In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (346 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
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Paper type: Journal Article,
Impact factor: 4.887, 5-year impact factor: 4.928
Url: http://www.scopus.com/record/display.url?eid=2-s2.0-84944339466&origin=inward
Keywords: Radiographic, Iodinated Agents, Mri, Cest, Iodixanol, Ioversol, Iohexol, Iomeprol, Contrast Agents, Tumor, X-Ray,
Affiliations:
*** IBB - CNR ***
From the *Istituto di Biostrutture e Bioimmagini - CNR, Molecular Biotechnology Center, and daggerDepartment of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Turin, Turin; double daggerDepartment of Science and Technological Innovation, Universita del Piemonte Orientale A. Avogadro, Alessandria, Italy; section signDepartment of Mathematics and Statistics, Hanshan Normal University, Guangdong, China; parallelAthinoula A. Martinos Center for Biomedical Imaging, Charlestown; Department of Radiology, Massachusetts General Hospital; and Harvard Medical School, Boston, MA.,
Universita degli Studi di Torino
References:
Kramer, R.A., Janetos, G.P., Peristein, G., An approach to contrast enhancement in computed tomography of the brain (1975) Radiology., 116, pp. 641-64
Miles, K.A., Functional computed tomography in oncology (2002) Eur J Cancer., 38, pp. 2079-2084
Dugdale, P.E., Miles, K.A., Bunce, I., CT measurement of perfusion and permeability within lymphoma masses and its ability to assess grade, activity, and chemotherapeutic response (1999) J Comput Assist Tomogr., 23, pp. 540-547
Hasebroock, K.M., Serkova, N.J., Toxicity of MRI and CT contrast agents (2009) Expert Opin Drug Metab Toxicol., 5, pp. 403-416
Aime, S., Nano, R., Grandi, M., A new class of contrast agents for magnetic resonance imaging based on selective reduction of water-T2 by chemical exchange (1988) Invest Radiol., 23, pp. S267-S270
Aime, S., Calabi, L., Biondi, L., Iopamidol: Exploring the potential use of awellestablished x-ray contrast agent for MRI (2005) Magn Reson Med., 53, pp. 830-834
Ward, K.M., Aletras, A.H., Balaban, R.S., A new class of contrast agents forMRI based on proton chemical exchange dependent saturation transfer (CEST) (2000) J Magn Reson., 143, pp. 79-87
Van Zijl, P.C., Yadav, N.N., Chemical exchange saturation transfer (CEST): What is in a name and what isn't? (2011) Magn Reson Med., 65, pp. 927-948
Vinogradov, E., Sherry, A.D., Lenkinski, R.E., CEST: From basic principles to applications, challenges and opportunities (2013) J Magn Reson., 229, pp. 155-172
Liu, G., Song, X., Chan, K.W., Nuts and bolts of chemical exchange saturation transfer MRI (2013) NMR Biomed., 26, pp. 810-828
Kogan, F., Hariharan, H., Reddy, R., Chemical exchange saturation transfer (CEST) imaging: Description of technique and potential clinical applications (2013) Curr Radiol Rep., 1, pp. 102-114
Castelli, D.D., Terreno, E., Longo, D., Nanoparticle-based chemical exchange saturation transfer (CEST) agents (2013) NMR Biomed., 26, pp. 839-849
Terreno, E., Castelli, D.D., Aime, S., Encoding the frequency dependence inMRI contrast media: The emerging class of CEST agents (2010) Contrast Media Mol Imaging., 5, pp. 78-98
Longo, D.L., Dastrù, W., Digilio, G., Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T (2011) Magn Reson Med., 65, pp. 202-211
Longo, D.L., Busato, A., Lanzardo, S., Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent (2013) Magn Reson Med., 70, pp. 859-864
Chen, L.Q., Howison, C.M., Jeffery, J.J., Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI (2014) Magn Reson Med., 72, pp. 1408-1417
Chen, L.Q., Randtke, E.A., Jones, K.M., Evaluations of tumor acidosis within in vivo tumor models using parametric maps generated with acidoCEST MRI (2015) Mol Imaging Biol., 17, pp. 488-496
Jones, K.M., Randtke, E.A., Howison, C.M., Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI (2015) Mol Imaging Biol., 17, pp. 177-184
Longo, D.L., Sun, P.Z., Consolino, L., A general MRI-CEST ratiometric approach for pH imaging: Demonstration of in vivo pH mapping with iobitridol (2014) J Am Chem Soc., 136, pp. 14333-14336
