Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme
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Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme (318 views)

Ferraro G, Pica A, Russo Krauss I, Pane F, Amoresano A, Merlino A

J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2016; N/D: 1-10.

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Paper type: Journal Article,

Impact factor: 2.894, 5-year impact factor: 2.681

Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84962145344&partnerID=40&md5=4da59018e31bc36a7100526355df83d8

Keywords: Cisplatin, Hen Egg White Lysozyme, Metallodrugs, Platinum-Based Drugs, Protein–ligand Interactions,

Affiliations:
*** IBB - CNR ***

Department of Chemical Sciences, University of Naples Federico II, via Cintia, Naples, Italy
CNR Institute of Biostructure and Bioimages, via Mezzocannone 16, Naples, Italy


References:
Not available.
Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme

The products of the reaction between cisplatin (CDDP) and the model protein hen egg white lysozyme (HEWL) at 20, 37 and 55 °C in pure water were studied by UV–Vis absorption spectroscopy, intrinsic fluorescence and circular dichroism, dynamic and electrophoretic light scattering and inductively coupled plasma mass spectrometry. X-ray structures were also solved for the adducts formed at 20 and 55 °C. Data demonstrate that high temperature facilitates the formation of CDDP-HEWL adducts, where Pt atoms bind ND1 atom of His15 or NE2 atom of His15 and NH1 atom of Arg14. Our study suggests that high human body temperature (fever) could increase the rate of drug binding to proteins thus enhancing possible toxic side effects related to CDDP administration. © 2016 SBIC
Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme

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Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme

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9 Records (9 excluding Abstracts).
Total impact factor: 47.344 (47.344 excluding Abstracts).
Total 5 year impact factor: 46.095 (46.095 excluding Abstracts).

Last modified by Gennaro Angrisano on Sunday 12 July 2020, 13:14:47
318 views. Last view on Thursday 12 September 2024, 19:13:00