Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures (387 views)
Nano Res (ISSN: 1998-0124), 2016; 9(3): 644-662.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.354, 5-year impact factor: 7.679
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84959470827&partnerID=40&md5=22dc094cc3848f21bdc91740ee8faab9
Keywords: Active Targeting, Cyclic Rgd Peptide, Magnetic Nanostructure, Nanocrystalline Heterostructures, Photoactive Semiconductor, αvβ3 Integrin,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, Italy
Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Via Orabona 4, Bari, Italy
Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone, 16, Napoli, Italy
Dipartimento di Farmacia – Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, Italy
Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, Italy
Istituto di Cristallografia-CNR, Via Amendola 122/O, Bari, Italy
References:
Park, K., Lee, S., Kang, E., Kim, K., Choi, K., Kwon, I.C., New generation of multifunctional nanoparticles for cancer imaging and therapy (2009) Adv. Funct. Mater., 19, pp. 1553-156
Bardhan, R., Lal, S., Joshi, A., Halas, N.J., Theranostic nanoshells: From probe design to imaging and treatment of cancer (2011) Acc. Chem. Res., 44, pp. 936-946
Fu, A.H., Wilson, R.J., Smith, B.R., Mullenix, J., Earhart, C., Akin, D., Guccione, S., Gambhir, S.S., Fluorescent magnetic nanoparticles for magnetically enhanced cancer imaging and targeting in living subjects (2012) ACS Nano, 6, pp. 6862-6869
Yu, J., Yang, C., Li, J., Ding, Y.C., Zhang, L., Yousaf, M.Z., Lin, J., Xu, L.L., Multifunctional Fe5C2 nanoparticles: A targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy (2014) Adv. Mater., 26, pp. 4114-4120
Tang, W., Zhen, Z.P., Yang, C., Wang, L.N., Cowger, T., Chen, H.M., Todd, T., Hou, Y.L., Fe5C2 nanoparticles with high MRI contrast enhancement for tumor imaging (2014) Small, 10, pp. 1245-1249
Bertrand, N., Wu, J., Xu, X.Y., Kamaly, N., Farokhzad, O.C., Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology (2014) Adv. Drug Deliv. Rev., 66, pp. 2-25
Banerjee, D., Harfouche, R., Sengupta, S., Nanotechnologymediated targeting of tumor angiogenesis (2011) Vascular Cell, 3, pp. 3-13
Montet, X., Montet-Abou, K., Reynolds, F., Weissleder, R., Josephson, L., Nanoparticle imaging of integrins on tumor cells (2006) Neoplasia, 8, pp. 214-222
Ye, Y.P., Chen, X.Y., Integrin targeting for tumor optical imaging (2011) Theranostics, 1, pp. 102-126
Danhier, F., Le Breton, A., Préat, V., RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis (2012) Mol. Pharm., 9, pp. 2961-2973
Scari, G., Porta, F., Fascio, U., Avvakumova, S.D., Santo, V.D., Simone, M., Saviano, M., Pedone, C., Gold nanoparticles capped by a GCcontaining peptide functionalized with an RGD motif for integrin targeting (2012) Bioconjugate Chem., 23, pp. 340-349
Lee, J., Lee, T.S., Ryu, J., Hong, S., Kang, M., Im, K., Kang, J.H., Song, R., RGD peptideconjugated multimodal NaGdF4: Yb3+/Er3+ nanophosphors for upconversion luminescence, MR, and PET imaging of tumor angiogenesis (2013) J. Nucl. Med., 54, pp. 96-103
Zhang, F., Huang, X.L., Zhu, L., Guo, N., Niu, G., Swierczewska, M., Lee, S., Mohamedali, K.A., Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles (2012) Biomaterials, 33, pp. 5414-5422
Shi, P., Chen, H.F., Cho, M.R., Stroscio, M.A., Peptidedirected binding of quantum dots to integrins in human fibroblast (2006) IEEE Trans. Nanobioscience, 5, pp. 15-19
Chen, H.W., Wang, L.Y., Yeh, J., Wu, X.Y., Cao, Z.H., Wang, Y.A., Zhang, M.M., Mao, H., Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-P?MPS copolymer coating (2010) Biomaterials, 31, pp. 5397-5407