Müller-Lutz, A., Khalil, N., Schmitt, B., Pilot study of iopamidol-based quantitative pH imaging on a clinical 3T MR scanner (2014) MAGMA, 27, pp. 477-485
Chan, K.W., McMahon, M.T., Kato, Y., Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer (2012) Magn Reson Med., 68, pp. 1764-1773
Nasrallah, F.A., Pages, G., Kuchel, P.W., Imaging brain deoxyglucose uptake and 1metabolism by glucoCEST MRI (2013) J Cereb Blood Flow Metab., 33, pp. 1270-1278
Rivlin, M., Horev, J., Tsarfaty, I., Molecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI (2013) Sci Rep., 3, p. 3045
Delli Castelli, D., Ferrauto, G., Cutrin, J.C., In vivo maps of extracellular pH in murine melanoma by CEST-MRI (2014) Magn Reson Med., 71, pp. 326-332
Sheth, V.R., Li, Y., Chen, L.Q., Measuring in vivo tumor pHe with CEST-FISP MRI (2012) Magn Reson Med., 67, pp. 760-768
Nanni, P., De Giovanni, C., Lollini, P.L., TS/A: A new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma (1983) Clin Exp Metastasis., 1, pp. 373-380
Terreno, E., Stancanello, J., Longo, D., Methods for an improved detection of the MRI-CEST effect (2009) Contrast Media Mol Imaging., 4, pp. 237-247
McMahon, M.T., Gilad, A.A., Zhou, J., Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly-L-lysine and a starburst dendrimer (2006) Magn Reson Med., 55, pp. 836-847
Nishino, M., Jagannathan, J.P., Ramaiya, N.H., Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know (2010) AJR Am J Roentgenol., 195, pp. 281-289
Gwyther, S.J., Schwartz, L.H., How to assess anti-tumour efficacy by imaging techniques (2008) Eur J Cancer., 44, pp. 39-45
Jiang, T., Kambadakone, A., Kulkarni, N.M., Monitoring response to antiangiogenic treatment and predicting outcomes in advanced hepatocellular carcinoma using image biomarkers, CT perfusion, tumor density, and tumor size (RECIST) (2012) Invest Radiol., 47, pp. 11-17
Reagan-Shaw, S., Nihal, M., Ahmad, N., Dose translation from animal to human studies revisited (2008) FASEB J., 22, pp. 659-661
Obeid, L., Deman, P., Tessier, A., Absolute perfusion measurements and associated iodinated contrast agent time course in brain metastasis: A study for contrastenhanced radiotherapy (2014) J Cereb Blood Flow Metab., 34, pp. 638-645
O'Connor, J.P., Rose, C.J., Waterton, J.C., Imaging intratumor heterogeneity: Role in therapy response, resistance, and clinical outcome (2015) Clin Cancer Res., 21, pp. 249-257
Miles, K.A., Lee, T.Y., Goh, V., Current status and guidelines for the assessment of tumour vascular support with dynamic contrast-enhanced computed tomography (2012) Eur Radiol., 22, pp. 1430-1441
Van Zijl, P.C., Jones, C.K., Ren, J., MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST) (2007) Proc Natl Acad Sci U S A., 104, pp. 4359-4364
Ling, W., Regatte, R.R., Navon, G., Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) (2008) Proc Natl Acad Sci U S A., 105, pp. 2266-2270
Zhou, J., Wilson, D.A., Sun, P.Z., Quantitative description of proton exchange processes between water and endogenous and exogenous agents forWEX, CEST, and APT experiments (2004) Magn Reson Med., 51, pp. 945-952
Zaiss, M., Schmitt, B., Bachert, P., Quantitative separation of CESTeffect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra (2011) J Magn Reson., 211, pp. 149-155
Yang, X., Song, X., Li, Y., Salicylic acid and analogues as diaCEST MRI contrast agents with highly shifted exchangeable proton frequencies (2013) Angew Chem Int Ed Engl., 52, pp. 8116-8119
Smolinske, S.C., Hall, A.H., Vandenberg, S.A., Toxic effects of nonsteroidal antiinflammatory drugs in overdose (1990) An Overview of Recent Evidence on Clinical Effects and Dose-response Relationships. Drug Saf., 5, pp. 252-274
Felder, E., Pitrè, D., Tirone, P., Radiopaque contrast media (1977) XLIV-Preclinical Studies with A New Nonionic Contrast Agent. Farmaco Sci., 32, pp. 835-844
Pitrè, D., Felder, E., Development, chemistry, and physical properties of iopamidol and its analogues (1980) Invest Radiol., 15, pp. S301-S309
