99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (373 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
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Paper type: Journal Article,
Impact factor: 1.623, 5-year impact factor: 2.442
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032590047&partnerID=40&md5=fbc951d995df01277a0c5b5150483e1e
Keywords: 3f8, 99mtc-Labeling, Biodistribution, Imaging, Monoclonal Antibody, Shnh, Ganglioside Gd2, Immunoglobulin G3, Succinylimidyl 6 Hydrazinonicotinate, Technetium 99m, Unclassified Drug, Diagnostic Agent, Drug Derivative, Nicotinamide, Radioactive Iodine, Radiopharmaceutical Agent, Succinimide Derivative, Succinimidyl 6 Hydrazinonicotinate, Succinimidyl 6-Hydrazinonicotinate, Technetium Complex, Article, Controlled Study, Drug Distribution, High Performance Liquid Chromatography, Human, Human Cell, Immunoscintigraphy, Isotope Labeling, Neuroblastoma Cell, Tumor, Animal, Cell Culture, Chemistry, Comparative Study, Mouse, Nude Mouse, Scintiscanning, Tissue Distribution, Xenograft, Antibodies, Iodine Radioisotopes, Niacinamide, Organotechnetium Compounds, Transplantation, Heterologous, Tumor Cells,
Affiliations:
Depts. of Dept. of Nuclear Medicine, Mem. Sloan-Kettering Cancer Center, New York, NY, United States
Department of Pediatrics, Mem. Sloan-Kettering Cancer Center, New York, NY, United States
AnorMed Inc., Langley, BC, Canada
References:
Abrams, M.J., Juweid, M., Tenkate, C.I., Schwartz, D.A., Hauser, M.M., Gaul, F.E., Fuccello, A.J., Fischman, A.J., Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats (1990) J. Nucl. Med., 31, pp. 2022-202
Arbit, E., Yeh, S.J., Cheung, N.K., Larson, S.M., Quantitative Immunoimaging of gliomas in humans with anti-ganglioside monoclonal antibodies [abstract] (1991) J. Neurosurg., 76, p. 399
Barrow, S.A., Graham, W., Jyawook, S., Dragotakes, S.C., Solomon, H.F., Babich, J.W., Rubin, R.H., Fischman, A.J., Localization of indium-111-immunoglobulin G, technetium-99m-immunoglobulin G and indium-111-labeled with blood cells at sites of acute bacterial infection in rabbits (1993) J. Nucl. Med., 34, pp. 1975-1979
Blauenstein, P., Locher, J.T., Seybold, K., Koprivova, H., Janoki, G.A., Mache, H.R., Hasler, P., Schubiger, P.A., Experience with the iodine-123 and technetium-99m labelled anti-granulocyte antibody Mab47: A comparison of labelling methods (1995) Eur. J. Nucl. Med., 22, pp. 690-698
Boonkitticharoen, V., James, H., Cheung, N.K.V., Larson, S.M., Finn, R.D., Optimizing the recovery of chemically reduced monoclonal antibody for site specific technetium-99m radiolabeling (1993) Biotechniques, 14, pp. 706-707
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-274
Brummendorf, T.H., Kaul, S., Schuhmacher, J., Baum, R.P., Matys, R., Klivenyi, G., Adams, S., Bastert, G., Immunoscintigraphy of human mammary carcinoma xenografts using monoclonal antibodies 12H12 and BM-2 labeled with 99mTc and radioiodine (1994) Cancer Res, 54, pp. 4162-4168
Callahan, R.J., Barrow, S.A., Abrams, M.J., Rubin, R.H., Fischman, A.J., Biodistribution and dosimetry of technetium-99m-hydrazino nicotinamide IgG: Comparison with indium-111-DTPA-IgG (1996) J. Nucl. Med., 37, pp. 843-846
Chang, H.R., Cordon-Cardo, C., Houghton, A.N., Cheung, N.K.V., Casper, E.S., Brennan, M.F., Expression of disialogangliosides GD2 and GD3 by human soft tissue sarcomas (1992) Cancer, 70, pp. 633-638
Cheung, N.K., Landmeier, B., Neely, J., Nelson, D., Abramowsky, C., Ellery, S., Adams, R., Miraldi, F.D., Complete tumor ablation with iodine 131-radiolabeled disialoganglioside GD2 specific monoclonal antibody against human neuroblastoma xenografted in nude mice (1986) J. Natl. Cancer Inst., 77, pp. 739-745