Wang, C., Bao, C.C., Liang, S.J., Fu, H.L., Wang, K., Deng, M., Liao, Q.D., Cui, D.X., RGD-conjugated silicacoated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer (2014) Nanoscale Res. Lett., 9, p. 264
Nazli, C., Ergenc, T.I., Yar, Y., Acar, H.Y., Kizilel, S., RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells (2012) Int. J. Nanomedicine, 7, pp. 1903-1920
Gao, J.H., Chen, K., Xie, R.G., Xie, J., Yan, Y.J., Cheng, Z., Peng, X.G., Chen, X.Y., In vivo tumor-targeted fluorescence imaging using near-infrared non-cadmium quantum dots (2010) Bioconjugate Chem., 21, pp. 604-609
Yin, H.Q., Mai, D.S., Gan, F., Chen, X.J., One-step synthesis of linear and cyclic RGD conjugated gold nanoparticles for tumour targeting and imaging (2014) RSC Adv., 4, pp. 9078-9085
Arosio, D., Manzoni, L., Araldi, E.M.V., Scolastico, C., Cyclic RGD functionalized gold nanoparticles for tumor targeting (2011) Bioconjugate Chem., 22, pp. 664-672
Depalo, N., Carrieri, P., Comparelli, R., Striccoli, M., Agostiano, A., Bertinetti, L., Innocenti, C., Curri, M.L., Biofunctionalization of anisotropic nanocrystalline semiconductor-magnetic heterostructures (2011) Langmuir, 27, pp. 6962-6970
Santhosh, P.B., Ulrih, N.P., Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics (2013) Cancer Lett., 336, pp. 8-17
Hao, R., Xing, R.J., Xu, Z.C., Hou, Y.L., Gao, S., Sun, S.H., Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles (2010) Adv. Mater., 22, pp. 2729-2742
Yin, Z.F., Wu, L., Yang, H.G., Su, Y.H., Recent progress in biomedical applications of titanium dioxide (2013) Phys. Chem. Chem. Phys., 15, pp. 4844-4858
Thurn, K.T., Arora, H., Paunesku, T., Wu, A.G., Brown, E.M.B., Doty, C., Kremer, J., Woloschak, G., Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells (2011) Nanomedicine, 7, pp. 123-130
Huang, K.Q., Chen, L., Deng, J.G., Xiong, J.W., Enhanced visible-light photocatalytic performance of nanosized anatase TiO2 doped with CdS quantum dots for cancer-cell treatment (2012) J. Nanomater., p. 2012
Mallik, A., Bryan, S., Puukila, S., Chen, A.C., Khaper, N., Efficacy of Pt-modified TiO2 nanoparticles in cardiac cells (2011) Exp. Clin. Cardiol., 16, pp. 6-10
Nolan, M., Electronic coupling in iron oxide-modified TiO2 leads to a reduced band gap and charge separation for visible light active photocatalysis (2011) Phys. Chem. Chem. Phys., 13, pp. 18194-18199
Jokerst, J.V., Lobovkina, T., Zare, R.N., Gambhir, S.S., Nanoparticle PEGylation for imaging and therapy (2011) Nanomedicine, 6, pp. 715-728
Buonsanti, R., Grillo, V., Carlino, E., Giannini, C., Curri, M.L., Innocenti, C., Sangregorio, C., Agostiano, A., Seeded growth of asymmetric binary nanocrystals made of a semiconductor TiO2 rodlike section and a magnetic Fe2O3spherical domain (2006) J. Am. Chem. Soc., 128, pp. 16953-16970
Dubertret, B., Skourides, P., Norris, D.J., Noireaux, V., Brivanlou, A.H., Libchaber, A., In vivo imaging of quantum dots encapsulated in phospholipid micelles (2002) Science, 298, pp. 1759-1762
Sarkar, R., Ghosh, M., Pal, S.K., Ultrafast relaxation dynamics of a biologically relevant probe dansyl at the micellar surface (2005) J. Photochem. Photobiol. B, 78, pp. 93-98
Holmes-Farley, S.R., Whitesides, G.M., Fluorescence properties of dansyl groups covalently bonded to the surface of oxidatively functionalized low-density polyethylene film (1986) Langmuir, 2, pp. 266-281
