Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study
Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study(453 views) Coppo C, Bonfanti D, Bo S, Giordanino C, Gallo M, Cococcia S, Ciccone G, Smedile A, Ciancio A, Bugianesi E, Fagoonee S, Pellicano R, Rizzetto M, Saracco GM
Gastroenterology Unit, Department of Oncology, University of Turin, Turin, Italy
Department of Medical Sciences, University of Turin, Turin, Italy
Unit of Cancer Epidemiology, University of Turin, Molinette Hospital and CPO Piemonte, Turin, Italy
Gastro-Hepatology Unit, Department of Medical Sciences, University of Turin, Turin, Italy
Institute for Biostructures and Bioimages (CNR), Molecular Biotechnology Center, University of Turin, Italy
References: Not available.
Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study
BACKGROUND:
Patients
with chronic hepatitis C have an increased risk of diabetes mellitus
but the type and risk of developing diabetes-related complications have
not yet been evaluated.
METHODS:
In
order to compare the incidence of diabetic microangiopathy in patients
with new onset diabetes without microangiopathy we recruited 54
hepatitis C virus (HCV)-positive and 119 HCV-negative patients from
January 2005 to December 2006. All patients were followed-up every 6
months for liver and diabetic complications and incidence of
cardiovascular diseases up to December 2012 when data were
retrospectively analyzed.
RESULTS:
The
two cohorts were comparable at enrolment except for mean body mass
index, obesity rate and family history of diabetes (p=0.007). After 7.2
years of follow-up, 13 HCV-positive (24.1%) and 37 HCV-negative patients
(31%) showed at least one microangiopathic complication (p=0.34); 5
HCV-positive (9.3%) and 13 HCV-negative patients (10.8%) reported
cardiovascular diseases (p=0.2); 14 HCV-positive (24.5%) compared to 0
HCV-negative patients developed liver-related complications (p=0.0003).
One HCV-positive patient died due to liver cancer, 1 HCV-negative
patient died from myocardial infarction (p=0.3). Increasing age
(HR=1.04, 95% CI: 1.00-1.07, p=0.04) and smoking (HR=2.94, 95% CI:
1.06-8.17, p=0.04) were positively associated to diabetic complications.
CONCLUSIONS:
Incidence of microangiopathy is not significantly different in diabetics with or without chronic hepatitis C.
Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study
Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study