potential in osteosarcoma and hepatocellular carcinoma cells. © 2015 Elsevier Ireland Ltd.
A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
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A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (441 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (489 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (505 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (432 views) (PDF 242 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (586 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (378 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (351 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (384 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (723 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (1108 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
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Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (237 views)
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Impact Factor: 0.56
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Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (604 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; 47(8): 1507-1515.
Impact Factor: 3.196
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (604 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (470 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (671 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (441 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (489 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
View Export to BibTeX Export to EndNote
Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (505 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (432 views) (PDF 242 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
View Export to BibTeX Export to EndNote
Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (586 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
View Export to BibTeX Export to EndNote
Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
View Export to BibTeX Export to EndNote
Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (378 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (351 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
View Export to BibTeX Export to EndNote
Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (384 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
View Export to BibTeX Export to EndNote
17 Records (14 excluding Abstracts).
Total impact factor: 64.099 (54.597 excluding Abstracts).
Total 5 year impact factor: 60.167 (50.244 excluding Abstracts).
Total impact factor: 64.099 (54.597 excluding Abstracts).
Total 5 year impact factor: 60.167 (50.244 excluding Abstracts).
931 views. Last view on Friday 27 January 2023, 16:39:53
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