Karabacak, M., Cinar, M., Kurt, M., Poiyamozhi, A., Sundaraganesan, N., The spectroscopic (FT-IR, FT-Raman, UV and NMR) first order hyperpolarizability and HOMO–LUMO analysis of dansyl chloride (2014) Spectrochim. Acta A Mol. Biomol. Spectrosc., 117, pp. 234-244
Capaßso, D., de Paola, I., Liguoro, A.D., Gatto, A., Di Gaetano, S., Guarnieri, D., Saviano, M., Zaccaro, L., RGDechihCit: avß3 selective pro-apoptotic peptide as potential carrier for drug delivery into melanoma metastatic cells (2014) PLoS One, 9, p. 10644
Graf, N., Bielenberg, D.R., Kolishetti, N., Muus, C., Banyard, J., Farokhzad, O.C., Lippard, S.J., avß3 integrintargeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug (2012) ACS Nano, 6, pp. 4530-4539
Castel, S., Pagan, R., Mitjans, F., Piulats, J., Goodman, S., Jonczyk, A., Huber, F., Reina, M., RGD peptides and monoclonal antibodies, antagonists of av-integrin, enter the cells by independent endocytic pathways (2001) Lab. Invest., 81, pp. 1615-1626
Aguzzi, M.S., Fortugno, P., Giampietri, C., Ragone, G., Capogrossi, M.C., Facchiano, A., Intracellular targets of RGDS peptide in melanoma cells (2010) Mol. Cancer, 9, p. 84
Nano Res (ISSN: 1998-0124), 2016; 9(3): 644-662.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 7.354, 5-year impact factor: 7.679
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84959470827&partnerID=40&md5=22dc094cc3848f21bdc91740ee8faab9
Keywords: Active Targeting, Cyclic Rgd Peptide, Magnetic Nanostructure, Nanocrystalline Heterostructures, Photoactive Semiconductor, αvβ3 Integrin,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, Italy
Istituto per i Processi Chimico-Fisici-CNR UOS Bari, Via Orabona 4, Bari, Italy
Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone, 16, Napoli, Italy
Dipartimento di Farmacia – Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, Italy
Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, Italy
Istituto di Cristallografia-CNR, Via Amendola 122/O, Bari, Italy
References:
Park, K., Lee, S., Kang, E., Kim, K., Choi, K., Kwon, I.C., New generation of multifunctional nanoparticles for cancer imaging and therapy (2009) Adv. Funct. Mater., 19, pp. 1553-156
Bardhan, R., Lal, S., Joshi, A., Halas, N.J., Theranostic nanoshells: From probe design to imaging and treatment of cancer (2011) Acc. Chem. Res., 44, pp. 936-946
Fu, A.H., Wilson, R.J., Smith, B.R., Mullenix, J., Earhart, C., Akin, D., Guccione, S., Gambhir, S.S., Fluorescent magnetic nanoparticles for magnetically enhanced cancer imaging and targeting in living subjects (2012) ACS Nano, 6, pp. 6862-6869
Yu, J., Yang, C., Li, J., Ding, Y.C., Zhang, L., Yousaf, M.Z., Lin, J., Xu, L.L., Multifunctional Fe5C2 nanoparticles: A targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy (2014) Adv. Mater., 26, pp. 4114-4120
Tang, W., Zhen, Z.P., Yang, C., Wang, L.N., Cowger, T., Chen, H.M., Todd, T., Hou, Y.L., Fe5C2 nanoparticles with high MRI contrast enhancement for tumor imaging (2014) Small, 10, pp. 1245-1249
Bertrand, N., Wu, J., Xu, X.Y., Kamaly, N., Farokhzad, O.C., Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology (2014) Adv. Drug Deliv. Rev., 66, pp. 2-25
Banerjee, D., Harfouche, R., Sengupta, S., Nanotechnologymediated targeting of tumor angiogenesis (2011) Vascular Cell, 3, pp. 3-13
Montet, X., Montet-Abou, K., Reynolds, F., Weissleder, R., Josephson, L., Nanoparticle imaging of integrins on tumor cells (2006) Neoplasia, 8, pp. 214-222
Ye, Y.P., Chen, X.Y., Integrin targeting for tumor optical imaging (2011) Theranostics, 1, pp. 102-126
Danhier, F., Le Breton, A., Préat, V., RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis (2012) Mol. Pharm., 9, pp. 2961-2973
