Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by (123)I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease (534 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Apr; 43(4): 729-739.
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Paper type: Journal Article,
Impact factor: 7.277, 5-year impact factor: 6.218
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84959108896&partnerID=40&md5=98a8818eaf7cdbdcc2d8eed84b05e5d7
Keywords: 123i-Metaiodobenzylguanidine, Anderson-Fabry Disease, Cardiac Sympathetic Function, Diastolic Dysfunction,
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy
National Council of Research, Institute of Biostructure and Bioimaging, Naples, Italy
Department of Public Health, University Federico II, Naples, Italy
IRCCS SDN, Naples, Italy
References:
Not available.
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Apr; 43(4): 729-739.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.277, 5-year impact factor: 6.218
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84959108896&partnerID=40&md5=98a8818eaf7cdbdcc2d8eed84b05e5d7
Keywords: 123i-Metaiodobenzylguanidine, Anderson-Fabry Disease, Cardiac Sympathetic Function, Diastolic Dysfunction,
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy
National Council of Research, Institute of Biostructure and Bioimaging, Naples, Italy
Department of Public Health, University Federico II, Naples, Italy
IRCCS SDN, Naples, Italy
References:
Not available.
Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by (123)I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease
Purpose: Whether cardiac sympathetic nervous function abnormalities may be present in patients with Anderson-Fabry disease (AFD) remains unexplored. We investigated the relationship between left ventricular (LV) function and cardiac sympathetic nervous function in patients with AFD. Methods: Twenty-five patients (12 men, mean age 43 ± 13 years) with genetically proved AFD and preserved LV ejection fraction and ten age and gender-matched control subjects underwent speckle tracking echocardiography and 123I-meta-iodobenzylguanidine (MIBG) imaging from which early and late heart to mediastinum (H/M) ratios and myocardial washout rate values were calculated. Results: In AFD patients, a significant correlation between late H/M ratio and LV mass index (r = −61, p = 0.001), left atrial volume (r = −0.72, p < 0.001), systolic pulmonary artery pressure (r = −0.75, p < 0.001), and early diastolic untwisting rate (r = −0.66, p < 0.001) was found. Ten AFD patients exhibited a late H/M ratio below two fold standard deviation of control subjects (≤1.75). Patients showing late H/M ratio ≤ 1.75 had significantly higher LV mass index, relative wall thickness, left atrial volume and systolic pulmonary artery pressure, lower systolic longitudinal strain and an early diastolic untwisting rate compared to patients with late H/M ratio > 1.75. At multivariable linear regression analysis, early diastolic untwisting rate was the only independent predictor of late H/M ratio ≤ 1.75 (odds ratio 1.15, 95 % confidence interval 1.07–1.31, p < 0.05). Conclusion: The present findings provide the first demonstration of a cardiac sympathetic derangement in AFD patients with preserved LV ejection fraction, which is mostly related to LV diastolic dysfunction. © 2015, Springer-Verlag Berlin Heidelberg.
Purpose: Whether cardiac sympathetic nervous function abnormalities may be present in patients with Anderson-Fabry disease (AFD) remains unexplored. We investigated the relationship between left ventricular (LV) function and cardiac sympathetic nervous function in patients with AFD. Methods: Twenty-five patients (12 men, mean age 43 ± 13 years) with genetically proved AFD and preserved LV ejection fraction and ten age and gender-matched control subjects underwent speckle tracking echocardiography and 123I-meta-iodobenzylguanidine (MIBG) imaging from which early and late heart to mediastinum (H/M) ratios and myocardial washout rate values were calculated. Results: In AFD patients, a significant correlation between late H/M ratio and LV mass index (r = −61, p = 0.001), left atrial volume (r = −0.72, p < 0.001), systolic pulmonary artery pressure (r = −0.75, p < 0.001), and early diastolic untwisting rate (r = −0.66, p < 0.001) was found. Ten AFD patients exhibited a late H/M ratio below two fold standard deviation of control subjects (≤1.75). Patients showing late H/M ratio ≤ 1.75 had significantly higher LV mass index, relative wall thickness, left atrial volume and systolic pulmonary artery pressure, lower systolic longitudinal strain and an early diastolic untwisting rate compared to patients with late H/M ratio > 1.75. At multivariable linear regression analysis, early diastolic untwisting rate was the only independent predictor of late H/M ratio ≤ 1.75 (odds ratio 1.15, 95 % confidence interval 1.07–1.31, p < 0.05). Conclusion: The present findings provide the first demonstration of a cardiac sympathetic derangement in AFD patients with preserved LV ejection fraction, which is mostly related to LV diastolic dysfunction. © 2015, Springer-Verlag Berlin Heidelberg.
Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by (123)I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease
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Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by (123)I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Pellegrino T, Petretta M, Paolillo S, Boemio A, Carotenuto R, Petretta MP, Di Nuzzo C, Perrone-filardi P, Cuocolo A
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Impact Factor: 5.217
View Export to BibTeX Export to EndNote
Pellegrino T, Petretta M, Boemio A, Carotenuto R, Petretta MP, Paolillo S, Filardi PP, Cuocolo A
* Reliability and Agreement of Planar and Single-Photon Emission Computed Tomography 123I-Metaiodobenzylguanidine Cardiac Imaging in Patients with Heart Failure (467 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
View Export to BibTeX Export to EndNote
Petretta M, Acampa W, Fiumara G, Cuocolo A
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Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2013; 1(5): 325-339.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Messalli G, Imbriaco M, Avitabile G, Russo R, Iodice D, Spinelli L, Dellegrottaglie S, Cademartiri F, Salvatore M, Pisani A
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Impact Factor: 1.461
View Export to BibTeX Export to EndNote
Imbriaco M, Messalli G, Avitabile G, Cuocolo A, Maurea S, Soscia F, Pisani A
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Impact Factor: 2.062
View Export to BibTeX Export to EndNote
Sorriento D, Iaccarino G, Trimarco B
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View Export to BibTeX Export to EndNote
Imbriaco M, Pisani A, Spinelli L, Cuocolo A, Messalli G, Capuano E, Marmo M, Liuzzi R, Visciano B, Cianciaruso B, Salvatore M
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Impact Factor: 5.385
View Export to BibTeX Export to EndNote
Spinelli L, Nicolai E, Acampa W, Imbriaco M, Pisani A, Rao MA, Scopacasa F, Cianciaruso B, De Luca N, Cuocolo A
* Cardiac performance during exercise in patients with Fabry's disease (876 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2008 Dec; 38(12): 910-917.
Impact Factor: 2.784
View Export to BibTeX Export to EndNote
De Simone A, Esposito L, Pedone C, Vitagliano L
* Insights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses (1469 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 Sep 15; 95(4): 1965-1973.
Impact Factor: 4.683
View Export to BibTeX Export to EndNote
16 Records (14 excluding Abstracts).
Total impact factor: 55.084 (47.805 excluding Abstracts).
Total 5 year impact factor: 52.468 (45.385 excluding Abstracts).
Total impact factor: 55.084 (47.805 excluding Abstracts).
Total 5 year impact factor: 52.468 (45.385 excluding Abstracts).
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