High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH (422 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7179linking), 2015 Nov 23; 11(8): 919-927.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.98, 5-year impact factor: 2.89
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84947975839&partnerID=40&md5=78126086aa258a05b61383e25ec43aae
Keywords: Nmr Spectroscopy, Yoph, Combinatorial Libraries, High-Throughput Screening (hts), Peptides, Protein-Protein Interactions,
Affiliations:
*** IBB - CNR ***
Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA)., Sanford Burnham Prebys Graduate School of Biomedical Sciences, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA)., Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, CA, 92521 (USA)., Institute of Biostructures & Bioimaging, National Research Council (IBB-CNR), Via De Amicis 95, Naples, 80145 (Italy)., Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA). maurizio.pellecchia@ucr.edu., Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, CA, 92521 (USA). maurizio.pellecchia@ucr.edu.,
1. Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA
References:
Baell, J.B., Holloway, G.A., (2010) J. Med. Chem., 53, pp. 2719-274
Baell, J., Walters, M.A., (2014) Nature, 513, pp. 481-483
Erlanson, D.A., McDowell, R.S., O'Brien, T., (2004) J. Med. Chem., 47, pp. 3463-3482
Alex, A.A., Flocco, M.M., (2007) Curr. Top. Med. Chem., 7, pp. 1544-1567
Michnick, S.W., Ear, P.H., Manderson, E.N., Remy, I., Stefan, E., (2007) Nat. Rev. Drug Discovery, 6, pp. 569-582
Congreve, M., Chessari, G., Tisi, D., Woodhead, A.J., (2008) J. Med. Chem., 51, pp. 3661-3680
Erlanson, D.A., (2011) Top. Curr. Chem., 317, pp. 1-32
Wyss, D.F., Wang, Y.S., Eaton, H.L., Strickland, C., Voigt, J.H., Zhu, Z., Stamford, A.W., (2011) Top. Curr. Chem., 317, pp. 83-114
Harner, M.J., Frank, A.O., Fesik, S.W., (2013) J. Biomol. NMR, 56, pp. 65-75
Wang, T., Wu, M.B., Chen, Z.J., Chen, H., Lin, J.P., Yang, L.R., (2015) Curr. Pharm. Biotechnol., 16, pp. 11-25
Bauman, J.D., Patel, D., Arnold, E., (2011) Top. Curr. Chem., 317, pp. 181-200
Visegrády, A., Keseru, G.M., (2013) Expert Opin. Drug Discovery, 8, pp. 811-820
Barile, E., Pellecchia, M., (2014) Chem. Rev., 114, pp. 4749-4763
Pellecchia, M., Bertini, I., Cowburn, D., Dalvit, C., Giralt, E., Jahnke, W., James, T.L., Siegal, G., (2008) Nat. Rev. Drug Discovery, 7, pp. 738-745
Pellecchia, M., (2005) Chem. Biol., 12, pp. 961-971
Pellecchia, M., Becattini, B., Crowell, K.J., Fattorusso, R., Forino, M., Fragai, M., Jung, D., Tautz, L., (2004) Expert Opin. Ther. Targets, 8, pp. 597-611
Wu, B., Barile, E., De, S.K., Wei, J., Purves, A., Pellecchia, M., (2015) Curr. Top. Med. Chem., 15, pp. 2032-2042
Pellecchia, M., Sem, D.S., Wuthrich, K., (2002) Nat. Rev. Drug Discovery, 1, pp. 211-219
Wu, B., Zhang, Z., Noberini, R., Barile, E., Giulianotti, M., Pinilla, C., Houghten, R.A., Pellecchia, M., (2013) Chem. Biol., 20, pp. 19-33
Pinilla, C., Appel, J.R., Blanc, P., Houghten, R.A., (1992) Biotechniques, 13, pp. 901-905
Dooley, C.T., Houghten, R.A., (1993) Life Sci., 52, pp. 1509-1517
Cornelis, G.R., (2002) Nat. Rev. Mol. Cell Biol., 3, pp. 742-752
Bliska, J.B., Guan, K.L., Dixon, J.E., Falkow, S., (1991) Proc. Natl. Acad. Sci. USA, 88, pp. 1187-1191
Viboud, G.I., Bliska, J.B., (2005) Annu. Rev. Microbiol., 59, pp. 69-89
Fällman, M., Andersson, K., Häkansson, S., Magnusson, K.E., Stendahl, O., Wolf-Watz, H., (1995) Infect. Immun., 63, pp. 3117-3124
Khandelwal, P., Keliikuli, K., Smith, C.L., Saper, M.A., Zuiderweg, E.R., (2002) Biochemistry, 41, pp. 11425-11437
Sory, M.P., Boland, A., Lambermont, I., Cornelis, G.R., (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 11998-12002
Black, D.S., Montagna, L.G., Zitsmann, S., Bliska, J.B., (1998) Mol. Microbiol., 29, pp. 1263-1274
Alonso, A., Bottini, N., Bruckner, S., Rahmouni, S., Williams, S., Schoenberger, S.P., Mustelin, T., (2004) J. Biol. Chem., 279, pp. 4922-4928
Salmond, R.J., Filby, A., Qureshi, I., Caserta, S., Zamoyska, R., (2009) Immunol. Rev., 228, pp. 9-22
Black, D.S., Marie-Cardine, A., Schraven, B., Bliska, J.B., (2000) Cell. Microbiol., 2, pp. 401-414
Marie-Cardine, A., Verhagen, A.M., Eckerskorn, C., Schraven, B., (1998) FEBS Lett., 435, pp. 55-60
Leone, M., Barile, E., Dahl, R., Pellecchia, M., (2011) Chem. Biol. Drug Des., 77, pp. 12-19
Bruckner, S., Rhamouni, S., Tautz, L., Denault, J.B., Alonso, A., Becattini, B., Salvesen, G.S., Mustelin, T., (2005) J. Biol. Chem., 280, pp. 10388-10394
Tautz, L., Pellecchia, M., Mustelin, T., (2006) Expert Opin. Ther. Targets, 10, pp. 157-177
Stanford, S.M., Krishnamurthy, D., Falk, M.D., Messina, R., Debnath, B., Li, S., Liu, T., Bottini, N., (2011) J. Med. Chem., 54, pp. 1640-1654
McCain, D.F., Wu, L., Nickel, P., Kassack, M.U., Kreimeyer, A., Gagliardi, A., Collins, D.C., Zhang, Z.Y., (2004) J. Biol. Chem., 279, pp. 14713-14725
Tautz, L., Bruckner, S., Sareth, S., Alonso, A., Bogetz, J., Bottini, N., Pellecchia, M., Mustelin, T., (2005) J. Biol. Chem., 280, pp. 9400-9408