Scari, G., Porta, F., Fascio, U., Avvakumova, S.D., Santo, V.D., Simone, M., Saviano, M., Pedone, C., Gold nanoparticles capped by a GCcontaining peptide functionalized with an RGD motif for integrin targeting (2012) Bioconjugate Chem., 23, pp. 340-349
Lee, J., Lee, T.S., Ryu, J., Hong, S., Kang, M., Im, K., Kang, J.H., Song, R., RGD peptideconjugated multimodal NaGdF4: Yb3+/Er3+ nanophosphors for upconversion luminescence, MR, and PET imaging of tumor angiogenesis (2013) J. Nucl. Med., 54, pp. 96-103
Zhang, F., Huang, X.L., Zhu, L., Guo, N., Niu, G., Swierczewska, M., Lee, S., Mohamedali, K.A., Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles (2012) Biomaterials, 33, pp. 5414-5422
Shi, P., Chen, H.F., Cho, M.R., Stroscio, M.A., Peptidedirected binding of quantum dots to integrins in human fibroblast (2006) IEEE Trans. Nanobioscience, 5, pp. 15-19
Chen, H.W., Wang, L.Y., Yeh, J., Wu, X.Y., Cao, Z.H., Wang, Y.A., Zhang, M.M., Mao, H., Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-P?MPS copolymer coating (2010) Biomaterials, 31, pp. 5397-5407
Wang, C., Bao, C.C., Liang, S.J., Fu, H.L., Wang, K., Deng, M., Liao, Q.D., Cui, D.X., RGD-conjugated silicacoated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer (2014) Nanoscale Res. Lett., 9, p. 264
Nazli, C., Ergenc, T.I., Yar, Y., Acar, H.Y., Kizilel, S., RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells (2012) Int. J. Nanomedicine, 7, pp. 1903-1920
Gao, J.H., Chen, K., Xie, R.G., Xie, J., Yan, Y.J., Cheng, Z., Peng, X.G., Chen, X.Y., In vivo tumor-targeted fluorescence imaging using near-infrared non-cadmium quantum dots (2010) Bioconjugate Chem., 21, pp. 604-609
Yin, H.Q., Mai, D.S., Gan, F., Chen, X.J., One-step synthesis of linear and cyclic RGD conjugated gold nanoparticles for tumour targeting and imaging (2014) RSC Adv., 4, pp. 9078-9085
Arosio, D., Manzoni, L., Araldi, E.M.V., Scolastico, C., Cyclic RGD functionalized gold nanoparticles for tumor targeting (2011) Bioconjugate Chem., 22, pp. 664-672
Depalo, N., Carrieri, P., Comparelli, R., Striccoli, M., Agostiano, A., Bertinetti, L., Innocenti, C., Curri, M.L., Biofunctionalization of anisotropic nanocrystalline semiconductor-magnetic heterostructures (2011) Langmuir, 27, pp. 6962-6970
Santhosh, P.B., Ulrih, N.P., Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics (2013) Cancer Lett., 336, pp. 8-17
Hao, R., Xing, R.J., Xu, Z.C., Hou, Y.L., Gao, S., Sun, S.H., Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles (2010) Adv. Mater., 22, pp. 2729-2742
Yin, Z.F., Wu, L., Yang, H.G., Su, Y.H., Recent progress in biomedical applications of titanium dioxide (2013) Phys. Chem. Chem. Phys., 15, pp. 4844-4858
Thurn, K.T., Arora, H., Paunesku, T., Wu, A.G., Brown, E.M.B., Doty, C., Kremer, J., Woloschak, G., Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells (2011) Nanomedicine, 7, pp. 123-130
Huang, K.Q., Chen, L., Deng, J.G., Xiong, J.W., Enhanced visible-light photocatalytic performance of nanosized anatase TiO2 doped with CdS quantum dots for cancer-cell treatment (2012) J. Nanomater., p. 2012
Mallik, A., Bryan, S., Puukila, S., Chen, A.C., Khaper, N., Efficacy of Pt-modified TiO2 nanoparticles in cardiac cells (2011) Exp. Clin. Cardiol., 16, pp. 6-10
Nolan, M., Electronic coupling in iron oxide-modified TiO2 leads to a reduced band gap and charge separation for visible light active photocatalysis (2011) Phys. Chem. Chem. Phys., 13, pp. 18194-18199
Jokerst, J.V., Lobovkina, T., Zare, R.N., Gambhir, S.S., Nanoparticle PEGylation for imaging and therapy (2011) Nanomedicine, 6, pp. 715-728