Cheung, N.K., Neely, J.E., Landmeier, B., Nelson, D., Miraldi, F., Targeting of ganglioside GD2 monoclonal antibody to neuroblastoma (1987) J. Nucl. Med., 28, pp. 1577-1583
Cheung, N.K., Pentlow, K., Graham, M.C., Yeh, S.D.J., Finn, R.D., Larson, S.M., Radioimmunotherapy of human neuroblastoma using monoclonal antibody 3F8 (1992) In: Fifth International Radiopharmaceutical Dosimetry Symposium, pp. 95-112. , Oak Ridge Associated Universities, Oak Ridge, TN
Cheung, N.K., Saarinen, U.M., Neely, J.E., Landmeier, B., Donovan, D., Coccia, P.F., Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells (1985) Cancer Res, 45, pp. 2642-2649
Childs, R.L., Hnatowich, D.J., Optimum conditions for labeling of DTPA-coupled antibodies with technetium-99m (1985) J. Nucl. Med., 26, pp. 293-299
Desphande, S.V., Denardo, S.J., Meares, C.F., Copper-67-labeled monoclonal antibody LYM-1 a potential radiopharmaceutical (1988) J. Nucl. Med., 29, pp. 217-225
Eckelman, W.C., Paik, C.H., Steigman, J., Three approaches to radiolabeling with 99mTc (1989) Nucl. Med. Biol., 16, pp. 171-176
Fraker, P.J., Speck, J.C., Protein and cell membrane iodinations with a sparingly soluble chloramide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-857
Fritzberg, A.R., Abrams, P.G., Beaumier, P.L., Kasina, S., Morgan, A.C., Rao, T.N., Reno, J.M., Vanderheyden, J.L., Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent (1988) Proc. Natl. Acad. Sci. USA, 85, pp. 4025-4029
Furukawa, K., Akagi, T., Nagata, Y., Yamada, Y., Shimotohno, K., Cheung, N.K.V., Shiku, H., Furukawa, K., GD2 ganglioside on human T lymphotropic virus type I-infected T cells: Possible activation of beta-1,4N-acetylgalactosaminyl-transferase gene by p40-tax (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 1972-1976
Grant, S.C., Kostakoglu, L., Kris, M.G., Yeh, S., Larson, S.M., Finn, R.D., Oettgen, H.F., Cheung, N.K.V., Radioimmunodetection of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: A pilot trial (1996) Eur. J. Nucl. Med., 23, pp. 145-149
Heiner, J., Miraldi, F.D., Kallick, S., Makley, J., Smith-Mensah, W.H., Neely, J., Cheung, N.K.V., In vivo targeting of GD2 specific monoclonal antibody in human osteogenic sarcoma xenografts (1987) Cancer Res, 47, pp. 5377-5381
Hiltunen, J.V., Search for new and improved radiolabeling methods for monoclonal antibodies (1993) Acta Oncol, 32, pp. 831-839
Hnatowich, D.J., Mardirossian, G., Rusckowski, M., Fogarasi, M., Virzi, F., Winnard P., Jr., Directly and indirectly technetium-99m-labeled antibodies - A comparison of in vitro and animal in vivo properties (1993) J. Nucl. Med., 34, pp. 109-119
Kozak, R.W., Raubitschek, A., Mirzadeh, S., Brechbiel, M.W., Junghaus, R., Gansow, O.A., Waldman, T.A., Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: Critical factors in determining in vivo survival and organ toxicity (1989) Cancer Res, 49, pp. 2639-2644
Larsen, S.K., Solomon, H.F., Caldwell, G., Abrams, M.J., 99mTc Tricine: A useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates (1995) Bioconjug. Chem., 6, pp. 635-638
Larson, S.M., Sgouros, G., Cheung, N.K., Antibodies in cancer therapy: Radioisotope conjugates (1995) Biologic Therapy of Cancer 2nd Edn, pp. 534-552. , V.T. DeVita, S. Hellman, & S.A. Rosenberg. Philadelphia: J.B. Lippincott
Mather, S.J., Ellison, D., Reduction-mediated technetium-99m labeling of monoclonal antibodies (1990) J. Nucl. Med., 31, pp. 692-697
Miraldi, F.D., Nelson, A.D., Kraly, C., Ellery, S., Landmeier, B., Coccia, P.F., Strandjord, S.E., Cheung, N.K.V., Diagnostic imaging of human neuroblastoma with radiolabeled antibody (1986) Radiology, 161, pp. 413-418