Sun, P.Z., Van Zijl, P.C., Zhou, J., Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments (2005) J Magn Reson., 175, pp. 193-200
Sun, P.Z., Longo, D.L., Hu, W., Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH (2014) Phys Med Biol., 59, pp. 4493-4504
Shah, T., Lu, L., Dell, K.M., CEST-FISP: A novel technique for rapid chemical exchange saturation transfer MRI at 7 T (2011) Magn Reson Med., 65, pp. 432-437
Zaiss, M., Xu, J., Goerke, S., Inverse Z-spectrum analysis for spillover-, MT-, and T1-corrected steady-state pulsed CEST-MRI - Application to pH-weighted MRI of acute stroke (2014) NMR Biomed., 27, pp. 240-252
Sun, P.Z., Cheung, J.S., Wang, E., Fast multislice pH-weighted chemical exchange saturation transfer (CEST) MRI with Unevenly segmented RF irradiation (2011) Magn Reson Med., 65, pp. 588-594
Zhu, H., Jones, C.K., Van Zijl, P.C., Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain (2010) Magn Reson Med., 64, pp. 638-644
Zaiss, M., Zu, Z., Xu, J., A combined analytical solution for chemical exchange saturation transfer and semi-solid magnetization transfer (2015) NMR Biomed., 28, pp. 217-230
Wu, R., Longo, D.L., Aime, S., Quantitative description of radiofrequency (RF) power-based ratiometric chemical exchange saturation transfer (CEST) pH imaging (2015) NMR Biomed., 28, pp. 555-565
SantosMello, R., Callisen, H., Winter, J., Radiation dose enhancement in tumors with iodine (1983) Med Phys., 10, pp. 75-78
Adam, J.F., Biston, M.C., Joubert, A., Enhanced delivery of iodine for synchrotron stereotactic radiotherapy by means of intracarotid injection and blood-brain barrier disruption: Quantitative iodine biodistribution studies and associated dosimetry (2005) Int J Radiat Oncol Biol Phys., 61, pp. 1173-1182
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.887, 5-year impact factor: 4.928
Url: http://www.scopus.com/record/display.url?eid=2-s2.0-84944339466&origin=inward
Keywords: Radiographic, Iodinated Agents, Mri, Cest, Iodixanol, Ioversol, Iohexol, Iomeprol, Contrast Agents, Tumor, X-Ray,
Affiliations:
*** IBB - CNR ***
From the *Istituto di Biostrutture e Bioimmagini - CNR, Molecular Biotechnology Center, and daggerDepartment of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Turin, Turin; double daggerDepartment of Science and Technological Innovation, Universita del Piemonte Orientale A. Avogadro, Alessandria, Italy; section signDepartment of Mathematics and Statistics, Hanshan Normal University, Guangdong, China; parallelAthinoula A. Martinos Center for Biomedical Imaging, Charlestown; Department of Radiology, Massachusetts General Hospital; and Harvard Medical School, Boston, MA.,
Universita degli Studi di Torino
References:
Kramer, R.A., Janetos, G.P., Peristein, G., An approach to contrast enhancement in computed tomography of the brain (1975) Radiology., 116, pp. 641-64
Miles, K.A., Functional computed tomography in oncology (2002) Eur J Cancer., 38, pp. 2079-2084
Dugdale, P.E., Miles, K.A., Bunce, I., CT measurement of perfusion and permeability within lymphoma masses and its ability to assess grade, activity, and chemotherapeutic response (1999) J Comput Assist Tomogr., 23, pp. 540-547
Hasebroock, K.M., Serkova, N.J., Toxicity of MRI and CT contrast agents (2009) Expert Opin Drug Metab Toxicol., 5, pp. 403-416
Aime, S., Nano, R., Grandi, M., A new class of contrast agents for magnetic resonance imaging based on selective reduction of water-T2 by chemical exchange (1988) Invest Radiol., 23, pp. S267-S270
Aime, S., Calabi, L., Biondi, L., Iopamidol: Exploring the potential use of awellestablished x-ray contrast agent for MRI (2005) Magn Reson Med., 53, pp. 830-834
Ward, K.M., Aletras, A.H., Balaban, R.S., A new class of contrast agents forMRI based on proton chemical exchange dependent saturation transfer (CEST) (2000) J Magn Reson., 143, pp. 79-87
Van Zijl, P.C., Yadav, N.N., Chemical exchange saturation transfer (CEST): What is in a name and what isn't? (2011) Magn Reson Med., 65, pp. 927-948
