Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (823 views) (PDF restricted 302 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.277, 5-year impact factor: 6.218
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84955614300&partnerID=40&md5=2184058c348d2cba42ba2dd9fb3b1a01
Keywords: 18f-Dpa-714, Sod1g93a, Tspo, Mice, Pet Ct, Carrier Protein, N Diethyl 2 [2 (4 (2fluoroethoxy)phenyl) 5, 7 Dimethylpyrazolo[1, 5 A]pyrimidin 3 Yl]acetamide F 18, Tracer, Translocator Protein 18, Unclassified Drug, 4 Aminobutyric Acid Receptor, Bzrp Protein, Mouse, N-Diethyl-2-(2-(4-(2-Fluoroethoxy)phenyl)-5, 7-Dimethylpyrazolo(1, 5-A)pyrimidin-3-Yl)acetamide, Pyrazole Derivative, Pyrimidine Derivative, Amyotrophic Lateral Sclerosis, Animal Care, Animal Experiment, Animal Model, Article, Association Cortex, Body Constitution, Body Weight, Brain Stem, Cervical Spinal Cord, Computer Assisted Emission Tomography, Controlled Study, Frontal Cortex, Histocompatibility Complex, Immunofluorescence, Immunohistochemistry, Motor Cortex, Neuroimaging, Nonhuman, Protein Expression, Diagnostic Imaging, Disease Model, Gene Expression Regulation, Metabolism, Positron Emission Tomography-Computed Tomography, Transport At The Cellular Level, Biological Transport, Positron Emission Tomography Computed Tomography, Gaba, Amyotrophic Lateral Sclerosis Diagnostic Imaging Metabolism , Brain Diagnostic Imaging Metabolism , Pyrazoles Metabolism , Pyrimidines Metabolism , Gaba Metabolism,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy., Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy., IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy., Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., CEA, Institute for Biomedical Imaging, 4 Place du General Leclerc, 91401, Orsay, France., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy. sabina.pappata@ibb.cnr.it.,
Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy.
IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy.
Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
CEA, Institute for Biomedical Imaging, 4 Place du Général Leclerc, 91401, Orsay, France.
References:
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.277, 5-year impact factor: 6.218
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84955614300&partnerID=40&md5=2184058c348d2cba42ba2dd9fb3b1a01
Keywords: 18f-Dpa-714, Sod1g93a, Tspo, Mice, Pet Ct, Carrier Protein, N Diethyl 2 [2 (4 (2fluoroethoxy)phenyl) 5, 7 Dimethylpyrazolo[1, 5 A]pyrimidin 3 Yl]acetamide F 18, Tracer, Translocator Protein 18, Unclassified Drug, 4 Aminobutyric Acid Receptor, Bzrp Protein, Mouse, N-Diethyl-2-(2-(4-(2-Fluoroethoxy)phenyl)-5, 7-Dimethylpyrazolo(1, 5-A)pyrimidin-3-Yl)acetamide, Pyrazole Derivative, Pyrimidine Derivative, Amyotrophic Lateral Sclerosis, Animal Care, Animal Experiment, Animal Model, Article, Association Cortex, Body Constitution, Body Weight, Brain Stem, Cervical Spinal Cord, Computer Assisted Emission Tomography, Controlled Study, Frontal Cortex, Histocompatibility Complex, Immunofluorescence, Immunohistochemistry, Motor Cortex, Neuroimaging, Nonhuman, Protein Expression, Diagnostic Imaging, Disease Model, Gene Expression Regulation, Metabolism, Positron Emission Tomography-Computed Tomography, Transport At The Cellular Level, Biological Transport, Positron Emission Tomography Computed Tomography, Gaba, Amyotrophic Lateral Sclerosis Diagnostic Imaging Metabolism , Brain Diagnostic Imaging Metabolism , Pyrazoles Metabolism , Pyrimidines Metabolism , Gaba Metabolism,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy., Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy., IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy., Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy., CEA, Institute for Biomedical Imaging, 4 Place du General Leclerc, 91401, Orsay, France., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy. sabina.pappata@ibb.cnr.it.,
Ceinge Biotecnologie Avanzate s. c. a r. l., Via G. Salvatore 486, 80145, Naples, Italy.
IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy.
Department of Advanced Biomedical Sciences, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, University "Federico II", Via S. Pansini 5, 80131, Naples, Italy.
CEA, Institute for Biomedical Imaging, 4 Place du Général Leclerc, 91401, Orsay, France.
References:
Ferraiuolo, L., Kirby, J., Grierson, A.J., Sendtner, M., Shaw, P.J., Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis (2011) Nat Rev Neurol, 7, pp. 616-630. , COI: 1:CAS:528:DC%2BC3MXhsVahur3O, PID: 2205191
Cleveland, D.W., Rothstein, J.D., From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS (2001) Nat Rev Neurosci, 2, pp. 806-819. , COI: 1:CAS:528:DC%2BD38Xmt1WitLs%3D, PID: 11715057
Van Damme, P., Robberecht, W., Recent advances in motor neuron disease (2009) Curr Opin Neurol, 22, pp. 486-492. , PID: 19593125
Kiernan, M.C., Vucic, S., Cheah, B.C., Turner, M.R., Eisen, A., Hardiman, O., Amyotrophic lateral sclerosis (2011) Lancet, 377, pp. 942-955. , COI: 1:CAS:528:DC%2BC3MXjtFWgsL8%3D, PID: 21296405
McGeer, P.L., McGeer, E.G., Inflammatory processes in amyotrophic lateral sclerosis (2002) Muscle Nerve, 26, pp. 459-470. , COI: 1:CAS:528:DC%2BD38Xot1Ggs7Y%3D, PID: 12362410
Appel, S.H., Zhao, W., Beers, D.R., Henkel, J.S., The microglial–motoneuron dialogue in ALS (2011) Acta Myol, 30, pp. 4-8. , COI: 1:CAS:528:DC%2BC3MXhtFCqsLnN, PID: 21842586
Philips, T., Robberecht, W., Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease (2011) Lancet Neurol, 10, pp. 253-263. , COI: 1:CAS:528:DC%2BC3MXit1Wktr8%3D, PID: 21349440
Brettschneider, J., Toledo, J.B., Van Deerlin, V.M., Elman, L., McCluskey, L., Lee, V.M., Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis (2012) PLoS One, 7, p. e39216. , COI: 1:CAS:528:DC%2BC38XptVOjsL0%3D, PID: 22720079
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Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT
Purpose: To evaluate the feasibility and sensitivity of 18F-DPA-714 for the study of microglial activation in the brain and spinal cord of transgenic SOD1G93A mice using high-resolution PET/CT and to evaluate the Iba1 and TSPO expression with immunohistochemistry. Methods: Nine symptomatic SOD1G93A mice (aged 117 ± 12.7 days, clinical score range 1 – 4) and five WT SOD1 control mice (aged 108 ± 28.5 days) underwent 18F-DPA-714 PET/CT. SUV ratios were calculated by normalizing the cerebellar (rCRB), brainstem (rBS), motor cortex (rMCX) and cervical spinal cord (rCSC) activities to that of the frontal association cortex. Two WT SOD1 and six symptomatic SOD1G93A mice were studied by immunohistochemistry. Results: In the symptomatic SOD1G93A mice, rCRB, rBS and rCSC were increased as compared to the values in WT SOD1 mice, with a statistically significantly difference in rBS (2.340 ± 0.784 vs 1.576 ± 0.287, p = 0.014). Immunofluorescence studies showed that TSPO expression was increased in the trigeminal, facial, ambiguus and hypoglossal nuclei, as well as in the spinal cord, of symptomatic SOD1G93A mice and was colocalized with increased Iba1 staining. Conclusion: Increased 18F-DPA-714 uptake can be detected with high-resolution PET/CT in the brainstem of transgenic SOD1G93A mice, a region known to be a site of degeneration and increased microglial activation in amyotrophic lateral sclerosis, in agreement with increased TSPO expression in the brainstem nuclei shown by immunostaining. Therefore, 18F-DPA-714 PET/CT might be a suitable tool to evaluate microglial activation in the SOD1G93A mouse model. © 2016, Springer-Verlag Berlin Heidelberg.