Vazquez, J., Tautz, L., Ryan, J.J., Vuori, K., Mustelin, T., Pellecchia, M., (2007) J. Med. Chem., 50, pp. 2137-2143
Wiesmann, C., Barr, K.J., Kung, J., Zhu, J., Erlanson, D.A., Shen, W., Fahr, B.J., Hansen, S.K., (2004) Nat. Struct. Mol. Biol., 11, pp. 730-737
Krueger, A.B., Drasin, D.J., Lea, W.A., Patrick, A.N., Patnaik, S., Backos, D.S., Matheson, C.J., Zhao, R., (2014) J. Biol. Chem., 289, pp. 16349-16361
Farmer, B.T., II, Constantine, K.L., Goldfarb, V., Friedrichs, M.S., Wittekind, M., Yanchunas, J., Jr., Robertson, J.G., Mueller, L., (1996) Nat. Struct. Biol., 3, pp. 995-997
Smet, C., Duckert, J.F., Wieruszeski, J.M., Landrieu, I., Buee, L., Lippens, G., Deprez, B., (2005) J. Med. Chem., 48, pp. 4815-4823
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7179linking), 2015 Nov 23; 11(8): 919-927.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.98, 5-year impact factor: 2.89
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84947975839&partnerID=40&md5=78126086aa258a05b61383e25ec43aae
Keywords: Nmr Spectroscopy, Yoph, Combinatorial Libraries, High-Throughput Screening (hts), Peptides, Protein-Protein Interactions,
Affiliations:
*** IBB - CNR ***
Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA)., Sanford Burnham Prebys Graduate School of Biomedical Sciences, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA)., Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, CA, 92521 (USA)., Institute of Biostructures & Bioimaging, National Research Council (IBB-CNR), Via De Amicis 95, Naples, 80145 (Italy)., Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA). maurizio.pellecchia@ucr.edu., Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, CA, 92521 (USA). maurizio.pellecchia@ucr.edu.,
1. Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037 (USA
References:
Baell, J.B., Holloway, G.A., (2010) J. Med. Chem., 53, pp. 2719-274
Baell, J., Walters, M.A., (2014) Nature, 513, pp. 481-483
Erlanson, D.A., McDowell, R.S., O'Brien, T., (2004) J. Med. Chem., 47, pp. 3463-3482
Alex, A.A., Flocco, M.M., (2007) Curr. Top. Med. Chem., 7, pp. 1544-1567
Michnick, S.W., Ear, P.H., Manderson, E.N., Remy, I., Stefan, E., (2007) Nat. Rev. Drug Discovery, 6, pp. 569-582
Congreve, M., Chessari, G., Tisi, D., Woodhead, A.J., (2008) J. Med. Chem., 51, pp. 3661-3680
Erlanson, D.A., (2011) Top. Curr. Chem., 317, pp. 1-32
Wyss, D.F., Wang, Y.S., Eaton, H.L., Strickland, C., Voigt, J.H., Zhu, Z., Stamford, A.W., (2011) Top. Curr. Chem., 317, pp. 83-114
Harner, M.J., Frank, A.O., Fesik, S.W., (2013) J. Biomol. NMR, 56, pp. 65-75
Wang, T., Wu, M.B., Chen, Z.J., Chen, H., Lin, J.P., Yang, L.R., (2015) Curr. Pharm. Biotechnol., 16, pp. 11-25
Bauman, J.D., Patel, D., Arnold, E., (2011) Top. Curr. Chem., 317, pp. 181-200
Visegrády, A., Keseru, G.M., (2013) Expert Opin. Drug Discovery, 8, pp. 811-820
Barile, E., Pellecchia, M., (2014) Chem. Rev., 114, pp. 4749-4763
Pellecchia, M., Bertini, I., Cowburn, D., Dalvit, C., Giralt, E., Jahnke, W., James, T.L., Siegal, G., (2008) Nat. Rev. Drug Discovery, 7, pp. 738-745
Pellecchia, M., (2005) Chem. Biol., 12, pp. 961-971
Pellecchia, M., Becattini, B., Crowell, K.J., Fattorusso, R., Forino, M., Fragai, M., Jung, D., Tautz, L., (2004) Expert Opin. Ther. Targets, 8, pp. 597-611
Wu, B., Barile, E., De, S.K., Wei, J., Purves, A., Pellecchia, M., (2015) Curr. Top. Med. Chem., 15, pp. 2032-2042
Pellecchia, M., Sem, D.S., Wuthrich, K., (2002) Nat. Rev. Drug Discovery, 1, pp. 211-219
Wu, B., Zhang, Z., Noberini, R., Barile, E., Giulianotti, M., Pinilla, C., Houghten, R.A., Pellecchia, M., (2013) Chem. Biol., 20, pp. 19-33
Pinilla, C., Appel, J.R., Blanc, P., Houghten, R.A., (1992) Biotechniques, 13, pp. 901-905
Dooley, C.T., Houghten, R.A., (1993) Life Sci., 52, pp. 1509-1517
Cornelis, G.R., (2002) Nat. Rev. Mol. Cell Biol., 3, pp. 742-752
Bliska, J.B., Guan, K.L., Dixon, J.E., Falkow, S., (1991) Proc. Natl. Acad. Sci. USA, 88, pp. 1187-1191
Viboud, G.I., Bliska, J.B., (2005) Annu. Rev. Microbiol., 59, pp. 69-89
Fällman, M., Andersson, K., Häkansson, S., Magnusson, K.E., Stendahl, O., Wolf-Watz, H., (1995) Infect. Immun., 63, pp. 3117-3124
Khandelwal, P., Keliikuli, K., Smith, C.L., Saper, M.A., Zuiderweg, E.R., (2002) Biochemistry, 41, pp. 11425-11437
Sory, M.P., Boland, A., Lambermont, I., Cornelis, G.R., (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 11998-12002
Black, D.S., Montagna, L.G., Zitsmann, S., Bliska, J.B., (1998) Mol. Microbiol., 29, pp. 1263-1274
Alonso, A., Bottini, N., Bruckner, S., Rahmouni, S., Williams, S., Schoenberger, S.P., Mustelin, T., (2004) J. Biol. Chem., 279, pp. 4922-4928
Salmond, R.J., Filby, A., Qureshi, I., Caserta, S., Zamoyska, R., (2009) Immunol. Rev., 228, pp. 9-22
Black, D.S., Marie-Cardine, A., Schraven, B., Bliska, J.B., (2000) Cell. Microbiol., 2, pp. 401-414
Marie-Cardine, A., Verhagen, A.M., Eckerskorn, C., Schraven, B., (1998) FEBS Lett., 435, pp. 55-60
Leone, M., Barile, E., Dahl, R., Pellecchia, M., (2011) Chem. Biol. Drug Des., 77, pp. 12-19