Buonsanti, R., Grillo, V., Carlino, E., Giannini, C., Curri, M.L., Innocenti, C., Sangregorio, C., Agostiano, A., Seeded growth of asymmetric binary nanocrystals made of a semiconductor TiO2 rodlike section and a magnetic Fe2O3spherical domain (2006) J. Am. Chem. Soc., 128, pp. 16953-16970
Dubertret, B., Skourides, P., Norris, D.J., Noireaux, V., Brivanlou, A.H., Libchaber, A., In vivo imaging of quantum dots encapsulated in phospholipid micelles (2002) Science, 298, pp. 1759-1762
Sarkar, R., Ghosh, M., Pal, S.K., Ultrafast relaxation dynamics of a biologically relevant probe dansyl at the micellar surface (2005) J. Photochem. Photobiol. B, 78, pp. 93-98
Holmes-Farley, S.R., Whitesides, G.M., Fluorescence properties of dansyl groups covalently bonded to the surface of oxidatively functionalized low-density polyethylene film (1986) Langmuir, 2, pp. 266-281
Karabacak, M., Cinar, M., Kurt, M., Poiyamozhi, A., Sundaraganesan, N., The spectroscopic (FT-IR, FT-Raman, UV and NMR) first order hyperpolarizability and HOMO–LUMO analysis of dansyl chloride (2014) Spectrochim. Acta A Mol. Biomol. Spectrosc., 117, pp. 234-244
Capaßso, D., de Paola, I., Liguoro, A.D., Gatto, A., Di Gaetano, S., Guarnieri, D., Saviano, M., Zaccaro, L., RGDechihCit: avß3 selective pro-apoptotic peptide as potential carrier for drug delivery into melanoma metastatic cells (2014) PLoS One, 9, p. 10644
Graf, N., Bielenberg, D.R., Kolishetti, N., Muus, C., Banyard, J., Farokhzad, O.C., Lippard, S.J., avß3 integrintargeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug (2012) ACS Nano, 6, pp. 4530-4539
Castel, S., Pagan, R., Mitjans, F., Piulats, J., Goodman, S., Jonczyk, A., Huber, F., Reina, M., RGD peptides and monoclonal antibodies, antagonists of av-integrin, enter the cells by independent endocytic pathways (2001) Lab. Invest., 81, pp. 1615-1626
Aguzzi, M.S., Fortugno, P., Giampietri, C., Ragone, G., Capogrossi, M.C., Facchiano, A., Intracellular targets of RGDS peptide in melanoma cells (2010) Mol. Cancer, 9, p. 84
Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures
Binary asymmetric nanocrystals (BNCs), composed of a photoactive TiO2 nanorod joined with a superparamagnetic γ-Fe2O3 spherical domain, were embedded in polyethylene glycol modified phospholipid micelle and successfully bioconjugated to a suitably designed peptide containing an RGD motif. BNCs represent a relevant multifunctional nanomaterial, owing to the coexistence of two distinct domains in one particle, characterized by high photoactivity and magnetic properties, that is particularly suited for use as a phototherapy and hyperthermia agent as well as a magnetic probe in biological imaging. We selected the RGD motif in order to target integrin expressed on activated endothelial cells and several types of cancer cells. The prepared RGD-peptide/BNC conjugates, comprehensively monitored by using complementary optical and structural techniques, demonstrated a high stability and uniform dispersibility in biological media. The cytotoxicity of the RGD-peptide/BNC conjugates was studied in vitro. The cellular uptake of RGD-peptide conjugates in the cells, assessed by means of two distinct approaches, namely confocal microscopy analysis and emission spectroscopy determination in cell lysates, displayed selectivity of the RGD-peptide-BNC conjugate for the αvβ3 integrin. These RGD-peptide-BNC conjugates have a high potential for theranostic treatment of cancer. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.