Purpose: To evaluate the feasibility and sensitivity of 18F-DPA-714 for the study of microglial activation in the brain and spinal cord of transgenic SOD1G93A mice using high-resolution PET/CT and to evaluate the Iba1 and TSPO expression with immunohistochemistry. Methods: Nine symptomatic SOD1G93A mice (aged 117 ± 12.7 days, clinical score range 1 – 4) and five WT SOD1 control mice (aged 108 ± 28.5 days) underwent 18F-DPA-714 PET/CT. SUV ratios were calculated by normalizing the cerebellar (rCRB), brainstem (rBS), motor cortex (rMCX) and cervical spinal cord (rCSC) activities to that of the frontal association cortex. Two WT SOD1 and six symptomatic SOD1G93A mice were studied by immunohistochemistry. Results: In the symptomatic SOD1G93A mice, rCRB, rBS and rCSC were increased as compared to the values in WT SOD1 mice, with a statistically significantly difference in rBS (2.340 ± 0.784 vs 1.576 ± 0.287, p = 0.014). Immunofluorescence studies showed that TSPO expression was increased in the trigeminal, facial, ambiguus and hypoglossal nuclei, as well as in the spinal cord, of symptomatic SOD1G93A mice and was colocalized with increased Iba1 staining. Conclusion: Increased 18F-DPA-714 uptake can be detected with high-resolution PET/CT in the brainstem of transgenic SOD1G93A mice, a region known to be a site of degeneration and increased microglial activation in amyotrophic lateral sclerosis, in agreement with increased TSPO expression in the brainstem nuclei shown by immunostaining. Therefore, 18F-DPA-714 PET/CT might be a suitable tool to evaluate microglial activation in the SOD1G93A mouse model. © 2016, Springer-Verlag Berlin Heidelberg.
Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT
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Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT
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Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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* Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection (213 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2018 Nov; 119: 758-769.
Impact Factor: 3.909
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Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (358 views)
Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
Impact Factor: 2.999
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Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (306 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
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Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (732 views) (PDF 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Impact Factor: 2.429
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Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (437 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
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Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
* Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (507 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013 Mar 1; 3: 1351-1351.
Impact Factor: 5.078
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Bartolucci S, Contursi P, Fiorentino G, Limauro D, Pedone E
* Responding to toxic compounds: a genomic and functional overview of Archaea (701 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2013 Jan 1; 18: 165-189.
Impact Factor: 4.249
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (445 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (401 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Nov 1; 67(11): 1462-1465.
Impact Factor: 0.506
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
* Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ (451 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2011 Jun 16; 117(24): 6520-6531.
Impact Factor: 9.898
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (583 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (438 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (381 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (590 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
Crystal Structure Of A Collagen-Like Polypeptide With Repeating Sequence Pro-Hyp-Gly At 1. 4 Ang Resolution: Implications For Collagen Hydration (436 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 8-13.
Impact Factor: 2.405
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (450 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (483 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
17 Records (16 excluding Abstracts).
Total impact factor: 72.329 (67.251 excluding Abstracts).
Total 5 year impact factor: 73.201 (68.123 excluding Abstracts).
Total impact factor: 72.329 (67.251 excluding Abstracts).
Total 5 year impact factor: 73.201 (68.123 excluding Abstracts).
823 views. Last view on Friday 17 March 2023, 3:23:55
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