Vinogradov, E., Sherry, A.D., Lenkinski, R.E., CEST: From basic principles to applications, challenges and opportunities (2013) J Magn Reson., 229, pp. 155-172
Liu, G., Song, X., Chan, K.W., Nuts and bolts of chemical exchange saturation transfer MRI (2013) NMR Biomed., 26, pp. 810-828
Kogan, F., Hariharan, H., Reddy, R., Chemical exchange saturation transfer (CEST) imaging: Description of technique and potential clinical applications (2013) Curr Radiol Rep., 1, pp. 102-114
Castelli, D.D., Terreno, E., Longo, D., Nanoparticle-based chemical exchange saturation transfer (CEST) agents (2013) NMR Biomed., 26, pp. 839-849
Terreno, E., Castelli, D.D., Aime, S., Encoding the frequency dependence inMRI contrast media: The emerging class of CEST agents (2010) Contrast Media Mol Imaging., 5, pp. 78-98
Longo, D.L., Dastrù, W., Digilio, G., Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T (2011) Magn Reson Med., 65, pp. 202-211
Longo, D.L., Busato, A., Lanzardo, S., Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent (2013) Magn Reson Med., 70, pp. 859-864
Chen, L.Q., Howison, C.M., Jeffery, J.J., Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI (2014) Magn Reson Med., 72, pp. 1408-1417
Chen, L.Q., Randtke, E.A., Jones, K.M., Evaluations of tumor acidosis within in vivo tumor models using parametric maps generated with acidoCEST MRI (2015) Mol Imaging Biol., 17, pp. 488-496
Jones, K.M., Randtke, E.A., Howison, C.M., Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI (2015) Mol Imaging Biol., 17, pp. 177-184
Longo, D.L., Sun, P.Z., Consolino, L., A general MRI-CEST ratiometric approach for pH imaging: Demonstration of in vivo pH mapping with iobitridol (2014) J Am Chem Soc., 136, pp. 14333-14336
Müller-Lutz, A., Khalil, N., Schmitt, B., Pilot study of iopamidol-based quantitative pH imaging on a clinical 3T MR scanner (2014) MAGMA, 27, pp. 477-485
Chan, K.W., McMahon, M.T., Kato, Y., Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer (2012) Magn Reson Med., 68, pp. 1764-1773
Nasrallah, F.A., Pages, G., Kuchel, P.W., Imaging brain deoxyglucose uptake and 1metabolism by glucoCEST MRI (2013) J Cereb Blood Flow Metab., 33, pp. 1270-1278
Rivlin, M., Horev, J., Tsarfaty, I., Molecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI (2013) Sci Rep., 3, p. 3045
Delli Castelli, D., Ferrauto, G., Cutrin, J.C., In vivo maps of extracellular pH in murine melanoma by CEST-MRI (2014) Magn Reson Med., 71, pp. 326-332
Sheth, V.R., Li, Y., Chen, L.Q., Measuring in vivo tumor pHe with CEST-FISP MRI (2012) Magn Reson Med., 67, pp. 760-768
Nanni, P., De Giovanni, C., Lollini, P.L., TS/A: A new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma (1983) Clin Exp Metastasis., 1, pp. 373-380
Terreno, E., Stancanello, J., Longo, D., Methods for an improved detection of the MRI-CEST effect (2009) Contrast Media Mol Imaging., 4, pp. 237-247
McMahon, M.T., Gilad, A.A., Zhou, J., Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly-L-lysine and a starburst dendrimer (2006) Magn Reson Med., 55, pp. 836-847
Nishino, M., Jagannathan, J.P., Ramaiya, N.H., Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know (2010) AJR Am J Roentgenol., 195, pp. 281-289
Gwyther, S.J., Schwartz, L.H., How to assess anti-tumour efficacy by imaging techniques (2008) Eur J Cancer., 44, pp. 39-45
Jiang, T., Kambadakone, A., Kulkarni, N.M., Monitoring response to antiangiogenic treatment and predicting outcomes in advanced hepatocellular carcinoma using image biomarkers, CT perfusion, tumor density, and tumor size (RECIST) (2012) Invest Radiol., 47, pp. 11-17
Reagan-Shaw, S., Nihal, M., Ahmad, N., Dose translation from animal to human studies revisited (2008) FASEB J., 22, pp. 659-661
Obeid, L., Deman, P., Tessier, A., Absolute perfusion measurements and associated iodinated contrast agent time course in brain metastasis: A study for contrastenhanced radiotherapy (2014) J Cereb Blood Flow Metab., 34, pp. 638-645
O'Connor, J.P., Rose, C.J., Waterton, J.C., Imaging intratumor heterogeneity: Role in therapy response, resistance, and clinical outcome (2015) Clin Cancer Res., 21, pp. 249-257