Binary asymmetric nanocrystals (BNCs), composed of a photoactive TiO2 nanorod joined with a superparamagnetic γ-Fe2O3 spherical domain, were embedded in polyethylene glycol modified phospholipid micelle and successfully bioconjugated to a suitably designed peptide containing an RGD motif. BNCs represent a relevant multifunctional nanomaterial, owing to the coexistence of two distinct domains in one particle, characterized by high photoactivity and magnetic properties, that is particularly suited for use as a phototherapy and hyperthermia agent as well as a magnetic probe in biological imaging. We selected the RGD motif in order to target integrin expressed on activated endothelial cells and several types of cancer cells. The prepared RGD-peptide/BNC conjugates, comprehensively monitored by using complementary optical and structural techniques, demonstrated a high stability and uniform dispersibility in biological media. The cytotoxicity of the RGD-peptide/BNC conjugates was studied in vitro. The cellular uptake of RGD-peptide conjugates in the cells, assessed by means of two distinct approaches, namely confocal microscopy analysis and emission spectroscopy determination in cell lysates, displayed selectivity of the RGD-peptide-BNC conjugate for the αvβ3 integrin. These RGD-peptide-BNC conjugates have a high potential for theranostic treatment of cancer. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.
Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures
| ▼ New synthetic molecules for active targeting of multifunctional theranostic nanosystems |
Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures
Other filter: ([btitle,keywords] "Active Targeting" OR ...
Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (416 views) (PDF 184 views)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
View Export to BibTeX Export to EndNote
Monaco I, Arena F, Biffi S, Locatelli E, Bortot B, La Cava F, Marini GM, Severini GM, Terreno E, Comes Franchini M
* Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging (371 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2017 May 17; 28(5): 1382-1390.
Impact Factor: 4.485
View Export to BibTeX Export to EndNote
Di Pietro P, Zaccaro L, Comegna D, Del Gatto A, Saviano M, Snyders R, Cossement D, Satriano C, Rizzarelli E
* Silver nanoparticles functionalized with a fluorescent cyclic RGD peptide: a versatile integrin targeting platform for cells and bacteria (311 views) (PDF 162 views)
The Royal Society Of Chemistry, 2016 Jan 01; 6: N/D-N/D.
Impact Factor: 3.564
View Export to BibTeX Export to EndNote
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (571 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
View Export to BibTeX Export to EndNote
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (416 views) (PDF 184 views)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
View Export to BibTeX Export to EndNote
Monaco I, Arena F, Biffi S, Locatelli E, Bortot B, La Cava F, Marini GM, Severini GM, Terreno E, Comes Franchini M
* Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging (371 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2017 May 17; 28(5): 1382-1390.
Impact Factor: 4.485
View Export to BibTeX Export to EndNote
Di Pietro P, Zaccaro L, Comegna D, Del Gatto A, Saviano M, Snyders R, Cossement D, Satriano C, Rizzarelli E
* Silver nanoparticles functionalized with a fluorescent cyclic RGD peptide: a versatile integrin targeting platform for cells and bacteria (311 views) (PDF 162 views)
The Royal Society Of Chemistry, 2016 Jan 01; 6: N/D-N/D.
Impact Factor: 3.564
View Export to BibTeX Export to EndNote
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (571 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
View Export to BibTeX Export to EndNote
4 Records (4 excluding Abstracts).
Total impact factor: 20.529 (20.529 excluding Abstracts).
Total 5 year impact factor: 17.442 (17.442 excluding Abstracts).
Total impact factor: 20.529 (20.529 excluding Abstracts).
Total 5 year impact factor: 17.442 (17.442 excluding Abstracts).
387 views. Last view on Tuesday 28 February 2023, 4:59:46
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