Bruckner, S., Rhamouni, S., Tautz, L., Denault, J.B., Alonso, A., Becattini, B., Salvesen, G.S., Mustelin, T., (2005) J. Biol. Chem., 280, pp. 10388-10394
Tautz, L., Pellecchia, M., Mustelin, T., (2006) Expert Opin. Ther. Targets, 10, pp. 157-177
Stanford, S.M., Krishnamurthy, D., Falk, M.D., Messina, R., Debnath, B., Li, S., Liu, T., Bottini, N., (2011) J. Med. Chem., 54, pp. 1640-1654
McCain, D.F., Wu, L., Nickel, P., Kassack, M.U., Kreimeyer, A., Gagliardi, A., Collins, D.C., Zhang, Z.Y., (2004) J. Biol. Chem., 279, pp. 14713-14725
Tautz, L., Bruckner, S., Sareth, S., Alonso, A., Bogetz, J., Bottini, N., Pellecchia, M., Mustelin, T., (2005) J. Biol. Chem., 280, pp. 9400-9408
Vazquez, J., Tautz, L., Ryan, J.J., Vuori, K., Mustelin, T., Pellecchia, M., (2007) J. Med. Chem., 50, pp. 2137-2143
Wiesmann, C., Barr, K.J., Kung, J., Zhu, J., Erlanson, D.A., Shen, W., Fahr, B.J., Hansen, S.K., (2004) Nat. Struct. Mol. Biol., 11, pp. 730-737
Krueger, A.B., Drasin, D.J., Lea, W.A., Patrick, A.N., Patnaik, S., Backos, D.S., Matheson, C.J., Zhao, R., (2014) J. Biol. Chem., 289, pp. 16349-16361
Farmer, B.T., II, Constantine, K.L., Goldfarb, V., Friedrichs, M.S., Wittekind, M., Yanchunas, J., Jr., Robertson, J.G., Mueller, L., (1996) Nat. Struct. Biol., 3, pp. 995-997
Smet, C., Duckert, J.F., Wieruszeski, J.M., Landrieu, I., Buee, L., Lippens, G., Deprez, B., (2005) J. Med. Chem., 48, pp. 4815-4823
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH
Recently we described a novel approach, named high-throughput screening (HTS) by NMR that allows the identification, from large combinatorial peptide libraries, of potent and selective peptide mimetics against a given target. Here, we deployed the "HTS by NMR" approach for the design of novel peptoid sequences targeting the N-terminal domain of Yersinia outer protein H (YopH-NT), a bacterial toxin essential for the virulence of Yersinia pestis. We aimed at disrupting the protein-protein interactions between YopH-NT and its cellular substrates, with the goal of inhibiting indirectly YopH enzymatic function. These studies resulted in a novel agent of sequence Ac-F-pY-cPG-d-P-NH2 (pY=phosphotyrosine; cPG=cyclopentyl glycine) with a Kd value against YopH-NT of 310 nm. We demonstrated that such a pharmacological inhibitor of YopH-NT results in the inhibition of the dephosphorylation by full-length YopH of a cellular substrate. Hence, potentially this agent represents a valuable stepping stone for the development of novel therapeutics against Yersinia infections. The data reported further demonstrate the utility of the HTS by NMR approach in deriving novel peptide mimetics targeting protein-protein interactions. HTS by NMR: High-throughput screening (HTS) by NMR is used to identify novel agents that can disrupt the protein-protein interactions between the Yersinia toxin YopH-NT and its cellular substrates. A novel agent was identified of the sequence Ac-F-pY-cPG-d-P-NH2 (pY=phosphotyrosine; cPG=cyclopentyl glycine) with a Kd value against YopH-NT of 310 nm. The data reported further demonstrate the utility of the "HTS by NMR" approach in deriving novel peptide mimetics targeting protein-protein interactions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Recently we described a novel approach, named high-throughput screening (HTS) by NMR that allows the identification, from large combinatorial peptide libraries, of potent and selective peptide mimetics against a given target. Here, we deployed the "HTS by NMR" approach for the design of novel peptoid sequences targeting the N-terminal domain of Yersinia outer protein H (YopH-NT), a bacterial toxin essential for the virulence of Yersinia pestis. We aimed at disrupting the protein-protein interactions between YopH-NT and its cellular substrates, with the goal of inhibiting indirectly YopH enzymatic function. These studies resulted in a novel agent of sequence Ac-F-pY-cPG-d-P-NH2 (pY=phosphotyrosine; cPG=cyclopentyl glycine) with a Kd value against YopH-NT of 310 nm. We demonstrated that such a pharmacological inhibitor of YopH-NT results in the inhibition of the dephosphorylation by full-length YopH of a cellular substrate. Hence, potentially this agent represents a valuable stepping stone for the development of novel therapeutics against Yersinia infections. The data reported further demonstrate the utility of the HTS by NMR approach in deriving novel peptide mimetics targeting protein-protein interactions. HTS by NMR: High-throughput screening (HTS) by NMR is used to identify novel agents that can disrupt the protein-protein interactions between the Yersinia toxin YopH-NT and its cellular substrates. A novel agent was identified of the sequence Ac-F-pY-cPG-d-P-NH2 (pY=phosphotyrosine; cPG=cyclopentyl glycine) with a Kd value against YopH-NT of 310 nm. The data reported further demonstrate the utility of the "HTS by NMR" approach in deriving novel peptide mimetics targeting protein-protein interactions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH
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Smaldone G, Diana D, Pollegioni L, Di Gaetano S, Fattorusso R, Pedone E
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Impact Factor: 3.519
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Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
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Impact Factor: 5.771
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
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Impact Factor: 2.85
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (437 views)
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Impact Factor: 3.234
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Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M
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Impact Factor: 3.088
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
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Impact Factor: 4.882
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
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Impact Factor: 3.447
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Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
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Impact Factor: 5.696
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Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
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Impact Factor: 3.191
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
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Impact Factor: 3.06
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (471 views)
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Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
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Impact Factor: 2.92
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
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Impact Factor: 2.87
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
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Impact Factor: 4.859
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
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Impact Factor: 2.282
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
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Impact Factor: 3.022
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
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Impact Factor: 2.733
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Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
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Impact Factor: 3.99
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Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
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Impact Factor: 3.129
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (507 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Abbate M, Casella G, Fiore T, Grasso G, Pellerito C, Scopelliti M, Spinella A, Pellerito L
* Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations (379 views)
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Impact Factor: 2.205
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (420 views)
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Impact Factor: 2.605
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
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Impact Factor: 2.473
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Molecular dynamics studies of the P pilus rod subunit PapA (572 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
Impact Factor: 1.807
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
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Impact Factor: 1.807
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
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Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
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Impact Factor: 2.648
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Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM
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Impact Factor: 1.654
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
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Impact Factor: 5.454
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (480 views)
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Impact Factor: 9.598
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (563 views)
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Impact Factor: 3.446
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
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Impact Factor: 10.031
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (617 views)
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Impact Factor: 4.1
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
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Impact Factor: 10.231
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (437 views)
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Impact Factor: 3.474
