Cationic porphyrins are tunable gatekeepers of the 20S proteasome
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Cationic porphyrins are tunable gatekeepers of the 20S proteasome (679 views) (PDF restricted 233 views)

Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R

Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.

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Paper type: Journal Article,

Impact factor: 8.668, 5-year impact factor: 8.733

Url: http://dx.doi.org/10.1039/C5SC03312H

Keywords: Aromatic Compounds, Binding Energy, Bioinformatics, Enzyme Kinetics, Isomers, Porphyrins, Reconfigurable Hardware, Aromatic Residues, Bioinformatic Analysis, Catalytic Chambers, Cationic Porphyrin, Gating Mechanisms, Ligand Interactions, Negatively Charged, Regulatory Mechanism, Enzyme Inhibition,

Affiliations:
*** IBB - CNR ***

Istituto di Biostrutture e Bioimmagini – CNR UOS di Catania, Via P. Gaifami 18, 95126 Catania, Italy.
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Dipartimento di Farmacia Università di Napoli “Federico II”, Via D. Montesano, 49 I-80131 Napoli, Italy.


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    Cationic porphyrins are tunable gatekeepers of the 20S proteasome

    The 20S proteasome is a barrel-shaped enzymatic assembly playing a critical role in proteome maintenance. Access of proteasome substrates to the catalytic chamber is finely regulated through gating mechanisms which involve aromatic and negatively charged residues located at the N-terminal tails of α subunits. However, despite the importance of gates in regulating proteasome function, up to now very few molecules have been shown to interfere with the equilibrium by which the catalytic channel exchanges between the open and closed states. In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine experimental (enzyme kinetics, UV stopped flow and NMR) and computational (bioinformatic analysis and docking studies) approaches to inspect proteasome inhibition by meso-tetrakis(4-N-methylpyridyl)-porphyrin (H2T4) and its two ortho- and meta-isomers. We show that in a first, fast binding event H2T4 accommodates in a pocket made of negatively charged and aromatic residues present in α1 (Asp10, Phe9), α3 (Tyr5), α5 (Asp9, Tyr8), α6 (Asp7, Tyr6) and α7 (Asp9, Tyr8) subunits thereby stabilizing the closed conformation. A second, slower binding mode involves interaction with the grooves which separate the α- from the β-rings. Of note, the proteasome inhibition by ortho- and meta-H2T4 decreases significantly if compared to the parent compound, thus underscoring the role played by spatial distribution of the four peripheral positive charges in regulating proteasome–ligand interactions. We think that our results may pave the way to further studies aimed at rationalizing the molecular basis of novel, and more sophisticated, proteasome regulatory mechanisms.
    Cationic porphyrins are tunable gatekeepers of the 20S proteasome

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    ▼    Structural characterization of the porphyrins/proteasome interaction
    Cationic porphyrins are tunable gatekeepers of the 20S proteasome

