Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (918 views) (PDF restricted 308 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
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Paper type: Journal Article,
Impact factor: 7.277, 5-year impact factor: 6.218
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84955614300&partnerID=40&md5=2184058c348d2cba42ba2dd9fb3b1a01
Keywords: 18f-Dpa-714, Sod1g93a, Tspo, Mice, Pet Ct, Carrier Protein, N Diethyl 2 [2 (4 (2fluoroethoxy)phenyl) 5, 7 Dimethylpyrazolo[1, 5 A]pyrimidin 3 Yl]acetamide F 18, Tracer, Translocator Protein 18, Unclassified Drug, 4 Aminobutyric Acid Receptor, Bzrp Protein, Mouse, N-Diethyl-2-(2-(4-(2-Fluoroethoxy)phenyl)-5, 7-Dimethylpyrazolo(1, 5-A)pyrimidin-3-Yl)acetamide, Pyrazole Derivative, Pyrimidine Derivative, Amyotrophic Lateral Sclerosis, Animal Care, Animal Experiment, Animal Model, Article, Association Cortex, Body Constitution, Body Weight, Brain Stem, Cervical Spinal Cord, Computer Assisted Emission Tomography, Controlled Study, Frontal Cortex, Histocompatibility Complex, Immunofluorescence, Immunohistochemistry, Motor Cortex, Neuroimaging, Nonhuman, Protein Expression, Diagnostic Imaging, Disease Model, Gene Expression Regulation, Metabolism, Positron Emission Tomography-Computed Tomography, Transport At The Cellular Level, Biological Transport, Positron Emission Tomography Computed Tomography, Gaba, Amyotrophic Lateral Sclerosis Diagnostic Imaging Metabolism , Brain Diagnostic Imaging Metabolism , Pyrazoles Metabolism , Pyrimidines Metabolism , Gaba Metabolism,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy., Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy., IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy., Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., CEA, Institute for Biomedical Imaging, 4 Place du General Leclerc, 91401, Orsay, France., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy. sabina.pappata@ibb.cnr.it.,
Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy.
IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy.
Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
CEA, Institute for Biomedical Imaging, 4 Place du Général Leclerc, 91401, Orsay, France.
References:
Not available.
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.277, 5-year impact factor: 6.218
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84955614300&partnerID=40&md5=2184058c348d2cba42ba2dd9fb3b1a01
Keywords: 18f-Dpa-714, Sod1g93a, Tspo, Mice, Pet Ct, Carrier Protein, N Diethyl 2 [2 (4 (2fluoroethoxy)phenyl) 5, 7 Dimethylpyrazolo[1, 5 A]pyrimidin 3 Yl]acetamide F 18, Tracer, Translocator Protein 18, Unclassified Drug, 4 Aminobutyric Acid Receptor, Bzrp Protein, Mouse, N-Diethyl-2-(2-(4-(2-Fluoroethoxy)phenyl)-5, 7-Dimethylpyrazolo(1, 5-A)pyrimidin-3-Yl)acetamide, Pyrazole Derivative, Pyrimidine Derivative, Amyotrophic Lateral Sclerosis, Animal Care, Animal Experiment, Animal Model, Article, Association Cortex, Body Constitution, Body Weight, Brain Stem, Cervical Spinal Cord, Computer Assisted Emission Tomography, Controlled Study, Frontal Cortex, Histocompatibility Complex, Immunofluorescence, Immunohistochemistry, Motor Cortex, Neuroimaging, Nonhuman, Protein Expression, Diagnostic Imaging, Disease Model, Gene Expression Regulation, Metabolism, Positron Emission Tomography-Computed Tomography, Transport At The Cellular Level, Biological Transport, Positron Emission Tomography Computed Tomography, Gaba, Amyotrophic Lateral Sclerosis Diagnostic Imaging Metabolism , Brain Diagnostic Imaging Metabolism , Pyrazoles Metabolism , Pyrimidines Metabolism , Gaba Metabolism,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy., Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy., IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy., Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., CEA, Institute for Biomedical Imaging, 4 Place du General Leclerc, 91401, Orsay, France., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy. sabina.pappata@ibb.cnr.it.,
Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy.
IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy.
Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
CEA, Institute for Biomedical Imaging, 4 Place du Général Leclerc, 91401, Orsay, France.
References:
Not available.
Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT
Purpose: To evaluate the feasibility and sensitivity of 18F-DPA-714 for the study of microglial activation in the brain and spinal cord of transgenic SOD1G93A mice using high-resolution PET/CT and to evaluate the Iba1 and TSPO expression with immunohistochemistry. Methods: Nine symptomatic SOD1G93A mice (aged 117 ± 12.7 days, clinical score range 1 – 4) and five WT SOD1 control mice (aged 108 ± 28.5 days) underwent 18F-DPA-714 PET/CT. SUV ratios were calculated by normalizing the cerebellar (rCRB), brainstem (rBS), motor cortex (rMCX) and cervical spinal cord (rCSC) activities to that of the frontal association cortex. Two WT SOD1 and six symptomatic SOD1G93A mice were studied by immunohistochemistry. Results: In the symptomatic SOD1G93A mice, rCRB, rBS and rCSC were increased as compared to the values in WT SOD1 mice, with a statistically significantly difference in rBS (2.340 ± 0.784 vs 1.576 ± 0.287, p = 0.014). Immunofluorescence studies showed that TSPO expression was increased in the trigeminal, facial, ambiguus and hypoglossal nuclei, as well as in the spinal cord, of symptomatic SOD1G93A mice and was colocalized with increased Iba1 staining. Conclusion: Increased 18F-DPA-714 uptake can be detected with high-resolution PET/CT in the brainstem of transgenic SOD1G93A mice, a region known to be a site of degeneration and increased microglial activation in amyotrophic lateral sclerosis, in agreement with increased TSPO expression in the brainstem nuclei shown by immunostaining. Therefore, 18F-DPA-714 PET/CT might be a suitable tool to evaluate microglial activation in the SOD1G93A mouse model. © 2016, Springer-Verlag Berlin Heidelberg.
Purpose: To evaluate the feasibility and sensitivity of 18F-DPA-714 for the study of microglial activation in the brain and spinal cord of transgenic SOD1G93A mice using high-resolution PET/CT and to evaluate the Iba1 and TSPO expression with immunohistochemistry. Methods: Nine symptomatic SOD1G93A mice (aged 117 ± 12.7 days, clinical score range 1 – 4) and five WT SOD1 control mice (aged 108 ± 28.5 days) underwent 18F-DPA-714 PET/CT. SUV ratios were calculated by normalizing the cerebellar (rCRB), brainstem (rBS), motor cortex (rMCX) and cervical spinal cord (rCSC) activities to that of the frontal association cortex. Two WT SOD1 and six symptomatic SOD1G93A mice were studied by immunohistochemistry. Results: In the symptomatic SOD1G93A mice, rCRB, rBS and rCSC were increased as compared to the values in WT SOD1 mice, with a statistically significantly difference in rBS (2.340 ± 0.784 vs 1.576 ± 0.287, p = 0.014). Immunofluorescence studies showed that TSPO expression was increased in the trigeminal, facial, ambiguus and hypoglossal nuclei, as well as in the spinal cord, of symptomatic SOD1G93A mice and was colocalized with increased Iba1 staining. Conclusion: Increased 18F-DPA-714 uptake can be detected with high-resolution PET/CT in the brainstem of transgenic SOD1G93A mice, a region known to be a site of degeneration and increased microglial activation in amyotrophic lateral sclerosis, in agreement with increased TSPO expression in the brainstem nuclei shown by immunostaining. Therefore, 18F-DPA-714 PET/CT might be a suitable tool to evaluate microglial activation in the SOD1G93A mouse model. © 2016, Springer-Verlag Berlin Heidelberg.
Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT
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Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT
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Impact Factor: 2.429
View Export to BibTeX Export to EndNote
Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
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Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (539 views)
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Impact Factor: 0.506
View Export to BibTeX Export to EndNote
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Impact Factor: 9.898
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 8.066
View Export to BibTeX Export to EndNote
Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
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Impact Factor: 5.359
View Export to BibTeX Export to EndNote
Berisio R, Vitagliano L, Mazzarella L, Zagari A
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Impact Factor: 2.405
View Export to BibTeX Export to EndNote
Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
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Impact Factor: 3.491
View Export to BibTeX Export to EndNote
Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
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Impact Factor: 2.425
View Export to BibTeX Export to EndNote
17 Records (16 excluding Abstracts).
Total impact factor: 72.329 (67.251 excluding Abstracts).
Total 5 year impact factor: 73.201 (68.123 excluding Abstracts).
Total impact factor: 72.329 (67.251 excluding Abstracts).
Total 5 year impact factor: 73.201 (68.123 excluding Abstracts).
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