Moffat, R., Pinsky, C.M., Hammershaimb, L., Petrelli, N.J., Patt, Y.Z., Whaley, F.S., Goldenberg, D.M., Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab′ antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: Results of a pivotal, phase III trial. The Immunomedics Study Group (1996) J. Clin. Oncol., 14, pp. 2295-2305
Ram, S., Buchsbaum, D.J., A peptide-based bifunctional chelating agent for Tc-99m and Re-186 labeling of monoclonal antibodies (1994) Cancer, 73, pp. 769-773
Rhodes, B.A., Zamora, P.O., Newell, K.D., Valdez, E.F., Technetium-99m labeling of murine monoclonal antibody fragments (1994) J. Nucl. Med., 27, pp. 685-693
Schwartz, A., Steinstrasser, A., A novel approach to Tc-99m-labeled monoclonal antibodies [abstract] (1987) J. Nucl. Med., 28, p. 721
Schwartz, D.A., Abrams, M.J., Hauser, M.M., Gal, F.E., Larsen, S.K., Rauh, D., Zubieta, J.A., Preparation of hydrazino-modified proteins and their use for the synthesis of 99mTc-protein conjugates (1991) Bioconjug. Chem., 2, pp. 333-336
Thakur, M.L., Defulvio, J.D., Technetium-99m-labeled monoclonal antibodies for immunoscintigraphy (1991) J. Immunol. Methods, 137, pp. 217-223
Thakur, M.L., Kolan, H.R., Rifat, S., Li, J., Rux, A., John, E., Halmos, G., Schally, A.V., Valpreotide labeled with Tc-99m for imaging tumors: Preparation and preliminary evaluation (1996) Int. J. Oncol., 9, pp. 445-451
Weinstein, J.N., Eger, R.R., Covell, D.G., Larson, S.M., Keenam, A.M., The pharmacology of monoclonal antibodies (1987) Ann. NY Acad. Sci., 507, pp. 199-210
Yeh, S.D., Larson, S.M., Burch, L., Kushner, B.H., Laquaglia, M., Finn, R., Cheung, N.K.V., Radioimmunodetection of neuroblastoma with iodine-131-3F8: Correlation with biopsy, iodine-131-Metaiodobenzylguanidine (MIBG) and standard diagnostic modalities (1991) J. Nucl. Med., 32, pp. 769-776
Zhang, S., Filippa, D.A., Zhang, H.S., Zelenetz, A., Scheinberg, D., Livingston, P., Expression of GM2 and GD2 in B cell lymphomas: Targets for immune attack [abstract] (1997) Proc. Am. Assoc. Cancer Res., 38, p. 404
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.623, 5-year impact factor: 2.442
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032590047&partnerID=40&md5=fbc951d995df01277a0c5b5150483e1e
Keywords: 3f8, 99mtc-Labeling, Biodistribution, Imaging, Monoclonal Antibody, Shnh, Ganglioside Gd2, Immunoglobulin G3, Succinylimidyl 6 Hydrazinonicotinate, Technetium 99m, Unclassified Drug, Diagnostic Agent, Drug Derivative, Nicotinamide, Radioactive Iodine, Radiopharmaceutical Agent, Succinimide Derivative, Succinimidyl 6 Hydrazinonicotinate, Succinimidyl 6-Hydrazinonicotinate, Technetium Complex, Article, Controlled Study, Drug Distribution, High Performance Liquid Chromatography, Human, Human Cell, Immunoscintigraphy, Isotope Labeling, Neuroblastoma Cell, Tumor, Animal, Cell Culture, Chemistry, Comparative Study, Mouse, Nude Mouse, Scintiscanning, Tissue Distribution, Xenograft, Antibodies, Iodine Radioisotopes, Niacinamide, Organotechnetium Compounds, Transplantation, Heterologous, Tumor Cells,
Affiliations:
Depts. of Dept. of Nuclear Medicine, Mem. Sloan-Kettering Cancer Center, New York, NY, United States
Department of Pediatrics, Mem. Sloan-Kettering Cancer Center, New York, NY, United States
AnorMed Inc., Langley, BC, Canada
References:
Abrams, M.J., Juweid, M., Tenkate, C.I., Schwartz, D.A., Hauser, M.M., Gaul, F.E., Fuccello, A.J., Fischman, A.J., Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats (1990) J. Nucl. Med., 31, pp. 2022-202
Arbit, E., Yeh, S.J., Cheung, N.K., Larson, S.M., Quantitative Immunoimaging of gliomas in humans with anti-ganglioside monoclonal antibodies [abstract] (1991) J. Neurosurg., 76, p. 399