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    Impact Factor: 2.572
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    Chino M, Leone L, Zambrano G, Pirro F, D'Alonzo D, Firpo V, Aref D, Lista L, Maglio O, Nastri F, Lombardi A
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    Impact Factor: 2.572
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    Fusco FA, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D
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    Impact Factor: 4.784
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    Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
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    Impact Factor: 3.451
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    Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
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    Impact Factor: 5.476
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    Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
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    Impact Factor: 5.16
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    Conti I, Martinez-fernandez L, Esposito L, Hofinger S, Nenov A, Garavelli M, Improta R
    * Multiple Electronic and Structural Factors Control Cyclobutane Pyrimidine Dimer and 6-4 Thymine-Thymine Photodimerization in a DNA Duplex (620 views)
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    Impact Factor: 5.16
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    Pepino AJ, Segarra-marti J, Nenov A, Improta R, Garavelli M
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    Impact Factor: 8.709
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    Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
    * Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (363 views)
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    Impact Factor: 5.16
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    Langella E, D'Ambrosio K, D'Ascenzio M, Carradori S, Monti SM, Supuran CT, De Simone G
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    Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
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    Impact Factor: 3.108
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    Roviello GN, Roviello V, Autiero I, Saviano M
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    Impact Factor: 3.108
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    Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
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    Impact Factor: 3.108
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    Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
    * Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners (418 views)
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    Impact Factor: 8.387
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    Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
    * The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
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    Impact Factor: 2.876
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    Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
    * An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization (447 views)
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    Impact Factor: 3.559
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    Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
    * Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (454 views)
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    Impact Factor: 5.771
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    GrassoG, Satriano C, Milardi D
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    Impact Factor: 2.363
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    Fahleson T, Kauczor J, Norman P, Santoro F, Improta R, Coriani S
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    Impact Factor: 2.883
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    Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
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    Impact Factor: 2.385
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    Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
    * Branched porphyrins as functional scaffolds for multisite bioconjugation (350 views)
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    Impact Factor: 1.362
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    Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
    * Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (468 views)
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    Impact Factor: 2.385
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    Lin L-L, Chen Y-Y, Chi M-C, Merlino A
    * Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (410 views)
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    Impact Factor: 4.882
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    Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
    * Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (404 views)
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    Impact Factor: 3.84
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    Di Natale G, Osz K, Kállay C, Pappalardo G, Sanna D, Impellizzeri G, Sóvágó I, Rizzarelli E
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    Impact Factor: 5.696
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    Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA
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    Impact Factor: 1.646
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    Improta R
    * Photophysics and photochemistry of thymine deoxy-dinucleotide in water: A PCM/TD-DFT quantum mechanical study (305 views)
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    Impact Factor: 3.607
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    Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
    * Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (452 views)
    Chem Rev (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
    Impact Factor: 41.298
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    Ruggiero A, Smaldone G, Squeglia F, Berisio R
    * Enhanced crystallizability by protein engineering approaches: A general overview (2078 views)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Jul; 19(7): 732-742.
    Impact Factor: 1.994
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    Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
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    Impact Factor: 10.677
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    Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M,  Leone M
    * Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (465 views)
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    Impact Factor: 3.377
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    Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
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    Impact Factor: 5.925
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    Tabbì G, Di Mauro G, Purrello R, Bonomo RP
    * Electrochemical characterization of ordered arrays of metallo-porphyrins in aqueous solution (380 views)
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    Impact Factor: 3.838
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    Nastri F, Lista L, Ringhieri P, Vitale R, Faiella M, Andreozzi C, Travascio P, Maglio O, Lombardi A, Pavone V
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    Impact Factor: 5.925
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    La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
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    Impact Factor: 3.647
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    Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
    * Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (562 views)
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    Impact Factor: 2.572
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    Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
    * An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (363 views)
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    Impact Factor: 5.328
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    Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
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    Impact Factor: 3.647
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    La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
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    Impact Factor: 5.476
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    Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
    * Free-Energy Profile for CO Binding to Separated Chains of Human and Trematomus newnesi Hemoglobin: Insights from Molecular Dynamics Simulations and Perturbed Matrix Method (301 views)
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    Impact Factor: 3.603
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    Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
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    Impact Factor: 3.068
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    Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
    * Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
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    Impact Factor: 3.647
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    Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
    * Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (413 views)
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    Impact Factor: 2.605
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    Vitagliano L, Stanzione F, De Simone A, Esposito L
    * Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (549 views)
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    Impact Factor: 2.605
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    Randazzo R, Lauceri R, Mammana A, D'Urso A, Purrello R
    * Interactions of Λ and Δ enantiomers of ruthenium(II) cationic complexes with achiral anionic porphyrins (361 views)
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    Impact Factor: 2.677
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    Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
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    Impact Factor: 5.52
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    Lauceri R, Fasciglione G, D'Urso A, Marini S, Purrello R, Coletta M
    * Kinetic investigation of porphyrin interaction with chiral templates reveals unexpected features of the induction and self-propagation mechanism of chiral memory (405 views)
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    Impact Factor: 8.091
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    Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
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    Impact Factor: 8.091
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    Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
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    Impact Factor: 2.565
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    Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
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    Impact Factor: 3.379