Miles, K.A., Lee, T.Y., Goh, V., Current status and guidelines for the assessment of tumour vascular support with dynamic contrast-enhanced computed tomography (2012) Eur Radiol., 22, pp. 1430-1441
Van Zijl, P.C., Jones, C.K., Ren, J., MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST) (2007) Proc Natl Acad Sci U S A., 104, pp. 4359-4364
Ling, W., Regatte, R.R., Navon, G., Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) (2008) Proc Natl Acad Sci U S A., 105, pp. 2266-2270
Zhou, J., Wilson, D.A., Sun, P.Z., Quantitative description of proton exchange processes between water and endogenous and exogenous agents forWEX, CEST, and APT experiments (2004) Magn Reson Med., 51, pp. 945-952
Zaiss, M., Schmitt, B., Bachert, P., Quantitative separation of CESTeffect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra (2011) J Magn Reson., 211, pp. 149-155
Yang, X., Song, X., Li, Y., Salicylic acid and analogues as diaCEST MRI contrast agents with highly shifted exchangeable proton frequencies (2013) Angew Chem Int Ed Engl., 52, pp. 8116-8119
Smolinske, S.C., Hall, A.H., Vandenberg, S.A., Toxic effects of nonsteroidal antiinflammatory drugs in overdose (1990) An Overview of Recent Evidence on Clinical Effects and Dose-response Relationships. Drug Saf., 5, pp. 252-274
Felder, E., Pitrè, D., Tirone, P., Radiopaque contrast media (1977) XLIV-Preclinical Studies with A New Nonionic Contrast Agent. Farmaco Sci., 32, pp. 835-844
Pitrè, D., Felder, E., Development, chemistry, and physical properties of iopamidol and its analogues (1980) Invest Radiol., 15, pp. S301-S309
Sun, P.Z., Van Zijl, P.C., Zhou, J., Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments (2005) J Magn Reson., 175, pp. 193-200
Sun, P.Z., Longo, D.L., Hu, W., Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH (2014) Phys Med Biol., 59, pp. 4493-4504
Shah, T., Lu, L., Dell, K.M., CEST-FISP: A novel technique for rapid chemical exchange saturation transfer MRI at 7 T (2011) Magn Reson Med., 65, pp. 432-437
Zaiss, M., Xu, J., Goerke, S., Inverse Z-spectrum analysis for spillover-, MT-, and T1-corrected steady-state pulsed CEST-MRI - Application to pH-weighted MRI of acute stroke (2014) NMR Biomed., 27, pp. 240-252
Sun, P.Z., Cheung, J.S., Wang, E., Fast multislice pH-weighted chemical exchange saturation transfer (CEST) MRI with Unevenly segmented RF irradiation (2011) Magn Reson Med., 65, pp. 588-594
Zhu, H., Jones, C.K., Van Zijl, P.C., Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain (2010) Magn Reson Med., 64, pp. 638-644
Zaiss, M., Zu, Z., Xu, J., A combined analytical solution for chemical exchange saturation transfer and semi-solid magnetization transfer (2015) NMR Biomed., 28, pp. 217-230
Wu, R., Longo, D.L., Aime, S., Quantitative description of radiofrequency (RF) power-based ratiometric chemical exchange saturation transfer (CEST) pH imaging (2015) NMR Biomed., 28, pp. 555-565
SantosMello, R., Callisen, H., Winter, J., Radiation dose enhancement in tumors with iodine (1983) Med Phys., 10, pp. 75-78
Adam, J.F., Biston, M.C., Joubert, A., Enhanced delivery of iodine for synchrotron stereotactic radiotherapy by means of intracarotid injection and blood-brain barrier disruption: Quantitative iodine biodistribution studies and associated dosimetry (2005) Int J Radiat Oncol Biol Phys., 61, pp. 1173-1182
In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents
The aimof this study was to evaluate 4 nonionic x-ray iodinated contrast agents (CAs), commonly used in radiographic procedures, as novel chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) agents by assessing their in vitro exchange properties and preliminary in vivo use as tumor enhancing agents. Materials and Methods: The CEST properties, as function of pH (range, 5.5-7.9) and of radio frequency conditions (irradiation field strength range of 1-9 μT and time of 1-9 seconds), have been determined at 7 T and 310 K for 4 x-ray CAs commonly used in clinical settings, namely, iomeprol, iohexol, ioversol, and iodixanol. Their