Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper (416 views)
Coord Chem Rev (ISSN: 0010-8545), 2016; 311: 125-167.
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Paper type: Journal Article,
Impact factor: 13.324, 5-year impact factor: 12.743
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84953888878&partnerID=40&md5=96775c8064538cb3e9cbc59162173222
Keywords: Cellular Metal Sensors, Confocal Microscopy, Cu Receptors, Intracellular Bioinorganic Chemistry, Metallome, Neuropathology, Zn Receptors,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Catania, viale Andrea Doria 6, Catania, Italy
Institute of Biostructures and Bioimages, National Council of Research (IBB-CNR), Via P. Gaifami 18, Catania, Italy
References:
Not available.
Coord Chem Rev (ISSN: 0010-8545), 2016; 311: 125-167.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 13.324, 5-year impact factor: 12.743
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84953888878&partnerID=40&md5=96775c8064538cb3e9cbc59162173222
Keywords: Cellular Metal Sensors, Confocal Microscopy, Cu Receptors, Intracellular Bioinorganic Chemistry, Metallome, Neuropathology, Zn Receptors,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Catania, viale Andrea Doria 6, Catania, Italy
Institute of Biostructures and Bioimages, National Council of Research (IBB-CNR), Via P. Gaifami 18, Catania, Italy
References:
Not available.
Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper
The intracellular tracking of zinc and copper, metals essential for life, is nowadays pivotal to unravel the complex mechanism that involves the physiological or pathological role of such elements. Traditional methods to determine cellular copper and zinc levels, including those based on the use of fluorescent probes, are aimed at scrutinizing the metallome, to identify both the individual species and their concentrations. The metallome, however, is also a nonstatic concept, as it responds to environmental perturbations in biologically relevant pathways, with highly dynamic spatiotemporal changes. Through an overview of improvements and limits of the state of the art of synthetic fluorescent probes for the detection of intracellular zinc and copper, we report here new routes for the design and the synthesis of novel metal coordination compounds able to overcome the present weaknesses for a new concept of dynamic metallostasis. © 2015 Elsevier B.V..
The intracellular tracking of zinc and copper, metals essential for life, is nowadays pivotal to unravel the complex mechanism that involves the physiological or pathological role of such elements. Traditional methods to determine cellular copper and zinc levels, including those based on the use of fluorescent probes, are aimed at scrutinizing the metallome, to identify both the individual species and their concentrations. The metallome, however, is also a nonstatic concept, as it responds to environmental perturbations in biologically relevant pathways, with highly dynamic spatiotemporal changes. Through an overview of improvements and limits of the state of the art of synthetic fluorescent probes for the detection of intracellular zinc and copper, we report here new routes for the design and the synthesis of novel metal coordination compounds able to overcome the present weaknesses for a new concept of dynamic metallostasis. © 2015 Elsevier B.V..
Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper
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Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper
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View Export to BibTeX Export to EndNote
Fragassi NA, Chiacchio L, Errichiello L, Pappata S, Tedeschi MR, Striano P, Striano S
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Neurol Sci (ISSN: 1590-1874, 1590-3478, 1590-1874linking), 2011 Dec; 32(6): 1129-1133.
Impact Factor: 1.315
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (470 views)
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
Impact Factor: 0
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (607 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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29 Records (27 excluding Abstracts).
Total impact factor: 114.643 (107.875 excluding Abstracts).
Total 5 year impact factor: 115.06 (107.343 excluding Abstracts).
Total impact factor: 114.643 (107.875 excluding Abstracts).
Total 5 year impact factor: 115.06 (107.343 excluding Abstracts).
416 views. Last view on Sunday 21 July 2024, 22:47:29
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