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    Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
    * Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (360 views)
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    Impact Factor: 2.531
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    D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
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    Impact Factor: 2.823
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    Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
    * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (479 views)
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
    Impact Factor: 4.399
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    Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
    * Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (401 views)
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    Impact Factor: 10.879
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    Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
    * Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (303 views)
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    Impact Factor: 2.436
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    Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
    * White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (303 views)
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    Impact Factor: 4.101
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    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (351 views)
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    Impact Factor: 3.664
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    Vitagliano L, Ruggiero A, Pedone C, Berisio R
    * A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (447 views)
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    Impact Factor: 4.472
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    Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
    * Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (549 views)
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    Impact Factor: 5.33
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    Matassa R, Carbone M, Lauceri R, Purrello R, Caminiti R
    * Supramolecular structure of extrinsically chiral porphyrin hetero-assemblies and achiral analogues (319 views)
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    Impact Factor: 8.191
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    Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
    * Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (338 views)
    Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2006 Dec 15; 400: 521-530.
    Impact Factor: 4.1
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    Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
    * Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
    Impact Factor: 3.633
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    Cappiello M, Alterio  V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * A new spot test for sulfhydryl-containing compounds (450 views)
    Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
    Impact Factor: 2.305
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    Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (723 views)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
    Impact Factor: 3.633
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    Arena G, Casnati A, Contino A, Magrì A, Sansone F, Sciotto D, Ungaro R
    * Inclusion of naturally occurring amino acids in water soluble calix[4]arenes: A microcalorimetric and 1H NMR investigation supported by molecular modeling (388 views)
    Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Jan 21; 4(2): 243-249.
    Impact Factor: 2.874
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    Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
    * Erratum: Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (Proteins: Structure, Function and Bioinformatics (2006) 62 (604-616)) (241 views)
    Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006; 65(2): 524-524.
    Impact Factor: 3.73
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    Berisio R, Loguercio S, De Simone A, Zagari A, Vitagliano L
    * Polyproline helices in protein structures: A statistical survey (333 views)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2006; 13(8): 847-854.
    Impact Factor: 1.13
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    Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
    * Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (406 views)
    Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
    Impact Factor: 5.854
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    Angela M, Massimo De N, Rosaria L, Roberto P
    * Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
    Impact Factor: 2.286
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    Esposito L, Daggett V
    * Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (438 views)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
    Impact Factor: 3.848
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    De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
    * Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
    Impact Factor: 2.545
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    Lauceria R, Purrellob R
    * Transfer, memory and amplification of chirality in porphyrin aggregates (303 views)
    Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
    Impact Factor: 1.715
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    Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
    * Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (378 views)
    J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
    Impact Factor: 3.3
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    Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
    * Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (384 views)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
    Impact Factor: 2.863
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    Caridi A, Cufari A, Lovino R, Palumbo R, Tedesco I
    * Influence of Yeast on Polyphenol Composition of Wine (243 views)
    Food Technol Biotechnol (ISSN: 1330-9862), 2004 Jan; 42(1): 37-40.
    Impact Factor: 0.475
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    De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
    * A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (460 views)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
    Impact Factor: 2.863
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    Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
    * Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (589 views)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
    Impact Factor: 2.863
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    Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
    * Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
    Impact Factor: 2.863
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    Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
    * Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (490 views)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
    Impact Factor: 6.201
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    Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
    * From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (668 views)
    J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
    Impact Factor: 9.023
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    Saracino GAA, Tedeschi A, D'Errico G, Improta R, Franco L, Ruzzi M, Corvaia C, Barone V
    * Solvent polarity and pH effects on the magnetic properties of ionizable nitroxide radicals: A combined computational and experimental study of 2, 2, 5, 5-tetramethyl-3-carboxypyrrolidine and 2, 2, 6, 6-tetramethyl-4-carboxypiperidine nitroxides (280 views)
    J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2002; 106(44): 10700-10706.
    Impact Factor: 2.765
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    Lauceri R, Purrello R, Shetty SJ, Vicente MGH
    * Interactions of anionic carboranylated porphyrins with DNA [3] (358 views)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2001 Jun 20; 123(24): 5835-5836.
    Impact Factor: 6.079
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    Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
    * Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (456 views)
    Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
    Impact Factor: 1.021
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    Bonomo RP, Boudet AM, Cozzolino R, Rizzarelli E, Santoro AM, Sterjiades R, Zappalà R
    A comparative study of two isoforms of laccase secreted by the 'white- rot' fungus Rigidoporus lignosus, exhibiting significant structural and functional differences (296 views)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1998 Sep; 71(3-4): 205-211.
    Impact Factor: 1.162
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    De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
    New synthetic tools for peptide-tetraphenylporphyrin derivatives (326 views)
    Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
    Impact Factor: 0.557
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    Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
    Miniaturized hemoproteins (423 views)
    Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
    Impact Factor: 2.086
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    Purrello R, Bellacchio E, Gurrieri S, Lauceri R, Raudino A, Monsù Scolaro L, Santoro AM
    Ph Modulation Of Porphyrins Self-Assembly Onto Polylisine (241 views)
    Journal Of Physical Chemistry B, 1998; N/D: 8852-8857.
    Impact Factor: 0
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    Colasanti A, Kisslinger A, Kusch D, Liuzzi R, Mastrocinque M, Montforts FP, Quarto M, Riccio P, Roberti G, Villani F
    In vitro photo-activation of newly synthesized chlorin derivatives with red-light-emitting diodes (331 views)
    J Photochem Photobiol B (ISSN: 1011-1344print, 1011-1344linking), 1997 Mar; 38(1): 54-60.
    Impact Factor: 1.381
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    Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
    Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
    Impact Factor: 2.425
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    Mastruzzo L, Woisard A, Ma DD, Rizzarelli E, Favre A, Le Doan T
    TARGETED PHOTOCHEMICAL MODIFICATION OF HIV-DERIVED OLIGORIBONUCLEOTIDES BY ANTISENSE OLIGODEOXYNUCLEOTIDES LINKED TO PORPHYRINS (275 views)
    Photochem Photobiol (ISSN: 0031-8655), 1994 Oct; 60(4): 316-322.
    Impact Factor: 2.426
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    Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
    Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (396 views)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
    Impact Factor: 2.425
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    95 Records (94 excluding Abstracts).
    Total impact factor: 401.274 (397.544 excluding Abstracts).
    Total 5 year impact factor: 411.654 (408.69 excluding Abstracts).

    Last modified by Marco Comerci on Sunday 12 July 2020, 13:14:47
    679 views. Last view on Thursday 09 March 2023, 18:11:58