in vivo properties have been investigated upon intravenous injection in a murine HER2+ breast tumor model (n = 4 mice for each CA) using both computed tomography (CT) and MRI modalities. Results: The prototropic exchange rates measured for the 4 investigated iodinated molecules showed strong pH dependence with base catalyzed exchange rate that was faster for monomeric compounds (20-4000 Hz in the pH range of 5.5- 7.9). Computed tomography quantification showed marked (up to 2 mg I/mL concentration) and prolonged accumulation (up to 30 minutes postinjection) inside tumor regions. Among the 4 agents we tested, iohexol and ioversol display good CEST contrast properties at 7 T, and in vivo results confirmed strong and prolonged contrast enhancement of the tumors, with elevated extravasation fractions (74%-91%). A strong and significant correlation was found between CT and CEST-MRI tumor-enhanced images (R2 = 0.70, P < 0.01). Conclusions: The obtained results demonstrate that iohexol and ioversol, 2 commonly used radiographic compounds, can be used as MRI perfusion agents, particularly useful when serial images acquisitions are needed to complement CT information. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
The aimof this study was to evaluate 4 nonionic x-ray iodinated contrast agents (CAs), commonly used in radiographic procedures, as novel chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) agents by assessing their in vitro exchange properties and preliminary in vivo use as tumor enhancing agents. Materials and Methods: The CEST properties, as function of pH (range, 5.5-7.9) and of radio frequency conditions (irradiation field strength range of 1-9 μT and time of 1-9 seconds), have been determined at 7 T and 310 K for 4 x-ray CAs commonly used in clinical settings, namely, iomeprol, iohexol, ioversol, and iodixanol. Their in vivo properties have been investigated upon intravenous injection in a murine HER2+ breast tumor model (n = 4 mice for each CA) using both computed tomography (CT) and MRI modalities. Results: The prototropic exchange rates measured for the 4 investigated iodinated molecules showed strong pH dependence with base catalyzed exchange rate that was faster for monomeric compounds (20-4000 Hz in the pH range of 5.5- 7.9). Computed tomography quantification showed marked (up to 2 mg I/mL concentration) and prolonged accumulation (up to 30 minutes postinjection) inside tumor regions. Among the 4 agents we tested, iohexol and ioversol display good CEST contrast properties at 7 T, and in vivo results confirmed strong and prolonged contrast enhancement of the tumors, with elevated extravasation fractions (74%-91%). A strong and significant correlation was found between CT and CEST-MRI tumor-enhanced images (R2 = 0.70, P < 0.01). Conclusions: The obtained results demonstrate that iohexol and ioversol, 2 commonly used radiographic compounds, can be used as MRI perfusion agents, particularly useful when serial images acquisitions are needed to complement CT information. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents
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In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents
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* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (23 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
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Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (74 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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Palma G, Monti S, Cella L
* Voxel-based analysis in radiation oncology: A methodological cookbook (70 views)
Phys Med (ISSN: 1120-1797linking), 2020 Jan; 69: 192-204.
Impact Factor: 2.485
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (135 views)
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
* MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis (283 views)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2019 Feb; 61(2): 155-162.