Barrow, S.A., Graham, W., Jyawook, S., Dragotakes, S.C., Solomon, H.F., Babich, J.W., Rubin, R.H., Fischman, A.J., Localization of indium-111-immunoglobulin G, technetium-99m-immunoglobulin G and indium-111-labeled with blood cells at sites of acute bacterial infection in rabbits (1993) J. Nucl. Med., 34, pp. 1975-1979
Blauenstein, P., Locher, J.T., Seybold, K., Koprivova, H., Janoki, G.A., Mache, H.R., Hasler, P., Schubiger, P.A., Experience with the iodine-123 and technetium-99m labelled anti-granulocyte antibody Mab47: A comparison of labelling methods (1995) Eur. J. Nucl. Med., 22, pp. 690-698
Boonkitticharoen, V., James, H., Cheung, N.K.V., Larson, S.M., Finn, R.D., Optimizing the recovery of chemically reduced monoclonal antibody for site specific technetium-99m radiolabeling (1993) Biotechniques, 14, pp. 706-707
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-274
Brummendorf, T.H., Kaul, S., Schuhmacher, J., Baum, R.P., Matys, R., Klivenyi, G., Adams, S., Bastert, G., Immunoscintigraphy of human mammary carcinoma xenografts using monoclonal antibodies 12H12 and BM-2 labeled with 99mTc and radioiodine (1994) Cancer Res, 54, pp. 4162-4168
Callahan, R.J., Barrow, S.A., Abrams, M.J., Rubin, R.H., Fischman, A.J., Biodistribution and dosimetry of technetium-99m-hydrazino nicotinamide IgG: Comparison with indium-111-DTPA-IgG (1996) J. Nucl. Med., 37, pp. 843-846
Chang, H.R., Cordon-Cardo, C., Houghton, A.N., Cheung, N.K.V., Casper, E.S., Brennan, M.F., Expression of disialogangliosides GD2 and GD3 by human soft tissue sarcomas (1992) Cancer, 70, pp. 633-638
Cheung, N.K., Landmeier, B., Neely, J., Nelson, D., Abramowsky, C., Ellery, S., Adams, R., Miraldi, F.D., Complete tumor ablation with iodine 131-radiolabeled disialoganglioside GD2 specific monoclonal antibody against human neuroblastoma xenografted in nude mice (1986) J. Natl. Cancer Inst., 77, pp. 739-745
Cheung, N.K., Neely, J.E., Landmeier, B., Nelson, D., Miraldi, F., Targeting of ganglioside GD2 monoclonal antibody to neuroblastoma (1987) J. Nucl. Med., 28, pp. 1577-1583
Cheung, N.K., Pentlow, K., Graham, M.C., Yeh, S.D.J., Finn, R.D., Larson, S.M., Radioimmunotherapy of human neuroblastoma using monoclonal antibody 3F8 (1992) In: Fifth International Radiopharmaceutical Dosimetry Symposium, pp. 95-112. , Oak Ridge Associated Universities, Oak Ridge, TN
Cheung, N.K., Saarinen, U.M., Neely, J.E., Landmeier, B., Donovan, D., Coccia, P.F., Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells (1985) Cancer Res, 45, pp. 2642-2649
Childs, R.L., Hnatowich, D.J., Optimum conditions for labeling of DTPA-coupled antibodies with technetium-99m (1985) J. Nucl. Med., 26, pp. 293-299
Desphande, S.V., Denardo, S.J., Meares, C.F., Copper-67-labeled monoclonal antibody LYM-1 a potential radiopharmaceutical (1988) J. Nucl. Med., 29, pp. 217-225
Eckelman, W.C., Paik, C.H., Steigman, J., Three approaches to radiolabeling with 99mTc (1989) Nucl. Med. Biol., 16, pp. 171-176
Fraker, P.J., Speck, J.C., Protein and cell membrane iodinations with a sparingly soluble chloramide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-857
Fritzberg, A.R., Abrams, P.G., Beaumier, P.L., Kasina, S., Morgan, A.C., Rao, T.N., Reno, J.M., Vanderheyden, J.L., Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent (1988) Proc. Natl. Acad. Sci. USA, 85, pp. 4025-4029
Furukawa, K., Akagi, T., Nagata, Y., Yamada, Y., Shimotohno, K., Cheung, N.K.V., Shiku, H., Furukawa, K., GD2 ganglioside on human T lymphotropic virus type I-infected T cells: Possible activation of beta-1,4N-acetylgalactosaminyl-transferase gene by p40-tax (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 1972-1976
