Cisplatin binding to proteins: A structural perspective (1085 views)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
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Paper type: Journal Article,
Impact factor: 13.324, 5-year impact factor: 12.743
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84958253810&partnerID=40&md5=2cfdbf82e17b3646e067691b1b5624ed
Keywords: Antitumor Agents, Bioinorganic Chemistry, Cisplatin, Medicinal Chemistry, Metallodrugs, Platinated Proteins,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI, Italy
CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, Napoli, Italy
References:
Not available.
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 13.324, 5-year impact factor: 12.743
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84958253810&partnerID=40&md5=2cfdbf82e17b3646e067691b1b5624ed
Keywords: Antitumor Agents, Bioinorganic Chemistry, Cisplatin, Medicinal Chemistry, Metallodrugs, Platinated Proteins,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI, Italy
CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, Napoli, Italy
References:
Not available.
Cisplatin binding to proteins: A structural perspective
The interactions of clinically established anticancer Pt-based drugs with proteins play crucial roles in Pt cellular uptake and biodistribution, as well as in determining side effects and resistance, thus affecting the overall pharmacological profile of this class of drugs. Here, we summarize a number of recent crystallographic studies of cisplatin/protein adducts that contribute unveiling the molecular basis for cisplatin-protein recognition. Details of each molecular structure are carefully and comparatively described; common trends and regularities occurring in the analyzed adducts are highlighted. Analysis of the structural features of its protein derivatives, integrated with selected results arising from the application of other biophysical methods on strictly related systems, allows an overall elucidation of the protein platination process and offers a more comprehensive understanding of the mode of action of cisplatin and its parent Pt-based drugs. © 2016 Elsevier B.V.
The interactions of clinically established anticancer Pt-based drugs with proteins play crucial roles in Pt cellular uptake and biodistribution, as well as in determining side effects and resistance, thus affecting the overall pharmacological profile of this class of drugs. Here, we summarize a number of recent crystallographic studies of cisplatin/protein adducts that contribute unveiling the molecular basis for cisplatin-protein recognition. Details of each molecular structure are carefully and comparatively described; common trends and regularities occurring in the analyzed adducts are highlighted. Analysis of the structural features of its protein derivatives, integrated with selected results arising from the application of other biophysical methods on strictly related systems, allows an overall elucidation of the protein platination process and offers a more comprehensive understanding of the mode of action of cisplatin and its parent Pt-based drugs. © 2016 Elsevier B.V.
Cisplatin binding to proteins: A structural perspective
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Cisplatin binding to proteins: A structural perspective
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20 Records (19 excluding Abstracts).
Total impact factor: 89.673 (84.558 excluding Abstracts).
Total 5 year impact factor: 84.254 (78.75 excluding Abstracts).
Total impact factor: 89.673 (84.558 excluding Abstracts).
Total 5 year impact factor: 84.254 (78.75 excluding Abstracts).
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