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Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (534 views)
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Impact Factor: 4.353
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (376 views)
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Impact Factor: 3.992
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
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Impact Factor: 2.92
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
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Impact Factor: 3.992
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Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (448 views)
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Impact Factor: 4.614
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Zanotti G, Falcigno L, Saviano M, D'Auria G, Bruno BM, Campanile T, Paolillo L
* Solid state and solution conformation of [Ala7]-phalloidin: A synthetic phallotoxin analogue (493 views)
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Impact Factor: 4.614
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Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (491 views)
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Impact Factor: 5.153
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D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (489 views)
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Impact Factor: 4.828
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* NMR spectroscopy in the conformational analysis of peptides: an overview (91 views)
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Impact Factor: 4.184
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Vincenzi M, Mercurio FA, Leone M
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Impact Factor: 4.184
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Tornatore L, Capece D, Sandomenico A, Verzella D, Vecchiotti D, Zazzeroni F, Ruvo M, Franzoso G
* The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-κB Pathway (9 views)
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Impact Factor: 1.17
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Riccardi C, Capasso D, Coppola A, Platella C, Montesarchio D, Di Gaetano S, Roviello GN, Musumeci D
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Impact Factor: 4.421
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Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (266 views)
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Impact Factor: 2.641
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
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Impact Factor: 3.224
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Vincenzi M, Mercurio FA, Leone M
* Sam Domains in Multiple Diseases (237 views)
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Impact Factor: 3.469
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Farina B, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Isernia C, Saviano M, Fattorusso R, Zaccaro L, Russo L
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Impact Factor: 1.807
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Grage SL, Kara S, Bordessa A, Doan V, Rizzolo F, Putzu M, Kubar T, Papini AM, Chaume G, Brigaud T, Afonin S, Ulrich AS
* Orthogonal (19) F-Labeling for Solid-State NMR Spectroscopy Reveals the Conformation and Orientation of Short Peptaibols in Membranes (347 views)
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Impact Factor: 5.476
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
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Impact Factor: 5.16
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
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Impact Factor: 2.881
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Cavallari E, Carrera C, Aime S, Reineri F
* (13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro (252 views)
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Impact Factor: 5.16
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Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E
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Impact Factor: 5.317
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Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
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Impact Factor: 3.112
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (442 views)
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Impact Factor: 5.317
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Farina B, De Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R
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Impact Factor: 5.317
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Smaldone G, Diana D, Pollegioni L, Di Gaetano S, Fattorusso R, Pedone E
* Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes (436 views)
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Impact Factor: 3.519