Impact Factor: 1.287
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Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (242 views)
Magn Reson Chem (ISSN: 0749-1581linking), 2019 Jan 24; N/D: N/D-N/D.
Impact Factor: 1.601
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Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
* Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (219 views)
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Impact Factor: 1.505
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Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL
* Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging (322 views)
J Magn Reson (ISSN: 1090-7807, 1090-7807linking), 2017 Dec 11; 287: 1-9.
Impact Factor: 2.586
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (320 views)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
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Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (349 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
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Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (520 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
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Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (211 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
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Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (455 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2016 Feb 23; 26(12): 4577-4584.
Impact Factor: 3.967
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (447 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (247 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
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Maffei E, Midiri M, Russo V, Rengo M, Tedeschi C, Spagnolo P, Seitun S, Francone M, Guaricci AI, Carrabba N, Malagò R, Cuocolo A, Arcadi T, Catalano OA, Cademartiri F
* Rationale, design and methods of CTCA-PRORECAD (Computed Tomography Coronary Angiography Prognostic Registry for Coronary Artery Disease): A multicentre and multivendor registry (345 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2013 Jun; 118(4): 591-607.
Impact Factor: 1.368
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
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Sica G, Guida F, Bocchini G, Codella U, Mainenti PP, Tanga M, Scaglione M
* Errors in Imaging Assessment of Polytrauma Patients (675 views)
Seminars In Ultrasound Ct And Mri (ISSN: 0887-2171), 2012 Sep; 33(4): 337-346.
Impact Factor: 1.289
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Mainenti PP, Iodice D, Cozzolino I, Segreto S, Capece S, Sica G, Magliulo M, Ciancia G, Pace L, Salvatore M
* Tomographic imaging of the spleen: the role of morphological and metabolic features in differentiating benign from malignant diseases (296 views)
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Impact Factor: 0.648
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (335 views)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (292 views)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
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Impact Factor: 1.95
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (415 views)
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Impact Factor: 6.069
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (600 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (432 views)
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Impact Factor: 1.807
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (254 views)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (575 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G
* Acute appendicitis: Diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings (366 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 2055-2061.
Impact Factor: 3.405
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (442 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Imbriaco M, Smeraldo D, Liuzzi R, Carrillo F, Cacace G, Vecchione D, Diglio A, Salvatore M
* Multislice CT with single-phase technique in patients with suspected pancreatic cancer (245 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Mar; 111(2): 159-166.
Impact Factor: 1.368
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Lauria A, Palmiero R, Forni G, Fantacci ME, Imbriaco M, Sodano A, Indovina PL
* A Study On Two Different Cad Systems For Mmammography As An Aid To Radiological Diagnosis In The Search Of Microcalcification Clusters (339 views)
Eur J Radiol (ISSN: 0720-048x), 2005; 55(2): 264-269.
Impact Factor: 1.888
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Alfano B, Bandettini A, Bencivelli W, Bertolucci E, Bottigli U, Conti M, Del Guerra A, Fantacci ME, Penkowski M, Randaccio P
1ST X-RAY IMAGES WITH A DOUBLE-SIDED MICROSTRIPS SILICON CRYSTAL - A NOVEL DETECTOR FOR DIGITAL RADIOGRAPHY (266 views)
Phys Med Biol (ISSN: 0031-9155, 0031-9155linking), 1992 May; 37(5): 1167-1170.
Impact Factor: 1.542
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (322 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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* A snapshot of the vast array of diamagnetic CEST MRI contrast agents (6 views)
Nmr Biomed (ISSN: 0952-3480linking), 2022 Feb 20; N/D: e4715-N/D.
Impact Factor: 4.044
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Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
* Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging (20 views)
Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
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Larobina M, Megna R, Solla R
* Comparison of three freeware software packages for (18)F-FDG PET texture feature calculation (74 views)
Jpn J Radiol (ISSN: 1867-1071linking), 2021 Jul; 39(7): 710-719.
Impact Factor: 1.439
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
* Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents (18 views)
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Impact Factor: 4.757
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (74 views)
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Impact Factor: 12.959
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Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (23 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
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Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (74 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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Palma G, Monti S, Cella L
* Voxel-based analysis in radiation oncology: A methodological cookbook (70 views)
Phys Med (ISSN: 1120-1797linking), 2020 Jan; 69: 192-204.