Grant, S.C., Kostakoglu, L., Kris, M.G., Yeh, S., Larson, S.M., Finn, R.D., Oettgen, H.F., Cheung, N.K.V., Radioimmunodetection of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: A pilot trial (1996) Eur. J. Nucl. Med., 23, pp. 145-149
Heiner, J., Miraldi, F.D., Kallick, S., Makley, J., Smith-Mensah, W.H., Neely, J., Cheung, N.K.V., In vivo targeting of GD2 specific monoclonal antibody in human osteogenic sarcoma xenografts (1987) Cancer Res, 47, pp. 5377-5381
Hiltunen, J.V., Search for new and improved radiolabeling methods for monoclonal antibodies (1993) Acta Oncol, 32, pp. 831-839
Hnatowich, D.J., Mardirossian, G., Rusckowski, M., Fogarasi, M., Virzi, F., Winnard P., Jr., Directly and indirectly technetium-99m-labeled antibodies - A comparison of in vitro and animal in vivo properties (1993) J. Nucl. Med., 34, pp. 109-119
Kozak, R.W., Raubitschek, A., Mirzadeh, S., Brechbiel, M.W., Junghaus, R., Gansow, O.A., Waldman, T.A., Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: Critical factors in determining in vivo survival and organ toxicity (1989) Cancer Res, 49, pp. 2639-2644
Larsen, S.K., Solomon, H.F., Caldwell, G., Abrams, M.J., 99mTc Tricine: A useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates (1995) Bioconjug. Chem., 6, pp. 635-638
Larson, S.M., Sgouros, G., Cheung, N.K., Antibodies in cancer therapy: Radioisotope conjugates (1995) Biologic Therapy of Cancer 2nd Edn, pp. 534-552. , V.T. DeVita, S. Hellman, & S.A. Rosenberg. Philadelphia: J.B. Lippincott
Mather, S.J., Ellison, D., Reduction-mediated technetium-99m labeling of monoclonal antibodies (1990) J. Nucl. Med., 31, pp. 692-697
Miraldi, F.D., Nelson, A.D., Kraly, C., Ellery, S., Landmeier, B., Coccia, P.F., Strandjord, S.E., Cheung, N.K.V., Diagnostic imaging of human neuroblastoma with radiolabeled antibody (1986) Radiology, 161, pp. 413-418
Moffat, R., Pinsky, C.M., Hammershaimb, L., Petrelli, N.J., Patt, Y.Z., Whaley, F.S., Goldenberg, D.M., Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab′ antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: Results of a pivotal, phase III trial. The Immunomedics Study Group (1996) J. Clin. Oncol., 14, pp. 2295-2305
Ram, S., Buchsbaum, D.J., A peptide-based bifunctional chelating agent for Tc-99m and Re-186 labeling of monoclonal antibodies (1994) Cancer, 73, pp. 769-773
Rhodes, B.A., Zamora, P.O., Newell, K.D., Valdez, E.F., Technetium-99m labeling of murine monoclonal antibody fragments (1994) J. Nucl. Med., 27, pp. 685-693
Schwartz, A., Steinstrasser, A., A novel approach to Tc-99m-labeled monoclonal antibodies [abstract] (1987) J. Nucl. Med., 28, p. 721
Schwartz, D.A., Abrams, M.J., Hauser, M.M., Gal, F.E., Larsen, S.K., Rauh, D., Zubieta, J.A., Preparation of hydrazino-modified proteins and their use for the synthesis of 99mTc-protein conjugates (1991) Bioconjug. Chem., 2, pp. 333-336
Thakur, M.L., Defulvio, J.D., Technetium-99m-labeled monoclonal antibodies for immunoscintigraphy (1991) J. Immunol. Methods, 137, pp. 217-223
Thakur, M.L., Kolan, H.R., Rifat, S., Li, J., Rux, A., John, E., Halmos, G., Schally, A.V., Valpreotide labeled with Tc-99m for imaging tumors: Preparation and preliminary evaluation (1996) Int. J. Oncol., 9, pp. 445-451
Weinstein, J.N., Eger, R.R., Covell, D.G., Larson, S.M., Keenam, A.M., The pharmacology of monoclonal antibodies (1987) Ann. NY Acad. Sci., 507, pp. 199-210
Yeh, S.D., Larson, S.M., Burch, L., Kushner, B.H., Laquaglia, M., Finn, R., Cheung, N.K.V., Radioimmunodetection of neuroblastoma with iodine-131-3F8: Correlation with biopsy, iodine-131-Metaiodobenzylguanidine (MIBG) and standard diagnostic modalities (1991) J. Nucl. Med., 32, pp. 769-776