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Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (445 views)
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Impact Factor: 5.771
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
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Impact Factor: 2.85
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (437 views)
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Impact Factor: 3.234
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Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M
* Conformational features of human melanin-concentrating hormone: an NMR and computational analysis (457 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2014 Sep 17; 4(1): 73-81.
Impact Factor: 3.088
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (371 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (389 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
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Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (471 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(8): 1572-1580.
Impact Factor: 3.191
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (838 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (471 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (504 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 May; 77(5): 319-327.
Impact Factor: 2.282
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (568 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
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Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (489 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
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Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (720 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (507 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Abbate M, Casella G, Fiore T, Grasso G, Pellerito C, Scopelliti M, Spinella A, Pellerito L
* Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations (379 views)
J Organomet Chem (ISSN: 0022-328x), 2010 May 1; 695(9): 1405-1413.
Impact Factor: 2.205
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (420 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (607 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Molecular dynamics studies of the P pilus rod subunit PapA (572 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
Impact Factor: 1.807
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (481 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (395 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Conformational states and association mechanism of Yersinia pestis Caf1 subunits (324 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2008 Sep 8; 372(4): 804-810.
Impact Factor: 2.648
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Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM
* Peptide antagonists of protein-protein interactions identified by screening protein fragments derived by enzyme degradation (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (480 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (563 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (437 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
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Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (534 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
Impact Factor: 4.353
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (376 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Sep 4; 4(8): 727-733.
Impact Factor: 3.992
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Aug 4; 4(8): 727-733.
Impact Factor: 2.92
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (430 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (448 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001 Mar 16; 7(6): 1176-1183.
Impact Factor: 4.614
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Zanotti G, Falcigno L, Saviano M, D'Auria G, Bruno BM, Campanile T, Paolillo L
* Solid state and solution conformation of [Ala7]-phalloidin: A synthetic phallotoxin analogue (493 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001; 7(7): 1479-1485.
Impact Factor: 4.614
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Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (491 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1998; 4(9): 1791-1798.
Impact Factor: 5.153
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D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 350-362.
Impact Factor: 4.828
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59 Records (57 excluding Abstracts).
Total impact factor: 234.783 (229.895 excluding Abstracts).
Total 5 year impact factor: 244.826 (239.342 excluding Abstracts).
Total impact factor: 234.783 (229.895 excluding Abstracts).
Total 5 year impact factor: 244.826 (239.342 excluding Abstracts).
422 views. Last view on Friday 24 February 2023, 14:27:59
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