Impact Factor: 2.485
View Export to BibTeX Export to EndNote
Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (135 views)
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
* MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis (283 views)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2019 Feb; 61(2): 155-162.
Impact Factor: 1.287
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Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (242 views)
Magn Reson Chem (ISSN: 0749-1581linking), 2019 Jan 24; N/D: N/D-N/D.
Impact Factor: 1.601
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Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
* Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (219 views)
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Impact Factor: 1.505
View Export to BibTeX Export to EndNote
Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL
* Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging (322 views)
J Magn Reson (ISSN: 1090-7807, 1090-7807linking), 2017 Dec 11; 287: 1-9.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (320 views)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
View Export to BibTeX Export to EndNote
Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (349 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
View Export to BibTeX Export to EndNote
Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (520 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (211 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
View Export to BibTeX Export to EndNote
Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (455 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2016 Feb 23; 26(12): 4577-4584.
Impact Factor: 3.967
View Export to BibTeX Export to EndNote
Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (447 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
View Export to BibTeX Export to EndNote
Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
View Export to BibTeX Export to EndNote
Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (247 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
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Maffei E, Midiri M, Russo V, Rengo M, Tedeschi C, Spagnolo P, Seitun S, Francone M, Guaricci AI, Carrabba N, Malagò R, Cuocolo A, Arcadi T, Catalano OA, Cademartiri F
* Rationale, design and methods of CTCA-PRORECAD (Computed Tomography Coronary Angiography Prognostic Registry for Coronary Artery Disease): A multicentre and multivendor registry (345 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2013 Jun; 118(4): 591-607.
Impact Factor: 1.368
View Export to BibTeX Export to EndNote
Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
View Export to BibTeX Export to EndNote
Sica G, Guida F, Bocchini G, Codella U, Mainenti PP, Tanga M, Scaglione M
* Errors in Imaging Assessment of Polytrauma Patients (675 views)
Seminars In Ultrasound Ct And Mri (ISSN: 0887-2171), 2012 Sep; 33(4): 337-346.
Impact Factor: 1.289
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Mainenti PP, Iodice D, Cozzolino I, Segreto S, Capece S, Sica G, Magliulo M, Ciancia G, Pace L, Salvatore M
* Tomographic imaging of the spleen: the role of morphological and metabolic features in differentiating benign from malignant diseases (296 views)
Clin Imaging (ISSN: 1873-4499, 0899-7071, 0899-7071linking), 2012 Sep; 36(5): 559-567.
Impact Factor: 0.648
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (335 views)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (292 views)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (415 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (600 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (432 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (254 views)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (575 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G
* Acute appendicitis: Diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings (366 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 2055-2061.
Impact Factor: 3.405
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (442 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Imbriaco M, Smeraldo D, Liuzzi R, Carrillo F, Cacace G, Vecchione D, Diglio A, Salvatore M
* Multislice CT with single-phase technique in patients with suspected pancreatic cancer (245 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Mar; 111(2): 159-166.
Impact Factor: 1.368
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Lauria A, Palmiero R, Forni G, Fantacci ME, Imbriaco M, Sodano A, Indovina PL
* A Study On Two Different Cad Systems For Mmammography As An Aid To Radiological Diagnosis In The Search Of Microcalcification Clusters (339 views)
Eur J Radiol (ISSN: 0720-048x), 2005; 55(2): 264-269.
Impact Factor: 1.888
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Alfano B, Bandettini A, Bencivelli W, Bertolucci E, Bottigli U, Conti M, Del Guerra A, Fantacci ME, Penkowski M, Randaccio P
1ST X-RAY IMAGES WITH A DOUBLE-SIDED MICROSTRIPS SILICON CRYSTAL - A NOVEL DETECTOR FOR DIGITAL RADIOGRAPHY (266 views)
Phys Med Biol (ISSN: 0031-9155, 0031-9155linking), 1992 May; 37(5): 1167-1170.
Impact Factor: 1.542
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (322 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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48 Records (45 excluding Abstracts).
Total impact factor: 170.483 (162.997 excluding Abstracts).
Total 5 year impact factor: 175.556 (167.562 excluding Abstracts).
Total impact factor: 170.483 (162.997 excluding Abstracts).
Total 5 year impact factor: 175.556 (167.562 excluding Abstracts).
346 views. Last view on Friday 02 June 2023, 21:31:23
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