Zhang, S., Filippa, D.A., Zhang, H.S., Zelenetz, A., Scheinberg, D., Livingston, P., Expression of GM2 and GD2 in B cell lymphomas: Targets for immune attack [abstract] (1997) Proc. Am. Assoc. Cancer Res., 38, p. 404
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors
3F8 is a murine IgG3 monoclonal antibody (MAb) selective for the ganglioside G(D2). Previous studies using 131I-3F8 have shown great potential in the imaging of neuroectodermal tumors and the therapy of human neuroblastoma. 131I is commonly used in radioimmunodiagnosis, but its relatively long half-life (8 days) and its high energy γ-emission (364 KeV) are suboptimal for imaging purposes when compared with 99mTc (6 h and 140 KeV, respectively). To label 3F8 with 99mTc, the antibody was first coupled with a heterobifunctional linker, succinimidyl-6-hydrazinonicotinate hydrochloride (SHNH), obtaining a hydrazinonicotinamide-antibody conjugate. Using 99mTc-Tricine as the precursor complex, 3F8-SHNH was coupled efficiently to 99mTc, resulting in >90% radiometal incorporation, with a specific activity >10 mCi/mg and retaining full immunoreactivity. Immunoscintigraphy at 6, 22, and 46 h after intravenous injection of 1 mCi of 99mTc-3F8 showed selective neuroblastoma localization in xenografted nude mice, comparable to that obtained with the injection of 100 μCi of 131I-3F8. Biodistribution studies of 131I-3F8 and 99mTc-3F8 in mice demonstrated comparable %ID/g uptake in tumor (with a T/B ratio: ~2.5 at 24 h and ~3.5 at 48 h) and normal organs, including blood, except for spleen and liver which had about a three times higher uptake of the 99mTc conjugate. In conclusion, 99mTc can be coupled conveniently at high specific activity to 3F8 without compromising immunoreactivity. SHNH appears to be a useful linker for 99mTc in tumor diagnostic imaging and may have potential utility in coupling other radioisotopes (e.g., 94mTc) for positron imaging and therapy. Copyright (C) 1999 Elsevier Science Inc.
3F8 is a murine IgG3 monoclonal antibody (MAb) selective for the ganglioside G(D2). Previous studies using 131I-3F8 have shown great potential in the imaging of neuroectodermal tumors and the therapy of human neuroblastoma. 131I is commonly used in radioimmunodiagnosis, but its relatively long half-life (8 days) and its high energy γ-emission (364 KeV) are suboptimal for imaging purposes when compared with 99mTc (6 h and 140 KeV, respectively). To label 3F8 with 99mTc, the antibody was first coupled with a heterobifunctional linker, succinimidyl-6-hydrazinonicotinate hydrochloride (SHNH), obtaining a hydrazinonicotinamide-antibody conjugate. Using 99mTc-Tricine as the precursor complex, 3F8-SHNH was coupled efficiently to 99mTc, resulting in >90% radiometal incorporation, with a specific activity >10 mCi/mg and retaining full immunoreactivity. Immunoscintigraphy at 6, 22, and 46 h after intravenous injection of 1 mCi of 99mTc-3F8 showed selective neuroblastoma localization in xenografted nude mice, comparable to that obtained with the injection of 100 μCi of 131I-3F8. Biodistribution studies of 131I-3F8 and 99mTc-3F8 in mice demonstrated comparable %ID/g uptake in tumor (with a T/B ratio: ~2.5 at 24 h and ~3.5 at 48 h) and normal organs, including blood, except for spleen and liver which had about a three times higher uptake of the 99mTc conjugate. In conclusion, 99mTc can be coupled conveniently at high specific activity to 3F8 without compromising immunoreactivity. SHNH appears to be a useful linker for 99mTc in tumor diagnostic imaging and may have potential utility in coupling other radioisotopes (e.g., 94mTc) for positron imaging and therapy. Copyright (C) 1999 Elsevier Science Inc.
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors
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99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors
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Impact Factor: 4.184
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
* Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer (111 views) (PDF 48 views)
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Impact Factor: 7.068
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Alterio V, Kellner M, Esposito D, Liesche-starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G
* Biochemical and structural insights into Carbonic Anhydrase XII/Fab6A10 complex (168 views)
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Impact Factor: 5.067
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (532 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
* Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy (499 views)
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Impact Factor: 2.881
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (315 views)
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Impact Factor: 3.469
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1299 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
* Effects of a novel Nodal-targeting monoclonal antibody in melanoma (392 views) (PDF 211 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015 Oct 27; 6(33): 34071-34086.
Impact Factor: 5.008
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (719 views) (PDF 265 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
Impact Factor: 3.257
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
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Impact Factor: 2.429
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (531 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (405 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
Impact Factor: 3.73
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (382 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (526 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
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Varrone A, Stepanov V, Nakao R, Toth M, Gulyas B, Emond P, Deloye JB, Vercouillie J, Stabin MG, Jonsson C, Guilloteau D, Halldin C
* Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates (515 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2011 Sep 1; 52(8): 1313-1321.
Impact Factor: 6.381
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (562 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (597 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (371 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (399 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (418 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (280 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (352 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (828 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (482 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (461 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (437 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (312 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (280 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (314 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (982 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (450 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (278 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (462 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (275 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (619 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (463 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (405 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (292 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (292 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (403 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (660 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (321 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (350 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (317 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (528 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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* Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry (17 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2021 Mar 20; 22(6): N/D-N/D.
Impact Factor: 4.556
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Sivaccumar J, Sandomenico A, Vitagliano L, Ruvo M
* Monoclonal Antibodies: A Prospective and Retrospective View (71 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(3): 435-471.
Impact Factor: 4.184
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
* Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer (111 views) (PDF 48 views)
J Exp Clin Canc Res (ISSN: 0392-9078linking, 1756-9966, 1756-9966electronic), 2020 Sep 7; 39(1): 180-180.
Impact Factor: 7.068
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Alterio V, Kellner M, Esposito D, Liesche-starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G
* Biochemical and structural insights into Carbonic Anhydrase XII/Fab6A10 complex (168 views)
J Mol Biol (ISSN: 0022-2836linking, 1089-8638), 2019 Dec 6; 431(24): 4910-4921.
Impact Factor: 5.067
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (532 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
* Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy (499 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Dec 15; 25(24): 6589-6596.
Impact Factor: 2.881
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (315 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3939-3941.
Impact Factor: 3.469
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1299 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
* Effects of a novel Nodal-targeting monoclonal antibody in melanoma (392 views) (PDF 211 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015 Oct 27; 6(33): 34071-34086.
Impact Factor: 5.008
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (719 views) (PDF 265 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
Impact Factor: 3.257
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (732 views) (PDF 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Impact Factor: 2.429
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (531 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1653 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (405 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
Impact Factor: 3.73
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (382 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (526 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
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Varrone A, Stepanov V, Nakao R, Toth M, Gulyas B, Emond P, Deloye JB, Vercouillie J, Stabin MG, Jonsson C, Guilloteau D, Halldin C
* Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates (515 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2011 Sep 1; 52(8): 1313-1321.
Impact Factor: 6.381
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (562 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (597 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (371 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (399 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (418 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (280 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (352 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (828 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (482 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (461 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (437 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (312 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (280 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (314 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (982 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (450 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (278 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (462 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (275 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (619 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (463 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (405 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (292 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (292 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (403 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (660 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (321 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (350 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (317 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (528 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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62 Records (58 excluding Abstracts).
Total impact factor: 238.684 (227.31 excluding Abstracts).
Total 5 year impact factor: 255.336 (240.057 excluding Abstracts).
Total impact factor: 238.684 (227.31 excluding Abstracts).
Total 5 year impact factor: 255.336 (240.057 excluding Abstracts).
373 views. Last view on Thursday 23 March 2023, 16:12:25
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